| 1 | Tue Nov 5 | at Alabama | W81-80 | 1-0 | 1.000 | - | | Coleman Coliseum · Tuscaloosa, AL |
| 2 | Sat Nov 9 | atRice | L61-80 | 1-1 | .500 | - | | Tudor Fieldhouse · Houston, TX |
| 3 | Wed Nov 13 | vsLa Salle | W75-59 | 2-1 | .667 | - | | The Palestra · Philadelphia, PA |
| 4 | Tue Nov 19 | atLafayette | L75-86 | 2-2 | .500 | - | | Kirby Sports Center · Easton, PA |
| 5 | Sat Nov 23 | atProvidence | W81-75 | 3-2 | .600 | - | FS2 | Amica Mutual Pavilion · Providence, RI |
| 6 | Thu Nov 28 | vsUCF | W68-67 | 4-2 | .667 | - | ESPNU | The Palestra · Philadelphia, PA |
| 7 | Fri Nov 29 | atArizona | L82-92 | 4-3 | .571 | - | ESPN2 | McKale Center · Tucson, AZ |
| 8 | Sun Dec 1 | vsLong Beach St | W95-79 | 5-3 | .625 | - | ESPN2 | The Palestra · Philadelphia, PA |
| 9 | Wed Dec 4 | at23Villanova | L69-80 | 5-4 | .556 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 10 | Sat Dec 21 | vsTBD | W105-57 | 6-4 | .600 | - | | The Palestra · Philadelphia, PA |
| 11 | Mon Dec 30 | atHoward | W81-62 | 7-4 | .636 | - | | Burr Gymnasium · Washington, D.C. |
| 12 | Sat Jan 4 | vsPrinceton | L64-78 | 7-5 | .583 | - | | The Palestra · Philadelphia, PA |
| 13 | Fri Jan 10 | atPrinceton | L58-63 | 7-6 | .538 | - | ESPNU | Jadwin Gymnasium · Princeton, NJ |
| 14 | Sat Jan 18 | vsSaint Joseph's | L81-87 | 7-7 | .500 | - | | The Palestra · Philadelphia, PA |
| 15 | Sat Jan 25 | vsTemple | W66-59 | 8-7 | .533 | - | | The Palestra · Philadelphia, PA |
| 16 | Fri Jan 31 | vsHarvard | W75-72 (OT) | 9-7 | .563 | - | ESPNU | The Palestra · Philadelphia, PA |
| 17 | Sat Feb 1 | vsDartmouth | W54-46 | 10-7 | .588 | - | | The Palestra · Philadelphia, PA |
| 18 | Fri Feb 7 | atColumbia | PPD | 0-0 | .000 | - | | Francis S. Levien Gymnasium · New York, NY |
| 19 | Sat Feb 8 | atColumbia | W76-67 | 11-7 | .611 | - | | Francis S. Levien Gymnasium · New York, NY |
| 20 | Sun Feb 9 | atCornell | W79-73 | 12-7 | .632 | - | | Newman Arena · Ithaca, NY |
| 21 | Fri Feb 14 | vsBrown | L63-75 | 12-8 | .600 | - | | The Palestra · Philadelphia, PA |
| 22 | Sat Feb 15 | vsYale | W69-61 | 13-8 | .619 | - | | The Palestra · Philadelphia, PA |
| 23 | Fri Feb 21 | atDartmouth | L59-66 | 13-9 | .591 | - | | Edward Leede Arena · Hanover, NH |
| 24 | Sat Feb 22 | atHarvard | L65-69 | 13-10 | .565 | - | | Lavietes Pavilion · Cambridge, MA |
| 25 | Fri Feb 28 | atYale | L73-76 | 13-11 | .542 | - | | John J. Lee Amphitheater · New Haven, CT |
| 26 | Sat Feb 29 | atBrown | W73-68 | 14-11 | .560 | - | | Pizzitola Sports Center · Providence, RI |
| 27 | Fri Mar 6 | vsCornell | W78-64 | 15-11 | .577 | - | | The Palestra · Philadelphia, PA |
| 28 | Sat Mar 7 | vsColumbia | W85-65 | 16-11 | .593 | - | | The Palestra · Philadelphia, PA |
