| 1 | Wed Oct 17 | vs Pelicans | L112-131 | 0-1 | .000 | Toyota Center · Houston, TX |
| 2 | Sat Oct 20 | at Lakers | W124-115 | 1-1 | .500 | Crypto.com Arena · Los Angeles, CA |
| 3 | Sun Oct 21 | at Clippers | L112-115 | 1-2 | .333 | Crypto.com Arena · Los Angeles, CA |
| 4 | Wed Oct 24 | vs Jazz | L89-100 | 1-3 | .250 | Toyota Center · Houston, TX |
| 5 | Fri Oct 26 | vsClippers | L113-133 | 1-4 | .200 | Toyota Center · Houston, TX |
| 6 | Tue Oct 30 | vs Blazers | L85-104 | 1-5 | .167 | Toyota Center · Houston, TX |
| 7 | Fri Nov 2 | at Nets | W119-111 | 2-5 | .286 | Barclays Center · Brooklyn, NY |
| 8 | Sat Nov 3 | at Bulls | W96-88 | 3-5 | .375 | United Center · Chicago, IL |
| 9 | Mon Nov 5 | at Pacers | W98-94 | 4-5 | .444 | Gainbridge Fieldhouse · Indianapolis, IN |
| 10 | Thu Nov 8 | at Thunder | L80-98 | 4-6 | .400 | Paycom Center · Oklahoma City, OK |
| 11 | Sat Nov 10 | at Spurs | L89-96 | 4-7 | .364 | AT&T Center · San Antonio, TX |
| 12 | Sun Nov 11 | vsPacers | W115-103 | 5-7 | .417 | Toyota Center · Houston, TX |
| 13 | Tue Nov 13 | at Nuggets | W109-99 | 6-7 | .462 | Ball Arena · Denver, CO |
| 14 | Thu Nov 15 | vs Warriors | W107-86 | 7-7 | .500 | Toyota Center · Houston, TX |
| 15 | Sat Nov 17 | vs Kings | W132-112 | 8-7 | .533 | Toyota Center · Houston, TX |
| 16 | Wed Nov 21 | vs Pistons | W126-124 | 9-7 | .563 | Toyota Center · Houston, TX |
| 17 | Fri Nov 23 | atPistons | L111-116 (OT) | 9-8 | .529 | Little Caesars Arena · Detroit, MI |
| 18 | Sat Nov 24 | at Cavaliers | L108-117 | 9-9 | .500 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 19 | Mon Nov 26 | at Wizards | L131-135 (OT) | 9-10 | .474 | Capital One Arena · Washington, D.C. |
| 20 | Wed Nov 28 | vs Mavericks | L108-128 | 9-11 | .450 | Toyota Center · Houston, TX |
| 21 | Fri Nov 30 | atSpurs | W136-105 | 10-11 | .476 | AT&T Center · San Antonio, TX |
| 22 | Sat Dec 1 | vsBulls | W121-105 | 11-11 | .500 | Toyota Center · Houston, TX |
| 23 | Mon Dec 3 | at T-wolves | L91-103 | 11-12 | .478 | Target Center · Minneapolis, MN |
| 24 | Thu Dec 6 | atJazz | L91-118 | 11-13 | .458 | Vivint Arena · Salt Lake City, UT |
| 25 | Sat Dec 8 | atMavericks | L104-107 | 11-14 | .440 | American Airlines Center · Dallas, TX |
| 26 | Tue Dec 11 | vsBlazers | W111-104 | 12-14 | .462 | Toyota Center · Houston, TX |
| 27 | Thu Dec 13 | vsLakers | W126-111 | 13-14 | .481 | Toyota Center · Houston, TX |
| 28 | Sat Dec 15 | at Grizzlies | W105-97 | 14-14 | .500 | FedExForum · Memphis, TN |
| 29 | Mon Dec 17 | vsJazz | W102-97 | 15-14 | .517 | Toyota Center · Houston, TX |
| 30 | Wed Dec 19 | vsWizards | W136-118 | 16-14 | .533 | Toyota Center · Houston, TX |
| 31 | Thu Dec 20 | at Heat | L99-101 | 16-15 | .516 | FTX Arena · Miami, FL |
| 32 | Sat Dec 22 | vsSpurs | W108-101 | 17-15 | .531 | Toyota Center · Houston, TX |
| 33 | Tue Dec 25 | vsThunder | W113-109 | 18-15 | .545 | Toyota Center · Houston, TX |
| 34 | Thu Dec 27 | vs Celtics | W127-113 | 19-15 | .559 | Toyota Center · Houston, TX |
| 35 | Sat Dec 29 | atPelicans | W108-104 | 20-15 | .571 | Smoothie King Center · New Orleans, LA |
| 36 | Mon Dec 31 | vsGrizzlies | W113-101 | 21-15 | .583 | Toyota Center · Houston, TX |
| 37 | Thu Jan 3 | atWarriors | W135-134 (OT) | 22-15 | .595 | Chase Center · San Francisco, CA |
| 38 | Sat Jan 5 | atBlazers | L101-110 | 22-16 | .579 | Moda Center · Portland, OR |
| 39 | Mon Jan 7 | vsNuggets | W125-113 | 23-16 | .590 | Toyota Center · Houston, TX |
| 40 | Wed Jan 9 | vs Bucks | L109-116 | 23-17 | .575 | Toyota Center · Houston, TX |
| 41 | Fri Jan 11 | vsCavaliers | W141-113 | 24-17 | .585 | Toyota Center · Houston, TX |
| 42 | Sun Jan 13 | at Magic | L109-116 | 24-18 | .571 | Amway Center · Orlando, FL |
| 43 | Mon Jan 14 | vsGrizzlies | W112-94 | 25-18 | .581 | Toyota Center · Houston, TX |
| 44 | Wed Jan 16 | vsNets | L142-145 (OT) | 25-19 | .568 | Toyota Center · Houston, TX |
| 45 | Sat Jan 19 | vsLakers | W138-134 (OT) | 26-19 | .578 | Toyota Center · Houston, TX |
| 46 | Mon Jan 21 | at 76ers | L93-121 | 26-20 | .565 | Wells Fargo Center · Philadelphia, PA |
| 47 | Wed Jan 23 | at Knicks | W114-110 | 27-20 | .574 | Madison Square Garden · Manhattan, NY |
| 48 | Fri Jan 25 | vs Raptors | W121-119 | 28-20 | .583 | Toyota Center · Houston, TX |
| 49 | Sun Jan 27 | vsMagic | W103-98 | 29-20 | .592 | Toyota Center · Houston, TX |
| 50 | Tue Jan 29 | vsPelicans | L116-121 | 29-21 | .580 | Toyota Center · Houston, TX |
| 51 | Fri Feb 1 | atNuggets | L122-136 | 29-22 | .569 | Ball Arena · Denver, CO |
| 52 | Sat Feb 2 | atJazz | W125-98 | 30-22 | .577 | Vivint Arena · Salt Lake City, UT |
| 53 | Mon Feb 4 | at Suns | W118-110 | 31-22 | .585 | Footprint Center · Phoenix, AZ |
| 54 | Wed Feb 6 | atKings | W127-101 | 32-22 | .593 | Golden 1 Center · Sacramento, CA |
| 55 | Sat Feb 9 | vsThunder | L112-117 | 32-23 | .582 | Toyota Center · Houston, TX |
| 56 | Mon Feb 11 | vsMavericks | W120-104 | 33-23 | .589 | Toyota Center · Houston, TX |
| 57 | Wed Feb 13 | atT-wolves | L111-121 | 33-24 | .579 | Target Center · Minneapolis, MN |
| 58 | Thu Feb 21 | atLakers | L106-111 | 33-25 | .569 | Crypto.com Arena · Los Angeles, CA |
| 59 | Sat Feb 23 | atWarriors | W118-112 | 34-25 | .576 | Chase Center · San Francisco, CA |
| 60 | Mon Feb 25 | vs Hawks | W119-111 | 35-25 | .583 | Toyota Center · Houston, TX |
| 61 | Wed Feb 27 | at Hornets | W118-113 | 36-25 | .590 | Spectrum Center · Charlotte, NC |
| 62 | Thu Feb 28 | vsHeat | W121-118 | 37-25 | .597 | Toyota Center · Houston, TX |
| 63 | Sun Mar 3 | atCeltics | W115-104 | 38-25 | .603 | TD Garden · Boston, MA |
| 64 | Tue Mar 5 | atRaptors | W107-95 | 39-25 | .609 | Scotiabank Arena · Toronto, ON |
| 65 | Fri Mar 8 | vs76ers | W107-91 | 40-25 | .615 | Toyota Center · Houston, TX |
| 66 | Sun Mar 10 | atMavericks | W94-93 | 41-25 | .621 | American Airlines Center · Dallas, TX |
| 67 | Mon Mar 11 | vsHornets | W118-106 | 42-25 | .627 | Toyota Center · Houston, TX |
| 68 | Wed Mar 13 | vsWarriors | L104-106 | 42-26 | .618 | Toyota Center · Houston, TX |
| 69 | Fri Mar 15 | vsSuns | W108-102 | 43-26 | .623 | Toyota Center · Houston, TX |
| 70 | Sun Mar 17 | vsT-wolves | W117-102 | 44-26 | .629 | Toyota Center · Houston, TX |
| 71 | Tue Mar 19 | atHawks | W121-105 | 45-26 | .634 | State Farm Arena · Atlanta, GA |
| 72 | Wed Mar 20 | atGrizzlies | L125-126 (OT) | 45-27 | .625 | FedExForum · Memphis, TN |
| 73 | Fri Mar 22 | vsSpurs | W111-105 | 46-27 | .630 | Toyota Center · Houston, TX |
| 74 | Sun Mar 24 | atPelicans | W113-90 | 47-27 | .635 | Smoothie King Center · New Orleans, LA |
| 75 | Tue Mar 26 | atBucks | L94-108 | 47-28 | .627 | Fiserv Forum · Milwaukee, WI |
| 76 | Thu Mar 28 | vsNuggets | W112-85 | 48-28 | .632 | Toyota Center · Houston, TX |
| 77 | Sat Mar 30 | vsKings | W119-108 | 49-28 | .636 | Toyota Center · Houston, TX |
| 78 | Tue Apr 2 | atKings | W130-105 | 50-28 | .641 | Golden 1 Center · Sacramento, CA |
| 79 | Wed Apr 3 | atClippers | W135-103 | 51-28 | .646 | Crypto.com Arena · Los Angeles, CA |
| 80 | Fri Apr 5 | vsKnicks | W120-96 | 52-28 | .650 | Toyota Center · Houston, TX |
| 81 | Sun Apr 7 | vsSuns | W149-113 | 53-28 | .654 | Toyota Center · Houston, TX |
| 82 | Tue Apr 9 | atThunder | L111-112 | 53-29 | .646 | Paycom Center · Oklahoma City, OK |
| 1 | Sun Apr 14 | vsJazz | W122-90 | 1-0 | 1.000 | Toyota Center · Houston, TX |
| 2 | Wed Apr 17 | vsJazz | W118-98 | 2-0 | 1.000 | Toyota Center · Houston, TX |
| 3 | Sat Apr 20 | atJazz | W104-101 | 3-0 | 1.000 | Vivint Arena · Salt Lake City, UT |
| 4 | Mon Apr 22 | atJazz | L91-107 | 3-1 | .750 | Vivint Arena · Salt Lake City, UT |
| 5 | Wed Apr 24 | vsJazz | W100-93 | 4-1 | .800 | Toyota Center · Houston, TX |
| 1 | Sun Apr 28 | atWarriors | L100-104 | 0-1 | .000 | Chase Center · San Francisco, CA |
| 2 | Tue Apr 30 | atWarriors | L109-115 | 0-2 | .000 | Chase Center · San Francisco, CA |
| 3 | Sat May 4 | vsWarriors | W126-121 (OT) | 1-2 | .333 | Toyota Center · Houston, TX |
| 4 | Mon May 6 | vsWarriors | W112-108 | 2-2 | .500 | Toyota Center · Houston, TX |
| 5 | Wed May 8 | atWarriors | L99-104 | 2-3 | .400 | Chase Center · San Francisco, CA |
| 6 | Fri May 10 | vsWarriors | L113-118 | 2-4 | .333 | Toyota Center · Houston, TX |
