| 1 | Tue Nov 5 | at Clemson | W67-60 | 1-0 | 1.000 | - | ESPNU | Littlejohn Coliseum · Clemson, SC |
| 2 | Fri Nov 8 | vsCoppin St | W74-42 | 2-0 | 1.000 | - | | Cassell Coliseum · Blacksburg, VA |
| 3 | Wed Nov 13 | vsSC Upstate | W80-57 | 3-0 | 1.000 | - | | Cassell Coliseum · Blacksburg, VA |
| 4 | Sat Nov 16 | vsLehigh | W79-53 | 4-0 | 1.000 | - | | Cassell Coliseum · Blacksburg, VA |
| 5 | Wed Nov 20 | vsDelaware St | W100-64 | 5-0 | 1.000 | - | | Cassell Coliseum · Blacksburg, VA |
| 6 | Mon Nov 25 | atMichigan St | W71-66 | 6-0 | 1.000 | - | ESPN2 | Breslin Center · East Lansing, MI |
| 7 | Tue Nov 26 | vsDayton | L62-89 | 6-1 | .857 | - | ESPN | Cassell Coliseum · Blacksburg, VA |
| 8 | Wed Nov 27 | atBYU | L77-90 | 6-2 | .750 | - | ESPN2 | Marriott Center · Provo, UT |
| 9 | Fri Dec 6 | vs10Duke | L63-77 | 6-3 | .667 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 10 | Wed Dec 11 | vsChattanooga | W63-58 | 7-3 | .700 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 11 | Sun Dec 15 | vsGardner-Webb | W73-46 | 8-3 | .727 | - | | Cassell Coliseum · Blacksburg, VA |
| 12 | Sat Dec 21 | vsVMI | W64-55 | 9-3 | .750 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 13 | Sun Dec 29 | vsMD-Eastern | W92-37 | 10-3 | .769 | - | | Cassell Coliseum · Blacksburg, VA |
| 14 | Sat Jan 4 | at19Virginia | L39-65 | 10-4 | .714 | - | | John Paul Jones Arena · Charlottesville, VA |
| 15 | Tue Jan 7 | atSyracuse | W67-63 | 11-4 | .733 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 16 | Sat Jan 11 | vsNC State | W72-58 | 12-4 | .750 | - | | Cassell Coliseum · Blacksburg, VA |
| 17 | Tue Jan 14 | atWake Forest | W80-70 | 13-4 | .765 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 18 | Sat Jan 18 | vsSyracuse | L69-71 | 13-5 | .722 | - | | Cassell Coliseum · Blacksburg, VA |
| 19 | Wed Jan 22 | vsUNC | W79-77 (2OT) | 14-5 | .737 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 20 | Sat Jan 25 | atBoston College | L56-61 | 14-6 | .700 | - | ESPNU | Silvio O. Conte Forum · Chestnut Hill, MA |
| 21 | Tue Jan 28 | atMiami | L61-71 | 14-7 | .667 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 22 | Sat Feb 1 | vs5Florida St | L63-74 | 14-8 | .636 | - | | Cassell Coliseum · Blacksburg, VA |
| 23 | Tue Feb 4 | atGeorgia Tech | L57-76 | 14-9 | .609 | - | ACC Network | McCamish Pavilion · Atlanta, GA |
| 24 | Sat Feb 8 | vsBoston College | L73-77 (OT) | 14-10 | .583 | - | | Cassell Coliseum · Blacksburg, VA |
| 25 | Sat Feb 15 | vsPitt | W67-57 | 15-10 | .600 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 26 | Wed Feb 19 | vsMiami | L95-102 (3OT) | 15-11 | .577 | - | | Cassell Coliseum · Blacksburg, VA |
| 27 | Sat Feb 22 | at6Duke | L64-88 | 15-12 | .556 | - | ESPN2 | Cameron Indoor Stadium · Durham, NC |
| 28 | Wed Feb 26 | vsVirginia | L53-56 | 15-13 | .536 | - | ESPN2 | Cassell Coliseum · Blacksburg, VA |
| 29 | Sun Mar 1 | at11Louisville | L52-68 | 15-14 | .517 | - | ACC Network | KFC Yum! Center · Louisville, KY |
| 30 | Wed Mar 4 | vsClemson | W70-58 | 16-14 | .533 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 31 | Sat Mar 7 | atNotre Dame | L56-64 | 16-15 | .516 | - | ACC Network | Purcell Pavilion · South Bend, IN |
| 32 | Tue Mar 10 | vsUNC | L56-78 | 16-16 | .500 | - | ACC Network | Greensboro Coliseum · Greensboro, NC |
