| 1 | Tue Oct 21 | at Thunder | L124-125 (2OT) | 0-1 | .000 | Peacock | Paycom Center · Oklahoma City, OK |
| 2 | Fri Oct 24 | vsPistons | L111-115 | 0-2 | .000 | | Toyota Center · Houston, TX |
| 3 | Mon Oct 27 | vsNets | W137-109 | 1-2 | .333 | | Toyota Center · Houston, TX |
| 4 | Wed Oct 29 | atRaptors | W139-121 | 2-2 | .500 | | Scotiabank Arena · Toronto, ON |
| 5 | Sat Nov 1 | atCeltics | W128-101 | 3-2 | .600 | | TD Garden · Boston, MA |
| 6 | Mon Nov 3 | vsMavericks | W110-102 | 4-2 | .667 | | Toyota Center · Houston, TX |
| 7 | Wed Nov 5 | atGrizzlies | W124-109 | 5-2 | .714 | | FedExForum · Memphis, TN |
| 8 | Fri Nov 7 | atSpurs | L110-121 | 5-3 | .625 | Amazon | AT&T Center · San Antonio, TX |
| 9 | Sun Nov 9 | atBucks | W122-115 | 6-3 | .667 | | Fiserv Forum · Milwaukee, WI |
| 10 | Wed Nov 12 | vsWizards | W135-112 | 7-3 | .700 | | Toyota Center · Houston, TX |
| 11 | Fri Nov 14 | vsBlazers | W140-116 | 8-3 | .727 | | Toyota Center · Houston, TX |
| 12 | Sun Nov 16 | vsMagic | W117-113 (OT) | 9-3 | .750 | | Toyota Center · Houston, TX |
| 13 | Wed Nov 19 | atCavaliers | W114-104 | 10-3 | .769 | ESPN | Rocket Mortgage FieldHouse · Cleveland, OH |
| 14 | Fri Nov 21 | vsNuggets | L109-112 | 10-4 | .714 | Amazon | Toyota Center · Houston, TX |
| 15 | Mon Nov 24 | atSuns | W114-92 | 11-4 | .733 | Peacock | Mortgage Matchup Center · Phoenix, AZ |
| 16 | Wed Nov 26 | atWarriors | W104-100 | 12-4 | .750 | ESPN | Chase Center · San Francisco, CA |
| 17 | Sun Nov 30 | atJazz | W129-101 | 13-4 | .765 | | Vivint Arena · Salt Lake City, UT |
| 18 | Mon Dec 1 | atJazz | L125-133 | 13-5 | .722 | | Vivint Arena · Salt Lake City, UT |
| 19 | Wed Dec 3 | vsKings | W121-95 | 14-5 | .737 | | Toyota Center · Houston, TX |
| 20 | Fri Dec 5 | vsSuns | W117-98 | 15-5 | .750 | | Toyota Center · Houston, TX |
| 21 | Sat Dec 6 | atMavericks | L109-122 | 15-6 | .714 | | American Airlines Center · Dallas, TX |
| 22 | Thu Dec 11 | vsClippers | W115-113 | 16-6 | .727 | | Toyota Center · Houston, TX |
| 23 | Mon Dec 15 | atNuggets | L125-128 (OT) | 16-7 | .696 | Peacock | Ball Arena · Denver, CO |
| 24 | Thu Dec 18 | atPelicans | L128-133 (OT) | 16-8 | .667 | | Smoothie King Center · New Orleans, LA |
| 25 | Sat Dec 20 | atNuggets | W115-101 | 17-8 | .680 | NBA TV | Ball Arena · Denver, CO |
| 26 | Sun Dec 21 | atKings | L124-125 (OT) | 17-9 | .654 | | Golden 1 Center · Sacramento, CA |
| 27 | Tue Dec 23 | atClippers | L108-128 | 17-10 | .630 | Peacock | Intuit Dome · Inglewood, CA |
| 28 | Thu Dec 25 | atLakers | W119-96 | 18-10 | .643 | ESPN | Crypto.com Arena · Los Angeles, CA |
| 29 | Sat Dec 27 | vsCavaliers | W117-100 | 19-10 | .655 | | Toyota Center · Houston, TX |
| 30 | Mon Dec 29 | vsPacers | W126-119 | 20-10 | .667 | | Toyota Center · Houston, TX |
| 31 | Thu Jan 1 | atNets | W120-96 | 21-10 | .677 | | Barclays Center · Brooklyn, NY |
| 32 | Sat Jan 3 | atMavericks | L104-110 | 21-11 | .656 | | American Airlines Center · Dallas, TX |
| 33 | Mon Jan 5 | vsSuns | W100-97 | 22-11 | .667 | | Toyota Center · Houston, TX |
| 34 | Wed Jan 7 | atBlazers | L102-103 | 22-12 | .647 | | Moda Center · Portland, OR |
| 35 | Fri Jan 9 | atBlazers | L105-111 | 22-13 | .629 | | Moda Center · Portland, OR |
| 36 | Sun Jan 11 | atKings | L98-111 | 22-14 | .611 | | Golden 1 Center · Sacramento, CA |
| 37 | Tue Jan 13 | vsBulls | W119-113 | 23-14 | .622 | | Toyota Center · Houston, TX |
| 38 | Thu Jan 15 | vsThunder | L91-111 | 23-15 | .605 | Amazon | Toyota Center · Houston, TX |
| 39 | Fri Jan 16 | vsT-wolves | W110-105 | 24-15 | .615 | ESPN | Toyota Center · Houston, TX |
| 40 | Sun Jan 18 | vsPelicans | W119-110 | 25-15 | .625 | | Toyota Center · Houston, TX |
| 41 | Tue Jan 20 | vsSpurs | W111-106 | 26-15 | .634 | Peacock | Toyota Center · Houston, TX |
| 42 | Thu Jan 22 | at76ers | L122-128 (OT) | 26-16 | .619 | | Wells Fargo Center · Philadelphia, PA |
| 43 | Fri Jan 23 | atPistons | W111-104 | 27-16 | .628 | Amazon | Little Caesars Arena · Detroit, MI |
| 44 | Mon Jan 26 | vsGrizzlies | W108-99 | 28-16 | .636 | | Toyota Center · Houston, TX |
| 45 | Wed Jan 28 | vsSpurs | L99-111 | 28-17 | .622 | ESPN | Toyota Center · Houston, TX |
| 46 | Thu Jan 29 | atHawks | W104-86 | 29-17 | .630 | | State Farm Arena · Atlanta, GA |
| 47 | Sat Jan 31 | vsMavericks | W111-107 | 30-17 | .638 | ABC | Toyota Center · Houston, TX |
| 48 | Mon Feb 2 | atPacers | W118-114 | 31-17 | .646 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 49 | Wed Feb 4 | vsCeltics | L93-114 | 31-18 | .633 | | Toyota Center · Houston, TX |
| 50 | Thu Feb 5 | vsHornets | L99-109 | 31-19 | .620 | | Toyota Center · Houston, TX |
| 51 | Sat Feb 7 | atThunder | W112-106 | 32-19 | .627 | ABC | Paycom Center · Oklahoma City, OK |
| 52 | Tue Feb 10 | vsClippers | W102-95 | 33-19 | .635 | NBA TV | Toyota Center · Houston, TX |
| 53 | Wed Feb 11 | vsClippers | L102-105 | 33-20 | .623 | | Toyota Center · Houston, TX |
| --all-star break-- |
| 54 | Thu Feb 19 | atHornets | W105-101 | 34-20 | .630 | | Spectrum Center · Charlotte, NC |
| 55 | Sat Feb 21 | atKnicks | L106-108 | 34-21 | .618 | ABC | Madison Square Garden · Manhattan, NY |
| 56 | Mon Feb 23 | vsJazz | W125-105 | 35-21 | .625 | Peacock | Toyota Center · Houston, TX |
| 57 | Wed Feb 25 | vsKings | W128-97 | 36-21 | .632 | | Toyota Center · Houston, TX |
| 58 | Thu Feb 26 | atMagic | W113-108 | 37-21 | .638 | Amazon | Kia Center · Orlando, FL |
| 59 | Sat Feb 28 | atHeat | L105-115 | 37-22 | .627 | Amazon | Kaseya Center · Miami, FL |
