| 1 | Wed Oct 26 | at Lakers | L114-120 | 0-1 | .000 | Crypto.com Arena · Los Angeles, CA |
| 2 | Fri Oct 28 | at Mavericks | W106-98 | 1-1 | .500 | American Airlines Center · Dallas, TX |
| 3 | Sun Oct 30 | vsMavericks | W93-92 | 2-1 | .667 | Toyota Center · Houston, TX |
| 4 | Tue Nov 1 | at Cavaliers | L120-128 | 2-2 | .500 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 5 | Wed Nov 2 | at Knicks | W118-99 | 3-2 | .600 | Madison Square Garden · Manhattan, NY |
| 6 | Sat Nov 5 | at Hawks | L97-112 | 3-3 | .500 | State Farm Arena · Atlanta, GA |
| 7 | Mon Nov 7 | at Wizards | W114-106 | 4-3 | .571 | Capital One Arena · Washington, D.C. |
| 8 | Wed Nov 9 | at Spurs | W101-99 | 5-3 | .625 | AT&T Center · San Antonio, TX |
| 9 | Sat Nov 12 | vsSpurs | L100-106 | 5-4 | .556 | Toyota Center · Houston, TX |
| 10 | Mon Nov 14 | vs 76ers | W115-88 | 6-4 | .600 | Toyota Center · Houston, TX |
| 11 | Wed Nov 16 | at Thunder | L103-105 | 6-5 | .545 | Paycom Center · Oklahoma City, OK |
| 12 | Thu Nov 17 | vs Blazers | W126-109 | 7-5 | .583 | Toyota Center · Houston, TX |
| 13 | Sat Nov 19 | vs Jazz | W111-102 | 8-5 | .615 | Toyota Center · Houston, TX |
| 14 | Mon Nov 21 | at Pistons | W99-96 | 9-5 | .643 | Little Caesars Arena · Detroit, MI |
| 15 | Wed Nov 23 | vs Raptors | L102-115 | 9-6 | .600 | Toyota Center · Houston, TX |
| 16 | Fri Nov 25 | at Kings | W117-104 | 10-6 | .625 | Golden 1 Center · Sacramento, CA |
| 17 | Sun Nov 27 | atBlazers | W130-114 | 11-6 | .647 | Moda Center · Portland, OR |
| 18 | Tue Nov 29 | atJazz | L101-120 | 11-7 | .611 | Vivint Arena · Salt Lake City, UT |
| 19 | Thu Dec 1 | at Warriors | W132-127 (2OT) | 12-7 | .632 | Chase Center · San Francisco, CA |
| 20 | Fri Dec 2 | at Nuggets | W128-110 | 13-7 | .650 | Ball Arena · Denver, CO |
| 21 | Mon Dec 5 | vs Celtics | W107-106 | 14-7 | .667 | Toyota Center · Houston, TX |
| 22 | Wed Dec 7 | vsLakers | W134-95 | 15-7 | .682 | Toyota Center · Houston, TX |
| 23 | Fri Dec 9 | atThunder | W102-99 | 16-7 | .696 | Paycom Center · Oklahoma City, OK |
| 24 | Sat Dec 10 | vsMavericks | W109-87 | 17-7 | .708 | Toyota Center · Houston, TX |
| 25 | Mon Dec 12 | vs Nets | W122-118 | 18-7 | .720 | Toyota Center · Houston, TX |
| 26 | Wed Dec 14 | vsKings | W132-98 | 19-7 | .731 | Toyota Center · Houston, TX |
| 27 | Fri Dec 16 | vs Pelicans | W122-100 | 20-7 | .741 | Toyota Center · Houston, TX |
| 28 | Sat Dec 17 | at T-wolves | W111-109 (OT) | 21-7 | .750 | Target Center · Minneapolis, MN |
| 29 | Tue Dec 20 | vsSpurs | L100-102 | 21-8 | .724 | Toyota Center · Houston, TX |
| 30 | Wed Dec 21 | at Suns | W125-111 | 22-8 | .733 | Footprint Center · Phoenix, AZ |
| 31 | Fri Dec 23 | at Grizzlies | L109-115 | 22-9 | .710 | FedExForum · Memphis, TN |
| 32 | Mon Dec 26 | vsSuns | W131-115 | 23-9 | .719 | Toyota Center · Houston, TX |
| 33 | Tue Dec 27 | atMavericks | W123-107 | 24-9 | .727 | American Airlines Center · Dallas, TX |
| 34 | Fri Dec 30 | vs Clippers | W140-116 | 25-9 | .735 | Toyota Center · Houston, TX |
| 35 | Sat Dec 31 | vsKnicks | W129-122 | 26-9 | .743 | Toyota Center · Houston, TX |
| 36 | Mon Jan 2 | vsWizards | W101-91 | 27-9 | .750 | Toyota Center · Houston, TX |
| 37 | Thu Jan 5 | vsThunder | W118-116 | 28-9 | .757 | Toyota Center · Houston, TX |
| 38 | Fri Jan 6 | at Magic | W100-93 | 29-9 | .763 | Amway Center · Orlando, FL |
| 39 | Sun Jan 8 | atRaptors | W129-122 | 30-9 | .769 | Scotiabank Arena · Toronto, ON |
| 40 | Tue Jan 10 | vs Hornets | W121-114 | 31-9 | .775 | Toyota Center · Houston, TX |
| 41 | Wed Jan 11 | atT-wolves | L105-119 | 31-10 | .756 | Target Center · Minneapolis, MN |
| 42 | Fri Jan 13 | vsGrizzlies | L105-110 | 31-11 | .738 | Toyota Center · Houston, TX |
| 43 | Sun Jan 15 | atNets | W137-112 | 32-11 | .744 | Barclays Center · Brooklyn, NY |
| 44 | Tue Jan 17 | at Heat | L103-109 | 32-12 | .727 | FTX Arena · Miami, FL |
| 45 | Wed Jan 18 | vs Bucks | W111-92 | 33-12 | .733 | Toyota Center · Houston, TX |
| 46 | Fri Jan 20 | vsWarriors | L108-125 | 33-13 | .717 | Toyota Center · Houston, TX |
| 47 | Sat Jan 21 | atGrizzlies | W119-95 | 34-13 | .723 | FedExForum · Memphis, TN |
| 48 | Mon Jan 23 | atBucks | L114-127 | 34-14 | .708 | Fiserv Forum · Milwaukee, WI |
| 49 | Wed Jan 25 | atCeltics | L109-120 | 34-15 | .694 | TD Garden · Boston, MA |
| 50 | Fri Jan 27 | at76ers | W123-118 | 35-15 | .700 | Wells Fargo Center · Philadelphia, PA |
| 51 | Sun Jan 29 | at Pacers | L101-120 | 35-16 | .686 | Gainbridge Fieldhouse · Indianapolis, IN |
| 52 | Tue Jan 31 | vsKings | W105-83 | 36-16 | .692 | Toyota Center · Houston, TX |
| 53 | Thu Feb 2 | vsHawks | L108-113 | 36-17 | .679 | Toyota Center · Houston, TX |
| 54 | Fri Feb 3 | vs Bulls | W121-117 (OT) | 37-17 | .685 | Toyota Center · Houston, TX |
| 55 | Tue Feb 7 | vsMagic | W128-104 | 38-17 | .691 | Toyota Center · Houston, TX |
| 56 | Thu Feb 9 | atHornets | W107-95 | 39-17 | .696 | Spectrum Center · Charlotte, NC |
| 57 | Sat Feb 11 | vsSuns | W133-102 | 40-17 | .702 | Toyota Center · Houston, TX |
| 58 | Wed Feb 15 | vsHeat | L109-117 | 40-18 | .690 | Toyota Center · Houston, TX |
| 59 | Thu Feb 23 | atPelicans | W129-99 | 41-18 | .695 | Smoothie King Center · New Orleans, LA |
| 60 | Sat Feb 25 | vsT-wolves | W142-130 | 42-18 | .700 | Toyota Center · Houston, TX |
| 61 | Mon Feb 27 | vsPacers | L108-117 | 42-19 | .689 | Toyota Center · Houston, TX |
| 62 | Wed Mar 1 | atClippers | W122-103 | 43-19 | .694 | Crypto.com Arena · Los Angeles, CA |
| 63 | Sat Mar 4 | vsGrizzlies | W123-108 | 44-19 | .698 | Toyota Center · Houston, TX |
| 64 | Mon Mar 6 | atSpurs | L110-112 | 44-20 | .688 | AT&T Center · San Antonio, TX |
| 65 | Wed Mar 8 | vsJazz | L108-115 | 44-21 | .677 | Toyota Center · Houston, TX |
| 66 | Fri Mar 10 | atBulls | W115-94 | 45-21 | .682 | United Center · Chicago, IL |
| 67 | Sun Mar 12 | vsCavaliers | W117-112 | 46-21 | .687 | Toyota Center · Houston, TX |
| 68 | Wed Mar 15 | vsLakers | W139-100 | 47-21 | .691 | Toyota Center · Houston, TX |
| 69 | Fri Mar 17 | atPelicans | L112-128 | 47-22 | .681 | Smoothie King Center · New Orleans, LA |
| 70 | Sat Mar 18 | atNuggets | W109-105 | 48-22 | .686 | Ball Arena · Denver, CO |
| 71 | Mon Mar 20 | vsNuggets | W125-124 | 49-22 | .690 | Toyota Center · Houston, TX |
| 72 | Fri Mar 24 | vsPelicans | W117-107 | 50-22 | .694 | Toyota Center · Houston, TX |
| 73 | Sun Mar 26 | vsThunder | W137-125 | 51-22 | .699 | Toyota Center · Houston, TX |
| 74 | Tue Mar 28 | vsWarriors | L106-113 | 51-23 | .689 | Toyota Center · Houston, TX |
| 75 | Thu Mar 30 | atBlazers | L107-117 | 51-24 | .680 | Moda Center · Portland, OR |
| 76 | Fri Mar 31 | atWarriors | L98-107 | 51-25 | .671 | Chase Center · San Francisco, CA |
| 77 | Sun Apr 2 | atSuns | W123-116 | 52-25 | .675 | Footprint Center · Phoenix, AZ |
| 78 | Wed Apr 5 | vsNuggets | W110-104 | 53-25 | .679 | Toyota Center · Houston, TX |
| 79 | Fri Apr 7 | vsPistons | L109-114 | 53-26 | .671 | Toyota Center · Houston, TX |
| 80 | Sun Apr 9 | atKings | W135-128 | 54-26 | .675 | Golden 1 Center · Sacramento, CA |
| 81 | Mon Apr 10 | atClippers | L96-125 | 54-27 | .667 | Crypto.com Arena · Los Angeles, CA |
| 82 | Wed Apr 12 | vsT-wolves | W123-118 | 55-27 | .671 | Toyota Center · Houston, TX |
| 1 | Sun Apr 16 | vsThunder | W118-87 | 1-0 | 1.000 | Toyota Center · Houston, TX |
| 2 | Wed Apr 19 | vsThunder | W115-111 | 2-0 | 1.000 | Toyota Center · Houston, TX |
| 3 | Fri Apr 21 | atThunder | L113-115 | 2-1 | .667 | Paycom Center · Oklahoma City, OK |
| 4 | Sun Apr 23 | atThunder | W113-109 | 3-1 | .750 | Paycom Center · Oklahoma City, OK |
| 5 | Tue Apr 25 | vsThunder | W105-99 | 4-1 | .800 | Toyota Center · Houston, TX |
| 1 | Mon May 1 | atSpurs | W126-99 | 1-0 | 1.000 | AT&T Center · San Antonio, TX |
| 2 | Wed May 3 | atSpurs | L96-121 | 1-1 | .500 | AT&T Center · San Antonio, TX |
| 3 | Fri May 5 | vsSpurs | L92-103 | 1-2 | .333 | Toyota Center · Houston, TX |
| 4 | Sun May 7 | vsSpurs | W125-104 | 2-2 | .500 | Toyota Center · Houston, TX |
| 5 | Tue May 9 | atSpurs | L107-110 (OT) | 2-3 | .400 | AT&T Center · San Antonio, TX |
| 6 | Thu May 11 | vsSpurs | L75-114 | 2-4 | .333 | Toyota Center · Houston, TX |
