| 1 | Sun Sep 7 | at Saints | W20-13 | 1-0 | 1.000 | Caesars Superdome · New Orleans, LA |
| 2 | Sun Sep 14 | vsPanthers | W27-22 | 2-0 | 1.000 | State Farm Stadium · Glendale, AZ |
| 3 | Sun Sep 21 | at49ers | L15-16 | 2-1 | .667 | Levi's® Stadium · Santa Clara, CA |
| 4 | Thu Sep 25 | vsSeahawks | L20-23 | 2-2 | .500 | State Farm Stadium · Glendale, AZ |
| 5 | Sun Oct 5 | vsTitans | L21-22 | 2-3 | .400 | State Farm Stadium · Glendale, AZ |
| 6 | Sun Oct 12 | atColts | L27-31 | 2-4 | .333 | Lucas Oil Stadium · Indianapolis, IN |
| 7 | Sun Oct 19 | vsPackers | L23-27 | 2-5 | .286 | State Farm Stadium · Glendale, AZ |
| --bye week-- |
| 9 | Mon Nov 3 | atCowboys | W27-17 | 3-5 | .375 | AT&T Stadium · Arlington, TX |
| 10 | Sun Nov 9 | atSeahawks | L22-44 | 3-6 | .333 | Lumen Field · Seattle, WA |
| 11 | Sun Nov 16 | vs49ers | L22-41 | 3-7 | .300 | State Farm Stadium · Glendale, AZ |
| 12 | Sun Nov 23 | vsJaguars | L24-27 (OT) | 3-8 | .273 | State Farm Stadium · Glendale, AZ |
| 13 | Sun Nov 30 | atBuccaneers | L17-20 | 3-9 | .250 | Raymond James Stadium · Tampa, FL |
| 14 | Sun Dec 7 | vsRams | L17-45 | 3-10 | .231 | State Farm Stadium · Glendale, AZ |
| 15 | Sun Dec 14 | atTexans | L20-40 | 3-11 | .214 | NRG Stadium · Houston, TX |
| 16 | Sun Dec 21 | vsFalcons | L19-26 | 3-12 | .200 | State Farm Stadium · Glendale, AZ |
| 17 | Sun Dec 28 | atBengals | L14-37 | 3-13 | .188 | Paycor Stadium · Cincinnati, OH |
| 18 | Sun Jan 4 | atRams | L20-37 | 3-14 | .176 | SoFi Stadium · Inglewood, CA |
