| 20 | Tue Dec 2 | vs Grizzlies | 8:00 PM | 8-12 | .400 | | AT&T Center · San Antonio, TX |
| 21 | Wed Dec 3 | atMagic | 7:00 PM | 12-8 | .600 | | Amway Center · Orlando, FL |
| 22 | Fri Dec 5 | atCavaliers | 7:30 PM | 12-9 | .571 | | Rocket Mortgage FieldHouse · Cleveland, OH |
| 23 | Mon Dec 8 | atPelicans | 8:00 PM | 3-17 | .150 | | Smoothie King Center · New Orleans, LA |
| 24 | Wed Dec 10 | atLakers | 10:00 PM | 14-4 | .778 | Amazon | Crypto.com Arena · Los Angeles, CA |
| 25 | Wed Dec 17 | vsWizards | 8:00 PM | 2-16 | .111 | | AT&T Center · San Antonio, TX |
| 26 | Fri Dec 19 | atHawks | 7:30 PM | 13-8 | .619 | | State Farm Arena · Atlanta, GA |
| 27 | Sun Dec 21 | atWizards | 7:00 PM | 2-16 | .111 | | Capital One Arena · Washington, D.C. |
| 28 | Tue Dec 23 | vsThunder | 8:30 PM | 20-1 | .952 | | AT&T Center · San Antonio, TX |
| 29 | Thu Dec 25 | atThunder | 2:30 PM | 20-1 | .952 | ABC | Paycom Center · Oklahoma City, OK |
| 30 | Sat Dec 27 | vsJazz | 8:00 PM | 6-13 | .316 | | AT&T Center · San Antonio, TX |
| 31 | Mon Dec 29 | vsCavaliers | 8:00 PM | 12-9 | .571 | NBC | AT&T Center · San Antonio, TX |
| 32 | Wed Dec 31 | vsKnicks | 7:00 PM | 13-6 | .684 | | AT&T Center · San Antonio, TX |
| 33 | Fri Jan 2 | atPacers | 7:00 PM | 4-16 | .200 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 34 | Sat Jan 3 | vsBlazers | 8:00 PM | 8-12 | .400 | | AT&T Center · San Antonio, TX |
| 35 | Tue Jan 6 | atGrizzlies | 8:00 PM | 8-12 | .400 | | FedExForum · Memphis, TN |
| 36 | Wed Jan 7 | vsLakers | 7:30 PM | 14-4 | .778 | ESPN | AT&T Center · San Antonio, TX |
| 37 | Sat Jan 10 | atCeltics | 8:00 PM | 11-9 | .550 | | TD Garden · Boston, MA |
| 38 | Sun Jan 11 | atT-wolves | 7:00 PM | 12-8 | .600 | | Target Center · Minneapolis, MN |
| 39 | Tue Jan 13 | atThunder | 8:00 PM | 20-1 | .952 | | Paycom Center · Oklahoma City, OK |
| 40 | Thu Jan 15 | vsBucks | 8:00 PM | 9-12 | .429 | | AT&T Center · San Antonio, TX |
| 41 | Sat Jan 17 | vsT-wolves | 8:00 PM | 12-8 | .600 | | AT&T Center · San Antonio, TX |
| 42 | Mon Jan 19 | vsJazz | 5:00 PM | 6-13 | .316 | | AT&T Center · San Antonio, TX |
| 43 | Tue Jan 20 | atRockets | 8:00 PM | 13-4 | .765 | NBC | Toyota Center · Houston, TX |
| 44 | Thu Jan 22 | atJazz | 9:00 PM | 6-13 | .316 | | Vivint Arena · Salt Lake City, UT |
| 45 | Sun Jan 25 | vsPelicans | 7:00 PM | 3-17 | .150 | | AT&T Center · San Antonio, TX |
| 46 | Wed Jan 28 | atRockets | 9:30 PM | 13-4 | .765 | ESPN | Toyota Center · Houston, TX |
| 47 | Sat Jan 31 | atHornets | 3:00 PM | 6-14 | .300 | Amazon | Spectrum Center · Charlotte, NC |
| 48 | Sun Feb 1 | vsMagic | 4:00 PM | 12-8 | .600 | | AT&T Center · San Antonio, TX |
| 49 | Wed Feb 4 | vsThunder | 9:30 PM | 20-1 | .952 | ESPN | AT&T Center · San Antonio, TX |
| 50 | Thu Feb 5 | atMavericks | 8:30 PM | 6-15 | .286 | | American Airlines Center · Dallas, TX |
| 51 | Sat Feb 7 | vsMavericks | 6:00 PM | 6-15 | .286 | Amazon | AT&T Center · San Antonio, TX |
| 52 | Tue Feb 10 | atLakers | 10:30 PM | 14-4 | .778 | NBA TV | Crypto.com Arena · Los Angeles, CA |
| 53 | Wed Feb 11 | atWarriors | 10:00 PM | 11-10 | .524 | | Chase Center · San Francisco, CA |
| --all-star break-- |
| 54 | Thu Feb 19 | vsSuns | 8:30 PM | 12-9 | .571 | | AT&T Center · San Antonio, TX |
| 55 | Sat Feb 21 | vsKings | 8:00 PM | 5-15 | .250 | | AT&T Center · San Antonio, TX |
| 56 | Mon Feb 23 | atPistons | 7:00 PM | 16-4 | .800 | Peacock | Little Caesars Arena · Detroit, MI |
| 57 | Wed Feb 25 | atRaptors | 7:30 PM | 14-7 | .667 | | Scotiabank Arena · Toronto, ON |
| 58 | Thu Feb 26 | atNets | 7:30 PM | 3-16 | .158 | | Barclays Center · Brooklyn, NY |
| 59 | Sun Mar 1 | atKnicks | 1:00 PM | 13-6 | .684 | ABC | Madison Square Garden · Manhattan, NY |
| 60 | Tue Mar 3 | at76ers | 8:00 PM | 10-9 | .526 | NBC | Wells Fargo Center · Philadelphia, PA |
| 61 | Thu Mar 5 | vsPistons | 8:00 PM | 16-4 | .800 | | AT&T Center · San Antonio, TX |
| 62 | Fri Mar 6 | vsClippers | 9:30 PM | 5-15 | .250 | ESPN | AT&T Center · San Antonio, TX |
| 63 | Sun Mar 8 | vsRockets | 8:00 PM | 13-4 | .765 | NBC | AT&T Center · San Antonio, TX |
| 64 | Tue Mar 10 | vsCeltics | 8:00 PM | 11-9 | .550 | | AT&T Center · San Antonio, TX |
| 65 | Thu Mar 12 | vsNuggets | 9:00 PM | 14-5 | .737 | | AT&T Center · San Antonio, TX |
| 66 | Sat Mar 14 | vsHornets | 8:00 PM | 6-14 | .300 | | AT&T Center · San Antonio, TX |
| 67 | Mon Mar 16 | atClippers | 10:30 PM | 5-15 | .250 | | Intuit Dome · Inglewood, CA |
| 68 | Tue Mar 17 | atKings | 11:00 PM | 5-15 | .250 | NBC | Golden 1 Center · Sacramento, CA |
| 69 | Thu Mar 19 | vsSuns | 8:00 PM | 12-9 | .571 | | AT&T Center · San Antonio, TX |
| 70 | Sat Mar 21 | vsPacers | 8:00 PM | 4-16 | .200 | | AT&T Center · San Antonio, TX |
| 71 | Mon Mar 23 | atHeat | 7:30 PM | 13-7 | .650 | | Kaseya Center · Miami, FL |
| 72 | Wed Mar 25 | atGrizzlies | 8:00 PM | 8-12 | .400 | | FedExForum · Memphis, TN |
| 73 | Sat Mar 28 | atBucks | 3:00 PM | 9-12 | .429 | Amazon | Fiserv Forum · Milwaukee, WI |
| 74 | Mon Mar 30 | vsBulls | 8:00 PM | 9-10 | .474 | | AT&T Center · San Antonio, TX |
| 75 | Wed Apr 1 | atWarriors | 10:00 PM | 11-10 | .524 | ESPN | Chase Center · San Francisco, CA |
| 76 | Thu Apr 2 | atClippers | 10:30 PM | 5-15 | .250 | | Intuit Dome · Inglewood, CA |
| 77 | Sat Apr 4 | atNuggets | 3:00 PM | 14-5 | .737 | Amazon | Ball Arena · Denver, CO |
| 78 | Mon Apr 6 | vs76ers | 8:00 PM | 10-9 | .526 | | AT&T Center · San Antonio, TX |
| 79 | Wed Apr 8 | vsBlazers | 8:00 PM | 8-12 | .400 | | AT&T Center · San Antonio, TX |
| 80 | Fri Apr 10 | vsMavericks | 8:00 PM | 6-15 | .286 | | AT&T Center · San Antonio, TX |
| 81 | Sun Apr 12 | vsNuggets | 8:30 PM | 14-5 | .737 | | AT&T Center · San Antonio, TX |
