| 1 | Wed Nov 25 | vs Radford | W77-62 | 1-0 | 1.000 | - | | Cassell Coliseum · Blacksburg, VA |
| 2 | Sat Nov 28 | atVillanova | W81-73 (OT) | 2-0 | 1.000 | - | ESPNU | Finneran Pavilion · Villanova, PA |
| 3 | Sun Nov 29 | vsSouth Florida | W76-58 | 3-0 | 1.000 | - | ESPN2 | Cassell Coliseum · Blacksburg, VA |
| 4 | Thu Dec 3 | vsVMI | W64-57 | 4-0 | 1.000 | #16 | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 5 | Tue Dec 8 | vsPenn State | L55-75 | 4-1 | .800 | - | ESPNU | Cassell Coliseum · Blacksburg, VA |
| 6 | Tue Dec 15 | vsClemson | W66-60 | 5-1 | .833 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 7 | Sat Dec 19 | vsCoppin St | W97-57 | 6-1 | .857 | - | | Cassell Coliseum · Blacksburg, VA |
| 8 | Mon Dec 21 | vsLongwood | W84-58 | 7-1 | .875 | #24 | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 9 | Tue Dec 29 | vsMiami | W80-78 | 8-1 | .889 | #24 | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 11 | Wed Jan 6 | atLouisville | L71-73 | 8-2 | .800 | #19 | ACC Network | KFC Yum! Center · Louisville, KY |
| 12 | Sun Jan 10 | vsNotre Dame | W77-63 | 9-2 | .818 | #19 | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 13 | Tue Jan 12 | vs#19Duke | W74-67 | 10-2 | .833 | #20 | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 14 | Sun Jan 17 | atWake Forest | W64-60 | 11-2 | .846 | #20 | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 16 | Sat Jan 23 | atSyracuse | L60-78 | 11-3 | .786 | #16 | | JMA Wireless Dome · Syracuse, NY |
| 17 | Wed Jan 27 | atNotre Dame | W62-51 | 12-3 | .800 | #20 | | Purcell Pavilion · South Bend, IN |
| 18 | Sat Jan 30 | vs#8Virginia | W65-51 | 13-3 | .813 | #20 | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 19 | Wed Feb 3 | atPitt | L72-83 | 13-4 | .765 | #16 | | Petersen Events Center · Pittsburgh, PA |
| 20 | Sat Feb 6 | atMiami | W80-76 (OT) | 14-4 | .778 | #16 | | Watsco Center · Coral Gables, FL |
| 24 | Tue Feb 23 | vsGeorgia Tech | L53-69 | 14-5 | .737 | #16 | | Cassell Coliseum · Blacksburg, VA |
| 25 | Sat Feb 27 | vsWake Forest | W84-46 | 15-5 | .750 | #16 | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 28 | Thu Mar 11 | vsUNC | L73-81 | 15-6 | .714 | - | ESPN | Cassell Coliseum · Blacksburg, VA |
| 29 | Fri Mar 19 | at#7Florida | L70-75 (OT) | 15-7 | .682 | #10 | CBS | O'Connell Center · Gainesville, FL |
