| 1 | Sun Sep 13 | at 49ers | W24-20 | 1-0 | 1.000 | Levi's® Stadium · Santa Clara, CA |
| 2 | Sun Sep 20 | vsCommanders | W30-15 | 2-0 | 1.000 | State Farm Stadium · Glendale, AZ |
| 3 | Sun Sep 27 | vsLions | L23-26 | 2-1 | .667 | State Farm Stadium · Glendale, AZ |
| 4 | Sun Oct 4 | atPanthers | L21-31 | 2-2 | .500 | Bank of America Stadium · Charlotte, NC |
| 5 | Sun Oct 11 | atJets | W30-10 | 3-2 | .600 | MetLife Stadium · East Rutherford, NJ |
| 6 | Mon Oct 19 | atCowboys | W38-10 | 4-2 | .667 | AT&T Stadium · Arlington, TX |
| 7 | Sun Oct 25 | vsSeahawks | W37-34 (OT) | 5-2 | .714 | State Farm Stadium · Glendale, AZ |
| --bye week-- |
| 9 | Sun Nov 8 | vsDolphins | L31-34 | 5-3 | .625 | State Farm Stadium · Glendale, AZ |
| 10 | Sun Nov 15 | vsBills | W32-30 | 6-3 | .667 | State Farm Stadium · Glendale, AZ |
| 11 | Thu Nov 19 | atSeahawks | L21-28 | 6-4 | .600 | Lumen Field · Seattle, WA |
| 12 | Sun Nov 29 | atPatriots | L17-20 | 6-5 | .545 | Gillette Stadium · Foxborough, MA |
| 13 | Sun Dec 6 | vsRams | L28-38 | 6-6 | .500 | State Farm Stadium · Glendale, AZ |
| 14 | Sun Dec 13 | atGiants | W26-7 | 7-6 | .538 | MetLife Stadium · East Rutherford, NJ |
| 15 | Sun Dec 20 | vsEagles | W33-26 | 8-6 | .571 | State Farm Stadium · Glendale, AZ |
| 16 | Sat Dec 26 | vs49ers | L12-20 | 8-7 | .533 | State Farm Stadium · Glendale, AZ |
| 17 | Sun Jan 3 | atRams | L7-18 | 8-8 | .500 | SoFi Stadium · Inglewood, CA |
