| 1 | Sun Sep 8 | vs Lions | T27-27 (OT) | 0-0-1 | .000 | State Farm Stadium · Glendale, AZ |
| 2 | Sun Sep 15 | atRavens | L17-23 | 0-1-1 | .250 | M&T Bank Stadium · Baltimore, MD |
| 3 | Sun Sep 22 | vsPanthers | L20-38 | 0-2-1 | .167 | State Farm Stadium · Glendale, AZ |
| 4 | Sun Sep 29 | vsSeahawks | L10-27 | 0-3-1 | .125 | State Farm Stadium · Glendale, AZ |
| 5 | Sun Oct 6 | atBengals | W26-23 | 1-3-1 | .300 | Paycor Stadium · Cincinnati, OH |
| 6 | Sun Oct 13 | vsFalcons | W34-33 | 2-3-1 | .417 | State Farm Stadium · Glendale, AZ |
| 7 | Sun Oct 20 | atGiants | W27-21 | 3-3-1 | .500 | MetLife Stadium · East Rutherford, NJ |
| 8 | Sun Oct 27 | atSaints | L9-31 | 3-4-1 | .438 | Caesars Superdome · New Orleans, LA |
| 9 | Thu Oct 31 | vs49ers | L25-28 | 3-5-1 | .389 | State Farm Stadium · Glendale, AZ |
| 10 | Sun Nov 10 | atBuccaneers | L27-30 | 3-6-1 | .350 | Raymond James Stadium · Tampa, FL |
| 11 | Sun Nov 17 | at49ers | L26-36 | 3-7-1 | .318 | Levi's® Stadium · Santa Clara, CA |
| --bye week-- |
| 13 | Sun Dec 1 | vsRams | L7-34 | 3-8-1 | .292 | State Farm Stadium · Glendale, AZ |
| 14 | Sun Dec 8 | vsSteelers | L17-23 | 3-9-1 | .269 | State Farm Stadium · Glendale, AZ |
| 15 | Sun Dec 15 | vsBrowns | W38-24 | 4-9-1 | .321 | State Farm Stadium · Glendale, AZ |
| 16 | Sun Dec 22 | atSeahawks | W27-13 | 5-9-1 | .367 | Lumen Field · Seattle, WA |
| 17 | Sun Dec 29 | atRams | L24-31 | 5-10-1 | .344 | SoFi Stadium · Inglewood, CA |
