| 1 | Tue Oct 21 | vs Warriors | L109-119 | 0-1 | .000 | Peacock | Crypto.com Arena · Los Angeles, CA |
| 2 | Fri Oct 24 | vsT-wolves | W128-110 | 1-1 | .500 | Amazon | Crypto.com Arena · Los Angeles, CA |
| 3 | Sun Oct 26 | atKings | W127-120 | 2-1 | .667 | | Golden 1 Center · Sacramento, CA |
| 4 | Mon Oct 27 | vsBlazers | L108-122 | 2-2 | .500 | | Crypto.com Arena · Los Angeles, CA |
| 5 | Wed Oct 29 | atT-wolves | W116-115 | 3-2 | .600 | ESPN | Target Center · Minneapolis, MN |
| 6 | Fri Oct 31 | atGrizzlies | W117-112 | 4-2 | .667 | Amazon | FedExForum · Memphis, TN |
| 7 | Sun Nov 2 | vsHeat | W130-120 | 5-2 | .714 | | Crypto.com Arena · Los Angeles, CA |
| 8 | Mon Nov 3 | atBlazers | W123-115 | 6-2 | .750 | NBA TV | Moda Center · Portland, OR |
| 9 | Wed Nov 5 | vsSpurs | W118-116 | 7-2 | .778 | ESPN | Crypto.com Arena · Los Angeles, CA |
| 10 | Sat Nov 8 | atHawks | L102-122 | 7-3 | .700 | NBA TV | State Farm Arena · Atlanta, GA |
| 11 | Mon Nov 10 | atHornets | W121-111 | 8-3 | .727 | | Spectrum Center · Charlotte, NC |
| 12 | Wed Nov 12 | atThunder | L92-121 | 8-4 | .667 | ESPN | Paycom Center · Oklahoma City, OK |
| 13 | Fri Nov 14 | atPelicans | W118-104 | 9-4 | .692 | | Smoothie King Center · New Orleans, LA |
| 14 | Sat Nov 15 | atBucks | W119-95 | 10-4 | .714 | NBA TV | Fiserv Forum · Milwaukee, WI |
| 15 | Tue Nov 18 | vsJazz | W140-126 | 11-4 | .733 | | Crypto.com Arena · Los Angeles, CA |
| 16 | Sun Nov 23 | atJazz | W108-106 | 12-4 | .750 | | Vivint Arena · Salt Lake City, UT |
| 17 | Tue Nov 25 | vsClippers | W135-118 | 13-4 | .765 | Peacock | Crypto.com Arena · Los Angeles, CA |
| 18 | Fri Nov 28 | vsMavericks | W129-119 | 14-4 | .778 | Amazon | Crypto.com Arena · Los Angeles, CA |
| 19 | Sun Nov 30 | vsPelicans | W133-121 | 15-4 | .789 | | Crypto.com Arena · Los Angeles, CA |
| 20 | Mon Dec 1 | vsSuns | L108-125 | 15-5 | .750 | Peacock | Crypto.com Arena · Los Angeles, CA |
| 21 | Thu Dec 4 | atRaptors | W123-120 | 16-5 | .762 | | Scotiabank Arena · Toronto, ON |
| 22 | Fri Dec 5 | atCeltics | L105-126 | 16-6 | .727 | Amazon | TD Garden · Boston, MA |
| 23 | Sun Dec 7 | at76ers | W112-108 | 17-6 | .739 | | Wells Fargo Center · Philadelphia, PA |
| 24 | Wed Dec 10 | vsSpurs | L119-132 | 17-7 | .708 | Amazon | Crypto.com Arena · Los Angeles, CA |
| 25 | Sun Dec 14 | atSuns | W116-114 | 18-7 | .720 | | Mortgage Matchup Center · Phoenix, AZ |
| 26 | Thu Dec 18 | atJazz | W143-135 | 19-7 | .731 | | Vivint Arena · Salt Lake City, UT |
| 27 | Sat Dec 20 | atClippers | L88-103 | 19-8 | .704 | NBA TV | Intuit Dome · Inglewood, CA |
| 28 | Tue Dec 23 | atSuns | L108-132 | 19-9 | .679 | | Mortgage Matchup Center · Phoenix, AZ |
| 29 | Thu Dec 25 | vsRockets | L96-119 | 19-10 | .655 | ESPN | Crypto.com Arena · Los Angeles, CA |
| 30 | Sun Dec 28 | vsKings | W125-101 | 20-10 | .667 | | Crypto.com Arena · Los Angeles, CA |
| 31 | Tue Dec 30 | vsPistons | L106-128 | 20-11 | .645 | Peacock | Crypto.com Arena · Los Angeles, CA |
| 32 | Fri Jan 2 | vsGrizzlies | W128-121 | 21-11 | .656 | | Crypto.com Arena · Los Angeles, CA |
| 33 | Sun Jan 4 | vsGrizzlies | W120-114 | 22-11 | .667 | | Crypto.com Arena · Los Angeles, CA |
| 34 | Tue Jan 6 | atPelicans | W111-103 | 23-11 | .676 | | Smoothie King Center · New Orleans, LA |
| 35 | Wed Jan 7 | atSpurs | L91-107 | 23-12 | .657 | ESPN | AT&T Center · San Antonio, TX |
| 36 | Fri Jan 9 | vsBucks | L101-105 | 23-13 | .639 | NBA TV | Crypto.com Arena · Los Angeles, CA |
| 37 | Mon Jan 12 | atKings | L112-124 | 23-14 | .622 | | Golden 1 Center · Sacramento, CA |
| 38 | Tue Jan 13 | vsHawks | W141-116 | 24-14 | .632 | | Crypto.com Arena · Los Angeles, CA |
| 39 | Thu Jan 15 | vsHornets | L117-135 | 24-15 | .615 | | Crypto.com Arena · Los Angeles, CA |
| 40 | Sat Jan 17 | atBlazers | L116-132 | 24-16 | .600 | NBA TV | Moda Center · Portland, OR |
| 41 | Sun Jan 18 | vsRaptors | W110-93 | 25-16 | .610 | | Crypto.com Arena · Los Angeles, CA |
| 42 | Tue Jan 20 | atNuggets | W115-107 | 26-16 | .619 | Peacock | Ball Arena · Denver, CO |
| 43 | Thu Jan 22 | atClippers | L104-112 | 26-17 | .605 | Amazon | Intuit Dome · Inglewood, CA |
| 44 | Sat Jan 24 | atMavericks | W116-110 | 27-17 | .614 | ABC | American Airlines Center · Dallas, TX |
| 45 | Mon Jan 26 | atBulls | W129-118 | 28-17 | .622 | | United Center · Chicago, IL |
| 46 | Wed Jan 28 | atCavaliers | L99-129 | 28-18 | .609 | ESPN | Rocket Mortgage FieldHouse · Cleveland, OH |
| 47 | Fri Jan 30 | atWizards | W142-111 | 29-18 | .617 | | Capital One Arena · Washington, D.C. |
| 48 | Sun Feb 1 | atKnicks | L100-112 | 29-19 | .604 | Peacock | Madison Square Garden · Manhattan, NY |
| 49 | Tue Feb 3 | atNets | W125-109 | 30-19 | .612 | | Barclays Center · Brooklyn, NY |
| 50 | Thu Feb 5 | vs76ers | W119-115 | 31-19 | .620 | | Crypto.com Arena · Los Angeles, CA |
| 51 | Sat Feb 7 | vsWarriors | W105-99 | 32-19 | .627 | ABC | Crypto.com Arena · Los Angeles, CA |
| 52 | Mon Feb 9 | vsThunder | L110-119 | 32-20 | .615 | Peacock | Crypto.com Arena · Los Angeles, CA |
| 53 | Tue Feb 10 | vsSpurs | L108-136 | 32-21 | .604 | NBA TV | Crypto.com Arena · Los Angeles, CA |
| 54 | Thu Feb 12 | vsMavericks | W124-104 | 33-21 | .611 | Amazon | Crypto.com Arena · Los Angeles, CA |
| --all-star break-- |
| 55 | Fri Feb 20 | vsClippers | W125-122 | 34-21 | .618 | ESPN | Crypto.com Arena · Los Angeles, CA |
| 56 | Sun Feb 22 | vsCeltics | L89-111 | 34-22 | .607 | Peacock | Crypto.com Arena · Los Angeles, CA |
| 57 | Tue Feb 24 | vsMagic | L109-110 | 34-23 | .596 | | Crypto.com Arena · Los Angeles, CA |
| 58 | Thu Feb 26 | atSuns | L110-113 | 34-24 | .586 | | Mortgage Matchup Center · Phoenix, AZ |
| 59 | Sat Feb 28 | atWarriors | W129-101 | 35-24 | .593 | ABC | Chase Center · San Francisco, CA |
| 60 | Sun Mar 1 | vsKings | W128-104 | 36-24 | .600 | | Crypto.com Arena · Los Angeles, CA |
| 61 | Tue Mar 3 | vsPelicans | W110-101 | 37-24 | .607 | | Crypto.com Arena · Los Angeles, CA |
| 62 | Thu Mar 5 | atNuggets | L113-120 | 37-25 | .597 | Amazon | Ball Arena · Denver, CO |
| 63 | Fri Mar 6 | vsPacers | W128-117 | 38-25 | .603 | | Crypto.com Arena · Los Angeles, CA |
| 64 | Sun Mar 8 | vsKnicks | W110-97 | 39-25 | .609 | ABC | Crypto.com Arena · Los Angeles, CA |
| 65 | Tue Mar 10 | vsT-wolves | W120-106 | 40-25 | .615 | Peacock | Crypto.com Arena · Los Angeles, CA |
| 66 | Thu Mar 12 | vsBulls | W142-130 | 41-25 | .621 | | Crypto.com Arena · Los Angeles, CA |
| 67 | Sat Mar 14 | vsNuggets | W127-125 (OT) | 42-25 | .627 | ABC | Crypto.com Arena · Los Angeles, CA |
| 68 | Mon Mar 16 | atRockets | W100-92 | 43-25 | .632 | NBCSN | Toyota Center · Houston, TX |
| 69 | Wed Mar 18 | atRockets | W124-116 | 44-25 | .638 | ESPN | Toyota Center · Houston, TX |
| 70 | Thu Mar 19 | atHeat | W134-126 | 45-25 | .643 | | Kaseya Center · Miami, FL |
| 71 | Sat Mar 21 | atMagic | W105-104 | 46-25 | .648 | NBA TV | Kia Center · Orlando, FL |
| 72 | Mon Mar 23 | atPistons | L110-113 | 46-26 | .639 | | Little Caesars Arena · Detroit, MI |
| 73 | Wed Mar 25 | atPacers | W137-130 | 47-26 | .644 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 74 | Fri Mar 27 | vsNets | W116-99 | 48-26 | .649 | | Crypto.com Arena · Los Angeles, CA |
| 75 | Mon Mar 30 | vsWizards | W120-101 | 49-26 | .653 | | Crypto.com Arena · Los Angeles, CA |
| 76 | Tue Mar 31 | vsCavaliers | W127-113 | 50-26 | .658 | | Crypto.com Arena · Los Angeles, CA |
| 77 | Thu Apr 2 | atThunder | L96-139 | 50-27 | .649 | Amazon | Paycom Center · Oklahoma City, OK |
| 78 | Sun Apr 5 | atMavericks | L128-134 | 50-28 | .641 | Peacock | American Airlines Center · Dallas, TX |
| 79 | Tue Apr 7 | vsThunder | L87-123 | 50-29 | .633 | | Crypto.com Arena · Los Angeles, CA |
| 80 | Thu Apr 9 | atWarriors | W119-103 | 51-29 | .637 | Amazon | Chase Center · San Francisco, CA |
| 81 | Fri Apr 10 | vsSuns | W101-73 | 52-29 | .642 | | Crypto.com Arena · Los Angeles, CA |
| 82 | Sun Apr 12 | vsJazz | W131-107 | 53-29 | .646 | | Crypto.com Arena · Los Angeles, CA |
