| 21 | Thu Dec 4 | at Raptors | 7:30 PM | 15-7 | .682 | | Scotiabank Arena · Toronto, ON |
| 22 | Fri Dec 5 | atCeltics | 7:00 PM | 12-9 | .571 | Amazon | TD Garden · Boston, MA |
| 23 | Sun Dec 7 | at76ers | 7:30 PM | 11-9 | .550 | | Wells Fargo Center · Philadelphia, PA |
| 24 | Wed Dec 10 | vsSpurs | 10:00 PM | 15-6 | .714 | Amazon | Crypto.com Arena · Los Angeles, CA |
| 25 | Thu Dec 18 | atJazz | 9:00 PM | 7-13 | .350 | | Vivint Arena · Salt Lake City, UT |
| 26 | Sat Dec 20 | atClippers | 10:30 PM | 6-16 | .273 | NBA TV | Intuit Dome · Inglewood, CA |
| 27 | Tue Dec 23 | atSuns | 9:00 PM | 13-9 | .591 | | Footprint Center · Phoenix, AZ |
| 28 | Thu Dec 25 | vsRockets | 8:00 PM | 14-5 | .737 | ABC | Crypto.com Arena · Los Angeles, CA |
| 29 | Sun Dec 28 | vsKings | 9:30 PM | 5-17 | .227 | | Crypto.com Arena · Los Angeles, CA |
| 30 | Tue Dec 30 | vsPistons | 10:30 PM | 17-5 | .773 | | Crypto.com Arena · Los Angeles, CA |
| 31 | Fri Jan 2 | vsGrizzlies | 10:30 PM | 9-13 | .409 | | Crypto.com Arena · Los Angeles, CA |
| 32 | Sun Jan 4 | vsGrizzlies | 9:30 PM | 9-13 | .409 | | Crypto.com Arena · Los Angeles, CA |
| 33 | Tue Jan 6 | atPelicans | 8:00 PM | 3-19 | .136 | | Smoothie King Center · New Orleans, LA |
| 34 | Wed Jan 7 | atSpurs | 7:30 PM | 15-6 | .714 | ESPN | AT&T Center · San Antonio, TX |
| 35 | Fri Jan 9 | vsBucks | 10:30 PM | 10-13 | .435 | NBA TV | Crypto.com Arena · Los Angeles, CA |
| 36 | Mon Jan 12 | atKings | 10:00 PM | 5-17 | .227 | Peacock | Golden 1 Center · Sacramento, CA |
| 37 | Tue Jan 13 | vsHawks | 10:30 PM | 13-10 | .565 | | Crypto.com Arena · Los Angeles, CA |
| 38 | Thu Jan 15 | vsHornets | 10:30 PM | 6-16 | .273 | | Crypto.com Arena · Los Angeles, CA |
| 39 | Sat Jan 17 | atBlazers | 10:00 PM | 9-13 | .409 | NBA TV | Moda Center · Portland, OR |
| 40 | Sun Jan 18 | vsRaptors | 9:30 PM | 15-7 | .682 | | Crypto.com Arena · Los Angeles, CA |
| 41 | Tue Jan 20 | atNuggets | 10:00 PM | 15-6 | .714 | NBC | Ball Arena · Denver, CO |
| 42 | Thu Jan 22 | atClippers | 10:00 PM | 6-16 | .273 | Amazon | Intuit Dome · Inglewood, CA |
| 43 | Sat Jan 24 | atMavericks | 8:30 PM | 8-15 | .348 | ABC | American Airlines Center · Dallas, TX |
| 44 | Mon Jan 26 | atBulls | 8:00 PM | 9-12 | .429 | | United Center · Chicago, IL |
| 45 | Wed Jan 28 | atCavaliers | 7:00 PM | 13-10 | .565 | ESPN | Rocket Mortgage FieldHouse · Cleveland, OH |
| 46 | Fri Jan 30 | atWizards | 7:00 PM | 3-17 | .150 | | Capital One Arena · Washington, D.C. |
| 47 | Sun Feb 1 | atKnicks | 7:00 PM | 14-7 | .667 | NBC | Madison Square Garden · Manhattan, NY |
| 48 | Tue Feb 3 | atNets | 7:30 PM | 5-16 | .238 | | Barclays Center · Brooklyn, NY |
| 49 | Thu Feb 5 | vs76ers | 10:00 PM | 11-9 | .550 | Amazon | Crypto.com Arena · Los Angeles, CA |
| 50 | Sat Feb 7 | vsWarriors | 8:30 PM | 11-11 | .500 | ABC | Crypto.com Arena · Los Angeles, CA |
| 51 | Mon Feb 9 | vsThunder | 10:00 PM | 21-1 | .955 | Peacock | Crypto.com Arena · Los Angeles, CA |
| 52 | Tue Feb 10 | vsSpurs | 10:30 PM | 15-6 | .714 | NBA TV | Crypto.com Arena · Los Angeles, CA |
| 53 | Thu Feb 12 | vsMavericks | 10:00 PM | 8-15 | .348 | Amazon | Crypto.com Arena · Los Angeles, CA |
| --all-star break-- |
| 54 | Fri Feb 20 | vsClippers | 10:00 PM | 6-16 | .273 | ESPN | Crypto.com Arena · Los Angeles, CA |
| 55 | Sun Feb 22 | vsCeltics | 6:30 PM | 12-9 | .571 | NBC | Crypto.com Arena · Los Angeles, CA |
| 56 | Tue Feb 24 | vsMagic | 10:30 PM | 13-9 | .591 | | Crypto.com Arena · Los Angeles, CA |
| 57 | Thu Feb 26 | atSuns | 9:00 PM | 13-9 | .591 | | Footprint Center · Phoenix, AZ |
| 58 | Sat Feb 28 | atWarriors | 8:30 PM | 11-11 | .500 | ABC | Chase Center · San Francisco, CA |
| 59 | Sun Mar 1 | vsKings | 9:30 PM | 5-17 | .227 | | Crypto.com Arena · Los Angeles, CA |
| 60 | Tue Mar 3 | vsPelicans | 10:30 PM | 3-19 | .136 | | Crypto.com Arena · Los Angeles, CA |
| 61 | Thu Mar 5 | atNuggets | 10:00 PM | 15-6 | .714 | Amazon | Ball Arena · Denver, CO |
| 62 | Fri Mar 6 | vsPacers | 10:30 PM | 4-18 | .182 | | Crypto.com Arena · Los Angeles, CA |
| 63 | Sun Mar 8 | vsKnicks | 3:30 PM | 14-7 | .667 | ABC | Crypto.com Arena · Los Angeles, CA |
| 64 | Tue Mar 10 | vsT-wolves | 11:00 PM | 13-8 | .619 | NBC | Crypto.com Arena · Los Angeles, CA |
| 65 | Thu Mar 12 | vsBulls | 10:30 PM | 9-12 | .429 | | Crypto.com Arena · Los Angeles, CA |
| 66 | Sat Mar 14 | vsNuggets | 8:30 PM | 15-6 | .714 | ABC | Crypto.com Arena · Los Angeles, CA |
| 67 | Mon Mar 16 | atRockets | 9:00 PM | 14-5 | .737 | Peacock | Toyota Center · Houston, TX |
| 68 | Wed Mar 18 | atRockets | 9:30 PM | 14-5 | .737 | ESPN | Toyota Center · Houston, TX |
| 69 | Thu Mar 19 | atHeat | 8:00 PM | 14-8 | .636 | | Kaseya Center · Miami, FL |
| 70 | Sat Mar 21 | atMagic | 7:00 PM | 13-9 | .591 | NBA TV | Amway Center · Orlando, FL |
| 71 | Mon Mar 23 | atPistons | 7:00 PM | 17-5 | .773 | | Little Caesars Arena · Detroit, MI |
| 72 | Wed Mar 25 | atPacers | 7:00 PM | 4-18 | .182 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 73 | Fri Mar 27 | vsNets | 10:30 PM | 5-16 | .238 | | Crypto.com Arena · Los Angeles, CA |
| 74 | Mon Mar 30 | vsWizards | 10:00 PM | 3-17 | .150 | | Crypto.com Arena · Los Angeles, CA |
| 75 | Tue Mar 31 | vsCavaliers | 10:30 PM | 13-10 | .565 | | Crypto.com Arena · Los Angeles, CA |
| 76 | Thu Apr 2 | atThunder | 7:30 PM | 21-1 | .955 | Amazon | Paycom Center · Oklahoma City, OK |
| 77 | Sun Apr 5 | atMavericks | 7:30 PM | 8-15 | .348 | NBC | American Airlines Center · Dallas, TX |
| 78 | Tue Apr 7 | vsThunder | 10:30 PM | 21-1 | .955 | | Crypto.com Arena · Los Angeles, CA |
| 79 | Thu Apr 9 | atWarriors | 10:00 PM | 11-11 | .500 | Amazon | Chase Center · San Francisco, CA |
| 80 | Fri Apr 10 | vsSuns | 10:30 PM | 13-9 | .591 | | Crypto.com Arena · Los Angeles, CA |
| 81 | Sun Apr 12 | vsJazz | 8:30 PM | 7-13 | .350 | | Crypto.com Arena · Los Angeles, CA |
