| 1 | Wed Oct 25 | at Magic | L86-116 | 0-1 | .000 | Amway Center · Orlando, FL |
| 2 | Fri Oct 27 | at Spurs | L122-126 (OT) | 0-2 | .000 | AT&T Center · San Antonio, TX |
| 3 | Sun Oct 29 | vs Warriors | L95-106 | 0-3 | .000 | Toyota Center · Houston, TX |
| 4 | Wed Nov 1 | vs Hornets | W128-119 | 1-3 | .250 | Toyota Center · Houston, TX |
| 5 | Sat Nov 4 | vs Kings | W107-89 | 2-3 | .400 | Toyota Center · Houston, TX |
| 6 | Mon Nov 6 | vsKings | W122-97 | 3-3 | .500 | Toyota Center · Houston, TX |
| 7 | Wed Nov 8 | vs Lakers | W128-94 | 4-3 | .571 | Toyota Center · Houston, TX |
| 8 | Fri Nov 10 | vs Pelicans | W104-101 | 5-3 | .625 | Toyota Center · Houston, TX |
| 9 | Sun Nov 12 | vs Nuggets | W107-104 | 6-3 | .667 | Toyota Center · Houston, TX |
| 10 | Fri Nov 17 | at Clippers | L100-106 | 6-4 | .600 | Crypto.com Arena · Los Angeles, CA |
| 11 | Sun Nov 19 | atLakers | L104-105 | 6-5 | .545 | Crypto.com Arena · Los Angeles, CA |
| 12 | Mon Nov 20 | atWarriors | L116-121 | 6-6 | .500 | Chase Center · San Francisco, CA |
| 13 | Wed Nov 22 | vs Grizzlies | W111-91 | 7-6 | .538 | Toyota Center · Houston, TX |
| 14 | Fri Nov 24 | vsNuggets | W105-86 | 8-6 | .571 | Toyota Center · Houston, TX |
| 15 | Tue Nov 28 | at Mavericks | L115-121 | 8-7 | .533 | American Airlines Center · Dallas, TX |
| 16 | Wed Nov 29 | atNuggets | L124-134 | 8-8 | .500 | Ball Arena · Denver, CO |
| 17 | Sat Dec 2 | atLakers | L97-107 | 8-9 | .471 | Crypto.com Arena · Los Angeles, CA |
| 18 | Wed Dec 6 | vs Thunder | W110-101 | 9-9 | .500 | Toyota Center · Houston, TX |
| 19 | Fri Dec 8 | atNuggets | W114-106 | 10-9 | .526 | Ball Arena · Denver, CO |
| 20 | Mon Dec 11 | vsSpurs | W93-82 | 11-9 | .550 | Toyota Center · Houston, TX |
| 21 | Wed Dec 13 | vsGrizzlies | W117-104 | 12-9 | .571 | Toyota Center · Houston, TX |
| 22 | Fri Dec 15 | atGrizzlies | W103-96 | 13-9 | .591 | FedExForum · Memphis, TN |
| 23 | Sun Dec 17 | at Bucks | L119-128 | 13-10 | .565 | Fiserv Forum · Milwaukee, WI |
| 24 | Mon Dec 18 | at Cavaliers | L130-135 (OT) | 13-11 | .542 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 25 | Wed Dec 20 | vs Hawks | L127-134 | 13-12 | .520 | Toyota Center · Houston, TX |
| 26 | Fri Dec 22 | vsMavericks | W122-96 | 14-12 | .538 | Toyota Center · Houston, TX |
| 27 | Sat Dec 23 | atPelicans | W106-104 | 15-12 | .556 | Smoothie King Center · New Orleans, LA |
| 28 | Tue Dec 26 | vs Pacers | L117-123 | 15-13 | .536 | Toyota Center · Houston, TX |
| 29 | Wed Dec 27 | vs Suns | L113-129 | 15-14 | .517 | Toyota Center · Houston, TX |
| 30 | Fri Dec 29 | vs 76ers | L127-131 | 15-15 | .500 | Toyota Center · Houston, TX |
| 31 | Mon Jan 1 | vs Pistons | W136-113 | 16-15 | .516 | Toyota Center · Houston, TX |
| 32 | Wed Jan 3 | vs Nets | W112-101 | 17-15 | .531 | Toyota Center · Houston, TX |
| 33 | Fri Jan 5 | vs T-wolves | L95-122 | 17-16 | .515 | Toyota Center · Houston, TX |
| 34 | Sat Jan 6 | vsBucks | W112-108 | 18-16 | .529 | Toyota Center · Houston, TX |
| 35 | Mon Jan 8 | at Heat | L113-120 | 18-17 | .514 | FTX Arena · Miami, FL |
| 36 | Wed Jan 10 | at Bulls | L119-124 (OT) | 18-18 | .500 | United Center · Chicago, IL |
| 37 | Fri Jan 12 | atPistons | W112-110 | 19-18 | .514 | Little Caesars Arena · Detroit, MI |
| 38 | Sat Jan 13 | at Celtics | L113-145 | 19-19 | .500 | TD Garden · Boston, MA |
| 39 | Mon Jan 15 | at76ers | L115-124 | 19-20 | .487 | Wells Fargo Center · Philadelphia, PA |
| 40 | Wed Jan 17 | at Knicks | L94-109 | 19-21 | .475 | Madison Square Garden · Manhattan, NY |
| 41 | Sat Jan 20 | vs Jazz | W127-126 (OT) | 20-21 | .488 | Toyota Center · Houston, TX |
| 42 | Sun Jan 21 | vsCeltics | L107-116 | 20-22 | .476 | Toyota Center · Houston, TX |
| 43 | Wed Jan 24 | vs Blazers | L131-137 (OT) | 20-23 | .465 | Toyota Center · Houston, TX |
| 44 | Fri Jan 26 | atHornets | W138-104 | 21-23 | .477 | Spectrum Center · Charlotte, NC |
| 45 | Sat Jan 27 | atNets | L104-106 | 21-24 | .467 | Barclays Center · Brooklyn, NY |
| 46 | Mon Jan 29 | vsLakers | W135-119 | 22-24 | .478 | Toyota Center · Houston, TX |
| 47 | Wed Jan 31 | vsPelicans | L99-110 | 22-25 | .468 | Toyota Center · Houston, TX |
| 48 | Fri Feb 2 | vs Raptors | W135-106 | 23-25 | .479 | Toyota Center · Houston, TX |
| 49 | Sun Feb 4 | atT-wolves | L90-111 | 23-26 | .469 | Target Center · Minneapolis, MN |
| 50 | Tue Feb 6 | atPacers | L129-132 | 23-27 | .460 | Gainbridge Fieldhouse · Indianapolis, IN |
| 51 | Fri Feb 9 | atRaptors | L104-107 | 23-28 | .451 | Scotiabank Arena · Toronto, ON |
| 52 | Sat Feb 10 | atHawks | L113-122 | 23-29 | .442 | State Farm Arena · Atlanta, GA |
| 53 | Mon Feb 12 | vsKnicks | W105-103 | 24-29 | .453 | Toyota Center · Houston, TX |
| 54 | Wed Feb 14 | atGrizzlies | L113-121 | 24-30 | .444 | FedExForum · Memphis, TN |
| 55 | Thu Feb 22 | atPelicans | L105-127 | 24-31 | .436 | Smoothie King Center · New Orleans, LA |
| 56 | Fri Feb 23 | vsSuns | W114-110 | 25-31 | .446 | Toyota Center · Houston, TX |
| 57 | Sun Feb 25 | vsThunder | L110-123 | 25-32 | .439 | Toyota Center · Houston, TX |
| 58 | Tue Feb 27 | atThunder | L95-112 | 25-33 | .431 | Paycom Center · Oklahoma City, OK |
| 59 | Thu Feb 29 | atSuns | L105-110 | 25-34 | .424 | Footprint Center · Phoenix, AZ |
| 60 | Sat Mar 2 | atSuns | W118-109 | 26-34 | .433 | Footprint Center · Phoenix, AZ |
| 61 | Tue Mar 5 | vsSpurs | W114-101 | 27-34 | .443 | Toyota Center · Houston, TX |
| 62 | Wed Mar 6 | vsClippers | L116-122 | 27-35 | .435 | Toyota Center · Houston, TX |
| 63 | Fri Mar 8 | atBlazers | W123-107 | 28-35 | .444 | Moda Center · Portland, OR |
| 64 | Sun Mar 10 | atKings | W112-104 | 29-35 | .453 | Golden 1 Center · Sacramento, CA |
| 65 | Tue Mar 12 | atSpurs | W103-101 | 30-35 | .462 | AT&T Center · San Antonio, TX |
| 66 | Thu Mar 14 | vs Wizards | W135-119 | 31-35 | .470 | Toyota Center · Houston, TX |
| 67 | Sat Mar 16 | vsCavaliers | W117-103 | 32-35 | .478 | Toyota Center · Houston, TX |
| 68 | Tue Mar 19 | atWizards | W137-114 | 33-35 | .485 | Capital One Arena · Washington, D.C. |
| 69 | Thu Mar 21 | vsBulls | W127-117 | 34-35 | .493 | Toyota Center · Houston, TX |
| 70 | Sat Mar 23 | vsJazz | W147-119 | 35-35 | .500 | Toyota Center · Houston, TX |
| 71 | Mon Mar 25 | vsBlazers | W110-92 | 36-35 | .507 | Toyota Center · Houston, TX |
| 72 | Wed Mar 27 | atThunder | W132-126 (OT) | 37-35 | .514 | Paycom Center · Oklahoma City, OK |
| 73 | Fri Mar 29 | atJazz | W101-100 | 38-35 | .521 | Vivint Arena · Salt Lake City, UT |
| 74 | Sun Mar 31 | vsMavericks | L107-125 | 38-36 | .514 | Toyota Center · Houston, TX |
| 75 | Tue Apr 2 | atT-wolves | L106-113 | 38-37 | .507 | Target Center · Minneapolis, MN |
| 76 | Thu Apr 4 | vsWarriors | L110-133 | 38-38 | .500 | Toyota Center · Houston, TX |
| 77 | Fri Apr 5 | vsHeat | L104-119 | 38-39 | .494 | Toyota Center · Houston, TX |
| 78 | Sun Apr 7 | atMavericks | L136-147 (OT) | 38-40 | .487 | American Airlines Center · Dallas, TX |
| 79 | Tue Apr 9 | vsMagic | W118-106 | 39-40 | .494 | Toyota Center · Houston, TX |
| 80 | Thu Apr 11 | atJazz | L121-124 | 39-41 | .487 | Vivint Arena · Salt Lake City, UT |
| 81 | Fri Apr 12 | atBlazers | W116-107 | 40-41 | .494 | Moda Center · Portland, OR |
| 82 | Sun Apr 14 | atClippers | W116-105 | 41-41 | .500 | Crypto.com Arena · Los Angeles, CA |
