| 1 | Sun Sep 12 | at Titans | W38-13 | 1-0 | 1.000 | Nissan Stadium · Nashville, TN |
| 2 | Sun Sep 19 | vs Vikings | W34-33 | 2-0 | 1.000 | State Farm Stadium · Glendale, AZ |
| 3 | Sun Sep 26 | at Jaguars | W31-19 | 3-0 | 1.000 | TIAA Bank Field · Jacksonville, FL |
| 4 | Sun Oct 3 | at Rams | W37-20 | 4-0 | 1.000 | SoFi Stadium · Inglewood, CA |
| 5 | Sun Oct 10 | vs 49ers | W17-10 | 5-0 | 1.000 | State Farm Stadium · Glendale, AZ |
| 6 | Sun Oct 17 | at Browns | W37-14 | 6-0 | 1.000 | FirstEnergy Stadium · Cleveland, OH |
| 7 | Sun Oct 24 | vs Texans | W31-5 | 7-0 | 1.000 | State Farm Stadium · Glendale, AZ |
| 8 | Thu Oct 28 | vs Packers | L21-24 | 7-1 | .875 | State Farm Stadium · Glendale, AZ |
| 9 | Sun Nov 7 | at49ers | W31-17 | 8-1 | .889 | Levi's® Stadium · Santa Clara, CA |
| 10 | Sun Nov 14 | vs Panthers | L10-34 | 8-2 | .800 | State Farm Stadium · Glendale, AZ |
| 11 | Sun Nov 21 | at Seahawks | W23-13 | 9-2 | .818 | Lumen Field · Seattle, WA |
| 12 | -- BYE WEEK -- |
| 13 | Sun Dec 5 | at Bears | W33-22 | 10-2 | .833 | Soldier Field · Chicago, IL |
| 14 | Mon Dec 13 | vsRams | L23-30 | 10-3 | .769 | State Farm Stadium · Glendale, AZ |
| 15 | Sun Dec 19 | at Lions | L12-30 | 10-4 | .714 | Ford Field · Detroit, MI |
| 16 | Sat Dec 25 | vs Colts | L16-22 | 10-5 | .667 | State Farm Stadium · Glendale, AZ |
| 17 | Sun Jan 2 | at Cowboys | W25-22 | 11-5 | .688 | AT&T Stadium · Arlington, TX |
| 18 | Sun Jan 9 | vsSeahawks | L30-38 | 11-6 | .647 | State Farm Stadium · Glendale, AZ |
| WC | Mon Jan 17 | atRams | L11-34 | 11-6 | .647 | SoFi Stadium · Inglewood, CA |
