| 1 | Wed Oct 19 | at Hawks | L107-117 | 0-1 | .000 | State Farm Arena · Atlanta, GA |
| 2 | Fri Oct 21 | vs Grizzlies | L122-129 | 0-2 | .000 | Toyota Center · Houston, TX |
| 3 | Sat Oct 22 | at Bucks | L105-125 | 0-3 | .000 | Fiserv Forum · Milwaukee, WI |
| 4 | Mon Oct 24 | vs Jazz | W114-108 | 1-3 | .250 | Toyota Center · Houston, TX |
| 5 | Wed Oct 26 | atJazz | L101-109 | 1-4 | .200 | Vivint Arena · Salt Lake City, UT |
| 6 | Fri Oct 28 | at Blazers | L111-125 | 1-5 | .167 | Moda Center · Portland, OR |
| 7 | Sun Oct 30 | at Suns | L109-124 | 1-6 | .143 | Footprint Center · Phoenix, AZ |
| 8 | Mon Oct 31 | at Clippers | L93-95 | 1-7 | .125 | Crypto.com Arena · Los Angeles, CA |
| 9 | Wed Nov 2 | vsClippers | L101-109 | 1-8 | .111 | Toyota Center · Houston, TX |
| 10 | Sat Nov 5 | at T-wolves | L117-129 | 1-9 | .100 | Target Center · Minneapolis, MN |
| 11 | Mon Nov 7 | at Magic | W134-127 | 2-9 | .182 | Amway Center · Orlando, FL |
| 12 | Wed Nov 9 | at Raptors | L109-116 | 2-10 | .167 | Scotiabank Arena · Toronto, ON |
| 13 | Sat Nov 12 | at Pelicans | L106-119 | 2-11 | .154 | Smoothie King Center · New Orleans, LA |
| 14 | Mon Nov 14 | vsClippers | L106-122 | 2-12 | .143 | Toyota Center · Houston, TX |
| 15 | Wed Nov 16 | at Mavericks | W101-92 | 3-12 | .200 | American Airlines Center · Dallas, TX |
| 16 | Fri Nov 18 | vs Pacers | L91-99 | 3-13 | .188 | Toyota Center · Houston, TX |
| 17 | Sun Nov 20 | vs Warriors | L120-127 | 3-14 | .176 | Toyota Center · Houston, TX |
| 18 | Fri Nov 25 | vsHawks | W128-122 | 4-14 | .222 | Toyota Center · Houston, TX |
| 19 | Sat Nov 26 | vs Thunder | W118-105 | 5-14 | .263 | Toyota Center · Houston, TX |
| 20 | Mon Nov 28 | at Nuggets | L113-129 | 5-15 | .250 | Ball Arena · Denver, CO |
| 21 | Wed Nov 30 | atNuggets | L100-120 | 5-16 | .238 | Ball Arena · Denver, CO |
| 22 | Fri Dec 2 | atSuns | W122-121 | 6-16 | .273 | Footprint Center · Phoenix, AZ |
| 23 | Sat Dec 3 | atWarriors | L101-120 | 6-17 | .261 | Chase Center · San Francisco, CA |
| 24 | Mon Dec 5 | vs 76ers | W132-123 (2OT) | 7-17 | .292 | Toyota Center · Houston, TX |
| 25 | Thu Dec 8 | at Spurs | L109-118 | 7-18 | .280 | AT&T Center · San Antonio, TX |
| 26 | Sun Dec 11 | vsBucks | W97-92 | 8-18 | .308 | Toyota Center · Houston, TX |
| 27 | Tue Dec 13 | vsSuns | W111-97 | 9-18 | .333 | Toyota Center · Houston, TX |
| 28 | Thu Dec 15 | vs Heat | L108-111 | 9-19 | .321 | Toyota Center · Houston, TX |
| 29 | Sat Dec 17 | vsBlazers | L95-107 | 9-20 | .310 | Toyota Center · Houston, TX |
| 30 | Mon Dec 19 | vsSpurs | L105-124 | 9-21 | .300 | Toyota Center · Houston, TX |
| 31 | Wed Dec 21 | vsMagic | L110-116 | 9-22 | .290 | Toyota Center · Houston, TX |
| 32 | Fri Dec 23 | vsMavericks | L106-112 | 9-23 | .281 | Toyota Center · Houston, TX |
| 33 | Mon Dec 26 | at Bulls | W133-118 | 10-23 | .303 | United Center · Chicago, IL |
| 34 | Tue Dec 27 | at Celtics | L102-126 | 10-24 | .294 | TD Garden · Boston, MA |
| 35 | Thu Dec 29 | atMavericks | L114-129 | 10-25 | .286 | American Airlines Center · Dallas, TX |
| 36 | Sat Dec 31 | vs Knicks | L88-108 | 10-26 | .278 | Toyota Center · Houston, TX |
| 37 | Mon Jan 2 | vsMavericks | L106-111 | 10-27 | .270 | Toyota Center · Houston, TX |
| 38 | Wed Jan 4 | atPelicans | L108-119 | 10-28 | .263 | Smoothie King Center · New Orleans, LA |
| 39 | Thu Jan 5 | vsJazz | L114-131 | 10-29 | .256 | Toyota Center · Houston, TX |
| 40 | Sun Jan 8 | vsT-wolves | L96-104 | 10-30 | .250 | Toyota Center · Houston, TX |
| 41 | Wed Jan 11 | at Kings | L115-135 | 10-31 | .244 | Golden 1 Center · Sacramento, CA |
| 42 | Fri Jan 13 | atKings | L114-139 | 10-32 | .238 | Golden 1 Center · Sacramento, CA |
| 43 | Sun Jan 15 | atClippers | L100-121 | 10-33 | .233 | Crypto.com Arena · Los Angeles, CA |
| 44 | Mon Jan 16 | at Lakers | L132-140 | 10-34 | .227 | Crypto.com Arena · Los Angeles, CA |
| 45 | Wed Jan 18 | vs Hornets | L117-122 | 10-35 | .222 | Toyota Center · Houston, TX |
| 46 | Sat Jan 21 | atT-wolves | L104-113 | 10-36 | .217 | Target Center · Minneapolis, MN |
| 47 | Mon Jan 23 | vsT-wolves | W119-114 | 11-36 | .234 | Toyota Center · Houston, TX |
| 48 | Wed Jan 25 | vs Wizards | L103-108 | 11-37 | .229 | Toyota Center · Houston, TX |
| 49 | Thu Jan 26 | vs Cavaliers | L95-113 | 11-38 | .224 | Toyota Center · Houston, TX |
| 50 | Sat Jan 28 | at Pistons | W117-114 | 12-38 | .240 | Little Caesars Arena · Detroit, MI |
| 51 | Wed Feb 1 | vsThunder | W112-106 | 13-38 | .255 | Toyota Center · Houston, TX |
| 52 | Fri Feb 3 | vsRaptors | L111-117 | 13-39 | .250 | Toyota Center · Houston, TX |
| 53 | Sat Feb 4 | atThunder | L121-153 | 13-40 | .245 | Paycom Center · Oklahoma City, OK |
| 54 | Mon Feb 6 | vsKings | L120-140 | 13-41 | .241 | Toyota Center · Houston, TX |
| 55 | Wed Feb 8 | vsKings | L128-130 | 13-42 | .236 | Toyota Center · Houston, TX |
| 56 | Fri Feb 10 | atHeat | L95-97 | 13-43 | .232 | FTX Arena · Miami, FL |
| 57 | Mon Feb 13 | at76ers | L104-123 | 13-44 | .228 | Wells Fargo Center · Philadelphia, PA |
| 58 | Wed Feb 15 | atThunder | L96-133 | 13-45 | .224 | Paycom Center · Oklahoma City, OK |
| 59 | Fri Feb 24 | atWarriors | L101-116 | 13-46 | .220 | Chase Center · San Francisco, CA |
| 60 | Sun Feb 26 | atBlazers | L114-131 | 13-47 | .217 | Moda Center · Portland, OR |
| 61 | Tue Feb 28 | vsNuggets | L112-133 | 13-48 | .213 | Toyota Center · Houston, TX |
| 62 | Wed Mar 1 | vsGrizzlies | L99-113 | 13-49 | .210 | Toyota Center · Houston, TX |
| 63 | Sat Mar 4 | atSpurs | W122-110 | 14-49 | .222 | AT&T Center · San Antonio, TX |
| 64 | Sun Mar 5 | vsSpurs | W142-110 | 15-49 | .234 | Toyota Center · Houston, TX |
| 65 | Tue Mar 7 | vs Nets | L96-118 | 15-50 | .231 | Toyota Center · Houston, TX |
| 66 | Thu Mar 9 | atPacers | L125-134 (OT) | 15-51 | .227 | Gainbridge Fieldhouse · Indianapolis, IN |
| 67 | Sat Mar 11 | vsBulls | L111-119 | 15-52 | .224 | Toyota Center · Houston, TX |
| 68 | Mon Mar 13 | vsCeltics | W111-109 | 16-52 | .235 | Toyota Center · Houston, TX |
| 69 | Wed Mar 15 | vsLakers | W114-110 | 17-52 | .246 | Toyota Center · Houston, TX |
| 70 | Fri Mar 17 | vsPelicans | W114-112 | 18-52 | .257 | Toyota Center · Houston, TX |
| 71 | Sun Mar 19 | vsPelicans | L107-117 | 18-53 | .254 | Toyota Center · Houston, TX |
| 72 | Mon Mar 20 | vsWarriors | L108-121 | 18-54 | .250 | Toyota Center · Houston, TX |
| 73 | Wed Mar 22 | atGrizzlies | L125-130 | 18-55 | .247 | FedExForum · Memphis, TN |
| 74 | Fri Mar 24 | atGrizzlies | L114-151 | 18-56 | .243 | FedExForum · Memphis, TN |
| 75 | Sun Mar 26 | atCavaliers | L91-108 | 18-57 | .240 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 76 | Mon Mar 27 | atKnicks | L115-137 | 18-58 | .237 | Madison Square Garden · Manhattan, NY |
| 77 | Wed Mar 29 | atNets | L114-123 | 18-59 | .234 | Barclays Center · Brooklyn, NY |
| 78 | Fri Mar 31 | vsPistons | W121-115 | 19-59 | .244 | Toyota Center · Houston, TX |
| 79 | Sun Apr 2 | vsLakers | L109-134 | 19-60 | .241 | Toyota Center · Houston, TX |
| 80 | Tue Apr 4 | vsNuggets | W124-103 | 20-60 | .250 | Toyota Center · Houston, TX |
| 81 | Fri Apr 7 | atHornets | W112-109 | 21-60 | .259 | Spectrum Center · Charlotte, NC |
| 82 | Sun Apr 9 | atWizards | W114-109 | 22-60 | .268 | Capital One Arena · Washington, D.C. |
