| 1 | Wed Dec 23 | vs Bucks | W122-121 | 1-0 | 1.000 | TD Garden · Boston, MA |
| 2 | Fri Dec 25 | vs Nets | L95-123 | 1-1 | .500 | TD Garden · Boston, MA |
| 3 | Sun Dec 27 | at Pacers | L107-108 | 1-2 | .333 | Gainbridge Fieldhouse · Indianapolis, IN |
| 4 | Tue Dec 29 | atPacers | W116-111 | 2-2 | .500 | Gainbridge Fieldhouse · Indianapolis, IN |
| 5 | Wed Dec 30 | vs Grizzlies | W126-107 | 3-2 | .600 | TD Garden · Boston, MA |
| 6 | Fri Jan 1 | at Pistons | L93-96 | 3-3 | .500 | Little Caesars Arena · Detroit, MI |
| 7 | Sun Jan 3 | atPistons | W122-120 | 4-3 | .571 | Little Caesars Arena · Detroit, MI |
| 8 | Mon Jan 4 | at Raptors | W126-114 | 5-3 | .625 | Scotiabank Arena · Toronto, ON |
| 9 | Wed Jan 6 | at Heat | W107-105 | 6-3 | .667 | FTX Arena · Miami, FL |
| 10 | Fri Jan 8 | vs Wizards | W116-107 | 7-3 | .700 | TD Garden · Boston, MA |
| 11 | Fri Jan 15 | vs Magic | W124-97 | 8-3 | .727 | TD Garden · Boston, MA |
| 12 | Sun Jan 17 | vs Knicks | L75-105 | 8-4 | .667 | TD Garden · Boston, MA |
| 13 | Wed Jan 20 | at 76ers | L109-117 | 8-5 | .615 | Wells Fargo Center · Philadelphia, PA |
| 14 | Fri Jan 22 | at76ers | L110-122 | 8-6 | .571 | Wells Fargo Center · Philadelphia, PA |
| 15 | Sun Jan 24 | vs Cavaliers | W141-103 | 9-6 | .600 | TD Garden · Boston, MA |
| 16 | Mon Jan 25 | at Bulls | W119-103 | 10-6 | .625 | United Center · Chicago, IL |
| 17 | Wed Jan 27 | at Spurs | L106-110 | 10-7 | .588 | AT&T Center · San Antonio, TX |
| 18 | Sat Jan 30 | vs Lakers | L95-96 | 10-8 | .556 | TD Garden · Boston, MA |
| 19 | Tue Feb 2 | at Warriors | W111-107 | 11-8 | .579 | Chase Center · San Francisco, CA |
| 20 | Wed Feb 3 | at Kings | L111-116 | 11-9 | .550 | Golden 1 Center · Sacramento, CA |
| 21 | Fri Feb 5 | at Clippers | W119-115 | 12-9 | .571 | Crypto.com Arena · Los Angeles, CA |
| 22 | Sun Feb 7 | at Suns | L91-100 | 12-10 | .545 | Footprint Center · Phoenix, AZ |
| 23 | Tue Feb 9 | at Jazz | L108-122 | 12-11 | .522 | Vivint Arena · Salt Lake City, UT |
| 24 | Thu Feb 11 | vsRaptors | W120-106 | 13-11 | .542 | TD Garden · Boston, MA |
| 25 | Fri Feb 12 | vsPistons | L102-108 | 13-12 | .520 | TD Garden · Boston, MA |
| 26 | Sun Feb 14 | atWizards | L91-104 | 13-13 | .500 | Capital One Arena · Washington, D.C. |
| 27 | Tue Feb 16 | vs Nuggets | W112-99 | 14-13 | .519 | TD Garden · Boston, MA |
| 28 | Wed Feb 17 | vs Hawks | L114-122 | 14-14 | .500 | TD Garden · Boston, MA |
| 29 | Fri Feb 19 | vsHawks | W121-109 | 15-14 | .517 | TD Garden · Boston, MA |
| 30 | Sun Feb 21 | at Pelicans | L115-120 (OT) | 15-15 | .500 | Smoothie King Center · New Orleans, LA |
| 31 | Tue Feb 23 | at Mavericks | L107-110 | 15-16 | .484 | American Airlines Center · Dallas, TX |
| 32 | Wed Feb 24 | atHawks | L112-127 | 15-17 | .469 | State Farm Arena · Atlanta, GA |
| 33 | Fri Feb 26 | vsPacers | W118-112 | 16-17 | .485 | TD Garden · Boston, MA |
| 34 | Sun Feb 28 | vsWizards | W111-110 | 17-17 | .500 | TD Garden · Boston, MA |
| 35 | Tue Mar 2 | vsClippers | W117-112 | 18-17 | .514 | TD Garden · Boston, MA |
| 36 | Thu Mar 4 | vsRaptors | W132-125 | 19-17 | .528 | TD Garden · Boston, MA |
| 37 | Thu Mar 11 | atNets | L109-121 | 19-18 | .514 | Barclays Center · Brooklyn, NY |
| 38 | Sun Mar 14 | at Rockets | W134-107 | 20-18 | .526 | Toyota Center · Houston, TX |
| 39 | Tue Mar 16 | vsJazz | L109-117 | 20-19 | .513 | TD Garden · Boston, MA |
| 40 | Wed Mar 17 | atCavaliers | L110-117 | 20-20 | .500 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 41 | Fri Mar 19 | vsKings | L96-107 | 20-21 | .488 | TD Garden · Boston, MA |
| 42 | Sun Mar 21 | vsMagic | W112-96 | 21-21 | .500 | TD Garden · Boston, MA |
| 43 | Mon Mar 22 | atGrizzlies | L126-132 (OT) | 21-22 | .488 | FedExForum · Memphis, TN |
| 44 | Wed Mar 24 | atBucks | L119-121 | 21-23 | .477 | Fiserv Forum · Milwaukee, WI |
| 45 | Fri Mar 26 | atBucks | W122-114 | 22-23 | .489 | Fiserv Forum · Milwaukee, WI |
| 46 | Sat Mar 27 | at Thunder | W111-94 | 23-23 | .500 | Paycom Center · Oklahoma City, OK |
| 47 | Mon Mar 29 | vsPelicans | L109-115 | 23-24 | .489 | TD Garden · Boston, MA |
| 48 | Wed Mar 31 | vsMavericks | L108-113 | 23-25 | .479 | TD Garden · Boston, MA |
| 49 | Fri Apr 2 | vsRockets | W118-102 | 24-25 | .490 | TD Garden · Boston, MA |
| 50 | Sun Apr 4 | vs Hornets | W116-86 | 25-25 | .500 | TD Garden · Boston, MA |
| 51 | Tue Apr 6 | vs76ers | L96-106 | 25-26 | .490 | TD Garden · Boston, MA |
| 52 | Wed Apr 7 | vsKnicks | W101-99 | 26-26 | .500 | TD Garden · Boston, MA |
| 53 | Fri Apr 9 | vs T-wolves | W145-136 (OT) | 27-26 | .509 | TD Garden · Boston, MA |
| 54 | Sun Apr 11 | atNuggets | W105-87 | 28-26 | .519 | Ball Arena · Denver, CO |
| 55 | Tue Apr 13 | at Blazers | W116-115 | 29-26 | .527 | Moda Center · Portland, OR |
| 56 | Thu Apr 15 | atLakers | W121-113 | 30-26 | .536 | Crypto.com Arena · Los Angeles, CA |
| 57 | Sat Apr 17 | vsWarriors | W119-114 | 31-26 | .544 | TD Garden · Boston, MA |
| 58 | Mon Apr 19 | vsBulls | L96-102 | 31-27 | .534 | TD Garden · Boston, MA |
| 59 | Thu Apr 22 | vsSuns | W99-86 | 32-27 | .542 | TD Garden · Boston, MA |
| 60 | Fri Apr 23 | atNets | L104-109 | 32-28 | .533 | Barclays Center · Brooklyn, NY |
| 61 | Sun Apr 25 | atHornets | L104-125 | 32-29 | .525 | Spectrum Center · Charlotte, NC |
| 62 | Tue Apr 27 | vsThunder | L115-119 | 32-30 | .516 | TD Garden · Boston, MA |
| 63 | Wed Apr 28 | vsHornets | W120-111 | 33-30 | .524 | TD Garden · Boston, MA |
| 64 | Fri Apr 30 | vsSpurs | W143-140 (OT) | 34-30 | .531 | TD Garden · Boston, MA |
| 65 | Sun May 2 | vsBlazers | L119-129 | 34-31 | .523 | TD Garden · Boston, MA |
| 66 | Wed May 5 | atMagic | W132-96 | 35-31 | .530 | Amway Center · Orlando, FL |
| 67 | Fri May 7 | atBulls | L99-121 | 35-32 | .522 | United Center · Chicago, IL |
| 68 | Sun May 9 | vsHeat | L124-130 | 35-33 | .515 | TD Garden · Boston, MA |
| 69 | Tue May 11 | vsHeat | L121-129 | 35-34 | .507 | TD Garden · Boston, MA |
| 70 | Wed May 12 | atCavaliers | L94-102 | 35-35 | .500 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 71 | Sat May 15 | atT-wolves | W124-108 | 36-35 | .507 | Target Center · Minneapolis, MN |
| 72 | Sun May 16 | atKnicks | L92-96 | 36-36 | .500 | Madison Square Garden · Manhattan, NY |
| 0 | Tue May 18 | vsWizards | W118-100 | 1-0 | 1.000 | TD Garden · Boston, MA |
| 1 | Sat May 22 | atNets | L93-104 | 0-1 | .000 | Barclays Center · Brooklyn, NY |
| 2 | Tue May 25 | atNets | L108-130 | 0-2 | .000 | Barclays Center · Brooklyn, NY |
| 3 | Fri May 28 | vsNets | W125-119 | 1-2 | .333 | TD Garden · Boston, MA |
| 4 | Sun May 30 | vsNets | L126-141 | 1-3 | .250 | TD Garden · Boston, MA |
| 5 | Tue Jun 1 | atNets | L109-123 | 1-4 | .200 | Barclays Center · Brooklyn, NY |
