| 5 | Wed Oct 28 | at Cavaliers | 7:00 PM | 2-1 | .667 | | Rocket Mortgage FieldHouse · Cleveland, OH |
| 6 | Fri Oct 30 | vs Hornets | 7:00 PM | 3-1 | .750 | | Capital One Arena · Washington, D.C. |
| 7 | Mon Nov 2 | at Magic | 7:30 PM | 1-2 | .333 | | Kia Center · Orlando, FL |
| 8 | Wed Nov 4 | vs Hawks | 7:00 PM | 2-2 | .500 | | Capital One Arena · Washington, D.C. |
| 9 | Fri Nov 6 | at Hawks | 7:00 PM | 2-2 | .500 | | State Farm Arena · Atlanta, GA |
| 10 | Sat Nov 7 | at Thunder | 8:00 PM | 4-0 | 1.000 | | Paycom Center · Oklahoma City, OK |
| 11 | Mon Nov 9 | at Pistons | 7:00 PM | 3-1 | .750 | NBCSN | Little Caesars Arena · Detroit, MI |
| 12 | Wed Nov 11 | at Pacers | 7:00 PM | 2-2 | .500 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 13 | Thu Nov 12 | vs Pistons | 7:00 PM | 3-1 | .750 | | Capital One Arena · Washington, D.C. |
| 14 | Sun Nov 15 | vs Rockets | 7:00 PM | 4-0 | 1.000 | | Capital One Arena · Washington, D.C. |
| 15 | Mon Nov 16 | vs Grizzlies | 7:00 PM | 4-0 | 1.000 | | Capital One Arena · Washington, D.C. |
| 16 | Wed Nov 18 | at Raptors | 7:30 PM | 2-1 | .667 | | Scotiabank Arena · Toronto, ON |
| 17 | Fri Nov 20 | at Bulls | 8:00 PM | 1-3 | .250 | | United Center · Chicago, IL |
| 18 | Sun Nov 22 | vs Magic | 7:00 PM | 1-2 | .333 | | Capital One Arena · Washington, D.C. |
| 19 | Tue Nov 24 | vs Celtics | 8:00 PM | 3-1 | .750 | NBC | Capital One Arena · Washington, D.C. |
| 20 | Sat Nov 28 | vs Magic | 5:00 PM | 1-2 | .333 | | Capital One Arena · Washington, D.C. |
| 21 | Mon Nov 30 | at Hornets | 7:00 PM | 3-1 | .750 | | Spectrum Center · Charlotte, NC |
| 22 | Thu Dec 3 | at Heat | 7:30 PM | 0-4 | .000 | | Kaseya Center · Miami, FL |
| 23 | Sat Dec 12 | vs Hornets | 7:00 PM | 3-1 | .750 | | Capital One Arena · Washington, D.C. |
| 24 | Mon Dec 14 | at Celtics | 7:30 PM | 3-1 | .750 | | TD Garden · Boston, MA |
| 25 | Wed Dec 16 | at Celtics | 7:00 PM | 3-1 | .750 | ESPN | TD Garden · Boston, MA |
| 26 | Fri Dec 18 | vs Knicks | 7:00 PM | 1-3 | .250 | | Capital One Arena · Washington, D.C. |
| 27 | Sun Dec 20 | at Nets | 3:00 PM | 0-4 | .000 | | Barclays Center · Brooklyn, NY |
| 28 | Tue Dec 22 | vs Raptors | 7:00 PM | 2-1 | .667 | | Capital One Arena · Washington, D.C. |
| 29 | Wed Dec 23 | vs Cavaliers | 7:00 PM | 2-1 | .667 | | Capital One Arena · Washington, D.C. |
| 30 | Sat Dec 26 | vs Blazers | 1:00 PM | 3-0 | 1.000 | NBA TV | Capital One Arena · Washington, D.C. |
| 31 | Sun Dec 27 | at Cavaliers | 6:00 PM | 2-1 | .667 | | Rocket Mortgage FieldHouse · Cleveland, OH |
| 32 | Wed Dec 30 | at Raptors | 7:30 PM | 2-1 | .667 | NBA TV | Scotiabank Arena · Toronto, ON |
| 33 | Fri Jan 1 | vs Spurs | 5:00 PM | 2-2 | .500 | NBA TV | Capital One Arena · Washington, D.C. |
| 34 | Sun Jan 3 | vs Clippers | 7:00 PM | 1-2 | .333 | | Capital One Arena · Washington, D.C. |
| 35 | Tue Jan 5 | vs Lakers | 7:00 PM | 3-1 | .750 | | Capital One Arena · Washington, D.C. |
| 36 | Thu Jan 7 | vs Thunder | 7:00 PM | 4-0 | 1.000 | | Capital One Arena · Washington, D.C. |
| 37 | Fri Jan 8 | vs T-wolves | 7:00 PM | 3-1 | .750 | | Capital One Arena · Washington, D.C. |
| 38 | Mon Jan 11 | vs Hawks | 7:00 PM | 2-2 | .500 | | Capital One Arena · Washington, D.C. |
| 39 | Tue Jan 12 | at 76ers | 8:00 PM | 3-1 | .750 | NBC | Xfinity Mobile Arena · Philadelphia, PA |
| 40 | Fri Jan 15 | at Rockets | 8:30 PM | 4-0 | 1.000 | | Toyota Center · Houston, TX |
| 41 | Sun Jan 17 | vs Pacers | 1:00 PM | 2-2 | .500 | | Capital One Arena · Washington, D.C. |
| 42 | Mon Jan 18 | vs Celtics | 3:00 PM | 3-1 | .750 | | Capital One Arena · Washington, D.C. |
| 43 | Thu Jan 21 | at Nuggets | 9:00 PM | 1-2 | .333 | | Ball Arena · Denver, CO |
| 44 | Fri Jan 22 | at Clippers | 10:30 PM | 1-2 | .333 | | Intuit Dome · Inglewood, CA |
| 45 | Sun Jan 24 | at Lakers | 4:00 PM | 3-1 | .750 | | Crypto.com Arena · Los Angeles, CA |
| 46 | Tue Jan 26 | at Blazers | 10:00 PM | 3-0 | 1.000 | | Moda Center · Portland, OR |
| 47 | Thu Jan 28 | vs Kings | 7:00 PM | 0-4 | .000 | | Capital One Arena · Washington, D.C. |
| 48 | Sat Jan 30 | at Pacers | 7:00 PM | 2-2 | .500 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 49 | Mon Feb 1 | at Hawks | 7:00 PM | 2-2 | .500 | | State Farm Arena · Atlanta, GA |
| 50 | Thu Feb 4 | vs Pelicans | 7:00 PM | 0-3 | .000 | | Capital One Arena · Washington, D.C. |
| 51 | Sat Feb 6 | at Nets | 6:00 PM | 0-4 | .000 | | Barclays Center · Brooklyn, NY |
| 52 | Mon Feb 8 | vs Bulls | 7:00 PM | 1-3 | .250 | | Capital One Arena · Washington, D.C. |
| 53 | Wed Feb 10 | vs Heat | 7:00 PM | 0-4 | .000 | | Capital One Arena · Washington, D.C. |
| 54 | Fri Feb 12 | vs Nets | 7:00 PM | 0-4 | .000 | | Capital One Arena · Washington, D.C. |
| 55 | Sat Feb 13 | vs Bucks | 7:00 PM | 1-3 | .250 | | Capital One Arena · Washington, D.C. |
| 56 | Mon Feb 15 | vs Suns | 7:00 PM | 1-2 | .333 | | Capital One Arena · Washington, D.C. |
| 57 | Wed Feb 17 | vs Heat | 7:00 PM | 0-4 | .000 | | Capital One Arena · Washington, D.C. |
| 58 | Thu Feb 25 | at Bucks | 8:00 PM | 1-3 | .250 | | Fiserv Forum · Milwaukee, WI |
| 59 | Sat Feb 27 | at Jazz | 3:00 PM | 1-3 | .250 | Prime Video | Vivint Arena · Salt Lake City, UT |
| 60 | Mon Mar 1 | at Suns | 9:30 PM | 1-2 | .333 | NBCSN | Mortgage Matchup Center · Phoenix, AZ |
| 61 | Tue Mar 2 | at Kings | 10:00 PM | 0-4 | .000 | | Golden 1 Center · Sacramento, CA |
| 62 | Thu Mar 4 | at Warriors | 10:00 PM | 1-3 | .250 | | Chase Center · San Francisco, CA |
| 63 | Sat Mar 6 | vs Jazz | 7:00 PM | 1-3 | .250 | | Capital One Arena · Washington, D.C. |
| 64 | Tue Mar 9 | at Spurs | 8:00 PM | 2-2 | .500 | | Frost Bank Center · San Antonio, TX |
| 65 | Thu Mar 11 | at Mavericks | 8:00 PM | 2-2 | .500 | | American Airlines Center · Dallas, TX |
| 66 | Sun Mar 14 | at T-wolves | 8:00 PM | 3-1 | .750 | | Target Center · Minneapolis, MN |
| 67 | Tue Mar 16 | vs Knicks | 7:00 PM | 1-3 | .250 | | Capital One Arena · Washington, D.C. |
| 68 | Thu Mar 18 | vs 76ers | 7:00 PM | 3-1 | .750 | NBA TV | Capital One Arena · Washington, D.C. |
| 69 | Sat Mar 20 | at Knicks | 1:00 PM | 1-3 | .250 | | Madison Square Garden · Manhattan, NY |
| 70 | Mon Mar 22 | at Bucks | 8:00 PM | 1-3 | .250 | | Fiserv Forum · Milwaukee, WI |
| 71 | Wed Mar 24 | vs Nuggets | 7:00 PM | 1-2 | .333 | | Capital One Arena · Washington, D.C. |
| 72 | Sat Mar 27 | vs Warriors | 7:00 PM | 1-3 | .250 | | Capital One Arena · Washington, D.C. |
| 73 | Sun Mar 28 | vs Mavericks | 6:00 PM | 2-2 | .500 | | Capital One Arena · Washington, D.C. |
| 74 | Wed Mar 31 | vs Bulls | 7:00 PM | 1-3 | .250 | | Capital One Arena · Washington, D.C. |
| 75 | Fri Apr 2 | vs 76ers | 7:00 PM | 3-1 | .750 | | Capital One Arena · Washington, D.C. |
| 76 | Sat Apr 3 | at Magic | 7:00 PM | 1-2 | .333 | | Kia Center · Orlando, FL |
| 77 | Mon Apr 5 | at Pelicans | 8:00 PM | 0-3 | .000 | | Smoothie King Center · New Orleans, LA |
| 78 | Wed Apr 7 | at Grizzlies | 8:00 PM | 4-0 | 1.000 | | FedExForum · Memphis, TN |
| 79 | Fri Apr 9 | at Heat | 8:00 PM | 0-4 | .000 | | Kaseya Center · Miami, FL |
| 80 | Sun Apr 11 | vs Pistons | 6:00 PM | 3-1 | .750 | | Capital One Arena · Washington, D.C. |