| 1 | Mon Nov 7 | at Iona | L50-78 | 0-1 | .000 | - | | Hynes Athletics Center · New Rochelle, NY |
| 2 | Fri Nov 11 | at Missouri | L85-92 | 0-2 | .000 | - | | Mizzou Arena · Columbia, MO |
| 3 | Sun Nov 13 | vs Towson | L74-80 | 0-3 | .000 | - | | The Palestra · Philadelphia, PA |
| 4 | Tue Nov 15 | at Drexel | W64-59 | 1-3 | .250 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 5 | Fri Nov 18 | at West Virginia | L58-92 | 1-4 | .200 | - | | WVU Coliseum · Morgantown, WV |
| 6 | Tue Nov 22 | at Lafayette | W74-68 (OT) | 2-4 | .333 | - | | Kirby Sports Center · Easton, PA |
| 7 | Fri Nov 25 | vs TBD | W75-55 | 3-4 | .429 | - | | The Palestra · Philadelphia, PA |
| 8 | Sat Nov 26 | vs Colgate | W81-69 | 4-4 | .500 | - | | The Palestra · Philadelphia, PA |
| 9 | Sun Nov 27 | vs Delaware | W86-73 | 5-4 | .556 | - | | The Palestra · Philadelphia, PA |
| 10 | Wed Nov 30 | vs Saint Joseph's | L80-85 (OT) | 5-5 | .500 | - | | The Palestra · Philadelphia, PA |
| 11 | Sat Dec 3 | vs La Salle | L81-84 (OT) | 5-6 | .455 | - | | The Palestra · Philadelphia, PA |
| 12 | Wed Dec 7 | at Villanova | L59-70 | 5-7 | .417 | - | CBS | Finneran Pavilion · Villanova, PA |
| 13 | Sat Dec 10 | vs Temple | W77-57 | 6-7 | .462 | - | | The Palestra · Philadelphia, PA |
| 14 | Wed Dec 28 | vsTBD | W93-61 | 7-7 | .500 | - | | The Palestra · Philadelphia, PA |
| 15 | Mon Jan 2 | at Brown | W76-68 | 8-7 | .533 | - | | Pizzitola Sports Center · Providence, RI |
| 16 | Fri Jan 6 | at Cornell | L69-88 | 8-8 | .500 | - | | Newman Arena · Ithaca, NY |
| 17 | Sat Jan 7 | at Columbia | W84-55 | 9-8 | .529 | - | | Francis S. Levien Gymnasium · New York, NY |
| 18 | Sat Jan 14 | at Dartmouth | L71-75 | 9-9 | .500 | - | | Edward Leede Arena · Hanover, NH |
| 19 | Mon Jan 16 | vs Princeton | L60-72 | 9-10 | .474 | - | | The Palestra · Philadelphia, PA |
| 20 | Sat Jan 21 | at Yale | L63-70 | 9-11 | .450 | - | | John J. Lee Amphitheater · New Haven, CT |
| 21 | Mon Jan 23 | atTBD | W76-52 | 10-11 | .476 | - | | Chase Arena |
| 22 | Sat Jan 28 | vs Harvard | W83-68 | 11-11 | .500 | - | | The Palestra · Philadelphia, PA |
| 23 | Fri Feb 3 | vsColumbia | W74-65 | 12-11 | .522 | - | | The Palestra · Philadelphia, PA |
| 24 | Sat Feb 4 | vsCornell | W92-86 | 13-11 | .542 | - | | The Palestra · Philadelphia, PA |
| 25 | Sat Feb 11 | atHarvard | W80-72 | 14-11 | .560 | - | | Lavietes Pavilion · Cambridge, MA |
| 26 | Fri Feb 17 | vsYale | W66-64 | 15-11 | .577 | - | ESPNEWS | The Palestra · Philadelphia, PA |
| 27 | Sat Feb 18 | vsBrown | W90-69 | 16-11 | .593 | - | | The Palestra · Philadelphia, PA |
| 28 | Sat Feb 25 | vsDartmouth | W89-79 | 17-11 | .607 | - | | The Palestra · Philadelphia, PA |
| 29 | Sat Mar 4 | atPrinceton | L69-77 (OT) | 17-12 | .586 | - | ESPNEWS | Jadwin Gymnasium · Princeton, NJ |
| 30 | Sat Mar 11 | atPrinceton | L70-77 | 17-13 | .567 | - | ESPNU | Jadwin Gymnasium · Princeton, NJ |
