| 1 | Sat Dec 26 | at Blazers | L126-128 (OT) | 0-1 | .000 | Moda Center · Portland, OR |
| 2 | Mon Dec 28 | at Nuggets | L111-124 | 0-2 | .000 | Ball Arena · Denver, CO |
| 3 | Thu Dec 31 | vs Kings | W122-119 | 1-2 | .333 | Toyota Center · Houston, TX |
| 4 | Sat Jan 2 | vsKings | W102-94 | 2-2 | .500 | Toyota Center · Houston, TX |
| 5 | Mon Jan 4 | vs Mavericks | L100-113 | 2-3 | .400 | Toyota Center · Houston, TX |
| 6 | Wed Jan 6 | at Pacers | L107-114 | 2-4 | .333 | Gainbridge Fieldhouse · Indianapolis, IN |
| 7 | Fri Jan 8 | vs Magic | W132-90 | 3-4 | .429 | Toyota Center · Houston, TX |
| 8 | Sun Jan 10 | vs Lakers | L102-120 | 3-5 | .375 | Toyota Center · Houston, TX |
| 9 | Tue Jan 12 | vsLakers | L100-117 | 3-6 | .333 | Toyota Center · Houston, TX |
| 10 | Thu Jan 14 | at Spurs | W109-105 | 4-6 | .400 | AT&T Center · San Antonio, TX |
| 11 | Sat Jan 16 | atSpurs | L91-103 | 4-7 | .364 | AT&T Center · San Antonio, TX |
| 12 | Mon Jan 18 | at Bulls | L120-125 | 4-8 | .333 | United Center · Chicago, IL |
| 13 | Wed Jan 20 | vs Suns | L103-109 | 4-9 | .308 | Toyota Center · Houston, TX |
| 14 | Fri Jan 22 | at Pistons | W103-102 | 5-9 | .357 | Little Caesars Arena · Detroit, MI |
| 15 | Sat Jan 23 | atMavericks | W133-108 | 6-9 | .400 | American Airlines Center · Dallas, TX |
| 16 | Tue Jan 26 | vs Wizards | W107-88 | 7-9 | .438 | Toyota Center · Houston, TX |
| 17 | Thu Jan 28 | vsBlazers | W104-101 | 8-9 | .471 | Toyota Center · Houston, TX |
| 18 | Sat Jan 30 | at Pelicans | W126-112 | 9-9 | .500 | Smoothie King Center · New Orleans, LA |
| 19 | Mon Feb 1 | at Thunder | W136-106 | 10-9 | .526 | Paycom Center · Oklahoma City, OK |
| 20 | Wed Feb 3 | atThunder | L87-104 | 10-10 | .500 | Paycom Center · Oklahoma City, OK |
| 21 | Thu Feb 4 | at Grizzlies | W115-103 | 11-10 | .524 | FedExForum · Memphis, TN |
| 22 | Sat Feb 6 | vsSpurs | L106-111 | 11-11 | .500 | Toyota Center · Houston, TX |
| 23 | Mon Feb 8 | at Hornets | L94-119 | 11-12 | .478 | Spectrum Center · Charlotte, NC |
| 24 | Tue Feb 9 | atPelicans | L101-130 | 11-13 | .458 | Smoothie King Center · New Orleans, LA |
| 25 | Thu Feb 11 | vs Heat | L94-101 | 11-14 | .440 | Toyota Center · Houston, TX |
| 26 | Sat Feb 13 | at Knicks | L99-121 | 11-15 | .423 | Madison Square Garden · Manhattan, NY |
| 27 | Mon Feb 15 | atWizards | L119-131 | 11-16 | .407 | Capital One Arena · Washington, D.C. |
| 28 | Wed Feb 17 | at 76ers | L113-118 | 11-17 | .393 | Wells Fargo Center · Philadelphia, PA |
| 29 | Mon Feb 22 | vsBulls | L100-120 | 11-18 | .379 | Toyota Center · Houston, TX |
| 30 | Wed Feb 24 | at Cavaliers | L96-112 | 11-19 | .367 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 31 | Fri Feb 26 | at Raptors | L111-122 | 11-20 | .355 | Scotiabank Arena · Toronto, ON |
| 32 | Sun Feb 28 | vsGrizzlies | L84-133 | 11-21 | .344 | Toyota Center · Houston, TX |
| 33 | Mon Mar 1 | vsCavaliers | L90-101 | 11-22 | .333 | Toyota Center · Houston, TX |
| 34 | Wed Mar 3 | vs Nets | L114-132 | 11-23 | .324 | Toyota Center · Houston, TX |
| 35 | Thu Mar 11 | atKings | L105-125 | 11-24 | .314 | Golden 1 Center · Sacramento, CA |
| 36 | Fri Mar 12 | at Jazz | L99-114 | 11-25 | .306 | Vivint Arena · Salt Lake City, UT |
| 37 | Sun Mar 14 | vs Celtics | L107-134 | 11-26 | .297 | Toyota Center · Houston, TX |
| 38 | Tue Mar 16 | vs Hawks | L107-119 | 11-27 | .289 | Toyota Center · Houston, TX |
| 39 | Wed Mar 17 | vs Warriors | L94-108 | 11-28 | .282 | Toyota Center · Houston, TX |
| 40 | Fri Mar 19 | vsPistons | L100-113 | 11-29 | .275 | Toyota Center · Houston, TX |
| 41 | Sun Mar 21 | vsThunder | L112-114 | 11-30 | .268 | Toyota Center · Houston, TX |
| 42 | Mon Mar 22 | vsRaptors | W117-99 | 12-30 | .286 | Toyota Center · Houston, TX |
| 43 | Wed Mar 24 | vsHornets | L97-122 | 12-31 | .279 | Toyota Center · Houston, TX |
| 44 | Fri Mar 26 | at T-wolves | L101-107 | 12-32 | .273 | Target Center · Minneapolis, MN |
| 45 | Sat Mar 27 | atT-wolves | W129-107 | 13-32 | .289 | Target Center · Minneapolis, MN |
| 46 | Mon Mar 29 | vsGrizzlies | L110-120 | 13-33 | .283 | Toyota Center · Houston, TX |
| 47 | Wed Mar 31 | atNets | L108-120 | 13-34 | .277 | Barclays Center · Brooklyn, NY |
| 48 | Fri Apr 2 | atCeltics | L102-118 | 13-35 | .271 | TD Garden · Boston, MA |
| 49 | Sun Apr 4 | vsPelicans | L115-122 | 13-36 | .265 | Toyota Center · Houston, TX |
| 50 | Mon Apr 5 | vsSuns | L130-133 | 13-37 | .260 | Toyota Center · Houston, TX |
| 51 | Wed Apr 7 | vsMavericks | W102-93 | 14-37 | .275 | Toyota Center · Houston, TX |
| 52 | Fri Apr 9 | at Clippers | L109-126 | 14-38 | .269 | Crypto.com Arena · Los Angeles, CA |
| 53 | Sat Apr 10 | atWarriors | L109-125 | 14-39 | .264 | Chase Center · San Francisco, CA |
| 54 | Mon Apr 12 | atSuns | L120-126 | 14-40 | .259 | Footprint Center · Phoenix, AZ |
| 55 | Wed Apr 14 | vsPacers | L124-132 | 14-41 | .255 | Toyota Center · Houston, TX |
| 56 | Fri Apr 16 | vsNuggets | L99-128 | 14-42 | .250 | Toyota Center · Houston, TX |
| 57 | Sun Apr 18 | atMagic | W114-110 | 15-42 | .263 | Amway Center · Orlando, FL |
| 58 | Mon Apr 19 | atHeat | L91-113 | 15-43 | .259 | FTX Arena · Miami, FL |
| 59 | Wed Apr 21 | vsJazz | L89-112 | 15-44 | .254 | Toyota Center · Houston, TX |
| 60 | Fri Apr 23 | vsClippers | L104-109 | 15-45 | .250 | Toyota Center · Houston, TX |
| 61 | Sat Apr 24 | atNuggets | L116-129 | 15-46 | .246 | Ball Arena · Denver, CO |
| 62 | Tue Apr 27 | vsT-wolves | L107-114 | 15-47 | .242 | Toyota Center · Houston, TX |
| 63 | Thu Apr 29 | vs Bucks | W143-136 | 16-47 | .254 | Toyota Center · Houston, TX |
| 64 | Sat May 1 | vsWarriors | L87-113 | 16-48 | .250 | Toyota Center · Houston, TX |
| 65 | Sun May 2 | vsKnicks | L97-122 | 16-49 | .246 | Toyota Center · Houston, TX |
| 66 | Wed May 5 | vs76ers | L115-135 | 16-50 | .242 | Toyota Center · Houston, TX |
| 67 | Fri May 7 | atBucks | L133-141 | 16-51 | .239 | Fiserv Forum · Milwaukee, WI |
| 68 | Sat May 8 | atJazz | L116-124 | 16-52 | .235 | Vivint Arena · Salt Lake City, UT |
| 69 | Mon May 10 | atBlazers | L129-140 | 16-53 | .232 | Moda Center · Portland, OR |
| 70 | Wed May 12 | atLakers | L122-124 | 16-54 | .229 | Crypto.com Arena · Los Angeles, CA |
| 71 | Fri May 14 | vsClippers | W122-115 | 17-54 | .239 | Toyota Center · Houston, TX |
| 72 | Sun May 16 | atHawks | L95-124 | 17-55 | .236 | State Farm Arena · Atlanta, GA |
