| 1 | Wed Dec 23 | vs Kings | L122-124 (OT) | 0-1 | .000 | | Ball Arena · Denver, CO |
| 2 | Fri Dec 25 | vsClippers | L108-121 | 0-2 | .000 | ESPN | Ball Arena · Denver, CO |
| 3 | Mon Dec 28 | vsRockets | W124-111 | 1-2 | .333 | | Ball Arena · Denver, CO |
| 4 | Tue Dec 29 | atKings | L115-125 | 1-3 | .250 | | Golden 1 Center · Sacramento, CA |
| 5 | Fri Jan 1 | vsSuns | L103-106 | 1-4 | .200 | | Ball Arena · Denver, CO |
| 6 | Sun Jan 3 | atT-wolves | W124-109 | 2-4 | .333 | | Target Center · Minneapolis, MN |
| 7 | Tue Jan 5 | vsT-wolves | W123-116 | 3-4 | .429 | | Ball Arena · Denver, CO |
| 8 | Thu Jan 7 | vsMavericks | L117-124 (OT) | 3-5 | .375 | TNT | Ball Arena · Denver, CO |
| 9 | Sat Jan 9 | at76ers | W115-103 | 4-5 | .444 | NBA TV | Wells Fargo Center · Philadelphia, PA |
| 10 | Sun Jan 10 | atKnicks | W114-89 | 5-5 | .500 | | Madison Square Garden · Manhattan, NY |
| 11 | Tue Jan 12 | atNets | L116-122 | 5-6 | .455 | | Barclays Center · Brooklyn, NY |
| 12 | Thu Jan 14 | vsWarriors | W114-104 | 6-6 | .500 | TNT | Ball Arena · Denver, CO |
| 13 | Sun Jan 17 | vsJazz | L105-109 | 6-7 | .462 | | Ball Arena · Denver, CO |
| 14 | Tue Jan 19 | vsThunder | W119-101 | 7-7 | .500 | | Ball Arena · Denver, CO |
| 15 | Fri Jan 22 | atSuns | W130-126 (OT) | 8-7 | .533 | ESPN | Footprint Center · Phoenix, AZ |
| 16 | Sat Jan 23 | atSuns | W120-112 (2OT) | 9-7 | .563 | | Footprint Center · Phoenix, AZ |
| 17 | Mon Jan 25 | atMavericks | W117-113 | 10-7 | .588 | | American Airlines Center · Dallas, TX |
| 18 | Wed Jan 27 | atHeat | W109-82 | 11-7 | .611 | | Kaseya Center · Miami, FL |
| 19 | Fri Jan 29 | atSpurs | L109-119 | 11-8 | .579 | | AT&T Center · San Antonio, TX |
| 20 | Sun Jan 31 | vsJazz | W128-117 | 12-8 | .600 | NBA TV | Ball Arena · Denver, CO |
| 21 | Thu Feb 4 | atLakers | L93-114 | 12-9 | .571 | TNT | Crypto.com Arena · Los Angeles, CA |
| 22 | Sat Feb 6 | atKings | L114-119 | 12-10 | .545 | NBA TV | Golden 1 Center · Sacramento, CA |
| 23 | Mon Feb 8 | vsBucks | L112-125 | 12-11 | .522 | NBA TV | Ball Arena · Denver, CO |
| 24 | Wed Feb 10 | vsCavaliers | W133-95 | 13-11 | .542 | | Ball Arena · Denver, CO |
| 25 | Fri Feb 12 | vsThunder | W97-95 | 14-11 | .560 | | Ball Arena · Denver, CO |
| 26 | Sun Feb 14 | vsLakers | W122-105 | 15-11 | .577 | ESPN | Ball Arena · Denver, CO |
| 27 | Tue Feb 16 | atCeltics | L99-112 | 15-12 | .556 | | TD Garden · Boston, MA |
| 28 | Wed Feb 17 | atWizards | L128-130 | 15-13 | .536 | | Capital One Arena · Washington, D.C. |
| 29 | Fri Feb 19 | atCavaliers | W120-103 | 16-13 | .552 | | Rocket Mortgage FieldHouse · Cleveland, OH |
| 30 | Sun Feb 21 | atHawks | L115-123 | 16-14 | .533 | | State Farm Arena · Atlanta, GA |
| 31 | Tue Feb 23 | vsBlazers | W111-106 | 17-14 | .548 | TNT | Ball Arena · Denver, CO |
| 32 | Thu Feb 25 | vsWizards | L110-112 | 17-15 | .531 | | Ball Arena · Denver, CO |
| 33 | Sat Feb 27 | atThunder | W126-96 | 18-15 | .545 | | Paycom Center · Oklahoma City, OK |
| 34 | Mon Mar 1 | atBulls | W118-112 | 19-15 | .559 | | United Center · Chicago, IL |
| 35 | Tue Mar 2 | atBucks | W128-97 | 20-15 | .571 | | Fiserv Forum · Milwaukee, WI |
| 36 | Thu Mar 4 | atPacers | W113-103 | 21-15 | .583 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 37 | Fri Mar 12 | atGrizzlies | W103-102 | 22-15 | .595 | NBA TV | FedExForum · Memphis, TN |
| 38 | Sat Mar 13 | vsMavericks | L103-116 | 22-16 | .579 | NBA TV | Ball Arena · Denver, CO |
| 39 | Mon Mar 15 | vsPacers | W121-106 | 23-16 | .590 | | Ball Arena · Denver, CO |
| 40 | Wed Mar 17 | vsHornets | W129-104 | 24-16 | .600 | | Ball Arena · Denver, CO |
| 41 | Fri Mar 19 | vsBulls | W131-127 (OT) | 25-16 | .610 | | Ball Arena · Denver, CO |
| 42 | Sun Mar 21 | vsPelicans | L108-113 | 25-17 | .595 | | Ball Arena · Denver, CO |
| 43 | Tue Mar 23 | atMagic | W110-99 | 26-17 | .605 | | Amway Center · Orlando, FL |
| 44 | Wed Mar 24 | atRaptors | L111-135 | 26-18 | .591 | | Scotiabank Arena · Toronto, ON |
| 45 | Fri Mar 26 | atPelicans | W113-108 | 27-18 | .600 | | Smoothie King Center · New Orleans, LA |
| 46 | Sun Mar 28 | vsHawks | W126-102 | 28-18 | .609 | NBA TV | Ball Arena · Denver, CO |
| 47 | Tue Mar 30 | vs76ers | W104-95 | 29-18 | .617 | NBA TV | Ball Arena · Denver, CO |
| 48 | Thu Apr 1 | atClippers | W101-94 | 30-18 | .625 | TNT | Intuit Dome · Inglewood, CA |
| 49 | Sun Apr 4 | vsMagic | W119-109 | 31-18 | .633 | NBA TV | Ball Arena · Denver, CO |
| 50 | Tue Apr 6 | vsPistons | W134-119 | 32-18 | .640 | | Ball Arena · Denver, CO |
| 51 | Wed Apr 7 | vsSpurs | W106-96 | 33-18 | .647 | | Ball Arena · Denver, CO |
| 52 | Fri Apr 9 | vsSpurs | W121-119 | 34-18 | .654 | | Ball Arena · Denver, CO |
| 53 | Sun Apr 11 | vsCeltics | L87-105 | 34-19 | .642 | NBA TV | Ball Arena · Denver, CO |
| 54 | Mon Apr 12 | atWarriors | L107-116 | 34-20 | .630 | ESPN | Chase Center · San Francisco, CA |
| 55 | Wed Apr 14 | vsHeat | W123-106 | 35-20 | .636 | | Ball Arena · Denver, CO |
| 56 | Fri Apr 16 | atRockets | W128-99 | 36-20 | .643 | | Toyota Center · Houston, TX |
| 57 | Mon Apr 19 | vsGrizzlies | W139-137 (2OT) | 37-20 | .649 | | Ball Arena · Denver, CO |
| 58 | Wed Apr 21 | atBlazers | W106-105 | 38-20 | .655 | | Moda Center · Portland, OR |
| 59 | Fri Apr 23 | atWarriors | L97-118 | 38-21 | .644 | ESPN | Chase Center · San Francisco, CA |
| 60 | Sat Apr 24 | vsRockets | W129-116 | 39-21 | .650 | | Ball Arena · Denver, CO |
| 61 | Mon Apr 26 | vsGrizzlies | W120-96 | 40-21 | .656 | | Ball Arena · Denver, CO |
| 62 | Wed Apr 28 | vsPelicans | W114-112 | 41-21 | .661 | | Ball Arena · Denver, CO |
| 63 | Thu Apr 29 | vsRaptors | W121-111 | 42-21 | .667 | | Ball Arena · Denver, CO |
| 64 | Sat May 1 | atClippers | W110-104 | 43-21 | .672 | ESPN | Intuit Dome · Inglewood, CA |
| 65 | Mon May 3 | atLakers | L89-93 | 43-22 | .662 | ESPN | Crypto.com Arena · Los Angeles, CA |
| 66 | Wed May 5 | vsKnicks | W113-97 | 44-22 | .667 | | Ball Arena · Denver, CO |
| 67 | Fri May 7 | atJazz | L120-127 | 44-23 | .657 | | Vivint Arena · Salt Lake City, UT |
| 68 | Sat May 8 | vsNets | L119-125 | 44-24 | .647 | NBA TV | Ball Arena · Denver, CO |
| 69 | Tue May 11 | atHornets | W117-112 | 45-24 | .652 | | Spectrum Center · Charlotte, NC |
| 70 | Thu May 13 | atT-wolves | W114-103 | 46-24 | .657 | | Target Center · Minneapolis, MN |
| 71 | Fri May 14 | atPistons | W104-91 | 47-24 | .662 | | Little Caesars Arena · Detroit, MI |
| 72 | Sun May 16 | atBlazers | L116-132 | 47-25 | .653 | | Moda Center · Portland, OR |
| 1 | Sat May 22 | vsBlazers | L109-123 | 0-1 | .000 | ESPN | Ball Arena · Denver, CO |
| 2 | Mon May 24 | vsBlazers | W128-109 | 1-1 | .500 | TNT | Ball Arena · Denver, CO |
| 3 | Thu May 27 | atBlazers | W120-115 | 2-1 | .667 | NBA TV | Moda Center · Portland, OR |
| 4 | Sat May 29 | atBlazers | L95-115 | 2-2 | .500 | TNT | Moda Center · Portland, OR |
| 5 | Tue Jun 1 | vsBlazers | W147-140 (2OT) | 3-2 | .600 | NBA TV | Ball Arena · Denver, CO |
| 6 | Thu Jun 3 | atBlazers | W126-115 | 4-2 | .667 | TNT | Moda Center · Portland, OR |
| 1 | Mon Jun 7 | atSuns | L105-122 | 0-1 | .000 | TNT | Footprint Center · Phoenix, AZ |
| 2 | Wed Jun 9 | atSuns | L98-123 | 0-2 | .000 | TNT | Footprint Center · Phoenix, AZ |
| 3 | Fri Jun 11 | vsSuns | L102-116 | 0-3 | .000 | ESPN | Ball Arena · Denver, CO |
| 4 | Sun Jun 13 | vsSuns | L118-125 | 0-4 | .000 | TNT | Ball Arena · Denver, CO |
