| 3 | Sat Nov 15 | at Drexel | 3:30 PM | 1-1 | .500 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 4 | Tue Nov 18 | vsMonmouth | 9:00 PM | 1-1 | .500 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 5 | Mon Nov 24 | at#2Houston | 6:00 PM | 2-0 | 1.000 | - | | Fertitta Center · Houston, TX |
| 6 | Tue Nov 25 | at#19Kansas | 3:30 PM | 1-1 | .500 | - | TNT | Allen Fieldhouse · Lawrence, KS |
| 7 | Tue Dec 2 | vs#18Tennessee | 7:00 PM | 2-0 | 1.000 | - | ESPN2 | JMA Wireless Dome · Syracuse, NY |
| 8 | Thu Dec 11 | vsSaint Joseph's | 9:00 PM | 2-0 | 1.000 | - | ACC Network | Thomas & Mack Center · Las Vegas, NV |
| 9 | Sat Dec 13 | vsHofstra | 4:00 PM | 0-2 | .000 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 10 | Wed Dec 17 | vsMercyhurst | 7:00 PM | 2-1 | .667 | - | ACC Extra | JMA Wireless Dome · Syracuse, NY |
| 11 | Sat Dec 20 | vsNortheastern | 4:00 PM | 1-1 | .500 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 12 | Mon Dec 22 | vsStonehill | 7:00 PM | 1-1 | .500 | - | ACC Extra | JMA Wireless Dome · Syracuse, NY |
| 13 | Wed Dec 31 | vsClemson | 2:00 PM | 2-0 | 1.000 | - | ESPN2 | JMA Wireless Dome · Syracuse, NY |
| 14 | Tue Jan 6 | atGeorgia Tech | 7:00 PM | 2-0 | 1.000 | - | ACC Network | McCamish Pavilion · Atlanta, GA |
| 15 | Sat Jan 10 | atPitt | 12:00 PM | 2-0 | 1.000 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 16 | Tue Jan 13 | vsFlorida St | 9:00 PM | 2-0 | 1.000 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 17 | Sat Jan 17 | atBoston College | 2:00 PM | 1-1 | .500 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 18 | Wed Jan 21 | vsVirginia Tech | 9:00 PM | 1-0 | 1.000 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 19 | Sat Jan 24 | vsMiami | 2:00 PM | 2-0 | 1.000 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 20 | Tue Jan 27 | atNC State | 7:00 PM | 2-0 | 1.000 | - | | PNC Arena · Raleigh, NC |
| 21 | Sat Jan 31 | vsNotre Dame | 6:00 PM | 2-0 | 1.000 | - | | JMA Wireless Dome · Syracuse, NY |
| 22 | Mon Feb 2 | at#25UNC | 7:00 PM | 2-0 | 1.000 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 23 | Sat Feb 7 | atVirginia | 12:00 PM | 2-0 | 1.000 | - | | John Paul Jones Arena · Charlottesville, VA |
| 24 | Wed Feb 11 | vsCalifornia | 7:00 PM | 2-0 | 1.000 | - | | JMA Wireless Dome · Syracuse, NY |
| 25 | Sat Feb 14 | vsSMU | 2:00 PM | 2-0 | 1.000 | - | | JMA Wireless Dome · Syracuse, NY |
| 26 | Mon Feb 16 | at#6Duke | 7:00 PM | 2-0 | 1.000 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 27 | Sat Feb 21 | vs#25UNC | 1:00 PM | 2-0 | 1.000 | - | ABC | JMA Wireless Dome · Syracuse, NY |
| 28 | Sat Feb 28 | atWake Forest | 5:45 PM | 2-0 | 1.000 | - | | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 29 | Tue Mar 3 | at#11Louisville | 9:00 PM | 2-0 | 1.000 | - | ACC Network | KFC Yum! Center · Louisville, KY |
| 30 | Sat Mar 7 | vsPitt | 5:00 PM | 2-0 | 1.000 | - | | JMA Wireless Dome · Syracuse, NY |
