| 1 | Wed Oct 22 | at Bulls | 8:00 PM | 0-0 | .000 | | United Center · Chicago, IL |
| 2 | Fri Oct 24 | atRockets | 8:00 PM | 0-0 | .000 | | Toyota Center · Houston, TX |
| 3 | Sun Oct 26 | vsCeltics | 3:30 PM | 0-0 | .000 | | Little Caesars Arena · Detroit, MI |
| 4 | Mon Oct 27 | vsCavaliers | 7:00 PM | 0-0 | .000 | Peacock | Little Caesars Arena · Detroit, MI |
| 5 | Wed Oct 29 | vsMagic | 7:00 PM | 0-0 | .000 | | Little Caesars Arena · Detroit, MI |
| 6 | Sat Nov 1 | vsMavericks | 10:00 PM | 0-0 | .000 | Peacock | Little Caesars Arena · Detroit, MI |
| 7 | Mon Nov 3 | atGrizzlies | 8:00 PM | 0-0 | .000 | | FedExForum · Memphis, TN |
| 8 | Wed Nov 5 | vsJazz | 7:00 PM | 0-0 | .000 | | Little Caesars Arena · Detroit, MI |
| 9 | Fri Nov 7 | atNets | 7:30 PM | 0-0 | .000 | | Barclays Center · Brooklyn, NY |
| 10 | Sun Nov 9 | at76ers | 7:30 PM | 0-0 | .000 | | Wells Fargo Center · Philadelphia, PA |
| 11 | Mon Nov 10 | vsWizards | 7:00 PM | 0-0 | .000 | Peacock | Little Caesars Arena · Detroit, MI |
| 12 | Wed Nov 12 | vsBulls | 7:00 PM | 0-0 | .000 | | Little Caesars Arena · Detroit, MI |
| 13 | Fri Nov 14 | vs76ers | 7:30 PM | 0-0 | .000 | | Little Caesars Arena · Detroit, MI |
| 14 | Mon Nov 17 | vsPacers | 7:00 PM | 0-0 | .000 | | Little Caesars Arena · Detroit, MI |
| 15 | Tue Nov 18 | atHawks | 8:00 PM | 0-0 | .000 | NBC | State Farm Arena · Atlanta, GA |
| 16 | Sat Nov 22 | atBucks | 8:00 PM | 0-0 | .000 | | Fiserv Forum · Milwaukee, WI |
| 17 | Mon Nov 24 | atPacers | 7:00 PM | 0-0 | .000 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 18 | Wed Nov 26 | atCeltics | 5:00 PM | 0-0 | .000 | ESPN | TD Garden · Boston, MA |
| 19 | Fri Nov 28 | vsMagic | 7:30 PM | 0-0 | .000 | | Little Caesars Arena · Detroit, MI |
| 20 | Sat Nov 29 | atHeat | 8:00 PM | 0-0 | .000 | | Kaseya Center · Miami, FL |
| 21 | Mon Dec 1 | vsHawks | 7:00 PM | 0-0 | .000 | | Little Caesars Arena · Detroit, MI |
| 22 | Wed Dec 3 | atBucks | 8:00 PM | 0-0 | .000 | | Fiserv Forum · Milwaukee, WI |
| 23 | Fri Dec 5 | vsBlazers | 7:30 PM | 0-0 | .000 | | Little Caesars Arena · Detroit, MI |
| 24 | Sat Dec 6 | vsBucks | 7:30 PM | 0-0 | .000 | | Little Caesars Arena · Detroit, MI |
| 25 | Thu Dec 18 | atMavericks | 8:30 PM | 0-0 | .000 | | American Airlines Center · Dallas, TX |
| 26 | Sat Dec 20 | vsHornets | 7:30 PM | 0-0 | .000 | | Little Caesars Arena · Detroit, MI |
| 27 | Mon Dec 22 | atBlazers | 10:00 PM | 0-0 | .000 | | Moda Center · Portland, OR |
| 28 | Tue Dec 23 | atKings | 10:00 PM | 0-0 | .000 | | Golden 1 Center · Sacramento, CA |
| 29 | Fri Dec 26 | atJazz | 9:30 PM | 0-0 | .000 | | Vivint Arena · Salt Lake City, UT |
| 30 | Sun Dec 28 | atClippers | 9:00 PM | 0-0 | .000 | | Intuit Dome · Inglewood, CA |
| 31 | Tue Dec 30 | atLakers | 10:30 PM | 0-0 | .000 | | Crypto.com Arena · Los Angeles, CA |
| 32 | Thu Jan 1 | vsHeat | 7:00 PM | 0-0 | .000 | | Little Caesars Arena · Detroit, MI |
| 33 | Sun Jan 4 | atCavaliers | 2:00 PM | 0-0 | .000 | | Rocket Mortgage FieldHouse · Cleveland, OH |
| 34 | Mon Jan 5 | vsKnicks | 7:00 PM | 0-0 | .000 | Peacock | Little Caesars Arena · Detroit, MI |
| 35 | Wed Jan 7 | vsBulls | 7:00 PM | 0-0 | .000 | | Little Caesars Arena · Detroit, MI |
| 36 | Sat Jan 10 | vsClippers | 7:30 PM | 0-0 | .000 | | Little Caesars Arena · Detroit, MI |
| 37 | Thu Jan 15 | vsSuns | 7:00 PM | 0-0 | .000 | | Little Caesars Arena · Detroit, MI |
| 38 | Sat Jan 17 | vsPacers | 7:30 PM | 0-0 | .000 | | Little Caesars Arena · Detroit, MI |
| 39 | Mon Jan 19 | vsCeltics | 8:00 PM | 0-0 | .000 | NBC | Little Caesars Arena · Detroit, MI |
| 40 | Wed Jan 21 | atPelicans | 8:00 PM | 0-0 | .000 | | Smoothie King Center · New Orleans, LA |
| 41 | Fri Jan 23 | vsRockets | 7:00 PM | 0-0 | .000 | Amazon | Little Caesars Arena · Detroit, MI |
| 42 | Sun Jan 25 | vsKings | 3:00 PM | 0-0 | .000 | | Little Caesars Arena · Detroit, MI |
| 43 | Tue Jan 27 | atNuggets | 9:00 PM | 0-0 | .000 | | Ball Arena · Denver, CO |
| 44 | Thu Jan 29 | atSuns | 9:00 PM | 0-0 | .000 | | Footprint Center · Phoenix, AZ |
| 45 | Fri Jan 30 | atWarriors | 10:00 PM | 0-0 | .000 | | Chase Center · San Francisco, CA |
| 46 | Sun Feb 1 | vsNets | 6:00 PM | 0-0 | .000 | | Little Caesars Arena · Detroit, MI |
| 47 | Tue Feb 3 | vsNuggets | 7:00 PM | 0-0 | .000 | | Little Caesars Arena · Detroit, MI |
| 48 | Thu Feb 5 | vsWizards | 7:00 PM | 0-0 | .000 | | Little Caesars Arena · Detroit, MI |
| 49 | Fri Feb 6 | vsKnicks | 7:30 PM | 0-0 | .000 | Amazon | Little Caesars Arena · Detroit, MI |
| 50 | Mon Feb 9 | atHornets | 7:00 PM | 0-0 | .000 | | Spectrum Center · Charlotte, NC |
| 51 | Wed Feb 11 | atRaptors | 7:30 PM | 0-0 | .000 | | Scotiabank Arena · Toronto, ON |
| 52 | Thu Feb 19 | atKnicks | 7:30 PM | 0-0 | .000 | Amazon | Madison Square Garden · Manhattan, NY |
| 53 | Sat Feb 21 | atBulls | 8:00 PM | 0-0 | .000 | | United Center · Chicago, IL |
| 54 | Mon Feb 23 | vsSpurs | 7:00 PM | 0-0 | .000 | Peacock | Little Caesars Arena · Detroit, MI |
| 55 | Wed Feb 25 | vsThunder | 7:00 PM | 0-0 | .000 | | Little Caesars Arena · Detroit, MI |
| 56 | Fri Feb 27 | vsCavaliers | 7:00 PM | 0-0 | .000 | ESPN | Little Caesars Arena · Detroit, MI |
| 57 | Sun Mar 1 | atMagic | 6:00 PM | 0-0 | .000 | | Amway Center · Orlando, FL |
| 58 | Tue Mar 3 | atCavaliers | 7:00 PM | 0-0 | .000 | | Rocket Mortgage FieldHouse · Cleveland, OH |
| 59 | Thu Mar 5 | atSpurs | 8:00 PM | 0-0 | .000 | | AT&T Center · San Antonio, TX |
| 60 | Sat Mar 7 | vsNets | 6:00 PM | 0-0 | .000 | | Little Caesars Arena · Detroit, MI |
| 61 | Sun Mar 8 | atHeat | 6:00 PM | 0-0 | .000 | | Kaseya Center · Miami, FL |
| 62 | Tue Mar 10 | atNets | 7:30 PM | 0-0 | .000 | | Barclays Center · Brooklyn, NY |
| 63 | Thu Mar 12 | vs76ers | 7:00 PM | 0-0 | .000 | Amazon | Little Caesars Arena · Detroit, MI |
| 64 | Fri Mar 13 | vsGrizzlies | 7:30 PM | 0-0 | .000 | | Little Caesars Arena · Detroit, MI |
| 65 | Sun Mar 15 | atRaptors | 3:30 PM | 0-0 | .000 | | Scotiabank Arena · Toronto, ON |
| 66 | Tue Mar 17 | atWizards | 7:00 PM | 0-0 | .000 | | Capital One Arena · Washington, D.C. |
| 67 | Thu Mar 19 | atWizards | 7:00 PM | 0-0 | .000 | | Capital One Arena · Washington, D.C. |
| 68 | Fri Mar 20 | vsWarriors | 7:30 PM | 0-0 | .000 | | Little Caesars Arena · Detroit, MI |
| 69 | Mon Mar 23 | vsLakers | 7:00 PM | 0-0 | .000 | | Little Caesars Arena · Detroit, MI |
| 70 | Wed Mar 25 | vsHawks | 7:00 PM | 0-0 | .000 | ESPN | Little Caesars Arena · Detroit, MI |
| 71 | Thu Mar 26 | vsPelicans | 7:00 PM | 0-0 | .000 | | Little Caesars Arena · Detroit, MI |
| 72 | Sat Mar 28 | atT-wolves | 8:00 PM | 0-0 | .000 | | Target Center · Minneapolis, MN |
| 73 | Mon Mar 30 | atThunder | 9:30 PM | 0-0 | .000 | Peacock | Paycom Center · Oklahoma City, OK |
| 74 | Tue Mar 31 | vsRaptors | 8:00 PM | 0-0 | .000 | | Little Caesars Arena · Detroit, MI |
| 75 | Thu Apr 2 | vsT-wolves | 7:00 PM | 0-0 | .000 | | Little Caesars Arena · Detroit, MI |
| 76 | Sat Apr 4 | at76ers | 7:00 PM | 0-0 | .000 | | Wells Fargo Center · Philadelphia, PA |
| 77 | Mon Apr 6 | atMagic | 7:00 PM | 0-0 | .000 | | Amway Center · Orlando, FL |
| 78 | Wed Apr 8 | vsBucks | 7:30 PM | 0-0 | .000 | ESPN | Little Caesars Arena · Detroit, MI |
| 79 | Fri Apr 10 | atHornets | 7:00 PM | 0-0 | .000 | | Spectrum Center · Charlotte, NC |
| 80 | Sun Apr 12 | atPacers | 6:00 PM | 0-0 | .000 | | Gainbridge Fieldhouse · Indianapolis, IN |
