| 1 | Sun Sep 11 | vs Chiefs | L21-44 | 0-1 | .000 | State Farm Stadium · Glendale, AZ |
| 2 | Sun Sep 18 | at Raiders | W29-23 (OT) | 1-1 | .500 | Allegiant Stadium · Las Vegas, NV |
| 3 | Sun Sep 25 | vs Rams | L12-20 | 1-2 | .333 | State Farm Stadium · Glendale, AZ |
| 4 | Sun Oct 2 | at Panthers | W26-16 | 2-2 | .500 | Bank of America Stadium · Charlotte, NC |
| 5 | Sun Oct 9 | vs Eagles | L17-20 | 2-3 | .400 | State Farm Stadium · Glendale, AZ |
| 6 | Sun Oct 16 | at Seahawks | L9-19 | 2-4 | .333 | Lumen Field · Seattle, WA |
| 7 | Thu Oct 20 | vs Saints | W42-34 | 3-4 | .429 | State Farm Stadium · Glendale, AZ |
| 8 | Sun Oct 30 | at Vikings | L26-34 | 3-5 | .375 | U.S. Bank Stadium · Minneapolis, MN |
| 9 | Sun Nov 6 | vsSeahawks | L21-31 | 3-6 | .333 | State Farm Stadium · Glendale, AZ |
| 10 | Sun Nov 13 | atRams | W27-17 | 4-6 | .400 | SoFi Stadium · Inglewood, CA |
| 11 | Mon Nov 21 | vs 49ers | L10-38 | 4-7 | .364 | State Farm Stadium · Glendale, AZ |
| 12 | Sun Nov 27 | vs Chargers | L24-25 | 4-8 | .333 | State Farm Stadium · Glendale, AZ |
| 13 | -- BYE WEEK -- |
| 14 | Mon Dec 12 | vs Patriots | L13-27 | 4-9 | .308 | State Farm Stadium · Glendale, AZ |
| 15 | Sun Dec 18 | at Broncos | L15-24 | 4-10 | .286 | Empower Field at Mile High · Denver, CO |
| 16 | Sun Dec 25 | vs Buccaneers | L16-19 (OT) | 4-11 | .267 | State Farm Stadium · Glendale, AZ |
| 17 | Sun Jan 1 | at Falcons | L19-20 | 4-12 | .250 | Mercedes-Benz Stadium · Atlanta, GA |
| 18 | Sun Jan 8 | at49ers | L13-38 | 4-13 | .235 | Levi's® Stadium · Santa Clara, CA |
