| 1 | Fri Nov 7 | vs TBD | TBD | 0-0 | .000 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 2 | Sun Nov 9 | atAmerican | 1:00 PM | 22-13 | .629 | - | ESPN+ | Bender Arena · Washington, D.C. |
| 3 | Tue Nov 11 | atProvidence | TBD | 12-20 | .375 | - | | Amica Mutual Pavilion · Providence, RI |
| 4 | Mon Nov 17 | vsSaint Joseph's | 7:00 PM | 22-13 | .629 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 5 | Fri Nov 21 | atDrexel | TBD | 18-15 | .545 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 6 | Fri Nov 28 | vsMerrimack | 4:30 PM | 18-15 | .545 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 7 | Sat Nov 29 | vsLa Salle | 4:30 PM | 14-19 | .424 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 8 | Sun Nov 30 | vsHofstra | 2:30 PM | 15-18 | .455 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 9 | Mon Dec 8 | vsLafayette | TBD | 13-20 | .394 | - | | The Palestra · Philadelphia, PA |
| 10 | Sat Dec 20 | atRutgers | TBD | 15-17 | .469 | - | | Jersey Mike’s Arena · Piscataway, NJ |
| 11 | Sun Dec 28 | atGeorge Mason | TBD | 27-9 | .750 | - | | EagleBank Arena · Fairfax, VA |
| 12 | Wed Dec 31 | vsNJIT | 2:00 PM | 6-25 | .194 | - | | The Palestra · Philadelphia, PA |
| 13 | Mon Jan 5 | atPrinceton | 7:00 PM | 19-11 | .633 | - | | Jadwin Gymnasium · Princeton, NJ |
| 14 | Sat Jan 10 | vsBrown | TBD | 14-13 | .519 | - | | The Palestra · Philadelphia, PA |
| 15 | Sat Jan 17 | atDartmouth | 3:00 PM | 14-14 | .500 | - | | Edward Leede Arena · Hanover, NH |
| 16 | Mon Jan 19 | atHarvard | TBD | 12-15 | .444 | - | | Lavietes Pavilion · Cambridge, MA |
| 17 | Sat Jan 24 | vsYale | 2:00 PM | 22-8 | .733 | - | | The Palestra · Philadelphia, PA |
| 18 | Fri Jan 30 | atColumbia | 7:00 PM | 12-15 | .444 | - | | Francis S. Levien Gymnasium · New York, NY |
| 19 | Sat Jan 31 | atCornell | 6:00 PM | 18-11 | .621 | - | | Newman Arena · Ithaca, NY |
| 20 | Sat Feb 7 | vsPrinceton | TBD | 19-11 | .633 | - | | The Palestra · Philadelphia, PA |
| 21 | Fri Feb 13 | vsColumbia | 7:00 PM | 12-15 | .444 | - | | The Palestra · Philadelphia, PA |
| 22 | Sat Feb 14 | vsCornell | 6:00 PM | 18-11 | .621 | - | | The Palestra · Philadelphia, PA |
| 23 | Sat Feb 21 | atYale | 2:00 PM | 22-8 | .733 | - | | John J. Lee Amphitheater · New Haven, CT |
| 24 | Fri Feb 27 | vsDartmouth | 7:00 PM | 14-14 | .500 | - | | The Palestra · Philadelphia, PA |
| 25 | Sat Feb 28 | vsHarvard | TBD | 12-15 | .444 | - | | The Palestra · Philadelphia, PA |
| 26 | Fri Mar 6 | atBrown | 7:00 PM | 14-13 | .519 | - | | Pizzitola Sports Center · Providence, RI |
