| 1 | Mon Nov 3 | vs Binghamton | W85-47 | 1-0 | 1.000 | - | ACC Extra | JMA Wireless Dome · Syracuse, NY |
| 2 | Sat Nov 8 | vsDelaware St | W83-43 | 2-0 | 1.000 | - | ACC Extra | JMA Wireless Dome · Syracuse, NY |
| 3 | Sat Nov 15 | vsDrexel | W80-50 | 3-0 | 1.000 | - | Peacock | JMA Wireless Dome · Syracuse, NY |
| 4 | Tue Nov 18 | vsMonmouth | W78-73 | 4-0 | 1.000 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 5 | Mon Nov 24 | at3Houston | L74-78 (OT) | 4-1 | .800 | - | TNT | Fertitta Center · Houston, TX |
| 6 | Tue Nov 25 | atKansas | L60-71 | 4-2 | .667 | - | TNT | Allen Fieldhouse · Lawrence, KS |
| 7 | Wed Nov 26 | at15Iowa State | L64-95 | 4-3 | .571 | - | TNT | James H. Hilton Coliseum · Ames, IA |
| 8 | Tue Dec 2 | vs13Tennessee | W62-60 | 5-3 | .625 | - | ESPN2 | JMA Wireless Dome · Syracuse, NY |
| 9 | Thu Dec 11 | vsSaint Joseph's | W71-63 | 6-3 | .667 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 10 | Sat Dec 13 | vsHofstra | L69-70 | 6-4 | .600 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 11 | Wed Dec 17 | vsMercyhurst | W76-62 | 7-4 | .636 | - | ACC Extra | JMA Wireless Dome · Syracuse, NY |
| 12 | Sat Dec 20 | vsNortheastern | W91-83 | 8-4 | .667 | - | ACC Extra | JMA Wireless Dome · Syracuse, NY |
| 13 | Mon Dec 22 | vsStonehill | W77-48 | 9-4 | .692 | - | ACC Extra | JMA Wireless Dome · Syracuse, NY |
| 14 | Wed Dec 31 | vsClemson | L61-64 | 9-5 | .643 | - | ESPN2 | JMA Wireless Dome · Syracuse, NY |
| 15 | Tue Jan 6 | atGeorgia Tech | W82-72 | 10-5 | .667 | - | ACC Network | McCamish Pavilion · Atlanta, GA |
| 16 | Sat Jan 10 | atPitt | W83-72 | 11-5 | .688 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 17 | Tue Jan 13 | vsFlorida St | W94-86 | 12-5 | .706 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 18 | Sat Jan 17 | atBoston College | L73-81 (OT) | 12-6 | .667 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 19 | Wed Jan 21 | vsVirginia Tech | L74-76 | 12-7 | .632 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 20 | Sat Jan 24 | vsMiami | L76-85 | 12-8 | .600 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 21 | Tue Jan 27 | atNC State | L68-88 | 12-9 | .571 | - | ESPNU | PNC Arena · Raleigh, NC |
| 22 | Sat Jan 31 | vsNotre Dame | W86-72 | 13-9 | .591 | - | The CW Network | JMA Wireless Dome · Syracuse, NY |
| 23 | Mon Feb 2 | at14UNC | L77-87 | 13-10 | .565 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 24 | Sat Feb 7 | at18Virginia | L59-72 | 13-11 | .542 | - | ESPN | John Paul Jones Arena · Charlottesville, VA |
| 25 | Wed Feb 11 | vsCalifornia | W107-100 (2OT) | 14-11 | .560 | - | ESPNU | JMA Wireless Dome · Syracuse, NY |
| 26 | Sat Feb 14 | vsSMU | W79-78 | 15-11 | .577 | - | The CW Network | JMA Wireless Dome · Syracuse, NY |
| 27 | Mon Feb 16 | at3Duke | L64-101 | 15-12 | .556 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 28 | Sat Feb 21 | vs16UNC | L64-77 | 15-13 | .536 | - | ABC | JMA Wireless Dome · Syracuse, NY |
| 29 | Sat Feb 28 | atWake Forest | L83-88 | 15-14 | .517 | - | The CW Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
