| 1 | Wed Oct 17 | vs T-wolves | W112-108 | 1-0 | 1.000 | AT&T Center · San Antonio, TX |
| 2 | Sat Oct 20 | at Blazers | L108-121 | 1-1 | .500 | Moda Center · Portland, OR |
| 3 | Mon Oct 22 | at Lakers | W143-142 (OT) | 2-1 | .667 | Crypto.com Arena · Los Angeles, CA |
| 4 | Wed Oct 24 | vs Pacers | L96-116 | 2-2 | .500 | AT&T Center · San Antonio, TX |
| 5 | Sat Oct 27 | vsLakers | W110-106 | 3-2 | .600 | AT&T Center · San Antonio, TX |
| 6 | Mon Oct 29 | vs Mavericks | W113-108 (OT) | 4-2 | .667 | AT&T Center · San Antonio, TX |
| 7 | Wed Oct 31 | at Suns | W120-90 | 5-2 | .714 | Footprint Center · Phoenix, AZ |
| 8 | Sat Nov 3 | vs Pelicans | W109-95 | 6-2 | .750 | AT&T Center · San Antonio, TX |
| 9 | Sun Nov 4 | vs Magic | L110-117 | 6-3 | .667 | AT&T Center · San Antonio, TX |
| 10 | Wed Nov 7 | at Heat | L88-95 | 6-4 | .600 | FTX Arena · Miami, FL |
| 11 | Sat Nov 10 | vs Rockets | W96-89 | 7-4 | .636 | AT&T Center · San Antonio, TX |
| 12 | Mon Nov 12 | at Kings | L99-104 | 7-5 | .583 | Golden 1 Center · Sacramento, CA |
| 13 | Wed Nov 14 | atSuns | L96-116 | 7-6 | .538 | Footprint Center · Phoenix, AZ |
| 14 | Thu Nov 15 | at Clippers | L111-116 | 7-7 | .500 | Crypto.com Arena · Los Angeles, CA |
| 15 | Sun Nov 18 | vs Warriors | W104-92 | 8-7 | .533 | AT&T Center · San Antonio, TX |
| 16 | Mon Nov 19 | atPelicans | L126-140 | 8-8 | .500 | Smoothie King Center · New Orleans, LA |
| 17 | Wed Nov 21 | vs Grizzlies | L103-104 | 8-9 | .471 | AT&T Center · San Antonio, TX |
| 18 | Fri Nov 23 | atPacers | W111-100 | 9-9 | .500 | Gainbridge Fieldhouse · Indianapolis, IN |
| 19 | Sat Nov 24 | at Bucks | L129-135 | 9-10 | .474 | Fiserv Forum · Milwaukee, WI |
| 20 | Mon Nov 26 | at Bulls | W108-107 | 10-10 | .500 | United Center · Chicago, IL |
| 21 | Wed Nov 28 | atT-wolves | L89-128 | 10-11 | .476 | Target Center · Minneapolis, MN |
| 22 | Fri Nov 30 | vsRockets | L105-136 | 10-12 | .455 | AT&T Center · San Antonio, TX |
| 23 | Sun Dec 2 | vsBlazers | W131-118 | 11-12 | .478 | AT&T Center · San Antonio, TX |
| 24 | Tue Dec 4 | at Jazz | L105-139 | 11-13 | .458 | Vivint Arena · Salt Lake City, UT |
| 25 | Wed Dec 5 | atLakers | L113-121 | 11-14 | .440 | Crypto.com Arena · Los Angeles, CA |
| 26 | Fri Dec 7 | vsLakers | W133-120 | 12-14 | .462 | AT&T Center · San Antonio, TX |
| 27 | Sun Dec 9 | vsJazz | W110-97 | 13-14 | .481 | AT&T Center · San Antonio, TX |
| 28 | Tue Dec 11 | vsSuns | W111-86 | 14-14 | .500 | AT&T Center · San Antonio, TX |
| 29 | Thu Dec 13 | vsClippers | W125-87 | 15-14 | .517 | AT&T Center · San Antonio, TX |
| 30 | Sat Dec 15 | vsBulls | L93-98 | 15-15 | .500 | AT&T Center · San Antonio, TX |
| 31 | Mon Dec 17 | vs 76ers | W123-96 | 16-15 | .516 | AT&T Center · San Antonio, TX |
| 32 | Wed Dec 19 | atMagic | W129-90 | 17-15 | .531 | Amway Center · Orlando, FL |
| 33 | Fri Dec 21 | vsT-wolves | W124-98 | 18-15 | .545 | AT&T Center · San Antonio, TX |
| 34 | Sat Dec 22 | atRockets | L101-108 | 18-16 | .529 | Toyota Center · Houston, TX |
| 35 | Wed Dec 26 | vs Nuggets | W111-103 | 19-16 | .543 | AT&T Center · San Antonio, TX |
| 36 | Fri Dec 28 | atNuggets | L99-102 | 19-17 | .528 | Ball Arena · Denver, CO |
| 37 | Sat Dec 29 | atClippers | W122-111 | 20-17 | .541 | Crypto.com Arena · Los Angeles, CA |
| 38 | Mon Dec 31 | vs Celtics | W120-111 | 21-17 | .553 | AT&T Center · San Antonio, TX |
| 39 | Thu Jan 3 | vs Raptors | W125-107 | 22-17 | .564 | AT&T Center · San Antonio, TX |
| 40 | Sat Jan 5 | vsGrizzlies | W108-88 | 23-17 | .575 | AT&T Center · San Antonio, TX |
| 41 | Mon Jan 7 | at Pistons | W119-107 | 24-17 | .585 | Little Caesars Arena · Detroit, MI |
| 42 | Wed Jan 9 | atGrizzlies | L86-96 | 24-18 | .571 | FedExForum · Memphis, TN |
| 43 | Thu Jan 10 | vs Thunder | W154-147 (2OT) | 25-18 | .581 | AT&T Center · San Antonio, TX |
| 44 | Sat Jan 12 | atThunder | L112-122 | 25-19 | .568 | Paycom Center · Oklahoma City, OK |
| 45 | Mon Jan 14 | vs Hornets | L93-108 | 25-20 | .556 | AT&T Center · San Antonio, TX |
| 46 | Wed Jan 16 | atMavericks | W105-101 | 26-20 | .565 | American Airlines Center · Dallas, TX |
| 47 | Fri Jan 18 | atT-wolves | W116-113 | 27-20 | .574 | Target Center · Minneapolis, MN |
| 48 | Sun Jan 20 | vsClippers | L95-103 | 27-21 | .563 | AT&T Center · San Antonio, TX |
| 49 | Wed Jan 23 | at76ers | L120-122 | 27-22 | .551 | Wells Fargo Center · Philadelphia, PA |
| 50 | Sat Jan 26 | atPelicans | W126-114 | 28-22 | .560 | Smoothie King Center · New Orleans, LA |
| 51 | Sun Jan 27 | vs Wizards | W132-119 | 29-22 | .569 | AT&T Center · San Antonio, TX |
| 52 | Tue Jan 29 | vsSuns | W126-124 | 30-22 | .577 | AT&T Center · San Antonio, TX |
| 53 | Thu Jan 31 | vs Nets | W117-114 | 31-22 | .585 | AT&T Center · San Antonio, TX |
| 54 | Sat Feb 2 | vsPelicans | W113-108 | 32-22 | .593 | AT&T Center · San Antonio, TX |
| 55 | Mon Feb 4 | atKings | L112-127 | 32-23 | .582 | Golden 1 Center · Sacramento, CA |
| 56 | Wed Feb 6 | atWarriors | L102-141 | 32-24 | .571 | Chase Center · San Francisco, CA |
| 57 | Thu Feb 7 | atBlazers | L118-127 | 32-25 | .561 | Moda Center · Portland, OR |
| 58 | Sat Feb 9 | atJazz | L105-125 | 32-26 | .552 | Vivint Arena · Salt Lake City, UT |
| 59 | Tue Feb 12 | atGrizzlies | W108-107 | 33-26 | .559 | FedExForum · Memphis, TN |
| 60 | Fri Feb 22 | atRaptors | L117-120 | 33-27 | .550 | Scotiabank Arena · Toronto, ON |
| 61 | Sun Feb 24 | at Knicks | L118-130 | 33-28 | .541 | Madison Square Garden · Manhattan, NY |
| 62 | Mon Feb 25 | atNets | L85-101 | 33-29 | .532 | Barclays Center · Brooklyn, NY |
| 63 | Wed Feb 27 | vsPistons | W105-93 | 34-29 | .540 | AT&T Center · San Antonio, TX |
| 64 | Sat Mar 2 | vsThunder | W116-102 | 35-29 | .547 | AT&T Center · San Antonio, TX |
| 65 | Mon Mar 4 | vsNuggets | W104-103 | 36-29 | .554 | AT&T Center · San Antonio, TX |
| 66 | Wed Mar 6 | at Hawks | W111-104 | 37-29 | .561 | State Farm Arena · Atlanta, GA |
| 67 | Sun Mar 10 | vsBucks | W121-114 | 38-29 | .567 | AT&T Center · San Antonio, TX |
| 68 | Tue Mar 12 | atMavericks | W112-105 | 39-29 | .574 | American Airlines Center · Dallas, TX |
| 69 | Fri Mar 15 | vsKnicks | W109-83 | 40-29 | .580 | AT&T Center · San Antonio, TX |
| 70 | Sat Mar 16 | vsBlazers | W108-103 | 41-29 | .586 | AT&T Center · San Antonio, TX |
| 71 | Mon Mar 18 | vsWarriors | W111-105 | 42-29 | .592 | AT&T Center · San Antonio, TX |
| 72 | Wed Mar 20 | vsHeat | L105-110 | 42-30 | .583 | AT&T Center · San Antonio, TX |
| 73 | Fri Mar 22 | atRockets | L105-111 | 42-31 | .575 | Toyota Center · Houston, TX |
| 74 | Sun Mar 24 | atCeltics | W115-96 | 43-31 | .581 | TD Garden · Boston, MA |
| 75 | Tue Mar 26 | atHornets | L116-125 (OT) | 43-32 | .573 | Spectrum Center · Charlotte, NC |
| 76 | Thu Mar 28 | vs Cavaliers | W116-110 | 44-32 | .579 | AT&T Center · San Antonio, TX |
| 77 | Sun Mar 31 | vsKings | L106-113 | 44-33 | .571 | AT&T Center · San Antonio, TX |
| 78 | Tue Apr 2 | vsHawks | W117-111 | 45-33 | .577 | AT&T Center · San Antonio, TX |
| 79 | Wed Apr 3 | atNuggets | L85-113 | 45-34 | .570 | Ball Arena · Denver, CO |
| 80 | Fri Apr 5 | atWizards | W129-112 | 46-34 | .575 | Capital One Arena · Washington, D.C. |
| 81 | Sun Apr 7 | atCavaliers | W112-90 | 47-34 | .580 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 82 | Wed Apr 10 | vsMavericks | W105-94 | 48-34 | .585 | AT&T Center · San Antonio, TX |
| 1 | Sat Apr 13 | atNuggets | W101-96 | 1-0 | 1.000 | Ball Arena · Denver, CO |
| 2 | Tue Apr 16 | atNuggets | L105-114 | 1-1 | .500 | Ball Arena · Denver, CO |
| 3 | Thu Apr 18 | vsNuggets | W118-108 | 2-1 | .667 | AT&T Center · San Antonio, TX |
| 4 | Sat Apr 20 | vsNuggets | L103-117 | 2-2 | .500 | AT&T Center · San Antonio, TX |
| 5 | Tue Apr 23 | atNuggets | L90-108 | 2-3 | .400 | Ball Arena · Denver, CO |
| 6 | Thu Apr 25 | vsNuggets | W120-103 | 3-3 | .500 | AT&T Center · San Antonio, TX |
| 7 | Sat Apr 27 | atNuggets | L86-90 | 3-4 | .429 | Ball Arena · Denver, CO |
