| 1 | Thu Oct 24 | vs Bucks | L111-117 | 0-1 | .000 | Toyota Center · Houston, TX |
| 2 | Sat Oct 26 | vs Pelicans | W126-123 | 1-1 | .500 | Toyota Center · Houston, TX |
| 3 | Mon Oct 28 | vs Thunder | W116-112 | 2-1 | .667 | Toyota Center · Houston, TX |
| 4 | Wed Oct 30 | at Wizards | W159-158 | 3-1 | .750 | Capital One Arena · Washington, D.C. |
| 5 | Fri Nov 1 | at Nets | L116-123 | 3-2 | .600 | Barclays Center · Brooklyn, NY |
| 6 | Sun Nov 3 | at Heat | L100-129 | 3-3 | .500 | FTX Arena · Miami, FL |
| 7 | Mon Nov 4 | at Grizzlies | W107-100 | 4-3 | .571 | FedExForum · Memphis, TN |
| 8 | Wed Nov 6 | vs Warriors | W129-112 | 5-3 | .625 | Toyota Center · Houston, TX |
| 9 | Sat Nov 9 | at Bulls | W117-94 | 6-3 | .667 | United Center · Chicago, IL |
| 10 | Mon Nov 11 | atPelicans | W122-116 | 7-3 | .700 | Smoothie King Center · New Orleans, LA |
| 11 | Wed Nov 13 | vs Clippers | W102-93 | 8-3 | .727 | Toyota Center · Houston, TX |
| 12 | Fri Nov 15 | vs Pacers | W111-102 | 9-3 | .750 | Toyota Center · Houston, TX |
| 13 | Sat Nov 16 | at T-wolves | W125-105 | 10-3 | .769 | Target Center · Minneapolis, MN |
| 14 | Mon Nov 18 | vs Blazers | W132-108 | 11-3 | .786 | Toyota Center · Houston, TX |
| 15 | Wed Nov 20 | at Nuggets | L95-105 | 11-4 | .733 | Ball Arena · Denver, CO |
| 16 | Fri Nov 22 | atClippers | L119-122 | 11-5 | .688 | Crypto.com Arena · Los Angeles, CA |
| 17 | Sun Nov 24 | vs Mavericks | L123-137 | 11-6 | .647 | Toyota Center · Houston, TX |
| 18 | Wed Nov 27 | vsHeat | W117-108 | 12-6 | .667 | Toyota Center · Houston, TX |
| 19 | Sat Nov 30 | vs Hawks | W158-111 | 13-6 | .684 | Toyota Center · Houston, TX |
| 20 | Tue Dec 3 | at Spurs | L133-135 (2OT) | 13-7 | .650 | AT&T Center · San Antonio, TX |
| 21 | Thu Dec 5 | at Raptors | W119-109 | 14-7 | .667 | Scotiabank Arena · Toronto, ON |
| 22 | Sat Dec 7 | vs Suns | W115-109 | 15-7 | .682 | Toyota Center · Houston, TX |
| 23 | Mon Dec 9 | vs Kings | L118-119 | 15-8 | .652 | Toyota Center · Houston, TX |
| 24 | Wed Dec 11 | at Cavaliers | W116-110 | 16-8 | .667 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 25 | Fri Dec 13 | at Magic | W130-107 | 17-8 | .680 | Amway Center · Orlando, FL |
| 26 | Sat Dec 14 | vs Pistons | L107-115 | 17-9 | .654 | Toyota Center · Houston, TX |
| 27 | Mon Dec 16 | vsSpurs | W109-107 | 18-9 | .667 | Toyota Center · Houston, TX |
| 28 | Thu Dec 19 | atClippers | W122-117 | 19-9 | .679 | Crypto.com Arena · Los Angeles, CA |
| 29 | Sat Dec 21 | atSuns | W139-125 | 20-9 | .690 | Footprint Center · Phoenix, AZ |
| 30 | Mon Dec 23 | atKings | W113-104 | 21-9 | .700 | Golden 1 Center · Sacramento, CA |
| 31 | Wed Dec 25 | atWarriors | L104-116 | 21-10 | .677 | Chase Center · San Francisco, CA |
| 32 | Sat Dec 28 | vsNets | W108-98 | 22-10 | .688 | Toyota Center · Houston, TX |
| 33 | Sun Dec 29 | atPelicans | L112-127 | 22-11 | .667 | Smoothie King Center · New Orleans, LA |
| 34 | Tue Dec 31 | vsNuggets | W130-104 | 23-11 | .676 | Toyota Center · Houston, TX |
| 35 | Fri Jan 3 | vs 76ers | W118-108 | 24-11 | .686 | Toyota Center · Houston, TX |
| 36 | Wed Jan 8 | atHawks | W122-115 | 25-11 | .694 | State Farm Arena · Atlanta, GA |
| 37 | Thu Jan 9 | atThunder | L92-113 | 25-12 | .676 | Paycom Center · Oklahoma City, OK |
| 38 | Sat Jan 11 | vsT-wolves | W139-109 | 26-12 | .684 | Toyota Center · Houston, TX |
| 39 | Tue Jan 14 | atGrizzlies | L110-121 | 26-13 | .667 | FedExForum · Memphis, TN |
| 40 | Wed Jan 15 | vsBlazers | L107-117 | 26-14 | .650 | Toyota Center · Houston, TX |
| 41 | Sat Jan 18 | vs Lakers | L115-124 | 26-15 | .634 | Toyota Center · Houston, TX |
| 42 | Mon Jan 20 | vsThunder | L107-112 | 26-16 | .619 | Toyota Center · Houston, TX |
| 43 | Wed Jan 22 | vsNuggets | W121-105 | 27-16 | .628 | Toyota Center · Houston, TX |
| 44 | Fri Jan 24 | atT-wolves | W131-124 | 28-16 | .636 | Target Center · Minneapolis, MN |
| 45 | Sun Jan 26 | atNuggets | L110-117 | 28-17 | .622 | Ball Arena · Denver, CO |
| 46 | Mon Jan 27 | at Jazz | W126-117 | 29-17 | .630 | Vivint Arena · Salt Lake City, UT |
| 47 | Wed Jan 29 | atBlazers | L112-125 | 29-18 | .617 | Moda Center · Portland, OR |
| 48 | Fri Jan 31 | vsMavericks | W128-121 | 30-18 | .625 | Toyota Center · Houston, TX |
| 49 | Sun Feb 2 | vsPelicans | W117-109 | 31-18 | .633 | Toyota Center · Houston, TX |
| 50 | Tue Feb 4 | vs Hornets | W125-110 | 32-18 | .640 | Toyota Center · Houston, TX |
| 51 | Thu Feb 6 | atLakers | W121-111 | 33-18 | .647 | Crypto.com Arena · Los Angeles, CA |
| 52 | Fri Feb 7 | atSuns | L91-127 | 33-19 | .635 | Footprint Center · Phoenix, AZ |
| 53 | Sun Feb 9 | vsJazz | L113-114 | 33-20 | .623 | Toyota Center · Houston, TX |
| 54 | Tue Feb 11 | vs Celtics | W116-105 | 34-20 | .630 | Toyota Center · Houston, TX |
| 55 | Thu Feb 20 | atWarriors | W135-105 | 35-20 | .636 | Chase Center · San Francisco, CA |
| 56 | Sat Feb 22 | atJazz | W120-110 | 36-20 | .643 | Vivint Arena · Salt Lake City, UT |
| 57 | Mon Feb 24 | vs Knicks | W123-112 | 37-20 | .649 | Toyota Center · Houston, TX |
| 58 | Wed Feb 26 | vsGrizzlies | W140-112 | 38-20 | .655 | Toyota Center · Houston, TX |
| 59 | Sat Feb 29 | atCeltics | W111-110 (OT) | 39-20 | .661 | TD Garden · Boston, MA |
| 60 | Mon Mar 2 | atKnicks | L123-125 | 39-21 | .650 | Madison Square Garden · Manhattan, NY |
| 61 | Thu Mar 5 | vsClippers | L105-120 | 39-22 | .639 | Toyota Center · Houston, TX |
| 62 | Sat Mar 7 | atHornets | L99-108 | 39-23 | .629 | Spectrum Center · Charlotte, NC |
| 63 | Sun Mar 8 | vsMagic | L106-126 | 39-24 | .619 | Toyota Center · Houston, TX |
| 64 | Tue Mar 10 | vsT-wolves | W117-111 | 40-24 | .625 | Toyota Center · Houston, TX |
| 65 | Fri Jul 31 | atMavericks | W153-149 (OT) | 41-24 | .631 | American Airlines Center · Dallas, TX |
| 66 | Sun Aug 2 | vsBucks | W120-116 | 42-24 | .636 | Toyota Center · Houston, TX |
| 67 | Tue Aug 4 | atBlazers | L102-110 | 42-25 | .627 | Moda Center · Portland, OR |
| 68 | Thu Aug 6 | vsLakers | W113-97 | 43-25 | .632 | Toyota Center · Houston, TX |
| 69 | Sun Aug 9 | atKings | W129-112 | 44-25 | .638 | Golden 1 Center · Sacramento, CA |
| 70 | Tue Aug 11 | atSpurs | L105-123 | 44-26 | .629 | AT&T Center · San Antonio, TX |
| 71 | Wed Aug 12 | vsPacers | L104-108 | 44-27 | .620 | Toyota Center · Houston, TX |
| 72 | Fri Aug 14 | vs76ers | L96-134 | 44-28 | .611 | Toyota Center · Houston, TX |
| 1 | Tue Aug 18 | vsThunder | W123-108 | 1-0 | 1.000 | Toyota Center · Houston, TX |
| 2 | Thu Aug 20 | vsThunder | W111-98 | 2-0 | 1.000 | Toyota Center · Houston, TX |
| 3 | Sat Aug 22 | atThunder | L107-119 (OT) | 2-1 | .667 | Paycom Center · Oklahoma City, OK |
| 4 | Mon Aug 24 | atThunder | L114-117 | 2-2 | .500 | Paycom Center · Oklahoma City, OK |
| 5 | Sat Aug 29 | vsThunder | W114-80 | 3-2 | .600 | Toyota Center · Houston, TX |
| 6 | Mon Aug 31 | atThunder | L100-104 | 3-3 | .500 | Paycom Center · Oklahoma City, OK |
| 7 | Wed Sep 2 | vsThunder | W104-102 | 4-3 | .571 | Toyota Center · Houston, TX |
| 1 | Fri Sep 4 | atLakers | W112-97 | 1-0 | 1.000 | Crypto.com Arena · Los Angeles, CA |
| 2 | Sun Sep 6 | atLakers | L109-117 | 1-1 | .500 | Crypto.com Arena · Los Angeles, CA |
| 3 | Tue Sep 8 | vsLakers | L102-112 | 1-2 | .333 | Toyota Center · Houston, TX |
| 4 | Thu Sep 10 | vsLakers | L100-110 | 1-3 | .250 | Toyota Center · Houston, TX |
| 5 | Sat Sep 12 | atLakers | L96-119 | 1-4 | .200 | Crypto.com Arena · Los Angeles, CA |
