| 1 | Tue Nov 9 | vs Lafayette | W97-63 | 1-0 | 1.000 | - | | JMA Wireless Dome · Syracuse, NY |
| 2 | Sun Nov 14 | vs Drexel | W75-60 | 2-0 | 1.000 | - | ESPN2 | JMA Wireless Dome · Syracuse, NY |
| 3 | Sat Nov 20 | vs Colgate | L85-100 | 2-1 | .667 | - | | JMA Wireless Dome · Syracuse, NY |
| 4 | Wed Nov 24 | vs VCU | L55-67 | 2-2 | .500 | - | ESPN2 | JMA Wireless Dome · Syracuse, NY |
| 5 | Thu Nov 25 | vs Arizona St | W92-84 | 3-2 | .600 | - | ESPN2 | JMA Wireless Dome · Syracuse, NY |
| 6 | Fri Nov 26 | at Auburn | L68-89 | 3-3 | .500 | - | ESPN2 | Neville Arena · Auburn, AL |
| 7 | Tue Nov 30 | vs Indiana | W112-110 (2OT) | 4-3 | .571 | - | ESPN2 | JMA Wireless Dome · Syracuse, NY |
| 8 | Sat Dec 4 | at Florida St | W63-60 | 5-3 | .625 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 9 | Tue Dec 7 | vs Villanova | L53-67 | 5-4 | .556 | - | ESPN | JMA Wireless Dome · Syracuse, NY |
| 10 | Sat Dec 11 | at Georgetown | L75-79 | 5-5 | .500 | - | FOX | Capital One Arena · Washington, D.C. |
| 12 | Tue Dec 21 | vs Cornell | PPD | 16-17 | .485 | - | | JMA Wireless Dome · Syracuse, NY |
| 13 | Mon Dec 27 | vs Brown | W93-62 | 6-5 | .545 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 14 | Wed Dec 29 | vsCornell | W80-68 | 7-5 | .583 | - | | JMA Wireless Dome · Syracuse, NY |
| 15 | Sat Jan 1 | vs Virginia | L69-74 | 7-6 | .538 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 16 | Wed Jan 5 | at Miami | L87-88 | 7-7 | .500 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 17 | Sat Jan 8 | at Wake Forest | L74-77 (OT) | 7-8 | .467 | - | | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 18 | Tue Jan 11 | vs Pitt | W77-61 | 8-8 | .500 | - | ESPNU | JMA Wireless Dome · Syracuse, NY |
| 19 | Sat Jan 15 | vsFlorida St | L71-76 | 8-9 | .471 | - | ESPN | JMA Wireless Dome · Syracuse, NY |
| 20 | Tue Jan 18 | vs Clemson | W91-78 | 9-9 | .500 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 21 | Sat Jan 22 | at #6Duke | L59-79 | 9-10 | .474 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 22 | Tue Jan 25 | atPitt | L53-64 | 9-11 | .450 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 23 | Sat Jan 29 | vsWake Forest | W94-72 | 10-11 | .476 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 24 | Wed Feb 2 | at NC State | W89-82 | 11-11 | .500 | - | ESPN2 | PNC Arena · Raleigh, NC |
| 25 | Sat Feb 5 | vs Louisville | W92-69 | 12-11 | .522 | - | ESPN2 | JMA Wireless Dome · Syracuse, NY |
| 26 | Tue Feb 8 | at Boston College | W73-64 | 13-11 | .542 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 27 | Sat Feb 12 | at Virginia Tech | L59-71 | 13-12 | .520 | - | ESPN2 | Cassell Coliseum · Blacksburg, VA |
| 28 | Sat Feb 19 | vsBoston College | W76-56 | 14-12 | .538 | - | ESPNU | JMA Wireless Dome · Syracuse, NY |
| 29 | Mon Feb 21 | vs Georgia Tech | W74-73 (OT) | 15-12 | .556 | - | | JMA Wireless Dome · Syracuse, NY |
| 30 | Wed Feb 23 | at Notre Dame | L69-79 | 15-13 | .536 | - | ESPNEWS | Purcell Pavilion · South Bend, IN |
| 31 | Sat Feb 26 | vs#7Duke | L72-97 | 15-14 | .517 | - | ESPN | JMA Wireless Dome · Syracuse, NY |
| 32 | Mon Feb 28 | at UNC | L79-88 (OT) | 15-15 | .500 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 33 | Sat Mar 5 | vsMiami | L72-75 | 15-16 | .484 | - | ESPNU | JMA Wireless Dome · Syracuse, NY |
| 34 | Wed Mar 9 | atFlorida St | W96-57 | 16-16 | .500 | - | ESPN | Donald L. Tucker Center · Tallahassee, FL |
| 35 | Thu Mar 10 | atDuke | L79-88 | 16-17 | .485 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
