| 1 | Wed Oct 23 | vs Hornets | L105-110 | 0-1 | .000 | | Toyota Center · Houston, TX |
| 2 | Fri Oct 25 | vs Grizzlies | W128-108 | 1-1 | .500 | | Toyota Center · Houston, TX |
| 3 | Sat Oct 26 | at Spurs | L106-109 | 1-2 | .333 | | AT&T Center · San Antonio, TX |
| 4 | Mon Oct 28 | atSpurs | W106-101 | 2-2 | .500 | | AT&T Center · San Antonio, TX |
| 5 | Thu Oct 31 | at Mavericks | W108-102 | 3-2 | .600 | | American Airlines Center · Dallas, TX |
| 6 | Sat Nov 2 | vs Warriors | L121-127 (OT) | 3-3 | .500 | | Toyota Center · Houston, TX |
| 7 | Mon Nov 4 | vs Knicks | W109-97 | 4-3 | .571 | | Toyota Center · Houston, TX |
| 8 | Wed Nov 6 | vsSpurs | W127-100 | 5-3 | .625 | | Toyota Center · Houston, TX |
| 9 | Fri Nov 8 | at Thunder | L107-126 | 5-4 | .556 | | Paycom Center · Oklahoma City, OK |
| 10 | Sun Nov 10 | at Pistons | W101-99 | 6-4 | .600 | | Little Caesars Arena · Detroit, MI |
| 11 | Mon Nov 11 | vs Wizards | W107-92 | 7-4 | .636 | | Toyota Center · Houston, TX |
| 12 | Wed Nov 13 | vs Clippers | W111-103 | 8-4 | .667 | | Toyota Center · Houston, TX |
| 13 | Fri Nov 15 | vsClippers | W125-104 | 9-4 | .692 | | Toyota Center · Houston, TX |
| 14 | Sun Nov 17 | at Bulls | W143-107 | 10-4 | .714 | | United Center · Chicago, IL |
| 15 | Mon Nov 18 | at Bucks | L100-101 | 10-5 | .667 | NBA TV | Fiserv Forum · Milwaukee, WI |
| 16 | Wed Nov 20 | vs Pacers | W130-113 | 11-5 | .688 | | Toyota Center · Houston, TX |
| 17 | Fri Nov 22 | vs Blazers | W116-88 | 12-5 | .706 | | Toyota Center · Houston, TX |
| 18 | Sat Nov 23 | vsBlazers | L98-104 | 12-6 | .667 | | Toyota Center · Houston, TX |
| 19 | Tue Nov 26 | at T-wolves | W117-111 (OT) | 13-6 | .684 | | Target Center · Minneapolis, MN |
| 20 | Wed Nov 27 | at 76ers | W122-115 (OT) | 14-6 | .700 | | Wells Fargo Center · Philadelphia, PA |
| 21 | Sun Dec 1 | vsThunder | W119-116 | 15-6 | .714 | | Toyota Center · Houston, TX |
| 22 | Tue Dec 3 | at Kings | L111-120 | 15-7 | .682 | | Golden 1 Center · Sacramento, CA |
| 23 | Thu Dec 5 | atWarriors | L93-99 | 15-8 | .652 | NBA TV | Chase Center · San Francisco, CA |
| 24 | Sun Dec 8 | atClippers | W117-106 | 16-8 | .667 | | Intuit Dome · Inglewood, CA |
| 25 | Wed Dec 11 | vsWarriors | W91-90 | 17-8 | .680 | TNT | Toyota Center · Houston, TX |
| 26 | Sat Dec 14 | atThunder | L96-111 | 17-9 | .654 | ABC | Paycom Center · Oklahoma City, OK |
| 27 | Thu Dec 19 | vs Pelicans | W133-113 | 18-9 | .667 | | Toyota Center · Houston, TX |
| 28 | Sun Dec 22 | at Raptors | W114-110 | 19-9 | .679 | | Scotiabank Arena · Toronto, ON |
| 29 | Mon Dec 23 | atHornets | W114-101 | 20-9 | .690 | | Spectrum Center · Charlotte, NC |
| 30 | Thu Dec 26 | atPelicans | W128-111 | 21-9 | .700 | | Smoothie King Center · New Orleans, LA |
| 31 | Fri Dec 27 | vsT-wolves | L112-113 | 21-10 | .677 | | Toyota Center · Houston, TX |
| 32 | Sun Dec 29 | vs Heat | L100-104 | 21-11 | .656 | | Toyota Center · Houston, TX |
| 33 | Wed Jan 1 | vsMavericks | W110-99 | 22-11 | .667 | | Toyota Center · Houston, TX |
| 34 | Fri Jan 3 | vs Celtics | L86-109 | 22-12 | .647 | | Toyota Center · Houston, TX |
| 35 | Sun Jan 5 | vs Lakers | W119-115 | 23-12 | .657 | | Toyota Center · Houston, TX |
| 36 | Tue Jan 7 | atWizards | W135-112 | 24-12 | .667 | | Capital One Arena · Washington, D.C. |
| 37 | Thu Jan 9 | atGrizzlies | W119-115 | 25-12 | .676 | | FedExForum · Memphis, TN |
| 38 | Mon Jan 13 | vsGrizzlies | W120-118 | 26-12 | .684 | NBA TV | Toyota Center · Houston, TX |
| 39 | Wed Jan 15 | at Nuggets | W128-108 | 27-12 | .692 | | Ball Arena · Denver, CO |
| 40 | Thu Jan 16 | atKings | L127-132 | 27-13 | .675 | TNT | Golden 1 Center · Sacramento, CA |
| 41 | Sat Jan 18 | atBlazers | W125-103 | 28-13 | .683 | | Moda Center · Portland, OR |
| 42 | Mon Jan 20 | vsPistons | L96-107 | 28-14 | .667 | | Toyota Center · Houston, TX |
| 43 | Wed Jan 22 | vs Cavaliers | W109-108 | 29-14 | .674 | | Toyota Center · Houston, TX |
| 44 | Sat Jan 25 | atCavaliers | W135-131 | 30-14 | .682 | | Rocket Mortgage FieldHouse · Cleveland, OH |
| 45 | Mon Jan 27 | atCeltics | W114-112 | 31-14 | .689 | | TD Garden · Boston, MA |
| 46 | Tue Jan 28 | at Hawks | W100-96 | 32-14 | .696 | | State Farm Arena · Atlanta, GA |
| 47 | Thu Jan 30 | atGrizzlies | L119-120 | 32-15 | .681 | TNT | FedExForum · Memphis, TN |
| 48 | Sat Feb 1 | vs Nets | L98-110 | 32-16 | .667 | | Toyota Center · Houston, TX |
| 49 | Mon Feb 3 | atKnicks | L118-124 | 32-17 | .653 | NBA TV | Madison Square Garden · Manhattan, NY |
| 50 | Tue Feb 4 | atNets | L97-99 | 32-18 | .640 | | Barclays Center · Brooklyn, NY |
| 51 | Thu Feb 6 | atT-wolves | L114-127 | 32-19 | .627 | | Target Center · Minneapolis, MN |
| 52 | Sat Feb 8 | atMavericks | L105-116 | 32-20 | .615 | | American Airlines Center · Dallas, TX |
| 53 | Sun Feb 9 | vsRaptors | W94-87 | 33-20 | .623 | | Toyota Center · Houston, TX |
| 54 | Wed Feb 12 | vs Suns | W119-111 | 34-20 | .630 | | Toyota Center · Houston, TX |
| 55 | Thu Feb 13 | vsWarriors | L98-105 | 34-21 | .618 | | Toyota Center · Houston, TX |
| --all-star break-- |
| 56 | Fri Feb 21 | vsT-wolves | W121-115 | 35-21 | .625 | ESPN | Toyota Center · Houston, TX |
| 57 | Sat Feb 22 | at Jazz | L115-124 | 35-22 | .614 | | Vivint Arena · Salt Lake City, UT |
| 58 | Tue Feb 25 | vsBucks | W100-97 | 36-22 | .621 | | Toyota Center · Houston, TX |
| 59 | Wed Feb 26 | vsSpurs | W118-106 | 37-22 | .627 | ESPN | Toyota Center · Houston, TX |
| 60 | Sat Mar 1 | vsKings | L103-113 | 37-23 | .617 | | Toyota Center · Houston, TX |
| 61 | Mon Mar 3 | atThunder | L128-137 | 37-24 | .607 | NBA TV | Paycom Center · Oklahoma City, OK |
| 62 | Tue Mar 4 | atPacers | L102-115 | 37-25 | .597 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 63 | Thu Mar 6 | atPelicans | W109-97 | 38-25 | .603 | | Smoothie King Center · New Orleans, LA |
| 64 | Sat Mar 8 | vsPelicans | W146-117 | 39-25 | .609 | | Toyota Center · Houston, TX |
| 65 | Mon Mar 10 | vs Magic | W97-84 | 40-25 | .615 | | Toyota Center · Houston, TX |
| 66 | Wed Mar 12 | vsSuns | W111-104 | 41-25 | .621 | | Toyota Center · Houston, TX |
| 67 | Fri Mar 14 | vsMavericks | W133-96 | 42-25 | .627 | | Toyota Center · Houston, TX |
| 68 | Sat Mar 15 | vsBulls | W117-114 | 43-25 | .632 | | Toyota Center · Houston, TX |
| 69 | Mon Mar 17 | vs76ers | W144-137 (OT) | 44-25 | .638 | | Toyota Center · Houston, TX |
| 70 | Wed Mar 19 | atMagic | W116-108 | 45-25 | .643 | | Amway Center · Orlando, FL |
| 71 | Fri Mar 21 | atHeat | W102-98 | 46-25 | .648 | NBA TV | Kaseya Center · Miami, FL |
| 72 | Sun Mar 23 | vsNuggets | L111-116 | 46-26 | .639 | | Toyota Center · Houston, TX |
| 73 | Tue Mar 25 | vsHawks | LIVE0-0 | 46-26 | .639 | | Toyota Center · Houston, TX |
