| 1 | Wed Nov 10 | at #20Florida St | L70-105 | 0-1 | .000 | - | | Donald L. Tucker Center · Tallahassee, FL |
| 2 | Fri Nov 12 | atGeorge Mason | L66-87 | 0-2 | .000 | - | | EagleBank Arena · Fairfax, VA |
| 3 | Sun Nov 14 | atBucknell | W73-68 | 1-2 | .333 | - | | Sojka Pavilion · Lewisburg, PA |
| 4 | Tue Nov 16 | vsLafayette | W85-57 | 2-2 | .500 | - | | The Palestra · Philadelphia, PA |
| 5 | Thu Nov 18 | atUtah State | L79-87 (2OT) | 2-3 | .400 | - | ESPNU | Dee Glen Smith Spectrum · Logan, UT |
| 6 | Fri Nov 19 | vsDavidson | L60-72 | 2-4 | .333 | - | ESPNU | The Palestra · Philadelphia, PA |
| 7 | Sun Nov 21 | atOld Dominion | W71-63 | 3-4 | .429 | - | ESPNEWS | Chartway Arena · Norfolk, VA |
| 8 | Tue Nov 23 | atTowson | L61-76 | 3-5 | .375 | - | | SECU Arena · Towson, MD |
| 9 | Sun Nov 28 | at#13Arkansas | L60-76 | 3-6 | .333 | - | SEC Network | Bud Walton Arena · Fayetteville, AR |
| 10 | Wed Dec 1 | vs#6Villanova | L56-71 | 3-7 | .300 | - | | The Palestra · Philadelphia, PA |
| 11 | Sat Dec 4 | atTemple | L72-81 | 3-8 | .273 | - | ESPNU | Liacouras Center · Philadelphia, PA |
| 12 | Wed Dec 8 | atSaint Joseph's | L71-78 | 3-9 | .250 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 13 | Sat Dec 11 | atLa Salle | L74-76 | 3-10 | .231 | - | | Tom Gola Arena · Philadelphia, PA |
| 16 | Sun Jan 2 | vsBrown | W77-73 | 4-10 | .286 | - | | The Palestra · Philadelphia, PA |
| 18 | Fri Jan 7 | vsCornell | W79-65 | 5-10 | .333 | - | | The Palestra · Philadelphia, PA |
| 19 | Sat Jan 8 | vsColumbia | L69-73 | 5-11 | .313 | - | | The Palestra · Philadelphia, PA |
| 20 | Sat Jan 15 | vsDartmouth | W78-68 | 6-11 | .353 | - | | The Palestra · Philadelphia, PA |
| 21 | Mon Jan 17 | atPrinceton | L64-74 | 6-12 | .333 | - | | Jadwin Gymnasium · Princeton, NJ |
| 22 | Sat Jan 22 | vsYale | W76-68 | 7-12 | .368 | - | | The Palestra · Philadelphia, PA |
| 23 | Fri Jan 28 | atHarvard | W78-74 | 8-12 | .400 | - | ESPNU | Lavietes Pavilion · Cambridge, MA |
| 24 | Fri Feb 4 | atColumbia | W81-66 | 9-12 | .429 | - | | Francis S. Levien Gymnasium · New York, NY |
| 25 | Sat Feb 5 | atCornell | W73-68 | 10-12 | .455 | - | | Newman Arena · Ithaca, NY |
| 26 | Sat Feb 12 | vsHarvard | W82-74 | 11-12 | .478 | - | | The Palestra · Philadelphia, PA |
| 27 | Fri Feb 18 | atYale | L72-81 | 11-13 | .458 | - | | John J. Lee Amphitheater · New Haven, CT |
| 28 | Sat Feb 19 | atBrown | W89-88 | 12-13 | .480 | - | | Pizzitola Sports Center · Providence, RI |
| 29 | Sat Feb 26 | atDartmouth | L70-84 | 12-14 | .462 | - | | Edward Leede Arena · Hanover, NH |
| 30 | Sat Mar 5 | vsPrinceton | L70-93 | 12-15 | .444 | - | | The Palestra · Philadelphia, PA |
| 31 | Sat Mar 12 | atYale | L61-67 | 12-16 | .429 | - | ESPNU | John J. Lee Amphitheater · New Haven, CT |
