| 1 | Wed Oct 22 | vs 76ers | L116-117 | 0-1 | .000 | | TD Garden · Boston, MA |
| 2 | Fri Oct 24 | atKnicks | L95-105 | 0-2 | .000 | Amazon | Madison Square Garden · Manhattan, NY |
| 3 | Sun Oct 26 | atPistons | L113-119 | 0-3 | .000 | | Little Caesars Arena · Detroit, MI |
| 4 | Mon Oct 27 | atPelicans | W122-90 | 1-3 | .250 | | Smoothie King Center · New Orleans, LA |
| 5 | Wed Oct 29 | vsCavaliers | W125-105 | 2-3 | .400 | ESPN | TD Garden · Boston, MA |
| 6 | Fri Oct 31 | at76ers | W109-108 | 3-3 | .500 | Amazon | Wells Fargo Center · Philadelphia, PA |
| 7 | Sat Nov 1 | vsRockets | L101-128 | 3-4 | .429 | | TD Garden · Boston, MA |
| 8 | Mon Nov 3 | vsJazz | L103-105 | 3-5 | .375 | | TD Garden · Boston, MA |
| 9 | Wed Nov 5 | vsWizards | W136-107 | 4-5 | .444 | | TD Garden · Boston, MA |
| 10 | Fri Nov 7 | atMagic | L110-123 | 4-6 | .400 | | Kia Center · Orlando, FL |
| 11 | Sun Nov 9 | atMagic | W111-107 | 5-6 | .455 | | Kia Center · Orlando, FL |
| 12 | Tue Nov 11 | at76ers | L100-102 | 5-7 | .417 | Peacock | Wells Fargo Center · Philadelphia, PA |
| 13 | Wed Nov 12 | vsGrizzlies | W131-95 | 6-7 | .462 | | TD Garden · Boston, MA |
| 14 | Sun Nov 16 | vsClippers | W121-118 | 7-7 | .500 | | TD Garden · Boston, MA |
| 15 | Tue Nov 18 | atNets | W113-99 | 8-7 | .533 | | Barclays Center · Brooklyn, NY |
| 16 | Fri Nov 21 | vsNets | L105-113 | 8-8 | .500 | | TD Garden · Boston, MA |
| 17 | Sun Nov 23 | vsMagic | W138-129 | 9-8 | .529 | | TD Garden · Boston, MA |
| 18 | Wed Nov 26 | vsPistons | W117-114 | 10-8 | .556 | ESPN | TD Garden · Boston, MA |
| 19 | Sat Nov 29 | atT-wolves | L115-119 | 10-9 | .526 | NBA TV | Target Center · Minneapolis, MN |
| 20 | Sun Nov 30 | atCavaliers | W117-115 | 11-9 | .550 | | Rocket Mortgage FieldHouse · Cleveland, OH |
| 21 | Tue Dec 2 | vsKnicks | W123-117 | 12-9 | .571 | Peacock | TD Garden · Boston, MA |
| 22 | Thu Dec 4 | atWizards | W146-101 | 13-9 | .591 | | Capital One Arena · Washington, D.C. |
| 23 | Fri Dec 5 | vsLakers | W126-105 | 14-9 | .609 | Amazon | TD Garden · Boston, MA |
| 24 | Sun Dec 7 | atRaptors | W121-113 | 15-9 | .625 | | Scotiabank Arena · Toronto, ON |
| 25 | Thu Dec 11 | atBucks | L101-116 | 15-10 | .600 | | Fiserv Forum · Milwaukee, WI |
| 26 | Mon Dec 15 | vsPistons | L105-112 | 15-11 | .577 | Peacock | TD Garden · Boston, MA |
| 27 | Fri Dec 19 | vsHeat | W129-116 | 16-11 | .593 | | TD Garden · Boston, MA |
| 28 | Sat Dec 20 | atRaptors | W112-96 | 17-11 | .607 | | Scotiabank Arena · Toronto, ON |
| 29 | Mon Dec 22 | vsPacers | W103-95 | 18-11 | .621 | | TD Garden · Boston, MA |
| 30 | Fri Dec 26 | atPacers | W140-122 | 19-11 | .633 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 31 | Sun Dec 28 | atBlazers | L108-114 | 19-12 | .613 | | Moda Center · Portland, OR |
| 32 | Tue Dec 30 | atJazz | W129-119 | 20-12 | .625 | | Vivint Arena · Salt Lake City, UT |
| 33 | Thu Jan 1 | atKings | W120-106 | 21-12 | .636 | | Golden 1 Center · Sacramento, CA |
| 34 | Sat Jan 3 | atClippers | W146-115 | 22-12 | .647 | NBA TV | Intuit Dome · Inglewood, CA |
| 35 | Mon Jan 5 | vsBulls | W115-101 | 23-12 | .657 | | TD Garden · Boston, MA |
| 36 | Wed Jan 7 | vsNuggets | L110-114 | 23-13 | .639 | ESPN | TD Garden · Boston, MA |
| 37 | Fri Jan 9 | vsRaptors | W125-117 | 24-13 | .649 | | TD Garden · Boston, MA |
| 38 | Sat Jan 10 | vsSpurs | L95-100 | 24-14 | .632 | | TD Garden · Boston, MA |
| 39 | Mon Jan 12 | atPacers | L96-98 | 24-15 | .615 | Peacock | Gainbridge Fieldhouse · Indianapolis, IN |
| 40 | Thu Jan 15 | atHeat | W119-114 | 25-15 | .625 | | Kaseya Center · Miami, FL |
| 41 | Sat Jan 17 | atHawks | W132-106 | 26-15 | .634 | | State Farm Arena · Atlanta, GA |
| 42 | Mon Jan 19 | atPistons | L103-104 | 26-16 | .619 | Peacock | Little Caesars Arena · Detroit, MI |
| 43 | Wed Jan 21 | vsPacers | W119-104 | 27-16 | .628 | | TD Garden · Boston, MA |
| 44 | Fri Jan 23 | atNets | W130-126 (2OT) | 28-16 | .636 | | Barclays Center · Brooklyn, NY |
| 45 | Sat Jan 24 | atBulls | L111-114 | 28-17 | .622 | | United Center · Chicago, IL |
| 46 | Mon Jan 26 | vsBlazers | W102-94 | 29-17 | .630 | Peacock | TD Garden · Boston, MA |
| 47 | Wed Jan 28 | vsHawks | L106-117 | 29-18 | .617 | | TD Garden · Boston, MA |
| 48 | Fri Jan 30 | vsKings | W112-93 | 30-18 | .625 | | TD Garden · Boston, MA |
| 49 | Sun Feb 1 | vsBucks | W107-79 | 31-18 | .633 | ESPN | TD Garden · Boston, MA |
| 50 | Tue Feb 3 | atMavericks | W110-100 | 32-18 | .640 | Peacock | American Airlines Center · Dallas, TX |
| 51 | Wed Feb 4 | atRockets | W114-93 | 33-18 | .647 | | Toyota Center · Houston, TX |
| 52 | Fri Feb 6 | vsHeat | W98-96 | 34-18 | .654 | | TD Garden · Boston, MA |
| 53 | Sun Feb 8 | vsKnicks | L89-111 | 34-19 | .642 | ABC | TD Garden · Boston, MA |
| 54 | Wed Feb 11 | vsBulls | W124-105 | 35-19 | .648 | | TD Garden · Boston, MA |
| --all-star break-- |
| 55 | Thu Feb 19 | atWarriors | W121-110 | 36-19 | .655 | Amazon | Chase Center · San Francisco, CA |
| 56 | Sun Feb 22 | atLakers | W111-89 | 37-19 | .661 | Peacock | Crypto.com Arena · Los Angeles, CA |
| 57 | Tue Feb 24 | atSuns | W97-81 | 38-19 | .667 | | Mortgage Matchup Center · Phoenix, AZ |
| 58 | Wed Feb 25 | atNuggets | L84-103 | 38-20 | .655 | ESPN | Ball Arena · Denver, CO |
| 59 | Fri Feb 27 | vsNets | W148-111 | 39-20 | .661 | | TD Garden · Boston, MA |
| 60 | Sun Mar 1 | vs76ers | W114-98 | 40-20 | .667 | Peacock | TD Garden · Boston, MA |
| 61 | Mon Mar 2 | atBucks | W108-81 | 41-20 | .672 | NBA TV | Fiserv Forum · Milwaukee, WI |
| 62 | Wed Mar 4 | vsHornets | L89-118 | 41-21 | .661 | | TD Garden · Boston, MA |
| 63 | Fri Mar 6 | vsMavericks | W120-100 | 42-21 | .667 | ESPN | TD Garden · Boston, MA |
| 64 | Sun Mar 8 | atCavaliers | W109-98 | 43-21 | .672 | ABC | Rocket Mortgage FieldHouse · Cleveland, OH |
| 65 | Tue Mar 10 | atSpurs | L116-125 | 43-22 | .662 | Peacock | AT&T Center · San Antonio, TX |
| 66 | Thu Mar 12 | atThunder | L102-104 | 43-23 | .652 | Amazon | Paycom Center · Oklahoma City, OK |
| 67 | Sat Mar 14 | vsWizards | W111-100 | 44-23 | .657 | NBA TV | TD Garden · Boston, MA |
