| 1 | Tue Oct 16 | vs 76ers | W105-87 | 1-0 | 1.000 | TD Garden · Boston, MA |
| 2 | Fri Oct 19 | at Raptors | L101-113 | 1-1 | .500 | Scotiabank Arena · Toronto, ON |
| 3 | Sat Oct 20 | at Knicks | W103-101 | 2-1 | .667 | Madison Square Garden · Manhattan, NY |
| 4 | Mon Oct 22 | vs Magic | L90-93 | 2-2 | .500 | TD Garden · Boston, MA |
| 5 | Thu Oct 25 | at Thunder | W101-95 | 3-2 | .600 | Paycom Center · Oklahoma City, OK |
| 6 | Sat Oct 27 | at Pistons | W109-89 | 4-2 | .667 | Little Caesars Arena · Detroit, MI |
| 7 | Tue Oct 30 | vsPistons | W108-105 | 5-2 | .714 | TD Garden · Boston, MA |
| 8 | Thu Nov 1 | vs Bucks | W117-113 | 6-2 | .750 | TD Garden · Boston, MA |
| 9 | Sat Nov 3 | at Pacers | L101-102 | 6-3 | .667 | Gainbridge Fieldhouse · Indianapolis, IN |
| 10 | Mon Nov 5 | at Nuggets | L107-115 | 6-4 | .600 | Ball Arena · Denver, CO |
| 11 | Thu Nov 8 | at Suns | W116-109 (OT) | 7-4 | .636 | Footprint Center · Phoenix, AZ |
| 12 | Fri Nov 9 | at Jazz | L115-123 | 7-5 | .583 | Vivint Arena · Salt Lake City, UT |
| 13 | Sun Nov 11 | at Blazers | L94-100 | 7-6 | .538 | Moda Center · Portland, OR |
| 14 | Wed Nov 14 | vs Bulls | W111-82 | 8-6 | .571 | TD Garden · Boston, MA |
| 15 | Fri Nov 16 | vsRaptors | W123-116 (OT) | 9-6 | .600 | TD Garden · Boston, MA |
| 16 | Sat Nov 17 | vsJazz | L86-98 | 9-7 | .563 | TD Garden · Boston, MA |
| 17 | Mon Nov 19 | at Hornets | L112-117 | 9-8 | .529 | Spectrum Center · Charlotte, NC |
| 18 | Wed Nov 21 | vsKnicks | L109-117 | 9-9 | .500 | TD Garden · Boston, MA |
| 19 | Fri Nov 23 | at Hawks | W114-96 | 10-9 | .526 | State Farm Arena · Atlanta, GA |
| 20 | Sat Nov 24 | at Mavericks | L104-113 | 10-10 | .500 | American Airlines Center · Dallas, TX |
| 21 | Mon Nov 26 | at Pelicans | W124-107 | 11-10 | .524 | Smoothie King Center · New Orleans, LA |
| 22 | Fri Nov 30 | vs Cavaliers | W128-95 | 12-10 | .545 | TD Garden · Boston, MA |
| 23 | Sat Dec 1 | at T-wolves | W118-109 | 13-10 | .565 | Target Center · Minneapolis, MN |
| 24 | Thu Dec 6 | vsKnicks | W128-100 | 14-10 | .583 | TD Garden · Boston, MA |
| 25 | Sat Dec 8 | atBulls | W133-77 | 15-10 | .600 | United Center · Chicago, IL |
| 26 | Mon Dec 10 | vsPelicans | W113-100 | 16-10 | .615 | TD Garden · Boston, MA |
| 27 | Wed Dec 12 | at Wizards | W130-125 (OT) | 17-10 | .630 | Capital One Arena · Washington, D.C. |
| 28 | Fri Dec 14 | vsHawks | W129-108 | 18-10 | .643 | TD Garden · Boston, MA |
| 29 | Sat Dec 15 | atPistons | L104-113 | 18-11 | .621 | Little Caesars Arena · Detroit, MI |
| 30 | Wed Dec 19 | vsSuns | L103-111 | 18-12 | .600 | TD Garden · Boston, MA |
| 31 | Fri Dec 21 | vsBucks | L107-120 | 18-13 | .581 | TD Garden · Boston, MA |
| 32 | Sun Dec 23 | vsHornets | W119-103 | 19-13 | .594 | TD Garden · Boston, MA |
| 33 | Tue Dec 25 | vs76ers | W121-114 (OT) | 20-13 | .606 | TD Garden · Boston, MA |
| 34 | Thu Dec 27 | at Rockets | L113-127 | 20-14 | .588 | Toyota Center · Houston, TX |
| 35 | Sat Dec 29 | at Grizzlies | W112-103 | 21-14 | .600 | FedExForum · Memphis, TN |
| 36 | Mon Dec 31 | at Spurs | L111-120 | 21-15 | .583 | AT&T Center · San Antonio, TX |
| 37 | Wed Jan 2 | vsT-wolves | W115-102 | 22-15 | .595 | TD Garden · Boston, MA |
| 38 | Fri Jan 4 | vsMavericks | W114-93 | 23-15 | .605 | TD Garden · Boston, MA |
| 39 | Mon Jan 7 | vs Nets | W116-95 | 24-15 | .615 | TD Garden · Boston, MA |
| 40 | Wed Jan 9 | vsPacers | W135-108 | 25-15 | .625 | TD Garden · Boston, MA |
| 41 | Thu Jan 10 | at Heat | L99-115 | 25-16 | .610 | FTX Arena · Miami, FL |
| 42 | Sat Jan 12 | atMagic | L103-105 | 25-17 | .595 | Amway Center · Orlando, FL |
| 43 | Mon Jan 14 | atNets | L102-109 | 25-18 | .581 | Barclays Center · Brooklyn, NY |
| 44 | Wed Jan 16 | vsRaptors | W117-108 | 26-18 | .591 | TD Garden · Boston, MA |
| 45 | Fri Jan 18 | vsGrizzlies | W122-116 | 27-18 | .600 | TD Garden · Boston, MA |
| 46 | Sat Jan 19 | atHawks | W113-105 | 28-18 | .609 | State Farm Arena · Atlanta, GA |
| 47 | Mon Jan 21 | vsHeat | W107-99 | 29-18 | .617 | TD Garden · Boston, MA |
| 48 | Wed Jan 23 | vsCavaliers | W123-103 | 30-18 | .625 | TD Garden · Boston, MA |
| 49 | Sat Jan 26 | vs Warriors | L111-115 | 30-19 | .612 | TD Garden · Boston, MA |
| 50 | Mon Jan 28 | vsNets | W112-104 | 31-19 | .620 | TD Garden · Boston, MA |
| 51 | Wed Jan 30 | vsHornets | W126-94 | 32-19 | .627 | TD Garden · Boston, MA |
| 52 | Fri Feb 1 | atKnicks | W113-99 | 33-19 | .635 | Madison Square Garden · Manhattan, NY |
| 53 | Sun Feb 3 | vsThunder | W134-129 | 34-19 | .642 | TD Garden · Boston, MA |
| 54 | Tue Feb 5 | atCavaliers | W103-96 | 35-19 | .648 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 55 | Thu Feb 7 | vs Lakers | L128-129 | 35-20 | .636 | TD Garden · Boston, MA |
| 56 | Sat Feb 9 | vs Clippers | L112-123 | 35-21 | .625 | TD Garden · Boston, MA |
| 57 | Tue Feb 12 | at76ers | W112-109 | 36-21 | .632 | Wells Fargo Center · Philadelphia, PA |
| 58 | Wed Feb 13 | vsPistons | W118-110 | 37-21 | .638 | TD Garden · Boston, MA |
| 59 | Thu Feb 21 | atBucks | L97-98 | 37-22 | .627 | Fiserv Forum · Milwaukee, WI |
| 60 | Sat Feb 23 | atBulls | L116-126 | 37-23 | .617 | United Center · Chicago, IL |
| 61 | Tue Feb 26 | atRaptors | L95-118 | 37-24 | .607 | Scotiabank Arena · Toronto, ON |
| 62 | Wed Feb 27 | vsBlazers | L92-97 | 37-25 | .597 | TD Garden · Boston, MA |
| 63 | Fri Mar 1 | vsWizards | W107-96 | 38-25 | .603 | TD Garden · Boston, MA |
| 64 | Sun Mar 3 | vsRockets | L104-115 | 38-26 | .594 | TD Garden · Boston, MA |
| 65 | Tue Mar 5 | atWarriors | W128-95 | 39-26 | .600 | Chase Center · San Francisco, CA |
| 66 | Wed Mar 6 | at Kings | W111-109 | 40-26 | .606 | Golden 1 Center · Sacramento, CA |
| 67 | Sat Mar 9 | atLakers | W120-107 | 41-26 | .612 | Crypto.com Arena · Los Angeles, CA |
| 68 | Mon Mar 11 | atClippers | L115-140 | 41-27 | .603 | Crypto.com Arena · Los Angeles, CA |
| 69 | Thu Mar 14 | vsKings | W126-120 | 42-27 | .609 | TD Garden · Boston, MA |
| 70 | Sat Mar 16 | vsHawks | W129-120 | 43-27 | .614 | TD Garden · Boston, MA |
| 71 | Mon Mar 18 | vsNuggets | L105-114 | 43-28 | .606 | TD Garden · Boston, MA |
| 72 | Wed Mar 20 | at76ers | L115-118 | 43-29 | .597 | Wells Fargo Center · Philadelphia, PA |
| 73 | Sat Mar 23 | atHornets | L117-124 | 43-30 | .589 | Spectrum Center · Charlotte, NC |
| 74 | Sun Mar 24 | vsSpurs | L96-115 | 43-31 | .581 | TD Garden · Boston, MA |
| 75 | Tue Mar 26 | atCavaliers | W116-106 | 44-31 | .587 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 76 | Fri Mar 29 | vsPacers | W114-112 | 45-31 | .592 | TD Garden · Boston, MA |
| 77 | Sat Mar 30 | atNets | L96-110 | 45-32 | .584 | Barclays Center · Brooklyn, NY |
| 78 | Mon Apr 1 | vsHeat | W110-105 | 46-32 | .590 | TD Garden · Boston, MA |
| 79 | Wed Apr 3 | atHeat | W112-102 | 47-32 | .595 | FTX Arena · Miami, FL |
| 80 | Fri Apr 5 | atPacers | W117-97 | 48-32 | .600 | Gainbridge Fieldhouse · Indianapolis, IN |
| 81 | Sun Apr 7 | vsMagic | L108-116 | 48-33 | .593 | TD Garden · Boston, MA |
| 82 | Tue Apr 9 | atWizards | W116-110 | 49-33 | .598 | Capital One Arena · Washington, D.C. |
| 1 | Sun Apr 14 | vsPacers | W84-74 | 1-0 | 1.000 | TD Garden · Boston, MA |
| 2 | Wed Apr 17 | vsPacers | W99-91 | 2-0 | 1.000 | TD Garden · Boston, MA |
| 3 | Fri Apr 19 | atPacers | W104-96 | 3-0 | 1.000 | Gainbridge Fieldhouse · Indianapolis, IN |
| 4 | Sun Apr 21 | atPacers | W110-106 | 4-0 | 1.000 | Gainbridge Fieldhouse · Indianapolis, IN |
| 1 | Sun Apr 28 | atBucks | W112-90 | 1-0 | 1.000 | Fiserv Forum · Milwaukee, WI |
| 2 | Tue Apr 30 | atBucks | L102-123 | 1-1 | .500 | Fiserv Forum · Milwaukee, WI |
| 3 | Fri May 3 | vsBucks | L116-123 | 1-2 | .333 | TD Garden · Boston, MA |
| 4 | Mon May 6 | vsBucks | L101-113 | 1-3 | .250 | TD Garden · Boston, MA |
| 5 | Wed May 8 | atBucks | L91-116 | 1-4 | .200 | Fiserv Forum · Milwaukee, WI |
