| 1 | Sun Sep 10 | at Commanders | L16-20 | 0-1 | .000 | FedEx Field · North Englewood, MD |
| 2 | Sun Sep 17 | vsGiants | L28-31 | 0-2 | .000 | State Farm Stadium · Glendale, AZ |
| 3 | Sun Sep 24 | vsCowboys | W28-16 | 1-2 | .333 | State Farm Stadium · Glendale, AZ |
| 4 | Sun Oct 1 | at49ers | L16-35 | 1-3 | .250 | Levi's® Stadium · Santa Clara, CA |
| 5 | Sun Oct 8 | vsBengals | L20-34 | 1-4 | .200 | State Farm Stadium · Glendale, AZ |
| 6 | Sun Oct 15 | atRams | L9-26 | 1-5 | .167 | SoFi Stadium · Inglewood, CA |
| 7 | Sun Oct 22 | atSeahawks | L10-20 | 1-6 | .143 | Lumen Field · Seattle, WA |
| 8 | Sun Oct 29 | vsRavens | L24-31 | 1-7 | .125 | State Farm Stadium · Glendale, AZ |
| 9 | Sun Nov 5 | atBrowns | L0-27 | 1-8 | .111 | FirstEnergy Stadium · Cleveland, OH |
| 10 | Sun Nov 12 | vsFalcons | W25-23 | 2-8 | .200 | State Farm Stadium · Glendale, AZ |
| 11 | Sun Nov 19 | atTexans | L16-21 | 2-9 | .182 | NRG Stadium · Houston, TX |
| 12 | Sun Nov 26 | vsRams | L14-37 | 2-10 | .167 | State Farm Stadium · Glendale, AZ |
| 13 | Sun Dec 3 | atSteelers | W24-10 | 3-10 | .231 | Acrisure Stadium · Pittsburgh, PA |
| --bye week-- |
| 15 | Sun Dec 17 | vs49ers | L29-45 | 3-11 | .214 | State Farm Stadium · Glendale, AZ |
| 16 | Sun Dec 24 | atBears | L16-27 | 3-12 | .200 | Soldier Field · Chicago, IL |
| 17 | Sun Dec 31 | atEagles | W35-31 | 4-12 | .250 | Lincoln Financial Field · Philadelphia, PA |
| 18 | Sun Jan 7 | vsSeahawks | L20-21 | 4-13 | .235 | State Farm Stadium · Glendale, AZ |
