| 1 | Mon Nov 6 | vs TBD | W102-57 | 1-0 | 1.000 | - | | The Palestra · Philadelphia, PA |
| 2 | Wed Nov 8 | vsBucknell | W80-61 | 2-0 | 1.000 | - | | The Palestra · Philadelphia, PA |
| 3 | Fri Nov 10 | atSaint Joseph's | L61-69 | 2-1 | .667 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 4 | Mon Nov 13 | vs#21Villanova | W76-72 | 3-1 | .750 | - | | The Palestra · Philadelphia, PA |
| 5 | Sat Nov 18 | atMD-Eastern | L80-83 (OT) | 3-2 | .600 | - | | Hytche Athletic Center · Princess Anne, MD |
| 6 | Fri Nov 24 | vsLafayette | W74-72 | 4-2 | .667 | - | | The Palestra · Philadelphia, PA |
| 7 | Sat Nov 25 | vsBelmont | L79-84 (OT) | 4-3 | .571 | - | | The Palestra · Philadelphia, PA |
| 8 | Sun Nov 26 | vsMonmouth | W76-61 | 5-3 | .625 | - | | The Palestra · Philadelphia, PA |
| 9 | Sat Dec 2 | atLa Salle | L92-93 (OT) | 5-4 | .556 | - | | Tom Gola Arena · Philadelphia, PA |
| 10 | Wed Dec 6 | vsTBD | W111-57 | 6-4 | .600 | - | | The Palestra · Philadelphia, PA |
| 11 | Sat Dec 9 | at#16Kentucky | L66-81 | 6-5 | .545 | - | ESPN2 | Rupp Arena · Lexington, KY |
| 12 | Mon Dec 11 | vsHoward | W78-68 | 7-5 | .583 | - | | The Palestra · Philadelphia, PA |
| 13 | Sat Dec 23 | atRider | W77-73 (OT) | 8-5 | .615 | - | | Alumni Gymnasium (Rider) · Lawrenceville, NJ |
| 14 | Sat Dec 30 | at#3Houston | L42-81 | 8-6 | .571 | - | | Fertitta Center · Houston, TX |
| 15 | Tue Jan 2 | at#25Auburn | L68-88 | 8-7 | .533 | - | SEC Network | Neville Arena · Auburn, AL |
| 16 | Sat Jan 6 | vsDartmouth | W80-51 | 9-7 | .563 | - | | The Palestra · Philadelphia, PA |
| 17 | Mon Jan 15 | atCornell | L60-77 | 9-8 | .529 | - | | Newman Arena · Ithaca, NY |
| 18 | Sat Jan 20 | vsHarvard | L61-70 | 9-9 | .500 | - | ESPNU | The Palestra · Philadelphia, PA |
| 19 | Sat Jan 27 | atColumbia | L81-84 | 9-10 | .474 | - | | Francis S. Levien Gymnasium · New York, NY |
| 20 | Fri Feb 2 | atBrown | L61-70 | 9-11 | .450 | - | | Pizzitola Sports Center · Providence, RI |
| 21 | Sat Feb 3 | atYale | L58-74 | 9-12 | .429 | - | | John J. Lee Amphitheater · New Haven, CT |
| 22 | Sat Feb 10 | atPrinceton | L70-77 | 9-13 | .409 | - | | Jadwin Gymnasium · Princeton, NJ |
| 23 | Fri Feb 16 | vsYale | L62-76 | 9-14 | .391 | - | | The Palestra · Philadelphia, PA |
| 24 | Sat Feb 17 | vsBrown | L64-71 | 9-15 | .375 | - | | The Palestra · Philadelphia, PA |
| 25 | Fri Feb 23 | atDartmouth | W82-69 | 10-15 | .400 | - | | Edward Leede Arena · Hanover, NH |
| 26 | Sat Feb 24 | atHarvard | L70-74 | 10-16 | .385 | - | | Lavietes Pavilion · Cambridge, MA |
| 27 | Fri Mar 1 | vsCornell | L81-87 | 10-17 | .370 | - | | The Palestra · Philadelphia, PA |
| 28 | Sat Mar 2 | vsColumbia | W84-72 | 11-17 | .393 | - | | The Palestra · Philadelphia, PA |
| 29 | Sat Mar 9 | vsPrinceton | L83-105 | 11-18 | .379 | - | | The Palestra · Philadelphia, PA |
