| 1 | Tue Oct 22 | vs T-wolves | W110-103 | 1-0 | 1.000 | TNT | Crypto.com Arena · Los Angeles, CA |
| 2 | Fri Oct 25 | vs Suns | W123-116 | 2-0 | 1.000 | ESPN | Crypto.com Arena · Los Angeles, CA |
| 3 | Sat Oct 26 | vs Kings | W131-127 | 3-0 | 1.000 | NBA TV | Crypto.com Arena · Los Angeles, CA |
| 4 | Mon Oct 28 | atSuns | L105-109 | 3-1 | .750 | NBA TV | Footprint Center · Phoenix, AZ |
| 5 | Wed Oct 30 | at Cavaliers | L110-134 | 3-2 | .600 | | Rocket Mortgage FieldHouse · Cleveland, OH |
| 6 | Fri Nov 1 | at Raptors | W131-125 | 4-2 | .667 | | Scotiabank Arena · Toronto, ON |
| 7 | Mon Nov 4 | at Pistons | L103-115 | 4-3 | .571 | | Little Caesars Arena · Detroit, MI |
| 8 | Wed Nov 6 | at Grizzlies | L114-131 | 4-4 | .500 | | FedExForum · Memphis, TN |
| 9 | Fri Nov 8 | vs 76ers | W116-106 | 5-4 | .556 | ESPN | Crypto.com Arena · Los Angeles, CA |
| 10 | Sun Nov 10 | vsRaptors | W123-103 | 6-4 | .600 | | Crypto.com Arena · Los Angeles, CA |
| 11 | Wed Nov 13 | vsGrizzlies | W128-123 | 7-4 | .636 | ESPN | Crypto.com Arena · Los Angeles, CA |
| 12 | Fri Nov 15 | at Spurs | W120-115 | 8-4 | .667 | ESPN | AT&T Center · San Antonio, TX |
| 13 | Sat Nov 16 | at Pelicans | W104-99 | 9-4 | .692 | | Smoothie King Center · New Orleans, LA |
| 14 | Tue Nov 19 | vs Jazz | W124-118 | 10-4 | .714 | | Crypto.com Arena · Los Angeles, CA |
| 15 | Thu Nov 21 | vs Magic | L118-119 | 10-5 | .667 | | Crypto.com Arena · Los Angeles, CA |
| 16 | Sat Nov 23 | vs Nuggets | L102-127 | 10-6 | .625 | NBA TV | Crypto.com Arena · Los Angeles, CA |
| 17 | Tue Nov 26 | atSuns | L100-127 | 10-7 | .588 | TNT | Footprint Center · Phoenix, AZ |
| 18 | Wed Nov 27 | atSpurs | W119-101 | 11-7 | .611 | | AT&T Center · San Antonio, TX |
| 19 | Fri Nov 29 | vs Thunder | L93-101 | 11-8 | .579 | ESPN | Crypto.com Arena · Los Angeles, CA |
| 20 | Sun Dec 1 | atJazz | W105-104 | 12-8 | .600 | | Vivint Arena · Salt Lake City, UT |
| 21 | Mon Dec 2 | atT-wolves | L80-109 | 12-9 | .571 | NBA TV | Target Center · Minneapolis, MN |
| 22 | Wed Dec 4 | at Heat | L93-134 | 12-10 | .545 | NBA TV | Kaseya Center · Miami, FL |
| 23 | Fri Dec 6 | at Hawks | L132-134 (OT) | 12-11 | .522 | | State Farm Arena · Atlanta, GA |
| 24 | Sun Dec 8 | vs Blazers | W107-98 | 13-11 | .542 | | Crypto.com Arena · Los Angeles, CA |
| 25 | Fri Dec 13 | atT-wolves | L87-97 | 13-12 | .520 | | Target Center · Minneapolis, MN |
| 26 | Sun Dec 15 | vsGrizzlies | W116-110 | 14-12 | .538 | | Crypto.com Arena · Los Angeles, CA |
| 27 | Thu Dec 19 | atKings | W113-100 | 15-12 | .556 | | Golden 1 Center · Sacramento, CA |
| 28 | Sat Dec 21 | atKings | W103-99 | 16-12 | .571 | | Golden 1 Center · Sacramento, CA |
| 29 | Mon Dec 23 | vsPistons | L114-117 | 16-13 | .552 | | Crypto.com Arena · Los Angeles, CA |
| 30 | Wed Dec 25 | at Warriors | W115-113 | 17-13 | .567 | ABC | Chase Center · San Francisco, CA |
| 31 | Sat Dec 28 | vsKings | W132-122 | 18-13 | .581 | | Crypto.com Arena · Los Angeles, CA |
| 32 | Tue Dec 31 | vsCavaliers | L110-122 | 18-14 | .563 | | Crypto.com Arena · Los Angeles, CA |
| 33 | Thu Jan 2 | vsBlazers | W114-106 | 19-14 | .576 | | Crypto.com Arena · Los Angeles, CA |
| 34 | Fri Jan 3 | vsHawks | W119-102 | 20-14 | .588 | NBA TV | Crypto.com Arena · Los Angeles, CA |
| 35 | Sun Jan 5 | at Rockets | L115-119 | 20-15 | .571 | | Toyota Center · Houston, TX |
| 36 | Tue Jan 7 | at Mavericks | L97-118 | 20-16 | .556 | TNT | American Airlines Center · Dallas, TX |
| 37 | Mon Jan 13 | vsSpurs | L102-126 | 20-17 | .541 | NBA TV | Crypto.com Arena · Los Angeles, CA |
| 38 | Wed Jan 15 | vsHeat | W117-108 | 21-17 | .553 | | Crypto.com Arena · Los Angeles, CA |
| 39 | Fri Jan 17 | vs Nets | W102-101 | 22-17 | .564 | | Crypto.com Arena · Los Angeles, CA |
| 40 | Sun Jan 19 | at Clippers | L102-116 | 22-18 | .550 | NBA TV | Intuit Dome · Inglewood, CA |
| 41 | Tue Jan 21 | vs Wizards | W111-88 | 23-18 | .561 | | Crypto.com Arena · Los Angeles, CA |
| 42 | Thu Jan 23 | vs Celtics | W117-96 | 24-18 | .571 | TNT | Crypto.com Arena · Los Angeles, CA |
| 43 | Sat Jan 25 | atWarriors | W118-108 | 25-18 | .581 | ABC | Chase Center · San Francisco, CA |
| 44 | Mon Jan 27 | at Hornets | W112-107 | 26-18 | .591 | | Spectrum Center · Charlotte, NC |
| 45 | Tue Jan 28 | at76ers | L104-118 | 26-19 | .578 | TNT | Wells Fargo Center · Philadelphia, PA |
| 46 | Thu Jan 30 | atWizards | W134-96 | 27-19 | .587 | | Capital One Arena · Washington, D.C. |
| 47 | Sat Feb 1 | at Knicks | W128-112 | 28-19 | .596 | ABC | Madison Square Garden · Manhattan, NY |
| 48 | Tue Feb 4 | atClippers | W122-97 | 29-19 | .604 | TNT | Intuit Dome · Inglewood, CA |
| 49 | Thu Feb 6 | vsWarriors | W120-112 | 30-19 | .612 | TNT | Crypto.com Arena · Los Angeles, CA |
| 50 | Sat Feb 8 | vs Pacers | W124-117 | 31-19 | .620 | ESPN | Crypto.com Arena · Los Angeles, CA |
| 51 | Mon Feb 10 | vsJazz | W132-113 | 32-19 | .627 | ESPN | Crypto.com Arena · Los Angeles, CA |
| 52 | Wed Feb 12 | atJazz | L119-131 | 32-20 | .615 | | Vivint Arena · Salt Lake City, UT |
| --all-star break-- |
| 53 | Wed Feb 19 | vsHornets | L97-100 | 32-21 | .604 | | Crypto.com Arena · Los Angeles, CA |
| 54 | Thu Feb 20 | atBlazers | W110-102 | 33-21 | .611 | | Moda Center · Portland, OR |
| 55 | Sat Feb 22 | atNuggets | W123-100 | 34-21 | .618 | ABC | Ball Arena · Denver, CO |
| 56 | Tue Feb 25 | vsMavericks | W107-99 | 35-21 | .625 | TNT | Crypto.com Arena · Los Angeles, CA |
| 57 | Thu Feb 27 | vsT-wolves | W111-102 | 36-21 | .632 | NBA TV | Crypto.com Arena · Los Angeles, CA |
| 58 | Fri Feb 28 | vsClippers | W106-102 | 37-21 | .638 | ESPN | Crypto.com Arena · Los Angeles, CA |
| 59 | Sun Mar 2 | vsClippers | W108-102 | 38-21 | .644 | | Crypto.com Arena · Los Angeles, CA |
| 60 | Tue Mar 4 | vsPelicans | W136-115 | 39-21 | .650 | | Crypto.com Arena · Los Angeles, CA |
| 61 | Thu Mar 6 | vsKnicks | W113-109 (OT) | 40-21 | .656 | TNT | Crypto.com Arena · Los Angeles, CA |
| 62 | Sat Mar 8 | atCeltics | L101-111 | 40-22 | .645 | ABC | TD Garden · Boston, MA |
| 63 | Mon Mar 10 | atNets | L108-111 | 40-23 | .635 | | Barclays Center · Brooklyn, NY |
| 64 | Thu Mar 13 | at Bucks | L106-126 | 40-24 | .625 | TNT | Fiserv Forum · Milwaukee, WI |
| 65 | Fri Mar 14 | atNuggets | L126-131 | 40-25 | .615 | NBA TV | Ball Arena · Denver, CO |
| 66 | Sun Mar 16 | vsSuns | W107-96 | 41-25 | .621 | ABC | Crypto.com Arena · Los Angeles, CA |
| 67 | Mon Mar 17 | vsSpurs | W125-109 | 42-25 | .627 | | Crypto.com Arena · Los Angeles, CA |
| 68 | Wed Mar 19 | vsNuggets | W120-108 | 43-25 | .632 | ESPN | Crypto.com Arena · Los Angeles, CA |
| 69 | Thu Mar 20 | vsBucks | L89-118 | 43-26 | .623 | | Crypto.com Arena · Los Angeles, CA |
| 70 | Sat Mar 22 | vs Bulls | L115-146 | 43-27 | .614 | | Crypto.com Arena · Los Angeles, CA |
| 71 | Mon Mar 24 | atMagic | L106-118 | 43-28 | .606 | NBA TV | Amway Center · Orlando, FL |
| 72 | Wed Mar 26 | atPacers | W120-119 | 44-28 | .611 | ESPN | Gainbridge Fieldhouse · Indianapolis, IN |
