| 1 | Wed Oct 25 | vs Mavericks | L119-126 | 0-1 | .000 | AT&T Center · San Antonio, TX |
| 2 | Fri Oct 27 | vs Rockets | W126-122 (OT) | 1-1 | .500 | AT&T Center · San Antonio, TX |
| 3 | Sun Oct 29 | at Clippers | L83-123 | 1-2 | .333 | Crypto.com Arena · Los Angeles, CA |
| 4 | Tue Oct 31 | at Suns | W115-114 | 2-2 | .500 | Footprint Center · Phoenix, AZ |
| 5 | Thu Nov 2 | atSuns | W132-121 | 3-2 | .600 | Footprint Center · Phoenix, AZ |
| 6 | Sun Nov 5 | vs Raptors | L116-123 (OT) | 3-3 | .500 | AT&T Center · San Antonio, TX |
| 7 | Mon Nov 6 | at Pacers | L111-152 | 3-4 | .429 | Gainbridge Fieldhouse · Indianapolis, IN |
| 8 | Wed Nov 8 | at Knicks | L105-126 | 3-5 | .375 | Madison Square Garden · Manhattan, NY |
| 9 | Fri Nov 10 | vs T-wolves | L110-117 | 3-6 | .333 | AT&T Center · San Antonio, TX |
| 10 | Sun Nov 12 | vs Heat | L113-118 | 3-7 | .300 | AT&T Center · San Antonio, TX |
| 11 | Tue Nov 14 | at Thunder | L87-123 | 3-8 | .273 | Paycom Center · Oklahoma City, OK |
| 12 | Fri Nov 17 | vs Kings | L120-129 | 3-9 | .250 | AT&T Center · San Antonio, TX |
| 13 | Sat Nov 18 | vs Grizzlies | L108-120 | 3-10 | .231 | AT&T Center · San Antonio, TX |
| 14 | Mon Nov 20 | vsClippers | L99-124 | 3-11 | .214 | AT&T Center · San Antonio, TX |
| 15 | Wed Nov 22 | vsClippers | L102-109 | 3-12 | .200 | AT&T Center · San Antonio, TX |
| 16 | Fri Nov 24 | at Warriors | L112-118 | 3-13 | .188 | Chase Center · San Francisco, CA |
| 17 | Sun Nov 26 | at Nuggets | L120-132 | 3-14 | .176 | Ball Arena · Denver, CO |
| 18 | Thu Nov 30 | vs Hawks | L135-137 | 3-15 | .167 | AT&T Center · San Antonio, TX |
| 19 | Fri Dec 1 | at Pelicans | L106-121 | 3-16 | .158 | Smoothie King Center · New Orleans, LA |
| 20 | Wed Dec 6 | atT-wolves | L94-102 | 3-17 | .150 | Target Center · Minneapolis, MN |
| 21 | Fri Dec 8 | vs Bulls | L112-121 | 3-18 | .143 | AT&T Center · San Antonio, TX |
| 22 | Mon Dec 11 | atRockets | L82-93 | 3-19 | .136 | Toyota Center · Houston, TX |
| 23 | Wed Dec 13 | vs Lakers | L119-122 | 3-20 | .130 | AT&T Center · San Antonio, TX |
| 24 | Fri Dec 15 | vsLakers | W129-115 | 4-20 | .167 | AT&T Center · San Antonio, TX |
| 25 | Sun Dec 17 | vsPelicans | L110-146 | 4-21 | .160 | AT&T Center · San Antonio, TX |
| 26 | Tue Dec 19 | at Bucks | L119-132 | 4-22 | .154 | Fiserv Forum · Milwaukee, WI |
| 27 | Thu Dec 21 | atBulls | L95-114 | 4-23 | .148 | United Center · Chicago, IL |
| 28 | Sat Dec 23 | atMavericks | L119-144 | 4-24 | .143 | American Airlines Center · Dallas, TX |
| 29 | Tue Dec 26 | vs Jazz | L118-130 | 4-25 | .138 | AT&T Center · San Antonio, TX |
| 30 | Thu Dec 28 | at Blazers | W118-105 | 5-25 | .167 | Moda Center · Portland, OR |
| 31 | Fri Dec 29 | atBlazers | L128-134 | 5-26 | .161 | Moda Center · Portland, OR |
| 32 | Sun Dec 31 | vs Celtics | L101-134 | 5-27 | .156 | AT&T Center · San Antonio, TX |
| 33 | Tue Jan 2 | atGrizzlies | L98-106 | 5-28 | .152 | FedExForum · Memphis, TN |
| 34 | Thu Jan 4 | vsBucks | L121-125 | 5-29 | .147 | AT&T Center · San Antonio, TX |
| 35 | Sun Jan 7 | at Cavaliers | L115-117 | 5-30 | .143 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 36 | Wed Jan 10 | at Pistons | W130-108 | 6-30 | .167 | Little Caesars Arena · Detroit, MI |
| 37 | Fri Jan 12 | vs Hornets | W135-99 | 7-30 | .189 | AT&T Center · San Antonio, TX |
| 38 | Sat Jan 13 | vsBulls | L116-122 | 7-31 | .184 | AT&T Center · San Antonio, TX |
| 39 | Mon Jan 15 | atHawks | L99-109 | 7-32 | .179 | State Farm Arena · Atlanta, GA |
| 40 | Wed Jan 17 | atCeltics | L98-117 | 7-33 | .175 | TD Garden · Boston, MA |
| 41 | Fri Jan 19 | atHornets | L120-124 | 7-34 | .171 | Spectrum Center · Charlotte, NC |
| 42 | Sat Jan 20 | at Wizards | W131-127 | 8-34 | .190 | Capital One Arena · Washington, D.C. |
| 43 | Mon Jan 22 | at 76ers | L123-133 | 8-35 | .186 | Wells Fargo Center · Philadelphia, PA |
| 44 | Wed Jan 24 | vsThunder | L114-140 | 8-36 | .182 | AT&T Center · San Antonio, TX |
| 45 | Fri Jan 26 | vsBlazers | W116-100 | 9-36 | .200 | AT&T Center · San Antonio, TX |
| 46 | Sat Jan 27 | vsT-wolves | W113-112 | 10-36 | .217 | AT&T Center · San Antonio, TX |
| 47 | Mon Jan 29 | vsWizards | L113-118 | 10-37 | .213 | AT&T Center · San Antonio, TX |
| 48 | Wed Jan 31 | vs Magic | L98-108 | 10-38 | .208 | AT&T Center · San Antonio, TX |
| 49 | Fri Feb 2 | vsPelicans | L113-114 | 10-39 | .204 | AT&T Center · San Antonio, TX |
| 50 | Sat Feb 3 | vsCavaliers | L101-117 | 10-40 | .200 | AT&T Center · San Antonio, TX |
| 51 | Wed Feb 7 | atHeat | L104-116 | 10-41 | .196 | FTX Arena · Miami, FL |
| 52 | Thu Feb 8 | atMagic | L111-127 | 10-42 | .192 | Amway Center · Orlando, FL |
| 53 | Sat Feb 10 | at Nets | L103-123 | 10-43 | .189 | Barclays Center · Brooklyn, NY |
| 54 | Mon Feb 12 | atRaptors | W122-99 | 11-43 | .204 | Scotiabank Arena · Toronto, ON |
| 55 | Wed Feb 14 | atMavericks | L93-116 | 11-44 | .200 | American Airlines Center · Dallas, TX |
| 56 | Thu Feb 22 | atKings | L122-127 | 11-45 | .196 | Golden 1 Center · Sacramento, CA |
| 57 | Fri Feb 23 | atLakers | L118-123 | 11-46 | .193 | Crypto.com Arena · Los Angeles, CA |
| 58 | Sun Feb 25 | atJazz | L109-128 | 11-47 | .190 | Vivint Arena · Salt Lake City, UT |
| 59 | Tue Feb 27 | atT-wolves | L105-114 | 11-48 | .186 | Target Center · Minneapolis, MN |
| 60 | Thu Feb 29 | vsThunder | W132-118 | 12-48 | .200 | AT&T Center · San Antonio, TX |
| 61 | Sun Mar 3 | vsPacers | W117-105 | 13-48 | .213 | AT&T Center · San Antonio, TX |
| 62 | Tue Mar 5 | atRockets | L101-114 | 13-49 | .210 | Toyota Center · Houston, TX |
| 63 | Thu Mar 7 | atKings | L129-131 | 13-50 | .206 | Golden 1 Center · Sacramento, CA |
| 64 | Sat Mar 9 | atWarriors | W126-113 | 14-50 | .219 | Chase Center · San Francisco, CA |
| 65 | Mon Mar 11 | vsWarriors | L102-112 | 14-51 | .215 | AT&T Center · San Antonio, TX |
| 66 | Tue Mar 12 | vsRockets | L101-103 | 14-52 | .212 | AT&T Center · San Antonio, TX |
| 67 | Fri Mar 15 | vsNuggets | L106-117 | 14-53 | .209 | AT&T Center · San Antonio, TX |
| 68 | Sun Mar 17 | vsNets | W122-115 (OT) | 15-53 | .221 | AT&T Center · San Antonio, TX |
| 69 | Tue Mar 19 | vsMavericks | L107-113 | 15-54 | .217 | AT&T Center · San Antonio, TX |
| 70 | Fri Mar 22 | vsGrizzlies | L97-99 | 15-55 | .214 | AT&T Center · San Antonio, TX |
| 71 | Sat Mar 23 | vsSuns | L106-131 | 15-56 | .211 | AT&T Center · San Antonio, TX |
| 72 | Mon Mar 25 | vsSuns | W104-102 | 16-56 | .222 | AT&T Center · San Antonio, TX |
| 73 | Wed Mar 27 | atJazz | W118-111 | 17-56 | .233 | Vivint Arena · Salt Lake City, UT |
| 74 | Fri Mar 29 | vsKnicks | W130-126 (OT) | 18-56 | .243 | AT&T Center · San Antonio, TX |
| 75 | Sun Mar 31 | vsWarriors | L113-117 | 18-57 | .240 | AT&T Center · San Antonio, TX |
| 76 | Tue Apr 2 | atNuggets | L105-110 | 18-58 | .237 | Ball Arena · Denver, CO |
| 77 | Fri Apr 5 | atPelicans | W111-109 | 19-58 | .247 | Smoothie King Center · New Orleans, LA |
| 78 | Sun Apr 7 | vs76ers | L126-133 (2OT) | 19-59 | .244 | AT&T Center · San Antonio, TX |
| 79 | Tue Apr 9 | atGrizzlies | W102-87 | 20-59 | .253 | FedExForum · Memphis, TN |
| 80 | Wed Apr 10 | atThunder | L89-127 | 20-60 | .250 | Paycom Center · Oklahoma City, OK |
| 81 | Fri Apr 12 | vsNuggets | W121-120 | 21-60 | .259 | AT&T Center · San Antonio, TX |
| 82 | Sun Apr 14 | vsPistons | W123-95 | 22-60 | .268 | AT&T Center · San Antonio, TX |
