| 1 | Mon Nov 4 | vs Delaware St | W83-60 | 1-0 | 1.000 | - | ESPN+ | Cassell Coliseum · Blacksburg, VA |
| 2 | Fri Nov 8 | vsSC Upstate | W93-74 | 2-0 | 1.000 | - | ESPN+ | Cassell Coliseum · Blacksburg, VA |
| 3 | Mon Nov 11 | vsWinthrop | W58-52 | 3-0 | 1.000 | - | ESPN+ | Cassell Coliseum · Blacksburg, VA |
| 4 | Fri Nov 15 | atPenn State | L64-86 | 3-1 | .750 | - | Peacock | Bryce Jordan Center · University Park, PA |
| 5 | Wed Nov 20 | vsJacksonville | L64-74 | 3-2 | .600 | - | ESPN+ | Cassell Coliseum · Blacksburg, VA |
| 6 | Mon Nov 25 | vsMichigan | L63-75 | 3-3 | .500 | - | FS1 | Cassell Coliseum · Blacksburg, VA |
| 7 | Wed Nov 27 | vsSouth Carolina | L60-70 | 3-4 | .429 | - | FS1 | Cassell Coliseum · Blacksburg, VA |
| 8 | Wed Dec 4 | vsVanderbilt | L64-80 | 3-5 | .375 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 9 | Sat Dec 7 | vs#18Pitt | L59-64 | 3-6 | .333 | - | ESPNU | Cassell Coliseum · Blacksburg, VA |
| 10 | Thu Dec 12 | vsNC A&T | W95-67 | 4-6 | .400 | - | ESPN+ | Cassell Coliseum · Blacksburg, VA |
| 11 | Sun Dec 15 | vsNavy | W80-72 | 5-6 | .455 | - | ESPN+ | Cassell Coliseum · Blacksburg, VA |
| 12 | Sat Dec 21 | atSaint Joseph's | L62-82 | 5-7 | .417 | - | CBS | The Palestra · Philadelphia, PA |
| 13 | Tue Dec 31 | at#4Duke | L65-88 | 5-8 | .385 | - | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 14 | Sat Jan 4 | vsMiami | W86-85 | 6-8 | .429 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 15 | Wed Jan 8 | atStanford | L59-70 | 6-9 | .400 | - | ACC Network | Maples Pavilion · Stanford, CA |
| 16 | Sat Jan 11 | atCalifornia | W71-68 | 7-9 | .438 | - | ACC Network | Haas Pavilion · Berkeley, CA |
| 17 | Wed Jan 15 | vsNC State | W79-76 | 8-9 | .471 | - | ESPNU | Cassell Coliseum · Blacksburg, VA |
| 18 | Sat Jan 18 | vsWake Forest | L63-72 | 8-10 | .444 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 19 | Wed Jan 22 | atGeorgia Tech | L64-71 | 8-11 | .421 | - | ESPNU | McCamish Pavilion · Atlanta, GA |
| 20 | Sat Jan 25 | vsClemson | L57-72 | 8-12 | .400 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 21 | Wed Jan 29 | atFlorida St | W76-66 | 9-12 | .429 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 22 | Sat Feb 1 | atVirginia | W75-74 | 10-12 | .455 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 23 | Wed Feb 5 | vsSMU | L75-81 | 10-13 | .435 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 24 | Sat Feb 8 | atNotre Dame | W65-63 | 11-13 | .458 | - | The CW Network | Purcell Pavilion · South Bend, IN |
| 25 | Sat Feb 15 | vsVirginia | L70-73 | 11-14 | .440 | - | The CW Network | Cassell Coliseum · Blacksburg, VA |
| 26 | Tue Feb 18 | atBoston College | L36-54 | 11-15 | .423 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 27 | Sat Feb 22 | atMiami | W81-68 | 12-15 | .444 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 28 | Tue Feb 25 | vs#19Louisville | L66-71 | 12-16 | .429 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 29 | Sat Mar 1 | vsSyracuse | W101-95 (OT) | 13-16 | .448 | - | The CW Network | Cassell Coliseum · Blacksburg, VA |
| 30 | Tue Mar 4 | vsUNC | L59-91 | 13-17 | .433 | - | ESPNU | Cassell Coliseum · Blacksburg, VA |
| 31 | Sat Mar 8 | at#11Clemson | L47-65 | 13-18 | .419 | - | ESPNU | Littlejohn Coliseum · Clemson, SC |
| 32 | Tue Mar 11 | vsCalifornia | L73-82 (2OT) | 13-19 | .406 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
