| 1 | Mon Nov 3 | vs Binghamton | 12:00 PM | 15-17 | .469 | - | ACC Extra | JMA Wireless Dome · Syracuse, NY |
| 2 | Sat Nov 8 | vsDelaware St | 12:00 PM | 16-14 | .533 | - | ACC Extra | JMA Wireless Dome · Syracuse, NY |
| 3 | Sat Nov 15 | atDrexel | TBD | 18-15 | .545 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 4 | Tue Nov 18 | vsMonmouth | 9:00 PM | 13-20 | .394 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 5 | Mon Nov 24 | at#2Houston | 6:00 PM | 35-5 | .875 | - | | Fertitta Center · Houston, TX |
| 6 | Tue Nov 25 | at#19Kansas | 3:30 PM | 21-13 | .618 | - | TNT | Allen Fieldhouse · Lawrence, KS |
| 7 | Tue Dec 2 | vs#18Tennessee | 7:00 PM | 30-8 | .789 | - | ESPN2 | JMA Wireless Dome · Syracuse, NY |
| 8 | Thu Dec 11 | vsSaint Joseph's | 9:00 PM | 22-13 | .629 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 9 | Sat Dec 13 | vsHofstra | 4:00 PM | 15-18 | .455 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 10 | Wed Dec 17 | vsMercyhurst | TBD | 15-16 | .484 | - | | JMA Wireless Dome · Syracuse, NY |
| 11 | Sat Dec 20 | vsNortheastern | 4:00 PM | 17-15 | .531 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 12 | Mon Dec 22 | vsStonehill | TBD | 15-17 | .469 | - | | JMA Wireless Dome · Syracuse, NY |
| 13 | Wed Dec 31 | vsClemson | 2:00 PM | 27-7 | .794 | - | ESPN2 | JMA Wireless Dome · Syracuse, NY |
| 14 | Tue Jan 6 | atGeorgia Tech | 7:00 PM | 17-17 | .500 | - | ACC Network | McCamish Pavilion · Atlanta, GA |
| 15 | Sat Jan 10 | atPitt | 2:00 PM | 17-15 | .531 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 16 | Tue Jan 13 | vsFlorida St | 9:00 PM | 17-15 | .531 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 17 | Sat Jan 17 | atBoston College | 2:00 PM | 12-19 | .387 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 18 | Wed Jan 21 | vsVirginia Tech | 9:00 PM | 13-19 | .406 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 19 | Sat Jan 24 | vsMiami | 2:00 PM | 7-24 | .226 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 20 | Tue Jan 27 | atNC State | TBD | 12-19 | .387 | - | | PNC Arena · Raleigh, NC |
| 21 | Sat Jan 31 | vsNotre Dame | TBD | 15-18 | .455 | - | | JMA Wireless Dome · Syracuse, NY |
| 22 | Mon Feb 2 | at#25UNC | 7:00 PM | 23-14 | .622 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 23 | Sat Feb 7 | atVirginia | TBD | 15-17 | .469 | - | | John Paul Jones Arena · Charlottesville, VA |
| 24 | Tue Feb 10 | vsCalifornia | TBD | 14-19 | .424 | - | | JMA Wireless Dome · Syracuse, NY |
| 25 | Sat Feb 14 | vsSMU | TBD | 24-11 | .686 | - | | JMA Wireless Dome · Syracuse, NY |
| 26 | Mon Feb 16 | at#6Duke | 7:00 PM | 35-4 | .897 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 27 | Sat Feb 21 | vs#25UNC | 1:00 PM | 23-14 | .622 | - | ABC | JMA Wireless Dome · Syracuse, NY |
| 28 | Sat Feb 28 | atWake Forest | TBD | 21-11 | .656 | - | | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 29 | Tue Mar 3 | at#11Louisville | 9:00 PM | 27-8 | .771 | - | ACC Network | KFC Yum! Center · Louisville, KY |
| 30 | Sat Mar 7 | vsPitt | TBD | 17-15 | .531 | - | | JMA Wireless Dome · Syracuse, NY |
