| 1 | Wed Oct 18 | vs T-wolves | W107-99 | 1-0 | 1.000 | AT&T Center · San Antonio, TX |
| 2 | Sat Oct 21 | at Bulls | W87-77 | 2-0 | 1.000 | United Center · Chicago, IL |
| 3 | Mon Oct 23 | vs Raptors | W101-97 | 3-0 | 1.000 | AT&T Center · San Antonio, TX |
| 4 | Wed Oct 25 | at Heat | W117-100 | 4-0 | 1.000 | FTX Arena · Miami, FL |
| 5 | Fri Oct 27 | at Magic | L87-114 | 4-1 | .800 | Amway Center · Orlando, FL |
| 6 | Sun Oct 29 | at Pacers | L94-97 | 4-2 | .667 | Gainbridge Fieldhouse · Indianapolis, IN |
| 7 | Mon Oct 30 | at Celtics | L94-108 | 4-3 | .571 | TD Garden · Boston, MA |
| 8 | Thu Nov 2 | vs Warriors | L92-112 | 4-4 | .500 | AT&T Center · San Antonio, TX |
| 9 | Fri Nov 3 | vs Hornets | W108-101 | 5-4 | .556 | AT&T Center · San Antonio, TX |
| 10 | Sun Nov 5 | vs Suns | W112-95 | 6-4 | .600 | AT&T Center · San Antonio, TX |
| 11 | Tue Nov 7 | vs Clippers | W120-107 | 7-4 | .636 | AT&T Center · San Antonio, TX |
| 12 | Fri Nov 10 | vs Bucks | L87-94 | 7-5 | .583 | AT&T Center · San Antonio, TX |
| 13 | Sat Nov 11 | vsBulls | W133-94 | 8-5 | .615 | AT&T Center · San Antonio, TX |
| 14 | Tue Nov 14 | at Mavericks | W97-91 | 9-5 | .643 | American Airlines Center · Dallas, TX |
| 15 | Wed Nov 15 | atT-wolves | L86-98 | 9-6 | .600 | Target Center · Minneapolis, MN |
| 16 | Fri Nov 17 | vs Thunder | W104-101 | 10-6 | .625 | AT&T Center · San Antonio, TX |
| 17 | Mon Nov 20 | vs Hawks | W96-85 | 11-6 | .647 | AT&T Center · San Antonio, TX |
| 18 | Wed Nov 22 | at Pelicans | L90-107 | 11-7 | .611 | Smoothie King Center · New Orleans, LA |
| 19 | Sat Nov 25 | atHornets | W106-86 | 12-7 | .632 | Spectrum Center · Charlotte, NC |
| 20 | Mon Nov 27 | vsMavericks | W115-108 | 13-7 | .650 | AT&T Center · San Antonio, TX |
| 21 | Wed Nov 29 | vs Grizzlies | W104-95 | 14-7 | .667 | AT&T Center · San Antonio, TX |
| 22 | Fri Dec 1 | atGrizzlies | W95-79 | 15-7 | .682 | FedExForum · Memphis, TN |
| 23 | Sun Dec 3 | atThunder | L87-90 | 15-8 | .652 | Paycom Center · Oklahoma City, OK |
| 24 | Mon Dec 4 | vs Pistons | W96-93 | 16-8 | .667 | AT&T Center · San Antonio, TX |
| 25 | Wed Dec 6 | vsHeat | W117-105 | 17-8 | .680 | AT&T Center · San Antonio, TX |
| 26 | Fri Dec 8 | vsCeltics | W105-102 | 18-8 | .692 | AT&T Center · San Antonio, TX |
| 27 | Sat Dec 9 | atSuns | W104-101 | 19-8 | .704 | Footprint Center · Phoenix, AZ |
| 28 | Tue Dec 12 | atMavericks | L89-95 | 19-9 | .679 | American Airlines Center · Dallas, TX |
| 29 | Fri Dec 15 | at Rockets | L109-124 | 19-10 | .655 | Toyota Center · Houston, TX |
| 30 | Sat Dec 16 | vsMavericks | W98-96 | 20-10 | .667 | AT&T Center · San Antonio, TX |
| 31 | Mon Dec 18 | vsClippers | W109-91 | 21-10 | .677 | AT&T Center · San Antonio, TX |
| 32 | Wed Dec 20 | at Blazers | W93-91 | 22-10 | .688 | Moda Center · Portland, OR |
| 33 | Thu Dec 21 | at Jazz | L89-100 | 22-11 | .667 | Vivint Arena · Salt Lake City, UT |
| 34 | Sat Dec 23 | at Kings | W108-99 | 23-11 | .676 | Golden 1 Center · Sacramento, CA |
| 35 | Tue Dec 26 | vs Nets | W109-97 | 24-11 | .686 | AT&T Center · San Antonio, TX |
| 36 | Thu Dec 28 | vs Knicks | W119-107 | 25-11 | .694 | AT&T Center · San Antonio, TX |
| 37 | Sat Dec 30 | atPistons | L79-93 | 25-12 | .676 | Little Caesars Arena · Detroit, MI |
| 38 | Tue Jan 2 | atKnicks | W100-91 | 26-12 | .684 | Madison Square Garden · Manhattan, NY |
| 39 | Wed Jan 3 | at 76ers | L106-112 | 26-13 | .667 | Wells Fargo Center · Philadelphia, PA |
| 40 | Fri Jan 5 | vsSuns | W103-89 | 27-13 | .675 | AT&T Center · San Antonio, TX |
| 41 | Sun Jan 7 | atBlazers | L110-111 | 27-14 | .659 | Moda Center · Portland, OR |
| 42 | Mon Jan 8 | atKings | W107-100 | 28-14 | .667 | Golden 1 Center · Sacramento, CA |
| 43 | Thu Jan 11 | at Lakers | L81-93 | 28-15 | .651 | Crypto.com Arena · Los Angeles, CA |
| 44 | Sat Jan 13 | vs Nuggets | W112-80 | 29-15 | .659 | AT&T Center · San Antonio, TX |
| 45 | Mon Jan 15 | atHawks | L99-102 | 29-16 | .644 | State Farm Arena · Atlanta, GA |
| 46 | Wed Jan 17 | atNets | W100-95 | 30-16 | .652 | Barclays Center · Brooklyn, NY |
| 47 | Fri Jan 19 | atRaptors | L83-86 | 30-17 | .638 | Scotiabank Arena · Toronto, ON |
| 48 | Sun Jan 21 | vsPacers | L86-94 | 30-18 | .625 | AT&T Center · San Antonio, TX |
| 49 | Tue Jan 23 | vs Cavaliers | W114-102 | 31-18 | .633 | AT&T Center · San Antonio, TX |
| 50 | Wed Jan 24 | atGrizzlies | W108-85 | 32-18 | .640 | FedExForum · Memphis, TN |
| 51 | Fri Jan 26 | vs76ers | L78-97 | 32-19 | .627 | AT&T Center · San Antonio, TX |
| 52 | Sun Jan 28 | vsKings | W113-98 | 33-19 | .635 | AT&T Center · San Antonio, TX |
| 53 | Tue Jan 30 | vsNuggets | W106-104 | 34-19 | .642 | AT&T Center · San Antonio, TX |
| 54 | Thu Feb 1 | vsRockets | L91-102 | 34-20 | .630 | AT&T Center · San Antonio, TX |
| 55 | Sat Feb 3 | vsJazz | L111-120 | 34-21 | .618 | AT&T Center · San Antonio, TX |
| 56 | Wed Feb 7 | atSuns | W129-81 | 35-21 | .625 | Footprint Center · Phoenix, AZ |
| 57 | Sat Feb 10 | atWarriors | L105-122 | 35-22 | .614 | Chase Center · San Francisco, CA |
| 58 | Mon Feb 12 | atJazz | L99-101 | 35-23 | .603 | Vivint Arena · Salt Lake City, UT |
| 59 | Tue Feb 13 | atNuggets | L109-117 | 35-24 | .593 | Ball Arena · Denver, CO |
| 60 | Fri Feb 23 | atNuggets | L119-122 | 35-25 | .583 | Ball Arena · Denver, CO |
| 61 | Sun Feb 25 | atCavaliers | W110-94 | 36-25 | .590 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 62 | Wed Feb 28 | vsPelicans | L116-121 | 36-26 | .581 | AT&T Center · San Antonio, TX |
| 63 | Sat Mar 3 | vsLakers | L112-116 | 36-27 | .571 | AT&T Center · San Antonio, TX |
| 64 | Mon Mar 5 | vsGrizzlies | W100-98 | 37-27 | .578 | AT&T Center · San Antonio, TX |
| 65 | Thu Mar 8 | atWarriors | L107-110 | 37-28 | .569 | Chase Center · San Francisco, CA |
| 66 | Sat Mar 10 | atThunder | L94-104 | 37-29 | .561 | Paycom Center · Oklahoma City, OK |
| 67 | Mon Mar 12 | atRockets | L93-109 | 37-30 | .552 | Toyota Center · Houston, TX |
| 68 | Tue Mar 13 | vsMagic | W108-72 | 38-30 | .559 | AT&T Center · San Antonio, TX |
| 69 | Thu Mar 15 | vsPelicans | W98-93 | 39-30 | .565 | AT&T Center · San Antonio, TX |
| 70 | Sat Mar 17 | vsT-wolves | W117-101 | 40-30 | .571 | AT&T Center · San Antonio, TX |
| 71 | Mon Mar 19 | vsWarriors | W89-75 | 41-30 | .577 | AT&T Center · San Antonio, TX |
| 72 | Wed Mar 21 | vs Wizards | W98-90 | 42-30 | .583 | AT&T Center · San Antonio, TX |
| 73 | Fri Mar 23 | vsJazz | W124-120 (OT) | 43-30 | .589 | AT&T Center · San Antonio, TX |
| 74 | Sun Mar 25 | atBucks | L103-106 | 43-31 | .581 | Fiserv Forum · Milwaukee, WI |
| 75 | Tue Mar 27 | atWizards | L106-116 | 43-32 | .573 | Capital One Arena · Washington, D.C. |
| 76 | Thu Mar 29 | vsThunder | W103-99 | 44-32 | .579 | AT&T Center · San Antonio, TX |
| 77 | Sun Apr 1 | vsRockets | W100-83 | 45-32 | .584 | AT&T Center · San Antonio, TX |
| 78 | Tue Apr 3 | atClippers | L110-113 | 45-33 | .577 | Crypto.com Arena · Los Angeles, CA |
| 79 | Wed Apr 4 | atLakers | L112-122 (OT) | 45-34 | .570 | Crypto.com Arena · Los Angeles, CA |
| 80 | Sat Apr 7 | vsBlazers | W116-105 | 46-34 | .575 | AT&T Center · San Antonio, TX |
| 81 | Mon Apr 9 | vsKings | W98-85 | 47-34 | .580 | AT&T Center · San Antonio, TX |
| 82 | Wed Apr 11 | atPelicans | L98-122 | 47-35 | .573 | Smoothie King Center · New Orleans, LA |
| 1 | Sat Apr 14 | atWarriors | L92-113 | 0-1 | .000 | Chase Center · San Francisco, CA |
| 2 | Mon Apr 16 | atWarriors | L101-116 | 0-2 | .000 | Chase Center · San Francisco, CA |
| 3 | Thu Apr 19 | vsWarriors | L97-110 | 0-3 | .000 | AT&T Center · San Antonio, TX |
| 4 | Sun Apr 22 | vsWarriors | W103-90 | 1-3 | .250 | AT&T Center · San Antonio, TX |
| 5 | Tue Apr 24 | atWarriors | L91-99 | 1-4 | .200 | Chase Center · San Francisco, CA |
