| 1 | Thu Oct 24 | vs Thunder | L87-102 | 0-1 | .000 | TNT | Ball Arena · Denver, CO |
| 2 | Sat Oct 26 | vs Clippers | L104-109 | 0-2 | .000 | NBA TV | Ball Arena · Denver, CO |
| 3 | Mon Oct 28 | at Raptors | W127-125 (OT) | 1-2 | .333 | | Scotiabank Arena · Toronto, ON |
| 4 | Tue Oct 29 | at Nets | W144-139 (OT) | 2-2 | .500 | | Barclays Center · Brooklyn, NY |
| 5 | Fri Nov 1 | at T-wolves | L116-119 | 2-3 | .400 | ESPN | Target Center · Minneapolis, MN |
| 6 | Sat Nov 2 | vs Jazz | W129-103 | 3-3 | .500 | | Ball Arena · Denver, CO |
| 7 | Mon Nov 4 | vsRaptors | W121-119 | 4-3 | .571 | | Ball Arena · Denver, CO |
| 8 | Wed Nov 6 | vsThunder | W124-122 | 5-3 | .625 | | Ball Arena · Denver, CO |
| 9 | Fri Nov 8 | vs Heat | W135-122 | 6-3 | .667 | | Ball Arena · Denver, CO |
| 10 | Sun Nov 10 | vs Mavericks | W122-120 | 7-3 | .700 | | Ball Arena · Denver, CO |
| 11 | Fri Nov 15 | at Pelicans | L94-101 | 7-4 | .636 | | Smoothie King Center · New Orleans, LA |
| 12 | Sun Nov 17 | at Grizzlies | L90-105 | 7-5 | .583 | | FedExForum · Memphis, TN |
| 13 | Tue Nov 19 | atGrizzlies | W122-110 | 8-5 | .615 | | FedExForum · Memphis, TN |
| 14 | Fri Nov 22 | vsMavericks | L120-123 | 8-6 | .571 | ESPN | Ball Arena · Denver, CO |
| 15 | Sat Nov 23 | at Lakers | W127-102 | 9-6 | .600 | NBA TV | Crypto.com Arena · Los Angeles, CA |
| 16 | Mon Nov 25 | vs Knicks | L118-145 | 9-7 | .563 | | Ball Arena · Denver, CO |
| 17 | Wed Nov 27 | atJazz | W122-103 | 10-7 | .588 | | Vivint Arena · Salt Lake City, UT |
| 18 | Sun Dec 1 | atClippers | L122-126 | 10-8 | .556 | | Intuit Dome · Inglewood, CA |
| 19 | Tue Dec 3 | vs Warriors | W119-115 | 11-8 | .579 | TNT | Ball Arena · Denver, CO |
| 20 | Thu Dec 5 | at Cavaliers | L114-126 | 11-9 | .550 | NBA TV | Rocket Mortgage FieldHouse · Cleveland, OH |
| 21 | Sat Dec 7 | at Wizards | L113-122 | 11-10 | .524 | | Capital One Arena · Washington, D.C. |
| 22 | Sun Dec 8 | at Hawks | W141-111 | 12-10 | .545 | | State Farm Arena · Atlanta, GA |
| 23 | Fri Dec 13 | vsClippers | W120-98 | 13-10 | .565 | NBA TV | Ball Arena · Denver, CO |
| 24 | Mon Dec 16 | at Kings | W130-129 | 14-10 | .583 | | Golden 1 Center · Sacramento, CA |
| 25 | Thu Dec 19 | at Blazers | L124-126 | 14-11 | .560 | | Moda Center · Portland, OR |
| 26 | Sun Dec 22 | atPelicans | W132-129 (OT) | 15-11 | .577 | | Smoothie King Center · New Orleans, LA |
| 27 | Mon Dec 23 | vs Suns | W117-90 | 16-11 | .593 | | Ball Arena · Denver, CO |
| 28 | Wed Dec 25 | atSuns | L100-110 | 16-12 | .571 | ABC | Footprint Center · Phoenix, AZ |
| 29 | Fri Dec 27 | vsCavaliers | L135-149 | 16-13 | .552 | | Ball Arena · Denver, CO |
| 30 | Sat Dec 28 | vs Pistons | W134-121 | 17-13 | .567 | | Ball Arena · Denver, CO |
| 31 | Mon Dec 30 | atJazz | W132-121 | 18-13 | .581 | | Vivint Arena · Salt Lake City, UT |
| 32 | Wed Jan 1 | vsHawks | W139-120 | 19-13 | .594 | | Ball Arena · Denver, CO |
| 33 | Fri Jan 3 | vs Spurs | L110-113 | 19-14 | .576 | | Ball Arena · Denver, CO |
| 34 | Sat Jan 4 | atSpurs | W122-111 (OT) | 20-14 | .588 | | AT&T Center · San Antonio, TX |
| 35 | Tue Jan 7 | vs Celtics | L106-118 | 20-15 | .571 | TNT | Ball Arena · Denver, CO |
| 36 | Wed Jan 8 | vsClippers | W126-103 | 21-15 | .583 | | Ball Arena · Denver, CO |
| 37 | Fri Jan 10 | vsNets | W124-105 | 22-15 | .595 | | Ball Arena · Denver, CO |
| 38 | Sun Jan 12 | atMavericks | W112-101 | 23-15 | .605 | | American Airlines Center · Dallas, TX |
| 39 | Tue Jan 14 | atMavericks | W118-99 | 24-15 | .615 | TNT | American Airlines Center · Dallas, TX |
| 40 | Wed Jan 15 | vs Rockets | L108-128 | 24-16 | .600 | | Ball Arena · Denver, CO |
| 41 | Fri Jan 17 | atHeat | W133-113 | 25-16 | .610 | | Kaseya Center · Miami, FL |
| 42 | Sun Jan 19 | at Magic | W113-100 | 26-16 | .619 | | Amway Center · Orlando, FL |
| 43 | Tue Jan 21 | vs 76ers | W144-109 | 27-16 | .628 | TNT | Ball Arena · Denver, CO |
| 44 | Thu Jan 23 | vsKings | W132-123 | 28-16 | .636 | | Ball Arena · Denver, CO |
| 45 | Sat Jan 25 | atT-wolves | L104-133 | 28-17 | .622 | ABC | Target Center · Minneapolis, MN |
| 46 | Mon Jan 27 | at Bulls | L121-129 | 28-18 | .609 | | United Center · Chicago, IL |
| 47 | Wed Jan 29 | atKnicks | L112-122 | 28-19 | .596 | ESPN | Madison Square Garden · Manhattan, NY |
| 48 | Fri Jan 31 | at76ers | W137-134 | 29-19 | .604 | ESPN | Wells Fargo Center · Philadelphia, PA |
| 49 | Sat Feb 1 | at Hornets | W107-104 | 30-19 | .612 | | Spectrum Center · Charlotte, NC |
| 50 | Mon Feb 3 | vsPelicans | W125-113 | 31-19 | .620 | | Ball Arena · Denver, CO |
| 51 | Wed Feb 5 | vsPelicans | W144-119 | 32-19 | .627 | | Ball Arena · Denver, CO |
| 52 | Thu Feb 6 | vsMagic | W112-90 | 33-19 | .635 | | Ball Arena · Denver, CO |
| 53 | Sat Feb 8 | atSuns | W122-105 | 34-19 | .642 | | Footprint Center · Phoenix, AZ |
| 54 | Mon Feb 10 | vsBlazers | W146-117 | 35-19 | .648 | | Ball Arena · Denver, CO |
| 55 | Wed Feb 12 | vsBlazers | W132-121 | 36-19 | .655 | | Ball Arena · Denver, CO |
| --all-star break-- |
| 56 | Thu Feb 20 | vsHornets | W129-115 | 37-19 | .661 | | Ball Arena · Denver, CO |
| 57 | Sat Feb 22 | vsLakers | L100-123 | 37-20 | .649 | ABC | Ball Arena · Denver, CO |
| 58 | Mon Feb 24 | at Pacers | W125-116 | 38-20 | .655 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 59 | Thu Feb 27 | at Bucks | L112-121 | 38-21 | .644 | TNT | Fiserv Forum · Milwaukee, WI |
| 60 | Fri Feb 28 | atPistons | W134-119 | 39-21 | .650 | | Little Caesars Arena · Detroit, MI |
| 61 | Sun Mar 2 | atCeltics | L103-110 | 39-22 | .639 | ABC | TD Garden · Boston, MA |
| 62 | Wed Mar 5 | vsKings | W116-110 | 40-22 | .645 | | Ball Arena · Denver, CO |
| 63 | Fri Mar 7 | vsSuns | W149-141 (OT) | 41-22 | .651 | ESPN | Ball Arena · Denver, CO |
| 64 | Sun Mar 9 | atThunder | L103-127 | 41-23 | .641 | ABC | Paycom Center · Oklahoma City, OK |
| 65 | Mon Mar 10 | atThunder | W140-127 | 42-23 | .646 | NBA TV | Paycom Center · Oklahoma City, OK |
| 66 | Wed Mar 12 | vsT-wolves | L95-115 | 42-24 | .636 | ESPN | Ball Arena · Denver, CO |
| 67 | Fri Mar 14 | vsLakers | W131-126 | 43-24 | .642 | NBA TV | Ball Arena · Denver, CO |
| 68 | Sat Mar 15 | vsWizards | L123-126 | 43-25 | .632 | | Ball Arena · Denver, CO |
| 69 | Mon Mar 17 | atWarriors | W114-105 | 44-25 | .638 | ESPN | Chase Center · San Francisco, CA |
| 70 | Wed Mar 19 | atLakers | L108-120 | 44-26 | .629 | ESPN | Crypto.com Arena · Los Angeles, CA |
| 71 | Fri Mar 21 | atBlazers | L109-128 | 44-27 | .620 | | Moda Center · Portland, OR |
| 72 | Sun Mar 23 | atRockets | W116-111 | 45-27 | .625 | | Toyota Center · Houston, TX |
| 73 | Mon Mar 24 | vsBulls | L119-129 | 45-28 | .616 | | Ball Arena · Denver, CO |
