| 1 | Mon Nov 7 | vs Lehigh | W90-72 | 1-0 | 1.000 | - | | JMA Wireless Dome · Syracuse, NY |
| 2 | Tue Nov 15 | vsColgate | L68-80 | 1-1 | .500 | - | | JMA Wireless Dome · Syracuse, NY |
| 3 | Sat Nov 19 | vsNortheastern | W76-48 | 2-1 | .667 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 4 | Mon Nov 21 | atRichmond | W74-71 (OT) | 3-1 | .750 | - | ESPN2 | Robins Center · Richmond, VA |
| 5 | Tue Nov 22 | atSt John's | L69-76 (OT) | 3-2 | .600 | - | ESPN2 | Carnesecca Arena · Queens, NY |
| 6 | Sat Nov 26 | vsBryant | L72-73 | 3-3 | .500 | - | | JMA Wireless Dome · Syracuse, NY |
| 7 | Tue Nov 29 | atIllinois | L44-73 | 3-4 | .429 | - | ESPN | State Farm Center · Champaign, IL |
| 8 | Sat Dec 3 | atNotre Dame | W62-61 | 4-4 | .500 | - | ESPN2 | Purcell Pavilion · South Bend, IN |
| 9 | Tue Dec 6 | vsOakland | W95-66 | 5-4 | .556 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 10 | Sat Dec 10 | vsGeorgetown | W83-64 | 6-4 | .600 | - | ABC | JMA Wireless Dome · Syracuse, NY |
| 11 | Mon Dec 12 | vsMonmouth | W86-71 | 7-4 | .636 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 12 | Sat Dec 17 | vsCornell | W78-63 | 8-4 | .667 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 13 | Tue Dec 20 | vsPitt | L82-84 | 8-5 | .615 | - | ESPNU | JMA Wireless Dome · Syracuse, NY |
| 14 | Sat Dec 31 | vsBoston College | W79-65 | 9-5 | .643 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 15 | Tue Jan 3 | atLouisville | W70-69 | 10-5 | .667 | - | ESPNEWS | KFC Yum! Center · Louisville, KY |
| 16 | Sat Jan 7 | at#11Virginia | L66-73 | 10-6 | .625 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 17 | Wed Jan 11 | vsVirginia Tech | W82-72 | 11-6 | .647 | - | | JMA Wireless Dome · Syracuse, NY |
| 18 | Sat Jan 14 | vsNotre Dame | W78-73 | 12-6 | .667 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 19 | Mon Jan 16 | at#17Miami | L78-82 | 12-7 | .632 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 20 | Sat Jan 21 | atGeorgia Tech | W80-63 | 13-7 | .650 | - | | McCamish Pavilion · Atlanta, GA |
| 21 | Tue Jan 24 | vsUNC | L68-72 | 13-8 | .619 | - | ESPN | JMA Wireless Dome · Syracuse, NY |
| 22 | Sat Jan 28 | atVirginia Tech | L70-85 | 13-9 | .591 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 23 | Mon Jan 30 | vs#6Virginia | L62-67 | 13-10 | .565 | - | ESPN | JMA Wireless Dome · Syracuse, NY |
| 24 | Sat Feb 4 | atBoston College | W77-68 | 14-10 | .583 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 25 | Wed Feb 8 | atFlorida St | W76-67 | 15-10 | .600 | - | ESPNU | Donald L. Tucker Center · Tallahassee, FL |
| 26 | Tue Feb 14 | vs#23NC State | W75-72 | 16-10 | .615 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 27 | Sat Feb 18 | vsDuke | L55-77 | 16-11 | .593 | - | ESPN | JMA Wireless Dome · Syracuse, NY |
| 28 | Wed Feb 22 | atClemson | L73-91 | 16-12 | .571 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 29 | Sat Feb 25 | atPitt | L82-99 | 16-13 | .552 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 30 | Tue Feb 28 | vsGeorgia Tech | L76-96 | 16-14 | .533 | - | | JMA Wireless Dome · Syracuse, NY |
| 31 | Sat Mar 4 | vsWake Forest | W72-63 | 17-14 | .548 | - | ERADM | JMA Wireless Dome · Syracuse, NY |
| 32 | Wed Mar 8 | vsWake Forest | L74-77 | 17-15 | .531 | - | ESPN | Greensboro Coliseum · Greensboro, NC |
