| 1 | Wed Oct 20 | at T-wolves | L106-124 | 0-1 | .000 | Target Center · Minneapolis, MN |
| 2 | Fri Oct 22 | vs Thunder | W124-91 | 1-1 | .500 | Toyota Center · Houston, TX |
| 3 | Sun Oct 24 | vs Celtics | L97-107 | 1-2 | .333 | Toyota Center · Houston, TX |
| 4 | Tue Oct 26 | at Mavericks | L106-116 | 1-3 | .250 | American Airlines Center · Dallas, TX |
| 5 | Thu Oct 28 | vs Jazz | L91-122 | 1-4 | .200 | Toyota Center · Houston, TX |
| 6 | Sun Oct 31 | at Lakers | L85-95 | 1-5 | .167 | Crypto.com Arena · Los Angeles, CA |
| 7 | Tue Nov 2 | atLakers | L117-119 | 1-6 | .143 | Crypto.com Arena · Los Angeles, CA |
| 8 | Thu Nov 4 | at Suns | L111-123 | 1-7 | .125 | Footprint Center · Phoenix, AZ |
| 9 | Sat Nov 6 | at Nuggets | L94-95 | 1-8 | .111 | Ball Arena · Denver, CO |
| 10 | Sun Nov 7 | at Warriors | L107-120 | 1-9 | .100 | Chase Center · San Francisco, CA |
| 11 | Wed Nov 10 | vs Pistons | L104-112 | 1-10 | .091 | Toyota Center · Houston, TX |
| 12 | Fri Nov 12 | vs Blazers | L92-104 | 1-11 | .083 | Toyota Center · Houston, TX |
| 13 | Sun Nov 14 | vsSuns | L89-115 | 1-12 | .077 | Toyota Center · Houston, TX |
| 14 | Mon Nov 15 | at Grizzlies | L102-136 | 1-13 | .071 | FedExForum · Memphis, TN |
| 15 | Wed Nov 17 | atThunder | L89-101 | 1-14 | .067 | Paycom Center · Oklahoma City, OK |
| 16 | Sat Nov 20 | at Knicks | L99-106 | 1-15 | .063 | Madison Square Garden · Manhattan, NY |
| 17 | Mon Nov 22 | atCeltics | L90-108 | 1-16 | .059 | TD Garden · Boston, MA |
| 18 | Wed Nov 24 | vs Bulls | W118-113 | 2-16 | .111 | Toyota Center · Houston, TX |
| 19 | Sat Nov 27 | vs Hornets | W146-143 (OT) | 3-16 | .158 | Toyota Center · Houston, TX |
| 20 | Mon Nov 29 | vsThunder | W102-89 | 4-16 | .200 | Toyota Center · Houston, TX |
| 21 | Wed Dec 1 | atThunder | W114-110 | 5-16 | .238 | Paycom Center · Oklahoma City, OK |
| 22 | Fri Dec 3 | vs Magic | W118-116 | 6-16 | .273 | Toyota Center · Houston, TX |
| 23 | Sun Dec 5 | vs Pelicans | W118-108 | 7-16 | .304 | Toyota Center · Houston, TX |
| 24 | Wed Dec 8 | vs Nets | W114-104 | 8-16 | .333 | Toyota Center · Houston, TX |
| 25 | Fri Dec 10 | vs Bucks | L114-123 | 8-17 | .320 | Toyota Center · Houston, TX |
| 26 | Sat Dec 11 | atGrizzlies | L106-113 | 8-18 | .308 | FedExForum · Memphis, TN |
| 27 | Mon Dec 13 | at Hawks | W132-126 | 9-18 | .333 | State Farm Arena · Atlanta, GA |
| 28 | Wed Dec 15 | at Cavaliers | L89-124 | 9-19 | .321 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 29 | Thu Dec 16 | vsKnicks | L103-116 | 9-20 | .310 | Toyota Center · Houston, TX |
| 30 | Sat Dec 18 | atPistons | W116-107 | 10-20 | .333 | Little Caesars Arena · Detroit, MI |
| 31 | Mon Dec 20 | atBulls | L118-133 | 10-21 | .323 | United Center · Chicago, IL |
| 32 | Wed Dec 22 | atBucks | L106-126 | 10-22 | .313 | Fiserv Forum · Milwaukee, WI |
| 33 | Thu Dec 23 | at Pacers | L106-118 | 10-23 | .303 | Gainbridge Fieldhouse · Indianapolis, IN |
| 34 | Mon Dec 27 | atHornets | L99-123 | 10-24 | .294 | Spectrum Center · Charlotte, NC |
| 35 | Tue Dec 28 | vsLakers | L123-132 | 10-25 | .286 | Toyota Center · Houston, TX |
| 36 | Fri Dec 31 | vs Heat | L110-120 | 10-26 | .278 | Toyota Center · Houston, TX |
| 37 | Sat Jan 1 | vsNuggets | L111-124 | 10-27 | .270 | Toyota Center · Houston, TX |
| 38 | Mon Jan 3 | at 76ers | L113-133 | 10-28 | .263 | Wells Fargo Center · Philadelphia, PA |
| 39 | Wed Jan 5 | at Wizards | W114-111 | 11-28 | .282 | Capital One Arena · Washington, D.C. |
| 40 | Fri Jan 7 | vsMavericks | L106-130 | 11-29 | .275 | Toyota Center · Houston, TX |
| 41 | Sun Jan 9 | vsT-wolves | L123-141 | 11-30 | .268 | Toyota Center · Houston, TX |
| 42 | Mon Jan 10 | vs76ers | L91-111 | 11-31 | .262 | Toyota Center · Houston, TX |
| 43 | Wed Jan 12 | at Spurs | W128-124 | 12-31 | .279 | AT&T Center · San Antonio, TX |
| 44 | Fri Jan 14 | at Kings | L114-126 | 12-32 | .273 | Golden 1 Center · Sacramento, CA |
| 45 | Sun Jan 16 | atKings | W118-112 | 13-32 | .289 | Golden 1 Center · Sacramento, CA |
| 46 | Wed Jan 19 | atJazz | W116-111 | 14-32 | .304 | Vivint Arena · Salt Lake City, UT |
| 47 | Fri Jan 21 | atWarriors | L103-105 | 14-33 | .298 | Chase Center · San Francisco, CA |
| 48 | Tue Jan 25 | vsSpurs | L104-134 | 14-34 | .292 | Toyota Center · Houston, TX |
| 49 | Fri Jan 28 | vsBlazers | L110-125 | 14-35 | .286 | Toyota Center · Houston, TX |
| 50 | Mon Jan 31 | vsWarriors | L108-122 | 14-36 | .280 | Toyota Center · Houston, TX |
| 51 | Wed Feb 2 | vsCavaliers | W115-104 | 15-36 | .294 | Toyota Center · Houston, TX |
| 52 | Fri Feb 4 | atSpurs | L106-131 | 15-37 | .288 | AT&T Center · San Antonio, TX |
| 53 | Sun Feb 6 | vsPelicans | L107-120 | 15-38 | .283 | Toyota Center · Houston, TX |
| 54 | Tue Feb 8 | atPelicans | L97-110 | 15-39 | .278 | Smoothie King Center · New Orleans, LA |
| 55 | Thu Feb 10 | vs Raptors | L120-139 | 15-40 | .273 | Toyota Center · Houston, TX |
| 56 | Mon Feb 14 | atJazz | L101-135 | 15-41 | .268 | Vivint Arena · Salt Lake City, UT |
| 57 | Wed Feb 16 | atSuns | L121-124 | 15-42 | .263 | Footprint Center · Phoenix, AZ |
| 58 | Thu Feb 17 | at Clippers | L111-142 | 15-43 | .259 | Crypto.com Arena · Los Angeles, CA |
| 59 | Fri Feb 25 | atMagic | L111-119 | 15-44 | .254 | Amway Center · Orlando, FL |
| 60 | Sun Feb 27 | vsClippers | L98-99 | 15-45 | .250 | Toyota Center · Houston, TX |
| 61 | Tue Mar 1 | vsClippers | L100-113 | 15-46 | .246 | Toyota Center · Houston, TX |
| 62 | Wed Mar 2 | vsJazz | L127-132 (OT) | 15-47 | .242 | Toyota Center · Houston, TX |
| 63 | Fri Mar 4 | atNuggets | L101-116 | 15-48 | .238 | Ball Arena · Denver, CO |
| 64 | Sun Mar 6 | vsGrizzlies | W123-112 | 16-48 | .250 | Toyota Center · Houston, TX |
| 65 | Mon Mar 7 | atHeat | L106-123 | 16-49 | .246 | FTX Arena · Miami, FL |
| 66 | Wed Mar 9 | vsLakers | W139-130 (OT) | 17-49 | .258 | Toyota Center · Houston, TX |
| 67 | Fri Mar 11 | vsMavericks | L100-113 | 17-50 | .254 | Toyota Center · Houston, TX |
| 68 | Sun Mar 13 | atPelicans | L105-130 | 17-51 | .250 | Smoothie King Center · New Orleans, LA |
| 69 | Wed Mar 16 | vsSuns | L112-129 | 17-52 | .246 | Toyota Center · Houston, TX |
| 70 | Fri Mar 18 | vsPacers | L118-121 | 17-53 | .243 | Toyota Center · Houston, TX |
| 71 | Sun Mar 20 | vsGrizzlies | L98-122 | 17-54 | .239 | Toyota Center · Houston, TX |
| 72 | Mon Mar 21 | vsWizards | W115-97 | 18-54 | .250 | Toyota Center · Houston, TX |
| 73 | Wed Mar 23 | atMavericks | L91-110 | 18-55 | .247 | American Airlines Center · Dallas, TX |
| 74 | Fri Mar 25 | atBlazers | W125-106 | 19-55 | .257 | Moda Center · Portland, OR |
| 75 | Sat Mar 26 | atBlazers | W115-98 | 20-55 | .267 | Moda Center · Portland, OR |
| 76 | Mon Mar 28 | vsSpurs | L120-123 | 20-56 | .263 | Toyota Center · Houston, TX |
| 77 | Wed Mar 30 | vsKings | L118-121 | 20-57 | .260 | Toyota Center · Houston, TX |
| 78 | Fri Apr 1 | vsKings | L117-122 | 20-58 | .256 | Toyota Center · Houston, TX |
| 79 | Sun Apr 3 | vsT-wolves | L132-139 | 20-59 | .253 | Toyota Center · Houston, TX |
| 80 | Tue Apr 5 | atNets | L105-118 | 20-60 | .250 | Barclays Center · Brooklyn, NY |
| 81 | Fri Apr 8 | atRaptors | L115-117 | 20-61 | .247 | Scotiabank Arena · Toronto, ON |
| 82 | Sun Apr 10 | vsHawks | L114-130 | 20-62 | .244 | Toyota Center · Houston, TX |
