| 1 | Wed Oct 23 | vs Knicks | W120-111 | 1-0 | 1.000 | AT&T Center · San Antonio, TX |
| 2 | Sat Oct 26 | vs Wizards | W124-122 | 2-0 | 1.000 | AT&T Center · San Antonio, TX |
| 3 | Mon Oct 28 | vs Blazers | W113-110 | 3-0 | 1.000 | AT&T Center · San Antonio, TX |
| 4 | Thu Oct 31 | at Clippers | L97-103 | 3-1 | .750 | Crypto.com Arena · Los Angeles, CA |
| 5 | Fri Nov 1 | at Warriors | W127-110 | 4-1 | .800 | Chase Center · San Francisco, CA |
| 6 | Sun Nov 3 | vs Lakers | L96-103 | 4-2 | .667 | AT&T Center · San Antonio, TX |
| 7 | Tue Nov 5 | at Hawks | L100-108 | 4-3 | .571 | State Farm Arena · Atlanta, GA |
| 8 | Thu Nov 7 | vs Thunder | W121-112 | 5-3 | .625 | AT&T Center · San Antonio, TX |
| 9 | Sat Nov 9 | vs Celtics | L115-135 | 5-4 | .556 | AT&T Center · San Antonio, TX |
| 10 | Mon Nov 11 | vs Grizzlies | L109-113 | 5-5 | .500 | AT&T Center · San Antonio, TX |
| 11 | Wed Nov 13 | at T-wolves | L114-129 | 5-6 | .455 | Target Center · Minneapolis, MN |
| 12 | Fri Nov 15 | at Magic | L109-111 | 5-7 | .417 | Amway Center · Orlando, FL |
| 13 | Sat Nov 16 | vsBlazers | L116-121 | 5-8 | .385 | AT&T Center · San Antonio, TX |
| 14 | Mon Nov 18 | at Mavericks | L110-117 | 5-9 | .357 | American Airlines Center · Dallas, TX |
| 15 | Wed Nov 20 | atWizards | L132-138 | 5-10 | .333 | Capital One Arena · Washington, D.C. |
| 16 | Fri Nov 22 | at 76ers | L104-115 | 5-11 | .313 | Wells Fargo Center · Philadelphia, PA |
| 17 | Sat Nov 23 | atKnicks | W111-104 | 6-11 | .353 | Madison Square Garden · Manhattan, NY |
| 18 | Mon Nov 25 | vsLakers | L104-114 | 6-12 | .333 | AT&T Center · San Antonio, TX |
| 19 | Wed Nov 27 | vsT-wolves | L101-113 | 6-13 | .316 | AT&T Center · San Antonio, TX |
| 20 | Fri Nov 29 | vsClippers | W107-97 | 7-13 | .350 | AT&T Center · San Antonio, TX |
| 21 | Sun Dec 1 | at Pistons | L98-132 | 7-14 | .333 | Little Caesars Arena · Detroit, MI |
| 22 | Tue Dec 3 | vs Rockets | W135-133 (2OT) | 8-14 | .364 | AT&T Center · San Antonio, TX |
| 23 | Fri Dec 6 | vs Kings | W105-104 (OT) | 9-14 | .391 | AT&T Center · San Antonio, TX |
| 24 | Thu Dec 12 | vs Cavaliers | L109-117 (OT) | 9-15 | .375 | AT&T Center · San Antonio, TX |
| 25 | Sat Dec 14 | at Suns | W121-119 (OT) | 10-15 | .400 | Footprint Center · Phoenix, AZ |
| 26 | Mon Dec 16 | atRockets | L107-109 | 10-16 | .385 | Toyota Center · Houston, TX |
| 27 | Thu Dec 19 | vs Nets | W118-105 | 11-16 | .407 | AT&T Center · San Antonio, TX |
| 28 | Sat Dec 21 | vsClippers | L109-134 | 11-17 | .393 | AT&T Center · San Antonio, TX |
| 29 | Mon Dec 23 | atGrizzlies | W145-115 | 12-17 | .414 | FedExForum · Memphis, TN |
| 30 | Thu Dec 26 | atMavericks | L98-102 | 12-18 | .400 | American Airlines Center · Dallas, TX |
| 31 | Sat Dec 28 | vsPistons | W136-109 | 13-18 | .419 | AT&T Center · San Antonio, TX |
| 32 | Tue Dec 31 | vsWarriors | W117-113 (OT) | 14-18 | .438 | AT&T Center · San Antonio, TX |
| 33 | Thu Jan 2 | vsThunder | L103-109 | 14-19 | .424 | AT&T Center · San Antonio, TX |
| 34 | Sat Jan 4 | at Bucks | L118-127 | 14-20 | .412 | Fiserv Forum · Milwaukee, WI |
| 35 | Mon Jan 6 | vsBucks | W126-104 | 15-20 | .429 | AT&T Center · San Antonio, TX |
| 36 | Wed Jan 8 | atCeltics | W129-114 | 16-20 | .444 | TD Garden · Boston, MA |
| 37 | Fri Jan 10 | atGrizzlies | L121-134 | 16-21 | .432 | FedExForum · Memphis, TN |
| 38 | Sun Jan 12 | at Raptors | W105-104 | 17-21 | .447 | Scotiabank Arena · Toronto, ON |
| 39 | Wed Jan 15 | at Heat | L100-106 | 17-22 | .436 | FTX Arena · Miami, FL |
| 40 | Fri Jan 17 | vsHawks | L120-121 | 17-23 | .425 | AT&T Center · San Antonio, TX |
| 41 | Sun Jan 19 | vsHeat | W107-102 | 18-23 | .439 | AT&T Center · San Antonio, TX |
| 42 | Mon Jan 20 | atSuns | W120-118 | 19-23 | .452 | Footprint Center · Phoenix, AZ |
| 43 | Wed Jan 22 | at Pelicans | W121-117 | 20-23 | .465 | Smoothie King Center · New Orleans, LA |
| 44 | Fri Jan 24 | vsSuns | L99-103 | 20-24 | .455 | AT&T Center · San Antonio, TX |
| 45 | Sun Jan 26 | vsRaptors | L106-110 | 20-25 | .444 | AT&T Center · San Antonio, TX |
| 46 | Mon Jan 27 | at Bulls | L109-110 | 20-26 | .435 | United Center · Chicago, IL |
| 47 | Wed Jan 29 | vs Jazz | W127-120 | 21-26 | .447 | AT&T Center · San Antonio, TX |
| 48 | Sat Feb 1 | vs Hornets | W114-90 | 22-26 | .458 | AT&T Center · San Antonio, TX |
| 49 | Mon Feb 3 | atClippers | L105-108 | 22-27 | .449 | Crypto.com Arena · Los Angeles, CA |
| 50 | Tue Feb 4 | atLakers | L102-129 | 22-28 | .440 | Crypto.com Arena · Los Angeles, CA |
| 51 | Thu Feb 6 | atBlazers | L117-125 | 22-29 | .431 | Moda Center · Portland, OR |
| 52 | Sat Feb 8 | atKings | L102-122 | 22-30 | .423 | Golden 1 Center · Sacramento, CA |
| 53 | Mon Feb 10 | at Nuggets | L120-127 | 22-31 | .415 | Ball Arena · Denver, CO |
| 54 | Tue Feb 11 | atThunder | W114-106 | 23-31 | .426 | Paycom Center · Oklahoma City, OK |
| 55 | Fri Feb 21 | atJazz | W113-104 | 24-31 | .436 | Vivint Arena · Salt Lake City, UT |
| 56 | Sun Feb 23 | atThunder | L103-131 | 24-32 | .429 | Paycom Center · Oklahoma City, OK |
| 57 | Wed Feb 26 | vsMavericks | L103-109 | 24-33 | .421 | AT&T Center · San Antonio, TX |
| 58 | Sat Feb 29 | vsMagic | W114-113 | 25-33 | .431 | AT&T Center · San Antonio, TX |
| 59 | Mon Mar 2 | vs Pacers | L111-116 | 25-34 | .424 | AT&T Center · San Antonio, TX |
| 60 | Tue Mar 3 | atHornets | W104-103 | 26-34 | .433 | Spectrum Center · Charlotte, NC |
| 61 | Fri Mar 6 | atNets | L120-139 | 26-35 | .426 | Barclays Center · Brooklyn, NY |
| 62 | Sun Mar 8 | atCavaliers | L129-132 (OT) | 26-36 | .419 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 63 | Tue Mar 10 | vsMavericks | W119-109 | 27-36 | .429 | AT&T Center · San Antonio, TX |
| 64 | Fri Jul 31 | vsKings | W129-120 | 28-36 | .438 | AT&T Center · San Antonio, TX |
| 65 | Sun Aug 2 | atGrizzlies | W108-106 | 29-36 | .446 | FedExForum · Memphis, TN |
| 66 | Mon Aug 3 | at76ers | L130-132 | 29-37 | .439 | Wells Fargo Center · Philadelphia, PA |
| 67 | Wed Aug 5 | vsNuggets | L126-132 | 29-38 | .433 | AT&T Center · San Antonio, TX |
| 68 | Fri Aug 7 | vsJazz | W119-111 | 30-38 | .441 | AT&T Center · San Antonio, TX |
| 69 | Sun Aug 9 | atPelicans | W122-113 | 31-38 | .449 | Smoothie King Center · New Orleans, LA |
| 70 | Tue Aug 11 | vsRockets | W123-105 | 32-38 | .457 | AT&T Center · San Antonio, TX |
| 71 | Thu Aug 13 | atJazz | L112-118 | 32-39 | .451 | Vivint Arena · Salt Lake City, UT |
