| 1 | Fri Nov 27 | vs Bryant | W85-84 | 1-0 | 1.000 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 2 | Thu Dec 3 | vsNiagara | W75-45 | 2-0 | 1.000 | - | | JMA Wireless Dome · Syracuse, NY |
| 3 | Sat Dec 5 | vsRider | W87-52 | 3-0 | 1.000 | - | | JMA Wireless Dome · Syracuse, NY |
| 4 | Tue Dec 8 | atRutgers | L69-79 | 3-1 | .750 | - | ESPN2 | Jersey Mike’s Arena · Piscataway, NJ |
| 5 | Sat Dec 12 | atBoston College | W101-63 | 4-1 | .800 | - | ESPNU | Silvio O. Conte Forum · Chestnut Hill, MA |
| 6 | Wed Dec 16 | vsNortheastern | W62-56 | 5-1 | .833 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 7 | Sat Dec 19 | vsBuffalo | W107-96 (OT) | 6-1 | .857 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 8 | Tue Dec 22 | vsNotre Dame | PPD | 18-10 | .643 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 10 | Wed Jan 6 | vsPitt | L60-63 | 6-2 | .750 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 11 | Sat Jan 9 | vsGeorgetown | W74-69 | 7-2 | .778 | - | ESPN | JMA Wireless Dome · Syracuse, NY |
| 12 | Tue Jan 12 | atUNC | L75-81 | 7-3 | .700 | - | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 13 | Sat Jan 16 | atPitt | L76-96 | 7-4 | .636 | - | | Petersen Events Center · Pittsburgh, PA |
| 14 | Tue Jan 19 | vsMiami | W83-57 | 8-4 | .667 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 15 | Sat Jan 23 | vs#16Virginia Tech | W78-60 | 9-4 | .692 | - | | JMA Wireless Dome · Syracuse, NY |
| 16 | Mon Jan 25 | at#8Virginia | L58-81 | 9-5 | .643 | - | ESPN | John Paul Jones Arena · Charlottesville, VA |
| 17 | Sun Jan 31 | vsNC State | W76-73 | 10-5 | .667 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 19 | Sat Feb 6 | atClemson | L61-78 | 10-6 | .625 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 20 | Tue Feb 9 | atNC State | W77-68 | 11-6 | .647 | - | ACC Network | PNC Arena · Raleigh, NC |
| 21 | Sat Feb 13 | vsBoston College | W75-67 | 12-6 | .667 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 23 | Sat Feb 20 | vsNotre Dame | W75-67 | 13-6 | .684 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 24 | Mon Feb 22 | atDuke | L71-85 | 13-7 | .650 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 25 | Sat Feb 27 | atGeorgia Tech | L77-84 | 13-8 | .619 | - | ACC Network | McCamish Pavilion · Atlanta, GA |
| 26 | Mon Mar 1 | vsUNC | W72-70 | 14-8 | .636 | - | ESPN | JMA Wireless Dome · Syracuse, NY |
| 27 | Wed Mar 3 | vsClemson | W64-54 | 15-8 | .652 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 28 | Wed Mar 10 | vsNC State | W89-68 | 16-8 | .667 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 29 | Thu Mar 11 | atVirginia | L69-72 | 16-9 | .640 | - | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 30 | Fri Mar 19 | at#6SDSU | W78-62 | 17-9 | .654 | #11 | CBS | Viejas Arena · San Diego, CA |
| 31 | Sun Mar 21 | at#3West Virginia | W75-72 | 18-9 | .667 | #11 | CBS | WVU Coliseum · Morgantown, WV |
| 32 | Sat Mar 27 | at#2Houston | L46-62 | 18-10 | .643 | #11 | TBS | Fertitta Center · Houston, TX |
