| 1 | Thu Oct 27 | at Hawks | L99-114 | 0-1 | .000 | | State Farm Arena · Atlanta, GA |
| 2 | Sun Oct 30 | at Grizzlies | L103-112 (OT) | 0-2 | .000 | NBA TV | FedExForum · Memphis, TN |
| 3 | Wed Nov 2 | vs Raptors | L103-113 | 0-3 | .000 | | Capital One Arena · Washington, D.C. |
| 4 | Fri Nov 4 | vs Hawks | W95-92 | 1-3 | .250 | | Capital One Arena · Washington, D.C. |
| 5 | Sat Nov 5 | at Magic | L86-88 | 1-4 | .200 | | Amway Center · Orlando, FL |
| 6 | Mon Nov 7 | vs Rockets | L106-114 | 1-5 | .167 | | Capital One Arena · Washington, D.C. |
| 7 | Wed Nov 9 | vs Celtics | W118-93 | 2-5 | .286 | | Capital One Arena · Washington, D.C. |
| 8 | Fri Nov 11 | vs Cavaliers | L94-105 | 2-6 | .250 | | Capital One Arena · Washington, D.C. |
| 9 | Sat Nov 12 | at Bulls | L95-106 | 2-7 | .222 | | United Center · Chicago, IL |
| 10 | Wed Nov 16 | at 76ers | L102-109 | 2-8 | .200 | | Wells Fargo Center · Philadelphia, PA |
| 11 | Thu Nov 17 | vs Knicks | W119-112 | 3-8 | .273 | | Capital One Arena · Washington, D.C. |
| 12 | Sat Nov 19 | vs Heat | L111-114 | 3-9 | .250 | | Capital One Arena · Washington, D.C. |
| 13 | Mon Nov 21 | vs Suns | W106-101 | 4-9 | .308 | | Capital One Arena · Washington, D.C. |
| 14 | Fri Nov 25 | at Magic | W94-91 | 5-9 | .357 | | Amway Center · Orlando, FL |
| 15 | Sat Nov 26 | vs Spurs | L100-112 | 5-10 | .333 | NBA TV | Capital One Arena · Washington, D.C. |
| 16 | Mon Nov 28 | vs Kings | W101-95 (OT) | 6-10 | .375 | | Capital One Arena · Washington, D.C. |
| 17 | Wed Nov 30 | at Thunder | L115-126 (OT) | 6-11 | .353 | | Paycom Center · Oklahoma City, OK |
| 18 | Fri Dec 2 | at Spurs | L105-107 | 6-12 | .333 | | AT&T Center · San Antonio, TX |
| 19 | Mon Dec 5 | at Nets | W118-113 | 7-12 | .368 | | Barclays Center · Brooklyn, NY |
| 20 | Tue Dec 6 | vs Magic | L116-124 | 7-13 | .350 | | Capital One Arena · Washington, D.C. |
| 21 | Thu Dec 8 | vs Nuggets | W92-85 | 8-13 | .381 | | Capital One Arena · Washington, D.C. |
| 22 | Sat Dec 10 | vs Bucks | W110-105 | 9-13 | .409 | | Capital One Arena · Washington, D.C. |
| 23 | Mon Dec 12 | at Heat | L101-112 | 9-14 | .391 | NBA TV | Kaseya Center · Miami, FL |
| 24 | Wed Dec 14 | vs Hornets | W109-106 | 10-14 | .417 | | Capital One Arena · Washington, D.C. |
| 25 | Fri Dec 16 | vs Pistons | W122-108 | 11-14 | .440 | | Capital One Arena · Washington, D.C. |
| 26 | Sun Dec 18 | vs Clippers | W117-110 | 12-14 | .462 | | Capital One Arena · Washington, D.C. |
| 27 | Mon Dec 19 | at Pacers | L105-107 | 12-15 | .444 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 28 | Wed Dec 21 | at Bulls | W107-97 | 13-15 | .464 | | United Center · Chicago, IL |
| 29 | Fri Dec 23 | at Bucks | L96-123 | 13-16 | .448 | | Fiserv Forum · Milwaukee, WI |
| 30 | Mon Dec 26 | vs Bucks | W107-102 | 14-16 | .467 | | Capital One Arena · Washington, D.C. |
| 31 | Wed Dec 28 | vs Pacers | W111-105 | 15-16 | .484 | | Capital One Arena · Washington, D.C. |
| 32 | Fri Dec 30 | vs Nets | W118-95 | 16-16 | .500 | | Capital One Arena · Washington, D.C. |
| 33 | Mon Jan 2 | at Rockets | L91-101 | 16-17 | .485 | | Toyota Center · Houston, TX |
| 34 | Tue Jan 3 | at Mavericks | L105-113 | 16-18 | .471 | | American Airlines Center · Dallas, TX |
| 35 | Fri Jan 6 | vs T-wolves | W112-105 | 17-18 | .486 | | Capital One Arena · Washington, D.C. |
| 36 | Sun Jan 8 | at Bucks | W107-101 | 18-18 | .500 | | Fiserv Forum · Milwaukee, WI |
| 37 | Tue Jan 10 | vs Bulls | W101-99 | 19-18 | .514 | | Capital One Arena · Washington, D.C. |
| 38 | Wed Jan 11 | at Celtics | L108-117 | 19-19 | .500 | | TD Garden · Boston, MA |
| 39 | Sat Jan 14 | vs 76ers | W109-93 | 20-19 | .513 | | Capital One Arena · Washington, D.C. |
| 40 | Mon Jan 16 | vs Blazers | W120-101 | 21-19 | .525 | | Capital One Arena · Washington, D.C. |
| 41 | Wed Jan 18 | vs Grizzlies | W104-101 | 22-19 | .537 | | Capital One Arena · Washington, D.C. |
| 42 | Thu Jan 19 | at Knicks | W113-110 | 23-19 | .548 | TNT | Madison Square Garden · Manhattan, NY |
| 43 | Sat Jan 21 | at Pistons | L112-113 | 23-20 | .535 | | Little Caesars Arena · Detroit, MI |
| 44 | Mon Jan 23 | at Hornets | W109-99 | 24-20 | .545 | | Spectrum Center · Charlotte, NC |
| 45 | Tue Jan 24 | vs Celtics | W123-108 | 25-20 | .556 | | Capital One Arena · Washington, D.C. |
| 46 | Fri Jan 27 | at Hawks | W112-86 | 26-20 | .565 | | State Farm Arena · Atlanta, GA |
| 47 | Sun Jan 29 | at Pelicans | W107-94 | 27-20 | .574 | NBA TV | Smoothie King Center · New Orleans, LA |
| 48 | Tue Jan 31 | vs Knicks | W117-101 | 28-20 | .583 | | Capital One Arena · Washington, D.C. |
| 49 | Thu Feb 2 | vs Lakers | W116-108 | 29-20 | .592 | | Capital One Arena · Washington, D.C. |
| 50 | Sat Feb 4 | vs Pelicans | W105-91 | 30-20 | .600 | | Capital One Arena · Washington, D.C. |
| 51 | Mon Feb 6 | vs Cavaliers | L135-140 (OT) | 30-21 | .588 | TNT | Capital One Arena · Washington, D.C. |
| 52 | Wed Feb 8 | at Nets | W114-110 (OT) | 31-21 | .596 | | Barclays Center · Brooklyn, NY |
| 53 | Fri Feb 10 | vs Pacers | W112-107 | 32-21 | .604 | ESPN | Capital One Arena · Washington, D.C. |
| 54 | Mon Feb 13 | vs Thunder | W120-98 | 33-21 | .611 | TNT | Capital One Arena · Washington, D.C. |
| 55 | Thu Feb 16 | at Pacers | W111-98 | 34-21 | .618 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 56 | Fri Feb 24 | at 76ers | L112-120 | 34-22 | .607 | | Wells Fargo Center · Philadelphia, PA |
| 57 | Sun Feb 26 | vs Jazz | L92-102 | 34-23 | .596 | | Capital One Arena · Washington, D.C. |
| 58 | Tue Feb 28 | vs Warriors | W112-108 | 35-23 | .603 | NBA TV | Capital One Arena · Washington, D.C. |
| 59 | Wed Mar 1 | at Raptors | W105-96 | 36-23 | .610 | | Scotiabank Arena · Toronto, ON |
| 60 | Fri Mar 3 | vs Raptors | L106-114 | 36-24 | .600 | | Capital One Arena · Washington, D.C. |
| 61 | Sun Mar 5 | vs Magic | W115-114 | 37-24 | .607 | | Capital One Arena · Washington, D.C. |
| 62 | Tue Mar 7 | at Suns | W131-127 | 38-24 | .613 | | Footprint Center · Phoenix, AZ |
| 63 | Wed Mar 8 | at Nuggets | W123-113 | 39-24 | .619 | | Ball Arena · Denver, CO |
| 64 | Fri Mar 10 | at Kings | W130-122 (OT) | 40-24 | .625 | NBA TV | Golden 1 Center · Sacramento, CA |
| 65 | Sat Mar 11 | at Blazers | W125-124 (OT) | 41-24 | .631 | | Moda Center · Portland, OR |
| 66 | Mon Mar 13 | at T-wolves | L104-119 | 41-25 | .621 | | Target Center · Minneapolis, MN |
| 67 | Wed Mar 15 | vs Mavericks | L107-112 | 41-26 | .612 | | Capital One Arena · Washington, D.C. |
| 68 | Fri Mar 17 | vs Bulls | W112-107 | 42-26 | .618 | | Capital One Arena · Washington, D.C. |
| 69 | Sat Mar 18 | at Hornets | L93-98 | 42-27 | .609 | | Spectrum Center · Charlotte, NC |
| 70 | Mon Mar 20 | at Celtics | L102-110 | 42-28 | .600 | | TD Garden · Boston, MA |
| 71 | Wed Mar 22 | vs Hawks | W104-100 | 43-28 | .606 | ESPN | Capital One Arena · Washington, D.C. |
| 72 | Fri Mar 24 | vs Nets | W129-108 | 44-28 | .611 | | Capital One Arena · Washington, D.C. |
| 73 | Sat Mar 25 | at Cavaliers | W127-115 | 45-28 | .616 | NBA TV | Rocket Mortgage FieldHouse · Cleveland, OH |
| 74 | Tue Mar 28 | at Lakers | W119-108 | 46-28 | .622 | NBA TV | Crypto.com Arena · Los Angeles, CA |
| 75 | Wed Mar 29 | at Clippers | L124-133 | 46-29 | .613 | | Intuit Dome · Inglewood, CA |
| 76 | Fri Mar 31 | at Jazz | L88-95 | 46-30 | .605 | | Vivint Arena · Salt Lake City, UT |
| 77 | Sun Apr 2 | at Warriors | L115-139 | 46-31 | .597 | | Chase Center · San Francisco, CA |
| 78 | Tue Apr 4 | vs Hornets | W118-111 | 47-31 | .603 | | Capital One Arena · Washington, D.C. |
| 79 | Thu Apr 6 | at Knicks | W106-103 | 48-31 | .608 | | Madison Square Garden · Manhattan, NY |
| 80 | Sat Apr 8 | vs Heat | L103-106 | 48-32 | .600 | | Capital One Arena · Washington, D.C. |
| 81 | Mon Apr 10 | at Pistons | W105-101 | 49-32 | .605 | TNT | Little Caesars Arena · Detroit, MI |
| 82 | Wed Apr 12 | at Heat | L102-110 | 49-33 | .598 | | Kaseya Center · Miami, FL |
| 1 | Sun Apr 16 | vs Hawks | W114-107 | 1-0 | 1.000 | TNT | Capital One Arena · Washington, D.C. |
| 2 | Wed Apr 19 | vs Hawks | W109-101 | 2-0 | 1.000 | NBA TV | Capital One Arena · Washington, D.C. |
| 3 | Sat Apr 22 | at Hawks | L98-116 | 2-1 | .667 | TNT | State Farm Arena · Atlanta, GA |
| 4 | Mon Apr 24 | at Hawks | L101-111 | 2-2 | .500 | TNT | State Farm Arena · Atlanta, GA |
| 5 | Wed Apr 26 | vs Hawks | W103-99 | 3-2 | .600 | TNT | Capital One Arena · Washington, D.C. |
| 6 | Fri Apr 28 | at Hawks | W115-99 | 4-2 | .667 | ESPNU | State Farm Arena · Atlanta, GA |
| 1 | Sun Apr 30 | at Celtics | L111-123 | 0-1 | .000 | ABC | TD Garden · Boston, MA |
| 2 | Tue May 2 | at Celtics | L119-129 (OT) | 0-2 | .000 | TNT | TD Garden · Boston, MA |
| 3 | Thu May 4 | vs Celtics | W116-89 | 1-2 | .333 | ESPN | Capital One Arena · Washington, D.C. |
| 4 | Sun May 7 | vs Celtics | W121-102 | 2-2 | .500 | TNT | Capital One Arena · Washington, D.C. |
| 5 | Wed May 10 | at Celtics | L101-123 | 2-3 | .400 | TNT | TD Garden · Boston, MA |
| 6 | Fri May 12 | vs Celtics | W92-91 | 3-3 | .500 | ESPN | Capital One Arena · Washington, D.C. |
| 7 | Mon May 15 | at Celtics | L105-115 | 3-4 | .429 | TNT | TD Garden · Boston, MA |