| 1 | Tue Nov 9 | vs Maine | W82-47 | 1-0 | 1.000 | - | | Cassell Coliseum · Blacksburg, VA |
| 2 | Fri Nov 12 | atNavy | W77-57 | 2-0 | 1.000 | - | CBS | Alumni Hall (Navy) · Annapolis, MD |
| 3 | Mon Nov 15 | vsRadford | W65-39 | 3-0 | 1.000 | - | | Cassell Coliseum · Blacksburg, VA |
| 4 | Thu Nov 18 | vsSt Francis PA | W85-55 | 4-0 | 1.000 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 5 | Sun Nov 21 | vsMerrimack | W72-43 | 5-0 | 1.000 | - | | Cassell Coliseum · Blacksburg, VA |
| 6 | Wed Nov 24 | vsMemphis | L61-69 | 5-1 | .833 | - | ESPNEWS | Cassell Coliseum · Blacksburg, VA |
| 7 | Fri Nov 26 | vsXavier | L58-59 | 5-2 | .714 | - | ESPN2 | Cassell Coliseum · Blacksburg, VA |
| 8 | Wed Dec 1 | atMaryland | W62-58 | 6-2 | .750 | - | ESPN2 | XFINITY Center · College Park, MD |
| 9 | Sat Dec 4 | vsWake Forest | L61-80 | 6-3 | .667 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 10 | Wed Dec 8 | vsCornell | W93-60 | 7-3 | .700 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 11 | Sun Dec 12 | atDayton | L57-62 | 7-4 | .636 | - | ESPN2 | UD Arena · Dayton, OH |
| 12 | Fri Dec 17 | vsSt Bonaventure | W86-49 | 8-4 | .667 | - | ESPN2 | Cassell Coliseum · Blacksburg, VA |
| 13 | Wed Dec 22 | at#2Duke | L65-76 | 8-5 | .615 | - | ESPN2 | Cameron Indoor Stadium · Durham, NC |
| 14 | Wed Dec 29 | atUNC | PPD | 23-13 | .639 | - | | Dean E. Smith Center · Chapel Hill, NC |
| 15 | Sat Jan 1 | vsPitt | PPD | 23-13 | .639 | - | | Cassell Coliseum · Blacksburg, VA |
| 16 | Tue Jan 4 | vsNC State | L63-68 | 8-6 | .571 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 17 | Wed Jan 12 | atVirginia | L52-54 | 8-7 | .533 | - | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 18 | Sat Jan 15 | vsNotre Dame | W79-73 | 9-7 | .563 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 19 | Wed Jan 19 | atNC State | W62-59 | 10-7 | .588 | - | ACC Network | PNC Arena · Raleigh, NC |
| 20 | Sat Jan 22 | atBoston College | L63-68 | 10-8 | .556 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 21 | Mon Jan 24 | atUNC | L68-78 | 10-9 | .526 | - | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 22 | Wed Jan 26 | vsMiami | L75-78 | 10-10 | .500 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 23 | Sat Jan 29 | atFlorida St | W85-72 | 11-10 | .524 | - | ABC | Donald L. Tucker Center · Tallahassee, FL |
| 24 | Wed Feb 2 | vsGeorgia Tech | W81-66 | 12-10 | .545 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 25 | Sat Feb 5 | atPitt | W76-71 | 13-10 | .565 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 26 | Mon Feb 7 | vsPitt | W74-47 | 14-10 | .583 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 27 | Sat Feb 12 | vsSyracuse | W71-59 | 15-10 | .600 | - | ESPN2 | Cassell Coliseum · Blacksburg, VA |
| 28 | Mon Feb 14 | vsVirginia | W62-53 | 16-10 | .615 | - | ESPN | Cassell Coliseum · Blacksburg, VA |
| 29 | Sat Feb 19 | vsUNC | L57-65 | 16-11 | .593 | - | ESPN2 | Cassell Coliseum · Blacksburg, VA |
| 30 | Wed Feb 23 | atGeorgia Tech | W62-58 | 17-11 | .607 | - | ACC Network | McCamish Pavilion · Atlanta, GA |
| 31 | Sat Feb 26 | atMiami | W71-70 | 18-11 | .621 | - | | Watsco Center · Coral Gables, FL |
| 32 | Tue Mar 1 | vsLouisville | W75-43 | 19-11 | .633 | - | ESPN2 | Cassell Coliseum · Blacksburg, VA |
| 33 | Sat Mar 5 | atClemson | L59-63 | 19-12 | .613 | - | | Littlejohn Coliseum · Clemson, SC |
| 34 | Wed Mar 9 | vsClemson | W76-75 (OT) | 20-12 | .625 | - | ESPN2 | Cassell Coliseum · Blacksburg, VA |
| 35 | Thu Mar 10 | atNotre Dame | W87-80 | 21-12 | .636 | - | ESPN2 | Purcell Pavilion · South Bend, IN |
| 36 | Fri Mar 11 | atUNC | W72-59 | 22-12 | .647 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 37 | Sat Mar 12 | atDuke | W82-67 | 23-12 | .657 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 38 | Fri Mar 18 | at#6Texas | L73-81 | 23-13 | .639 | #11 | TBS | Moody Center · Austin, TX |
