| 12 | Fri Nov 14 | vs Kings | 8:00 PM | 3-7 | .300 | | Target Center · Minneapolis, MN |
| 13 | Sat Nov 15 | vs Nuggets | 8:00 PM | 7-2 | .778 | | Target Center · Minneapolis, MN |
| 14 | Mon Nov 17 | vs Mavericks | 8:00 PM | 3-8 | .273 | | Target Center · Minneapolis, MN |
| 15 | Wed Nov 19 | vs Wizards | 8:00 PM | 1-10 | .091 | | Target Center · Minneapolis, MN |
| 16 | Fri Nov 21 | at Suns | 9:00 PM | 6-5 | .545 | | Footprint Center · Phoenix, AZ |
| 17 | Mon Nov 24 | at Kings | 10:00 PM | 3-7 | .300 | | Golden 1 Center · Sacramento, CA |
| 18 | Wed Nov 26 | at Thunder | 7:30 PM | 10-1 | .909 | ESPN | Paycom Center · Oklahoma City, OK |
| 19 | Sat Nov 29 | vs Celtics | 5:00 PM | 5-6 | .455 | NBA TV | Target Center · Minneapolis, MN |
| 20 | Sun Nov 30 | vs Spurs | 7:00 PM | 8-2 | .800 | | Target Center · Minneapolis, MN |
| 21 | Tue Dec 2 | at Pelicans | 8:00 PM | 2-8 | .200 | | Smoothie King Center · New Orleans, LA |
| 22 | Thu Dec 4 | at Pelicans | 8:00 PM | 2-8 | .200 | | Smoothie King Center · New Orleans, LA |
| 23 | Sat Dec 6 | vs Clippers | 8:00 PM | 3-7 | .300 | | Target Center · Minneapolis, MN |
| 24 | Mon Dec 8 | vs Suns | 8:00 PM | 6-5 | .545 | | Target Center · Minneapolis, MN |
| 25 | Wed Dec 17 | vs Grizzlies | 8:00 PM | 4-7 | .364 | | Target Center · Minneapolis, MN |
| 26 | Fri Dec 19 | vs Thunder | 9:30 PM | 10-1 | .909 | Amazon | Target Center · Minneapolis, MN |
| 27 | Sun Dec 21 | vs Bucks | 7:00 PM | 7-4 | .636 | | Target Center · Minneapolis, MN |
| 28 | Tue Dec 23 | vs Knicks | 8:00 PM | 6-3 | .667 | | Target Center · Minneapolis, MN |
| 29 | Thu Dec 25 | at Nuggets | 10:30 PM | 7-2 | .778 | ABC | Ball Arena · Denver, CO |
| 30 | Sat Dec 27 | vs Nets | 8:00 PM | 1-9 | .100 | | Target Center · Minneapolis, MN |
| 31 | Mon Dec 29 | at Bulls | 8:00 PM | 6-4 | .600 | | United Center · Chicago, IL |
| 32 | Wed Dec 31 | at Hawks | 3:00 PM | 6-5 | .545 | | State Farm Arena · Atlanta, GA |
| 33 | Sat Jan 3 | at Heat | 5:00 PM | 7-4 | .636 | NBA TV | Kaseya Center · Miami, FL |
| 34 | Sun Jan 4 | at Wizards | 6:00 PM | 1-10 | .091 | | Capital One Arena · Washington, D.C. |
| 35 | Tue Jan 6 | vs Heat | 8:00 PM | 7-4 | .636 | NBC | Target Center · Minneapolis, MN |
| 36 | Thu Jan 8 | vs Cavaliers | 8:00 PM | 7-4 | .636 | | Target Center · Minneapolis, MN |
| 37 | Sat Jan 10 | at Cavaliers | 1:00 PM | 7-4 | .636 | Amazon | Rocket Mortgage FieldHouse · Cleveland, OH |
| 38 | Sun Jan 11 | vs Spurs | 7:00 PM | 8-2 | .800 | | Target Center · Minneapolis, MN |
| 39 | Tue Jan 13 | at Bucks | 8:00 PM | 7-4 | .636 | NBC | Fiserv Forum · Milwaukee, WI |
| 40 | Fri Jan 16 | at Rockets | 9:30 PM | 6-3 | .667 | ESPN | Toyota Center · Houston, TX |
| 41 | Sat Jan 17 | at Spurs | 8:00 PM | 8-2 | .800 | | AT&T Center · San Antonio, TX |
| 42 | Tue Jan 20 | at Jazz | 9:00 PM | 3-7 | .300 | | Vivint Arena · Salt Lake City, UT |
| 43 | Thu Jan 22 | vs Bulls | 8:00 PM | 6-4 | .600 | | Target Center · Minneapolis, MN |
| 44 | Sat Jan 24 | vs Warriors | 5:30 PM | 6-5 | .545 | ABC | Target Center · Minneapolis, MN |
| 45 | Mon Jan 26 | vs Warriors | 9:30 PM | 6-5 | .545 | Peacock | Target Center · Minneapolis, MN |
| 46 | Wed Jan 28 | at Mavericks | 8:30 PM | 3-8 | .273 | | American Airlines Center · Dallas, TX |
| 47 | Thu Jan 29 | vs Thunder | 9:30 PM | 10-1 | .909 | Amazon | Target Center · Minneapolis, MN |
| 48 | Sat Jan 31 | at Grizzlies | 8:00 PM | 4-7 | .364 | | FedExForum · Memphis, TN |
| 49 | Mon Feb 2 | at Grizzlies | 9:30 PM | 4-7 | .364 | Peacock | FedExForum · Memphis, TN |
| 50 | Wed Feb 4 | at Raptors | 7:30 PM | 5-5 | .500 | | Scotiabank Arena · Toronto, ON |
| 51 | Fri Feb 6 | vs Pelicans | 8:00 PM | 2-8 | .200 | | Target Center · Minneapolis, MN |
| 52 | Sun Feb 8 | vs Clippers | 3:00 PM | 3-7 | .300 | ESPN | Target Center · Minneapolis, MN |
| 53 | Mon Feb 9 | vs Hawks | 8:00 PM | 6-5 | .545 | | Target Center · Minneapolis, MN |
| 54 | Wed Feb 11 | vs Blazers | 8:00 PM | 5-5 | .500 | | Target Center · Minneapolis, MN |
| 55 | Fri Feb 20 | vs Mavericks | 7:30 PM | 3-8 | .273 | ESPN | Target Center · Minneapolis, MN |
| 56 | Sun Feb 22 | vs 76ers | 7:00 PM | 6-4 | .600 | | Target Center · Minneapolis, MN |
| 57 | Tue Feb 24 | at Blazers | 11:00 PM | 5-5 | .500 | NBC | Moda Center · Portland, OR |
| 58 | Thu Feb 26 | at Clippers | 10:00 PM | 3-7 | .300 | Amazon | Intuit Dome · Inglewood, CA |
| 59 | Sun Mar 1 | at Nuggets | 3:30 PM | 7-2 | .778 | ABC | Ball Arena · Denver, CO |
| 60 | Tue Mar 3 | vs Grizzlies | 8:00 PM | 4-7 | .364 | | Target Center · Minneapolis, MN |
| 61 | Thu Mar 5 | vs Raptors | 8:00 PM | 5-5 | .500 | | Target Center · Minneapolis, MN |
| 62 | Sat Mar 7 | vs Magic | 3:00 PM | 5-6 | .455 | Amazon | Target Center · Minneapolis, MN |
| 63 | Tue Mar 10 | at Lakers | 11:00 PM | 8-3 | .727 | NBC | Crypto.com Arena · Los Angeles, CA |
| 64 | Wed Mar 11 | at Clippers | 10:30 PM | 3-7 | .300 | | Intuit Dome · Inglewood, CA |
| 65 | Fri Mar 13 | at Warriors | 10:00 PM | 6-5 | .545 | Amazon | Chase Center · San Francisco, CA |
| 66 | Sun Mar 15 | at Thunder | 1:00 PM | 10-1 | .909 | ABC | Paycom Center · Oklahoma City, OK |
| 67 | Tue Mar 17 | vs Suns | 8:00 PM | 6-5 | .545 | | Target Center · Minneapolis, MN |
| 68 | Wed Mar 18 | vs Jazz | 8:00 PM | 3-7 | .300 | | Target Center · Minneapolis, MN |
| 69 | Fri Mar 20 | vs Blazers | 8:00 PM | 5-5 | .500 | | Target Center · Minneapolis, MN |
| 70 | Sun Mar 22 | at Celtics | 8:00 PM | 5-6 | .455 | NBC | TD Garden · Boston, MA |
| 71 | Wed Mar 25 | vs Rockets | 9:30 PM | 6-3 | .667 | ESPN | Target Center · Minneapolis, MN |
| 72 | Sat Mar 28 | vs Pistons | 8:00 PM | 9-2 | .818 | | Target Center · Minneapolis, MN |
| 73 | Mon Mar 30 | at Mavericks | 8:30 PM | 3-8 | .273 | | American Airlines Center · Dallas, TX |
| 74 | Thu Apr 2 | at Pistons | 7:00 PM | 9-2 | .818 | | Little Caesars Arena · Detroit, MI |
| 75 | Fri Apr 3 | at 76ers | 7:00 PM | 6-4 | .600 | | Wells Fargo Center · Philadelphia, PA |
| 76 | Sun Apr 5 | vs Hornets | 7:00 PM | 3-7 | .300 | | Target Center · Minneapolis, MN |
| 77 | Tue Apr 7 | at Pacers | 8:00 PM | 1-9 | .100 | NBC | Gainbridge Fieldhouse · Indianapolis, IN |
| 78 | Wed Apr 8 | at Magic | 7:00 PM | 5-6 | .455 | | Amway Center · Orlando, FL |
| 79 | Fri Apr 10 | at Rockets | 8:00 PM | 6-3 | .667 | | Toyota Center · Houston, TX |
| 80 | Sun Apr 12 | vs Pelicans | 8:30 PM | 2-8 | .200 | | Target Center · Minneapolis, MN |