| 1 | Tue Oct 25 | at Warriors | W129-100 | 1-0 | 1.000 | Chase Center · San Francisco, CA |
| 2 | Thu Oct 27 | at Kings | W102-94 | 2-0 | 1.000 | Golden 1 Center · Sacramento, CA |
| 3 | Sat Oct 29 | vs Pelicans | W98-79 | 3-0 | 1.000 | AT&T Center · San Antonio, TX |
| 4 | Sun Oct 30 | at Heat | W106-99 | 4-0 | 1.000 | FTX Arena · Miami, FL |
| 5 | Tue Nov 1 | vs Jazz | L91-106 | 4-1 | .800 | AT&T Center · San Antonio, TX |
| 6 | Fri Nov 4 | atJazz | W100-86 | 5-1 | .833 | Vivint Arena · Salt Lake City, UT |
| 7 | Sat Nov 5 | vs Clippers | L92-116 | 5-2 | .714 | AT&T Center · San Antonio, TX |
| 8 | Wed Nov 9 | vs Rockets | L99-101 | 5-3 | .625 | AT&T Center · San Antonio, TX |
| 9 | Fri Nov 11 | vs Pistons | W96-86 | 6-3 | .667 | AT&T Center · San Antonio, TX |
| 10 | Sat Nov 12 | atRockets | W106-100 | 7-3 | .700 | Toyota Center · Houston, TX |
| 11 | Mon Nov 14 | vsHeat | W94-90 | 8-3 | .727 | AT&T Center · San Antonio, TX |
| 12 | Wed Nov 16 | atKings | W110-105 | 9-3 | .750 | Golden 1 Center · Sacramento, CA |
| 13 | Fri Nov 18 | at Lakers | W116-107 | 10-3 | .769 | Crypto.com Arena · Los Angeles, CA |
| 14 | Mon Nov 21 | vs Mavericks | W96-91 | 11-3 | .786 | AT&T Center · San Antonio, TX |
| 15 | Wed Nov 23 | at Hornets | W119-114 | 12-3 | .800 | Spectrum Center · Charlotte, NC |
| 16 | Fri Nov 25 | at Celtics | W109-103 | 13-3 | .813 | TD Garden · Boston, MA |
| 17 | Sat Nov 26 | at Wizards | W112-100 | 14-3 | .824 | Capital One Arena · Washington, D.C. |
| 18 | Tue Nov 29 | vs Magic | L83-95 | 14-4 | .778 | AT&T Center · San Antonio, TX |
| 19 | Wed Nov 30 | atMavericks | W94-87 | 15-4 | .789 | American Airlines Center · Dallas, TX |
| 20 | Fri Dec 2 | vsWizards | W107-105 | 16-4 | .800 | AT&T Center · San Antonio, TX |
| 21 | Mon Dec 5 | at Bucks | W97-96 | 17-4 | .810 | Fiserv Forum · Milwaukee, WI |
| 22 | Tue Dec 6 | at T-wolves | W105-91 | 18-4 | .818 | Target Center · Minneapolis, MN |
| 23 | Thu Dec 8 | at Bulls | L91-95 | 18-5 | .783 | United Center · Chicago, IL |
| 24 | Sat Dec 10 | vs Nets | W130-101 | 19-5 | .792 | AT&T Center · San Antonio, TX |
| 25 | Wed Dec 14 | vsCeltics | W108-101 | 20-5 | .800 | AT&T Center · San Antonio, TX |
| 26 | Thu Dec 15 | at Suns | W107-92 | 21-5 | .808 | Footprint Center · Phoenix, AZ |
| 27 | Sun Dec 18 | vsPelicans | W113-100 | 22-5 | .815 | AT&T Center · San Antonio, TX |
| 28 | Tue Dec 20 | atRockets | W102-100 | 23-5 | .821 | Toyota Center · Houston, TX |
| 29 | Thu Dec 22 | atClippers | L101-106 | 23-6 | .793 | Crypto.com Arena · Los Angeles, CA |
| 30 | Fri Dec 23 | at Blazers | W110-90 | 24-6 | .800 | Moda Center · Portland, OR |
| 31 | Sun Dec 25 | vsBulls | W119-100 | 25-6 | .806 | AT&T Center · San Antonio, TX |
| 32 | Wed Dec 28 | vsSuns | W119-98 | 26-6 | .813 | AT&T Center · San Antonio, TX |
| 33 | Fri Dec 30 | vsBlazers | W110-94 | 27-6 | .818 | AT&T Center · San Antonio, TX |
| 34 | Sun Jan 1 | at Hawks | L112-114 (OT) | 27-7 | .794 | State Farm Arena · Atlanta, GA |
| 35 | Tue Jan 3 | vs Raptors | W110-82 | 28-7 | .800 | AT&T Center · San Antonio, TX |
| 36 | Thu Jan 5 | at Nuggets | W127-99 | 29-7 | .806 | Ball Arena · Denver, CO |
| 37 | Sat Jan 7 | vsHornets | W102-85 | 30-7 | .811 | AT&T Center · San Antonio, TX |
| 38 | Tue Jan 10 | vsBucks | L107-109 | 30-8 | .789 | AT&T Center · San Antonio, TX |
| 39 | Thu Jan 12 | vsLakers | W134-94 | 31-8 | .795 | AT&T Center · San Antonio, TX |
| 40 | Sat Jan 14 | atSuns | L105-108 | 31-9 | .775 | Footprint Center · Phoenix, AZ |
| 41 | Tue Jan 17 | vsT-wolves | W122-114 | 32-9 | .780 | AT&T Center · San Antonio, TX |
| 42 | Thu Jan 19 | vsNuggets | W118-104 | 33-9 | .786 | AT&T Center · San Antonio, TX |
| 43 | Sat Jan 21 | at Cavaliers | W118-115 (OT) | 34-9 | .791 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 44 | Mon Jan 23 | atNets | W112-86 | 35-9 | .795 | Barclays Center · Brooklyn, NY |
| 45 | Tue Jan 24 | atRaptors | W108-106 | 36-9 | .800 | Scotiabank Arena · Toronto, ON |
| 46 | Fri Jan 27 | atPelicans | L103-119 | 36-10 | .783 | Smoothie King Center · New Orleans, LA |
| 47 | Sun Jan 29 | vsMavericks | L101-105 | 36-11 | .766 | AT&T Center · San Antonio, TX |
| 48 | Tue Jan 31 | vs Thunder | W108-94 | 37-11 | .771 | AT&T Center · San Antonio, TX |
| 49 | Thu Feb 2 | vs 76ers | W102-86 | 38-11 | .776 | AT&T Center · San Antonio, TX |
| 50 | Sat Feb 4 | vsNuggets | W121-97 | 39-11 | .780 | AT&T Center · San Antonio, TX |
| 51 | Mon Feb 6 | at Grizzlies | L74-89 | 39-12 | .765 | FedExForum · Memphis, TN |
| 52 | Wed Feb 8 | at76ers | W111-103 | 40-12 | .769 | Wells Fargo Center · Philadelphia, PA |
| 53 | Fri Feb 10 | atPistons | W103-92 | 41-12 | .774 | Little Caesars Arena · Detroit, MI |
| 54 | Sun Feb 12 | at Knicks | L90-94 | 41-13 | .759 | Madison Square Garden · Manhattan, NY |
| 55 | Mon Feb 13 | at Pacers | W110-106 | 42-13 | .764 | Gainbridge Fieldhouse · Indianapolis, IN |
| 56 | Wed Feb 15 | atMagic | W107-79 | 43-13 | .768 | Amway Center · Orlando, FL |
| 57 | Fri Feb 24 | atClippers | W105-97 | 44-13 | .772 | Crypto.com Arena · Los Angeles, CA |
| 58 | Sun Feb 26 | atLakers | W119-98 | 45-13 | .776 | Crypto.com Arena · Los Angeles, CA |
| 59 | Wed Mar 1 | vsPacers | W100-99 | 46-13 | .780 | AT&T Center · San Antonio, TX |
| 60 | Fri Mar 3 | atPelicans | W101-98 (OT) | 47-13 | .783 | Smoothie King Center · New Orleans, LA |
| 61 | Sat Mar 4 | vsT-wolves | W97-90 (OT) | 48-13 | .787 | AT&T Center · San Antonio, TX |
| 62 | Mon Mar 6 | vsRockets | W112-110 | 49-13 | .790 | AT&T Center · San Antonio, TX |
| 63 | Wed Mar 8 | vsKings | W114-104 | 50-13 | .794 | AT&T Center · San Antonio, TX |
| 64 | Thu Mar 9 | atThunder | L92-102 | 50-14 | .781 | Paycom Center · Oklahoma City, OK |
| 65 | Sat Mar 11 | vsWarriors | W107-85 | 51-14 | .785 | AT&T Center · San Antonio, TX |
| 66 | Mon Mar 13 | vsHawks | W107-99 | 52-14 | .788 | AT&T Center · San Antonio, TX |
| 67 | Wed Mar 15 | vsBlazers | L106-110 | 52-15 | .776 | AT&T Center · San Antonio, TX |
| 68 | Sat Mar 18 | atGrizzlies | L96-104 | 52-16 | .765 | FedExForum · Memphis, TN |
| 69 | Sun Mar 19 | vsKings | W118-102 | 53-16 | .768 | AT&T Center · San Antonio, TX |
| 70 | Tue Mar 21 | atT-wolves | W100-93 | 54-16 | .771 | Target Center · Minneapolis, MN |
| 71 | Thu Mar 23 | vsGrizzlies | W97-90 | 55-16 | .775 | AT&T Center · San Antonio, TX |
| 72 | Sat Mar 25 | vsKnicks | W106-98 | 56-16 | .778 | AT&T Center · San Antonio, TX |
| 73 | Mon Mar 27 | vsCavaliers | W103-74 | 57-16 | .781 | AT&T Center · San Antonio, TX |
| 74 | Wed Mar 29 | vsWarriors | L98-110 | 57-17 | .770 | AT&T Center · San Antonio, TX |
| 75 | Fri Mar 31 | atThunder | W100-95 | 58-17 | .773 | Paycom Center · Oklahoma City, OK |
| 76 | Sun Apr 2 | vsJazz | W109-103 | 59-17 | .776 | AT&T Center · San Antonio, TX |
| 77 | Tue Apr 4 | vsGrizzlies | W95-89 (OT) | 60-17 | .779 | AT&T Center · San Antonio, TX |
| 78 | Wed Apr 5 | vsLakers | L95-102 | 60-18 | .769 | AT&T Center · San Antonio, TX |
| 79 | Fri Apr 7 | atMavericks | W102-89 | 61-18 | .772 | American Airlines Center · Dallas, TX |
| 80 | Sat Apr 8 | vsClippers | L87-98 | 61-19 | .762 | AT&T Center · San Antonio, TX |
| 81 | Mon Apr 10 | atBlazers | L98-99 | 61-20 | .753 | Moda Center · Portland, OR |
| 82 | Wed Apr 12 | atJazz | L97-101 | 61-21 | .744 | Vivint Arena · Salt Lake City, UT |
| 1 | Sat Apr 15 | vsGrizzlies | W111-82 | 1-0 | 1.000 | AT&T Center · San Antonio, TX |
| 2 | Mon Apr 17 | vsGrizzlies | W96-82 | 2-0 | 1.000 | AT&T Center · San Antonio, TX |
| 3 | Thu Apr 20 | atGrizzlies | L94-105 | 2-1 | .667 | FedExForum · Memphis, TN |
| 4 | Sat Apr 22 | atGrizzlies | L108-110 (OT) | 2-2 | .500 | FedExForum · Memphis, TN |
| 5 | Tue Apr 25 | vsGrizzlies | W116-103 | 3-2 | .600 | AT&T Center · San Antonio, TX |
| 6 | Thu Apr 27 | atGrizzlies | W103-96 | 4-2 | .667 | FedExForum · Memphis, TN |
| 1 | Mon May 1 | vsRockets | L99-126 | 0-1 | .000 | AT&T Center · San Antonio, TX |
| 2 | Wed May 3 | vsRockets | W121-96 | 1-1 | .500 | AT&T Center · San Antonio, TX |
| 3 | Fri May 5 | atRockets | W103-92 | 2-1 | .667 | Toyota Center · Houston, TX |
| 4 | Sun May 7 | atRockets | L104-125 | 2-2 | .500 | Toyota Center · Houston, TX |
| 5 | Tue May 9 | vsRockets | W110-107 (OT) | 3-2 | .600 | AT&T Center · San Antonio, TX |
| 6 | Thu May 11 | atRockets | W114-75 | 4-2 | .667 | Toyota Center · Houston, TX |
| 1 | Sun May 14 | atWarriors | L111-113 | 0-1 | .000 | Chase Center · San Francisco, CA |
| 2 | Tue May 16 | atWarriors | L100-136 | 0-2 | .000 | Chase Center · San Francisco, CA |
| 3 | Sat May 20 | vsWarriors | L108-120 | 0-3 | .000 | AT&T Center · San Antonio, TX |
| 4 | Mon May 22 | vsWarriors | L115-129 | 0-4 | .000 | AT&T Center · San Antonio, TX |
