| 1 | Mon Nov 6 | vs New Hampshire | W83-72 | 1-0 | 1.000 | - | | JMA Wireless Dome · Syracuse, NY |
| 2 | Wed Nov 8 | vs Canisius | W89-77 | 2-0 | 1.000 | - | | JMA Wireless Dome · Syracuse, NY |
| 3 | Tue Nov 14 | vs Colgate | W79-75 | 3-0 | 1.000 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 4 | Mon Nov 20 | vs #7Tennessee | L56-73 | 3-1 | .750 | - | ESPN2 | JMA Wireless Dome · Syracuse, NY |
| 5 | Tue Nov 21 | at #11Gonzaga | L57-76 | 3-2 | .600 | - | ESPN2 | McCarthey Athletic Center · Spokane, WA |
| 6 | Wed Nov 22 | at TBD | W105-56 | 4-2 | .667 | - | ESPNU | Stan Sheriff Center |
| 7 | Tue Nov 28 | vs LSU | W80-57 | 5-2 | .714 | - | ESPN2 | JMA Wireless Dome · Syracuse, NY |
| 8 | Sat Dec 2 | at Virginia | L62-84 | 5-3 | .625 | - | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 9 | Tue Dec 5 | vs Cornell | W81-70 | 6-3 | .667 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 10 | Sat Dec 9 | at Georgetown | W80-68 | 7-3 | .700 | - | FOX | Capital One Arena · Washington, D.C. |
| 11 | Sun Dec 17 | at Oregon | W83-63 | 8-3 | .727 | - | CBS | Matthew Knight Arena · Eugene, OR |
| 12 | Thu Dec 21 | vs Niagara | W83-71 | 9-3 | .750 | - | | JMA Wireless Dome · Syracuse, NY |
| 13 | Sat Dec 30 | vs Pitt | W81-73 | 10-3 | .769 | - | The CW Network | JMA Wireless Dome · Syracuse, NY |
| 14 | Tue Jan 2 | at #14Duke | L66-86 | 10-4 | .714 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 15 | Wed Jan 10 | vs Boston College | W69-59 | 11-4 | .733 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 16 | Sat Jan 13 | at #7UNC | L67-103 | 11-5 | .688 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 17 | Tue Jan 16 | atPitt | W69-58 | 12-5 | .706 | - | ESPN | Petersen Events Center · Pittsburgh, PA |
| 18 | Sat Jan 20 | vs Miami | W72-69 | 13-5 | .722 | - | ESPN2 | JMA Wireless Dome · Syracuse, NY |
| 19 | Tue Jan 23 | vs Florida St | L69-85 | 13-6 | .684 | - | ESPN2 | JMA Wireless Dome · Syracuse, NY |
| 20 | Sat Jan 27 | vs NC State | W77-65 | 14-6 | .700 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 21 | Tue Jan 30 | atBoston College | L75-80 | 14-7 | .667 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 22 | Sat Feb 3 | at Wake Forest | L70-99 | 14-8 | .636 | - | The CW Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 23 | Wed Feb 7 | vs Louisville | W94-92 | 15-8 | .652 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 24 | Sat Feb 10 | vs Clemson | L68-77 | 15-9 | .625 | - | ESPN2 | JMA Wireless Dome · Syracuse, NY |
| 25 | Tue Feb 13 | vs#7UNC | W86-79 | 16-9 | .640 | - | ESPN | JMA Wireless Dome · Syracuse, NY |
| 26 | Sat Feb 17 | at Georgia Tech | L60-65 | 16-10 | .615 | - | The CW Network | McCamish Pavilion · Atlanta, GA |
| 27 | Tue Feb 20 | atNC State | W87-83 | 17-10 | .630 | - | ESPN2 | PNC Arena · Raleigh, NC |
| 28 | Sat Feb 24 | vs Notre Dame | W88-85 | 18-10 | .643 | - | ESPN | JMA Wireless Dome · Syracuse, NY |
| 29 | Tue Feb 27 | vs Virginia Tech | W84-71 | 19-10 | .655 | - | ESPNU | JMA Wireless Dome · Syracuse, NY |
| 30 | Sat Mar 2 | atLouisville | W82-76 | 20-10 | .667 | - | ACC Network | KFC Yum! Center · Louisville, KY |
| 31 | Tue Mar 5 | atClemson | L75-90 | 20-11 | .645 | - | ESPN2 | Littlejohn Coliseum · Clemson, SC |
| 32 | Wed Mar 13 | vsNC State | L65-83 | 20-12 | .625 | - | ESPN2 | JMA Wireless Dome · Syracuse, NY |
