| 1 | Tue Oct 17 | at Warriors | W122-121 | 1-0 | 1.000 | Chase Center · San Francisco, CA |
| 2 | Wed Oct 18 | at Kings | W105-100 | 2-0 | 1.000 | Golden 1 Center · Sacramento, CA |
| 3 | Sat Oct 21 | vs Mavericks | W107-91 | 3-0 | 1.000 | Toyota Center · Houston, TX |
| 4 | Mon Oct 23 | vs Grizzlies | L90-98 | 3-1 | .750 | Toyota Center · Houston, TX |
| 5 | Wed Oct 25 | at 76ers | W105-104 | 4-1 | .800 | Wells Fargo Center · Philadelphia, PA |
| 6 | Fri Oct 27 | at Hornets | W109-93 | 5-1 | .833 | Spectrum Center · Charlotte, NC |
| 7 | Sat Oct 28 | atGrizzlies | L89-103 | 5-2 | .714 | FedExForum · Memphis, TN |
| 8 | Mon Oct 30 | vs76ers | L107-115 | 5-3 | .625 | Toyota Center · Houston, TX |
| 9 | Wed Nov 1 | at Knicks | W119-97 | 6-3 | .667 | Madison Square Garden · Manhattan, NY |
| 10 | Fri Nov 3 | at Hawks | W119-104 | 7-3 | .700 | State Farm Arena · Atlanta, GA |
| 11 | Sun Nov 5 | vs Jazz | W137-110 | 8-3 | .727 | Toyota Center · Houston, TX |
| 12 | Thu Nov 9 | vs Cavaliers | W117-113 | 9-3 | .750 | Toyota Center · Houston, TX |
| 13 | Sat Nov 11 | vsGrizzlies | W111-96 | 10-3 | .769 | Toyota Center · Houston, TX |
| 14 | Sun Nov 12 | at Pacers | W118-95 | 11-3 | .786 | Gainbridge Fieldhouse · Indianapolis, IN |
| 15 | Tue Nov 14 | vs Raptors | L113-129 | 11-4 | .733 | Toyota Center · Houston, TX |
| 16 | Thu Nov 16 | at Suns | W142-116 | 12-4 | .750 | Footprint Center · Phoenix, AZ |
| 17 | Sat Nov 18 | atGrizzlies | W105-83 | 13-4 | .765 | FedExForum · Memphis, TN |
| 18 | Wed Nov 22 | vs Nuggets | W125-95 | 14-4 | .778 | Toyota Center · Houston, TX |
| 19 | Sat Nov 25 | vsKnicks | W117-102 | 15-4 | .789 | Toyota Center · Houston, TX |
| 20 | Mon Nov 27 | vs Nets | W117-103 | 16-4 | .800 | Toyota Center · Houston, TX |
| 21 | Wed Nov 29 | vsPacers | W118-97 | 17-4 | .810 | Toyota Center · Houston, TX |
| 22 | Sun Dec 3 | at Lakers | W118-95 | 18-4 | .818 | Crypto.com Arena · Los Angeles, CA |
| 23 | Thu Dec 7 | atJazz | W112-101 | 19-4 | .826 | Vivint Arena · Salt Lake City, UT |
| 24 | Sat Dec 9 | at Blazers | W124-117 | 20-4 | .833 | Moda Center · Portland, OR |
| 25 | Mon Dec 11 | vs Pelicans | W130-123 | 21-4 | .840 | Toyota Center · Houston, TX |
| 26 | Wed Dec 13 | vsHornets | W108-96 | 22-4 | .846 | Toyota Center · Houston, TX |
| 27 | Fri Dec 15 | vs Spurs | W124-109 | 23-4 | .852 | Toyota Center · Houston, TX |
| 28 | Sat Dec 16 | vs Bucks | W115-111 | 24-4 | .857 | Toyota Center · Houston, TX |
| 29 | Mon Dec 18 | vsJazz | W120-99 | 25-4 | .862 | Toyota Center · Houston, TX |
| 30 | Wed Dec 20 | vsLakers | L116-122 | 25-5 | .833 | Toyota Center · Houston, TX |
| 31 | Fri Dec 22 | vs Clippers | L118-128 | 25-6 | .806 | Toyota Center · Houston, TX |
| 32 | Mon Dec 25 | at Thunder | L107-112 | 25-7 | .781 | Paycom Center · Oklahoma City, OK |
| 33 | Thu Dec 28 | at Celtics | L98-99 | 25-8 | .758 | TD Garden · Boston, MA |
| 34 | Fri Dec 29 | at Wizards | L103-121 | 25-9 | .735 | Capital One Arena · Washington, D.C. |
| 35 | Sun Dec 31 | vsLakers | W148-142 (2OT) | 26-9 | .743 | Toyota Center · Houston, TX |
| 36 | Wed Jan 3 | at Magic | W116-98 | 27-9 | .750 | Amway Center · Orlando, FL |
| 37 | Thu Jan 4 | vsWarriors | L114-124 | 27-10 | .730 | Toyota Center · Houston, TX |
| 38 | Sat Jan 6 | at Pistons | L101-108 | 27-11 | .711 | Little Caesars Arena · Detroit, MI |
| 39 | Mon Jan 8 | at Bulls | W116-107 | 28-11 | .718 | United Center · Chicago, IL |
| 40 | Wed Jan 10 | vsBlazers | W121-112 | 29-11 | .725 | Toyota Center · Houston, TX |
| 41 | Fri Jan 12 | atSuns | W112-95 | 30-11 | .732 | Footprint Center · Phoenix, AZ |
| 42 | Mon Jan 15 | atClippers | L102-113 | 30-12 | .714 | Crypto.com Arena · Los Angeles, CA |
| 43 | Thu Jan 18 | vs T-wolves | W116-98 | 31-12 | .721 | Toyota Center · Houston, TX |
| 44 | Sat Jan 20 | vsWarriors | W116-108 | 32-12 | .727 | Toyota Center · Houston, TX |
| 45 | Mon Jan 22 | vs Heat | W99-90 | 33-12 | .733 | Toyota Center · Houston, TX |
| 46 | Wed Jan 24 | atMavericks | W104-97 | 34-12 | .739 | American Airlines Center · Dallas, TX |
| 47 | Fri Jan 26 | atPelicans | L113-115 | 34-13 | .723 | Smoothie King Center · New Orleans, LA |
| 48 | Sun Jan 28 | vsSuns | W113-103 | 35-13 | .729 | Toyota Center · Houston, TX |
| 49 | Tue Jan 30 | vsMagic | W114-107 | 36-13 | .735 | Toyota Center · Houston, TX |
| 50 | Thu Feb 1 | atSpurs | W102-91 | 37-13 | .740 | AT&T Center · San Antonio, TX |
| 51 | Sat Feb 3 | atCavaliers | W120-88 | 38-13 | .745 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 52 | Tue Feb 6 | atNets | W123-113 | 39-13 | .750 | Barclays Center · Brooklyn, NY |
| 53 | Wed Feb 7 | atHeat | W109-101 | 40-13 | .755 | FTX Arena · Miami, FL |
| 54 | Fri Feb 9 | vsNuggets | W130-104 | 41-13 | .759 | Toyota Center · Houston, TX |
| 55 | Sun Feb 11 | vsMavericks | W104-97 | 42-13 | .764 | Toyota Center · Houston, TX |
| 56 | Tue Feb 13 | atT-wolves | W126-108 | 43-13 | .768 | Target Center · Minneapolis, MN |
| 57 | Wed Feb 14 | vsKings | W100-91 | 44-13 | .772 | Toyota Center · Houston, TX |
| 58 | Fri Feb 23 | vsT-wolves | W120-102 | 45-13 | .776 | Toyota Center · Houston, TX |
| 59 | Sun Feb 25 | atNuggets | W119-114 | 46-13 | .780 | Ball Arena · Denver, CO |
| 60 | Mon Feb 26 | atJazz | W96-85 | 47-13 | .783 | Vivint Arena · Salt Lake City, UT |
| 61 | Wed Feb 28 | atClippers | W105-92 | 48-13 | .787 | Crypto.com Arena · Los Angeles, CA |
| 62 | Sat Mar 3 | vsCeltics | W123-120 | 49-13 | .790 | Toyota Center · Houston, TX |
| 63 | Tue Mar 6 | atThunder | W122-112 | 50-13 | .794 | Paycom Center · Oklahoma City, OK |
| 64 | Wed Mar 7 | atBucks | W110-99 | 51-13 | .797 | Fiserv Forum · Milwaukee, WI |
| 65 | Fri Mar 9 | atRaptors | L105-108 | 51-14 | .785 | Scotiabank Arena · Toronto, ON |
| 66 | Sun Mar 11 | atMavericks | W105-82 | 52-14 | .788 | American Airlines Center · Dallas, TX |
| 67 | Mon Mar 12 | vsSpurs | W109-93 | 53-14 | .791 | Toyota Center · Houston, TX |
| 68 | Thu Mar 15 | vsClippers | W101-96 | 54-14 | .794 | Toyota Center · Houston, TX |
| 69 | Sat Mar 17 | atPelicans | W107-101 | 55-14 | .797 | Smoothie King Center · New Orleans, LA |
| 70 | Sun Mar 18 | atT-wolves | W129-120 | 56-14 | .800 | Target Center · Minneapolis, MN |
| 71 | Tue Mar 20 | atBlazers | W115-111 | 57-14 | .803 | Moda Center · Portland, OR |
| 72 | Thu Mar 22 | vsPistons | W100-96 (OT) | 58-14 | .806 | Toyota Center · Houston, TX |
| 73 | Sat Mar 24 | vsPelicans | W114-91 | 59-14 | .808 | Toyota Center · Houston, TX |
| 74 | Sun Mar 25 | vsHawks | W118-99 | 60-14 | .811 | Toyota Center · Houston, TX |
| 75 | Tue Mar 27 | vsBulls | W118-86 | 61-14 | .813 | Toyota Center · Houston, TX |
| 76 | Fri Mar 30 | vsSuns | W104-103 | 62-14 | .816 | Toyota Center · Houston, TX |
| 77 | Sun Apr 1 | atSpurs | L83-100 | 62-15 | .805 | AT&T Center · San Antonio, TX |
| 78 | Tue Apr 3 | vsWizards | W120-104 | 63-15 | .808 | Toyota Center · Houston, TX |
| 79 | Thu Apr 5 | vsBlazers | W96-94 | 64-15 | .810 | Toyota Center · Houston, TX |
| 80 | Sat Apr 7 | vsThunder | L102-108 | 64-16 | .800 | Toyota Center · Houston, TX |
| 81 | Tue Apr 10 | atLakers | W105-99 | 65-16 | .802 | Crypto.com Arena · Los Angeles, CA |
| 82 | Wed Apr 11 | atKings | L83-96 | 65-17 | .793 | Golden 1 Center · Sacramento, CA |
| 1 | Sun Apr 15 | vsT-wolves | W104-101 | 1-0 | 1.000 | Toyota Center · Houston, TX |
| 2 | Wed Apr 18 | vsT-wolves | W102-82 | 2-0 | 1.000 | Toyota Center · Houston, TX |
| 3 | Sat Apr 21 | atT-wolves | L105-121 | 2-1 | .667 | Target Center · Minneapolis, MN |
| 4 | Mon Apr 23 | atT-wolves | W119-100 | 3-1 | .750 | Target Center · Minneapolis, MN |
| 5 | Wed Apr 25 | vsT-wolves | W122-104 | 4-1 | .800 | Toyota Center · Houston, TX |
| 1 | Sun Apr 29 | vsJazz | W110-96 | 1-0 | 1.000 | Toyota Center · Houston, TX |
| 2 | Wed May 2 | vsJazz | L108-116 | 1-1 | .500 | Toyota Center · Houston, TX |
| 3 | Fri May 4 | atJazz | W113-92 | 2-1 | .667 | Vivint Arena · Salt Lake City, UT |
| 4 | Sun May 6 | atJazz | W100-87 | 3-1 | .750 | Vivint Arena · Salt Lake City, UT |
| 5 | Tue May 8 | vsJazz | W112-102 | 4-1 | .800 | Toyota Center · Houston, TX |
| 1 | Mon May 14 | vsWarriors | L106-119 | 0-1 | .000 | Toyota Center · Houston, TX |
| 2 | Wed May 16 | vsWarriors | W127-105 | 1-1 | .500 | Toyota Center · Houston, TX |
| 3 | Sun May 20 | atWarriors | L85-126 | 1-2 | .333 | Chase Center · San Francisco, CA |
| 4 | Tue May 22 | atWarriors | W95-92 | 2-2 | .500 | Chase Center · San Francisco, CA |
| 5 | Thu May 24 | vsWarriors | W98-94 | 3-2 | .600 | Toyota Center · Houston, TX |
| 6 | Sat May 26 | atWarriors | L86-115 | 3-3 | .500 | Chase Center · San Francisco, CA |
| 7 | Mon May 28 | vsWarriors | L92-101 | 3-4 | .429 | Toyota Center · Houston, TX |
