| 1 | Wed Oct 23 | at Blazers | W108-100 | 1-0 | 1.000 | Moda Center · Portland, OR |
| 2 | Fri Oct 25 | vs Suns | W108-107 (OT) | 2-0 | 1.000 | Ball Arena · Denver, CO |
| 3 | Mon Oct 28 | at Kings | W101-94 | 3-0 | 1.000 | Golden 1 Center · Sacramento, CA |
| 4 | Tue Oct 29 | vs Mavericks | L106-109 | 3-1 | .750 | Ball Arena · Denver, CO |
| 5 | Thu Oct 31 | at Pelicans | L107-122 | 3-2 | .600 | Smoothie King Center · New Orleans, LA |
| 6 | Sat Nov 2 | at Magic | W91-87 | 4-2 | .667 | Amway Center · Orlando, FL |
| 7 | Tue Nov 5 | vs Heat | W109-89 | 5-2 | .714 | Ball Arena · Denver, CO |
| 8 | Fri Nov 8 | vs 76ers | W100-97 | 6-2 | .750 | Ball Arena · Denver, CO |
| 9 | Sun Nov 10 | at T-wolves | W100-98 (OT) | 7-2 | .778 | Target Center · Minneapolis, MN |
| 10 | Tue Nov 12 | vs Hawks | L121-125 | 7-3 | .700 | Ball Arena · Denver, CO |
| 11 | Thu Nov 14 | vs Nets | W101-93 | 8-3 | .727 | Ball Arena · Denver, CO |
| 12 | Sun Nov 17 | at Grizzlies | W131-114 | 9-3 | .750 | FedExForum · Memphis, TN |
| 13 | Wed Nov 20 | vs Rockets | W105-95 | 10-3 | .769 | Ball Arena · Denver, CO |
| 14 | Fri Nov 22 | vs Celtics | W96-92 | 11-3 | .786 | Ball Arena · Denver, CO |
| 15 | Sun Nov 24 | vsSuns | W116-104 | 12-3 | .800 | Ball Arena · Denver, CO |
| 16 | Tue Nov 26 | vs Wizards | W117-104 | 13-3 | .813 | Ball Arena · Denver, CO |
| 17 | Sat Nov 30 | atKings | L97-100 (OT) | 13-4 | .765 | Golden 1 Center · Sacramento, CA |
| 18 | Tue Dec 3 | vs Lakers | L96-105 | 13-5 | .722 | Ball Arena · Denver, CO |
| 19 | Thu Dec 5 | at Knicks | W129-92 | 14-5 | .737 | Madison Square Garden · Manhattan, NY |
| 20 | Fri Dec 6 | atCeltics | L95-108 | 14-6 | .700 | TD Garden · Boston, MA |
| 21 | Sun Dec 8 | atNets | L102-105 | 14-7 | .667 | Barclays Center · Brooklyn, NY |
| 22 | Tue Dec 10 | at76ers | L92-97 | 14-8 | .636 | Wells Fargo Center · Philadelphia, PA |
| 23 | Thu Dec 12 | vsBlazers | W114-99 | 15-8 | .652 | Ball Arena · Denver, CO |
| 24 | Sat Dec 14 | vs Thunder | W110-102 | 16-8 | .667 | Ball Arena · Denver, CO |
| 25 | Sun Dec 15 | vsKnicks | W111-105 | 17-8 | .680 | Ball Arena · Denver, CO |
| 26 | Wed Dec 18 | vsMagic | W113-104 | 18-8 | .692 | Ball Arena · Denver, CO |
| 27 | Fri Dec 20 | vsT-wolves | W109-100 | 19-8 | .704 | Ball Arena · Denver, CO |
| 28 | Sun Dec 22 | atLakers | W128-104 | 20-8 | .714 | Crypto.com Arena · Los Angeles, CA |
| 29 | Mon Dec 23 | atSuns | W113-111 | 21-8 | .724 | Footprint Center · Phoenix, AZ |
| 30 | Wed Dec 25 | vsPelicans | L100-112 | 21-9 | .700 | Ball Arena · Denver, CO |
| 31 | Sat Dec 28 | vsGrizzlies | W119-110 | 22-9 | .710 | Ball Arena · Denver, CO |
| 32 | Sun Dec 29 | vsKings | W120-115 | 23-9 | .719 | Ball Arena · Denver, CO |
| 33 | Tue Dec 31 | atRockets | L104-130 | 23-10 | .697 | Toyota Center · Houston, TX |
| 34 | Thu Jan 2 | at Pacers | W124-116 | 24-10 | .706 | Gainbridge Fieldhouse · Indianapolis, IN |
| 35 | Sat Jan 4 | atWizards | L114-128 | 24-11 | .686 | Capital One Arena · Washington, D.C. |
| 36 | Mon Jan 6 | atHawks | W123-115 | 25-11 | .694 | State Farm Arena · Atlanta, GA |
| 37 | Wed Jan 8 | atMavericks | W107-106 | 26-11 | .703 | American Airlines Center · Dallas, TX |
| 38 | Sat Jan 11 | vs Cavaliers | L103-111 | 26-12 | .684 | Ball Arena · Denver, CO |
| 39 | Sun Jan 12 | vs Clippers | W114-104 | 27-12 | .692 | Ball Arena · Denver, CO |
| 40 | Wed Jan 15 | vs Hornets | W100-86 | 28-12 | .700 | Ball Arena · Denver, CO |
| 41 | Thu Jan 16 | at Warriors | W134-131 (OT) | 29-12 | .707 | Chase Center · San Francisco, CA |
| 42 | Sun Jan 19 | vsPacers | L107-115 | 29-13 | .690 | Ball Arena · Denver, CO |
| 43 | Mon Jan 20 | atT-wolves | W107-100 | 30-13 | .698 | Target Center · Minneapolis, MN |
| 44 | Wed Jan 22 | atRockets | L105-121 | 30-14 | .682 | Toyota Center · Houston, TX |
| 45 | Fri Jan 24 | atPelicans | W113-106 | 31-14 | .689 | Smoothie King Center · New Orleans, LA |
| 46 | Sun Jan 26 | vsRockets | W117-110 | 32-14 | .696 | Ball Arena · Denver, CO |
| 47 | Tue Jan 28 | atGrizzlies | L96-104 | 32-15 | .681 | FedExForum · Memphis, TN |
| 48 | Thu Jan 30 | vs Jazz | W106-100 | 33-15 | .688 | Ball Arena · Denver, CO |
| 49 | Fri Jan 31 | at Bucks | W127-115 | 34-15 | .694 | Fiserv Forum · Milwaukee, WI |
| 50 | Sun Feb 2 | at Pistons | L123-128 (OT) | 34-16 | .680 | Little Caesars Arena · Detroit, MI |
| 51 | Tue Feb 4 | vsBlazers | W127-99 | 35-16 | .686 | Ball Arena · Denver, CO |
| 52 | Wed Feb 5 | atJazz | W98-95 | 36-16 | .692 | Vivint Arena · Salt Lake City, UT |
| 53 | Sat Feb 8 | atSuns | W117-108 | 37-16 | .698 | Footprint Center · Phoenix, AZ |
| 54 | Mon Feb 10 | vs Spurs | W127-120 | 38-16 | .704 | Ball Arena · Denver, CO |
| 55 | Wed Feb 12 | vsLakers | L116-120 (OT) | 38-17 | .691 | Ball Arena · Denver, CO |
| 56 | Fri Feb 21 | atThunder | L101-113 | 38-18 | .679 | Paycom Center · Oklahoma City, OK |
| 57 | Sun Feb 23 | vsT-wolves | W128-116 | 39-18 | .684 | Ball Arena · Denver, CO |
| 58 | Tue Feb 25 | vsPistons | W115-98 | 40-18 | .690 | Ball Arena · Denver, CO |
| 59 | Fri Feb 28 | atClippers | L103-132 | 40-19 | .678 | Crypto.com Arena · Los Angeles, CA |
| 60 | Sun Mar 1 | vs Raptors | W133-118 | 41-19 | .683 | Ball Arena · Denver, CO |
| 61 | Tue Mar 3 | vsWarriors | L100-116 | 41-20 | .672 | Ball Arena · Denver, CO |
| 62 | Thu Mar 5 | atHornets | W114-112 | 42-20 | .677 | Spectrum Center · Charlotte, NC |
| 63 | Sat Mar 7 | atCavaliers | L102-104 | 42-21 | .667 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 64 | Mon Mar 9 | vsBucks | W109-95 | 43-21 | .672 | Ball Arena · Denver, CO |
| 65 | Wed Mar 11 | atMavericks | L97-113 | 43-22 | .662 | American Airlines Center · Dallas, TX |
| 66 | Sat Aug 1 | vsHeat | L105-125 | 43-23 | .652 | Ball Arena · Denver, CO |
| 67 | Mon Aug 3 | atThunder | W121-113 (OT) | 44-23 | .657 | Paycom Center · Oklahoma City, OK |
| 68 | Wed Aug 5 | atSpurs | W132-126 | 45-23 | .662 | AT&T Center · San Antonio, TX |
| 69 | Thu Aug 6 | vsBlazers | L115-125 | 45-24 | .652 | Ball Arena · Denver, CO |
| 70 | Sat Aug 8 | vsJazz | W134-132 (2OT) | 46-24 | .657 | Ball Arena · Denver, CO |
| 71 | Mon Aug 10 | atLakers | L121-124 | 46-25 | .648 | Crypto.com Arena · Los Angeles, CA |
| 72 | Wed Aug 12 | vsClippers | L111-124 | 46-26 | .639 | Ball Arena · Denver, CO |
| 73 | Fri Aug 14 | atRaptors | L109-117 | 46-27 | .630 | Scotiabank Arena · Toronto, ON |
| 1 | Mon Aug 17 | vsJazz | W135-125 (OT) | 1-0 | 1.000 | Ball Arena · Denver, CO |
| 2 | Wed Aug 19 | vsJazz | L105-124 | 1-1 | .500 | Ball Arena · Denver, CO |
| 3 | Fri Aug 21 | atJazz | L87-124 | 1-2 | .333 | Vivint Arena · Salt Lake City, UT |
| 4 | Sun Aug 23 | atJazz | L127-129 | 1-3 | .250 | Vivint Arena · Salt Lake City, UT |
| 5 | Tue Aug 25 | vsJazz | W117-107 | 2-3 | .400 | Ball Arena · Denver, CO |
| 6 | Sun Aug 30 | atJazz | W119-107 | 3-3 | .500 | Vivint Arena · Salt Lake City, UT |
| 7 | Tue Sep 1 | vsJazz | W80-78 | 4-3 | .571 | Ball Arena · Denver, CO |
| 1 | Thu Sep 3 | atClippers | L97-120 | 0-1 | .000 | Crypto.com Arena · Los Angeles, CA |
| 2 | Sat Sep 5 | atClippers | W110-101 | 1-1 | .500 | Crypto.com Arena · Los Angeles, CA |
| 3 | Mon Sep 7 | vsClippers | L107-113 | 1-2 | .333 | Ball Arena · Denver, CO |
| 4 | Wed Sep 9 | vsClippers | L85-96 | 1-3 | .250 | Ball Arena · Denver, CO |
| 5 | Fri Sep 11 | atClippers | W111-105 | 2-3 | .400 | Crypto.com Arena · Los Angeles, CA |
| 6 | Sun Sep 13 | vsClippers | W111-98 | 3-3 | .500 | Ball Arena · Denver, CO |
| 7 | Tue Sep 15 | atClippers | W104-89 | 4-3 | .571 | Crypto.com Arena · Los Angeles, CA |
| 1 | Fri Sep 18 | atLakers | L114-126 | 0-1 | .000 | Crypto.com Arena · Los Angeles, CA |
| 2 | Sun Sep 20 | atLakers | L103-105 | 0-2 | .000 | Crypto.com Arena · Los Angeles, CA |
| 3 | Tue Sep 22 | vsLakers | W114-106 | 1-2 | .333 | Ball Arena · Denver, CO |
| 4 | Thu Sep 24 | vsLakers | L108-114 | 1-3 | .250 | Ball Arena · Denver, CO |
| 5 | Sat Sep 26 | atLakers | L107-117 | 1-4 | .200 | Crypto.com Arena · Los Angeles, CA |
