| 1 | Mon Nov 3 | vs Charleston So | 7:00 PM | 10-22 | .313 | - | | Cassell Coliseum · Blacksburg, VA |
| 2 | Sat Nov 8 | vsProvidence | 4:00 PM | 12-20 | .375 | - | Peacock | Cassell Coliseum · Blacksburg, VA |
| 3 | Wed Nov 12 | vsSaint Joseph's | TBD | 22-13 | .629 | - | | Cassell Coliseum · Blacksburg, VA |
| 4 | Sun Nov 16 | vsCharlotte | TBD | 11-22 | .333 | - | | Cassell Coliseum · Blacksburg, VA |
| 5 | Wed Nov 19 | vsBryant | TBD | 23-12 | .657 | - | | Cassell Coliseum · Blacksburg, VA |
| 6 | Wed Nov 26 | vsColorado St | 5:00 PM | 26-10 | .722 | - | | Cassell Coliseum · Blacksburg, VA |
| 7 | Tue Dec 2 | atSouth Carolina | 7:00 PM | 12-20 | .375 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 8 | Sat Dec 6 | vsGeorge Mason | TBD | 27-9 | .750 | - | | Cassell Coliseum · Blacksburg, VA |
| 9 | Thu Dec 11 | vsW Carolina | TBD | 8-22 | .267 | - | | Cassell Coliseum · Blacksburg, VA |
| 10 | Sun Dec 14 | vsMD-Eastern | TBD | 6-25 | .194 | - | | Cassell Coliseum · Blacksburg, VA |
| 11 | Sat Dec 20 | vsElon | TBD | 17-16 | .515 | - | | Cassell Coliseum · Blacksburg, VA |
| 12 | Wed Dec 31 | vsVirginia | 2:00 PM | 15-17 | .469 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 13 | Sat Jan 3 | atWake Forest | 12:00 PM | 21-11 | .656 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 14 | Wed Jan 7 | vsStanford | 7:00 PM | 21-14 | .600 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 15 | Sat Jan 10 | vsCalifornia | 4:00 PM | 14-19 | .424 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 16 | Tue Jan 13 | atSMU | TBD | 24-11 | .686 | - | | Moody Coliseum · Dallas, TX |
| 17 | Sat Jan 17 | vsNotre Dame | 12:00 PM | 15-18 | .455 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 18 | Wed Jan 21 | atSyracuse | 9:00 PM | 14-19 | .424 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 19 | Sat Jan 24 | at#11Louisville | TBD | 27-8 | .771 | - | | KFC Yum! Center · Louisville, KY |
| 20 | Tue Jan 27 | vsGeorgia Tech | 8:00 PM | 17-17 | .500 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 21 | Sat Jan 31 | vs#6Duke | 12:00 PM | 35-4 | .897 | - | ESPN | Cassell Coliseum · Blacksburg, VA |
| 22 | Sat Feb 7 | atNC State | TBD | 12-19 | .387 | - | | PNC Arena · Raleigh, NC |
| 23 | Wed Feb 11 | atClemson | 7:00 PM | 27-7 | .794 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 24 | Sat Feb 14 | vsFlorida St | 2:00 PM | 17-15 | .531 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 25 | Tue Feb 17 | atMiami | 8:00 PM | 7-24 | .226 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 26 | Sat Feb 21 | vsWake Forest | 12:00 PM | 21-11 | .656 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 27 | Sat Feb 28 | at#25UNC | TBD | 23-14 | .622 | - | | Dean E. Smith Center · Chapel Hill, NC |
| 28 | Tue Mar 3 | vsBoston College | 9:00 PM | 12-19 | .387 | - | ESPNU | Cassell Coliseum · Blacksburg, VA |
| 29 | Sat Mar 7 | atVirginia | TBD | 15-17 | .469 | - | | John Paul Jones Arena · Charlottesville, VA |
