| 1 | Wed Oct 20 | vs Magic | W123-97 | 1-0 | 1.000 | AT&T Center · San Antonio, TX |
| 2 | Fri Oct 22 | at Nuggets | L96-102 | 1-1 | .500 | Ball Arena · Denver, CO |
| 3 | Sat Oct 23 | vs Bucks | L111-121 | 1-2 | .333 | AT&T Center · San Antonio, TX |
| 4 | Tue Oct 26 | vs Lakers | L121-125 (OT) | 1-3 | .250 | AT&T Center · San Antonio, TX |
| 5 | Thu Oct 28 | at Mavericks | L99-104 | 1-4 | .200 | American Airlines Center · Dallas, TX |
| 6 | Sat Oct 30 | atBucks | W102-93 | 2-4 | .333 | Fiserv Forum · Milwaukee, WI |
| 7 | Mon Nov 1 | at Pacers | L118-131 | 2-5 | .286 | Gainbridge Fieldhouse · Indianapolis, IN |
| 8 | Wed Nov 3 | vsMavericks | L108-109 | 2-6 | .250 | AT&T Center · San Antonio, TX |
| 9 | Fri Nov 5 | atMagic | W102-89 | 3-6 | .333 | Amway Center · Orlando, FL |
| 10 | Sun Nov 7 | at Thunder | L94-99 | 3-7 | .300 | Paycom Center · Oklahoma City, OK |
| 11 | Wed Nov 10 | vs Kings | W136-117 | 4-7 | .364 | AT&T Center · San Antonio, TX |
| 12 | Fri Nov 12 | vsMavericks | L109-123 | 4-8 | .333 | AT&T Center · San Antonio, TX |
| 13 | Sun Nov 14 | atLakers | L106-114 | 4-9 | .308 | Crypto.com Arena · Los Angeles, CA |
| 14 | Tue Nov 16 | at Clippers | L92-106 | 4-10 | .286 | Crypto.com Arena · Los Angeles, CA |
| 15 | Thu Nov 18 | at T-wolves | L90-115 | 4-11 | .267 | Target Center · Minneapolis, MN |
| 16 | Mon Nov 22 | vs Suns | L111-115 | 4-12 | .250 | AT&T Center · San Antonio, TX |
| 17 | Wed Nov 24 | vs Hawks | L106-124 | 4-13 | .235 | AT&T Center · San Antonio, TX |
| 18 | Fri Nov 26 | vs Celtics | W96-88 | 5-13 | .278 | AT&T Center · San Antonio, TX |
| 19 | Mon Nov 29 | vs Wizards | W116-99 | 6-13 | .316 | AT&T Center · San Antonio, TX |
| 20 | Thu Dec 2 | at Blazers | W114-83 | 7-13 | .350 | Moda Center · Portland, OR |
| 21 | Sat Dec 4 | at Warriors | W112-107 | 8-13 | .381 | Chase Center · San Francisco, CA |
| 22 | Mon Dec 6 | atSuns | L104-108 | 8-14 | .364 | Footprint Center · Phoenix, AZ |
| 23 | Tue Dec 7 | vs Knicks | L109-121 | 8-15 | .348 | AT&T Center · San Antonio, TX |
| 24 | Thu Dec 9 | vsNuggets | W123-111 | 9-15 | .375 | AT&T Center · San Antonio, TX |
| 25 | Sat Dec 11 | vsNuggets | L112-127 | 9-16 | .360 | AT&T Center · San Antonio, TX |
| 26 | Sun Dec 12 | vs Pelicans | W112-97 | 10-16 | .385 | AT&T Center · San Antonio, TX |
| 27 | Wed Dec 15 | vs Hornets | L115-131 | 10-17 | .370 | AT&T Center · San Antonio, TX |
| 28 | Fri Dec 17 | at Jazz | W128-126 | 11-17 | .393 | Vivint Arena · Salt Lake City, UT |
| 29 | Sun Dec 19 | atKings | L114-121 | 11-18 | .379 | Golden 1 Center · Sacramento, CA |
| 30 | Mon Dec 20 | atClippers | W116-92 | 12-18 | .400 | Crypto.com Arena · Los Angeles, CA |
| 31 | Thu Dec 23 | atLakers | W138-110 | 13-18 | .419 | Crypto.com Arena · Los Angeles, CA |
| 32 | Sun Dec 26 | vs Pistons | W144-109 | 14-18 | .438 | AT&T Center · San Antonio, TX |
| 33 | Mon Dec 27 | vsJazz | L104-110 | 14-19 | .424 | AT&T Center · San Antonio, TX |
| 34 | Fri Dec 31 | at Grizzlies | L105-118 | 14-20 | .412 | FedExForum · Memphis, TN |
| 35 | Sat Jan 1 | atPistons | L116-117 (OT) | 14-21 | .400 | Little Caesars Arena · Detroit, MI |
| 36 | Tue Jan 4 | at Raptors | L104-129 | 14-22 | .389 | Scotiabank Arena · Toronto, ON |
| 37 | Wed Jan 5 | atCeltics | W99-97 | 15-22 | .405 | TD Garden · Boston, MA |
| 38 | Fri Jan 7 | at 76ers | L100-119 | 15-23 | .395 | Wells Fargo Center · Philadelphia, PA |
| 39 | Sun Jan 9 | at Nets | L119-121 (OT) | 15-24 | .385 | Barclays Center · Brooklyn, NY |
| 40 | Mon Jan 10 | atKnicks | L96-111 | 15-25 | .375 | Madison Square Garden · Manhattan, NY |
| 41 | Wed Jan 12 | vs Rockets | L124-128 | 15-26 | .366 | AT&T Center · San Antonio, TX |
| 42 | Fri Jan 14 | vs Cavaliers | L109-114 | 15-27 | .357 | AT&T Center · San Antonio, TX |
| 43 | Sat Jan 15 | vsClippers | W101-94 | 16-27 | .372 | AT&T Center · San Antonio, TX |
| 44 | Mon Jan 17 | vsSuns | L107-121 | 16-28 | .364 | AT&T Center · San Antonio, TX |
| 45 | Wed Jan 19 | vsThunder | W118-96 | 17-28 | .378 | AT&T Center · San Antonio, TX |
| 46 | Fri Jan 21 | vsNets | L102-117 | 17-29 | .370 | AT&T Center · San Antonio, TX |
| 47 | Sun Jan 23 | vs76ers | L109-115 | 17-30 | .362 | AT&T Center · San Antonio, TX |
| 48 | Tue Jan 25 | atRockets | W134-104 | 18-30 | .375 | Toyota Center · Houston, TX |
| 49 | Wed Jan 26 | vsGrizzlies | L110-118 | 18-31 | .367 | AT&T Center · San Antonio, TX |
| 50 | Fri Jan 28 | vs Bulls | W131-122 | 19-31 | .380 | AT&T Center · San Antonio, TX |
| 51 | Sun Jan 30 | atSuns | L110-115 | 19-32 | .373 | Footprint Center · Phoenix, AZ |
| 52 | Tue Feb 1 | vsWarriors | L120-124 | 19-33 | .365 | AT&T Center · San Antonio, TX |
| 53 | Thu Feb 3 | vs Heat | L95-112 | 19-34 | .358 | AT&T Center · San Antonio, TX |
| 54 | Fri Feb 4 | vsRockets | W131-106 | 20-34 | .370 | AT&T Center · San Antonio, TX |
| 55 | Wed Feb 9 | atCavaliers | L92-105 | 20-35 | .364 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 56 | Fri Feb 11 | atHawks | W136-121 | 21-35 | .375 | State Farm Arena · Atlanta, GA |
| 57 | Sat Feb 12 | atPelicans | W124-114 | 22-35 | .386 | Smoothie King Center · New Orleans, LA |
| 58 | Mon Feb 14 | atBulls | L109-120 | 22-36 | .379 | United Center · Chicago, IL |
| 59 | Wed Feb 16 | atThunder | W114-106 | 23-36 | .390 | Paycom Center · Oklahoma City, OK |
| 60 | Fri Feb 25 | atWizards | W157-153 (2OT) | 24-36 | .400 | Capital One Arena · Washington, D.C. |
| 61 | Sat Feb 26 | atHeat | L129-133 | 24-37 | .393 | FTX Arena · Miami, FL |
| 62 | Mon Feb 28 | atGrizzlies | L105-118 | 24-38 | .387 | FedExForum · Memphis, TN |
| 63 | Thu Mar 3 | vsKings | L112-115 | 24-39 | .381 | AT&T Center · San Antonio, TX |
| 64 | Sat Mar 5 | atHornets | L117-123 | 24-40 | .375 | Spectrum Center · Charlotte, NC |
| 65 | Mon Mar 7 | vsLakers | W117-110 | 25-40 | .385 | AT&T Center · San Antonio, TX |
| 66 | Wed Mar 9 | vsRaptors | L104-119 | 25-41 | .379 | AT&T Center · San Antonio, TX |
| 67 | Fri Mar 11 | vsJazz | W104-102 | 26-41 | .388 | AT&T Center · San Antonio, TX |
| 68 | Sat Mar 12 | vsPacers | L108-119 | 26-42 | .382 | AT&T Center · San Antonio, TX |
| 69 | Mon Mar 14 | vsT-wolves | L139-149 | 26-43 | .377 | AT&T Center · San Antonio, TX |
| 70 | Wed Mar 16 | vsThunder | W122-120 | 27-43 | .386 | AT&T Center · San Antonio, TX |
| 71 | Fri Mar 18 | vsPelicans | L91-124 | 27-44 | .380 | AT&T Center · San Antonio, TX |
| 72 | Sun Mar 20 | atWarriors | W110-108 | 28-44 | .389 | Chase Center · San Francisco, CA |
| 73 | Wed Mar 23 | atBlazers | W133-96 | 29-44 | .397 | Moda Center · Portland, OR |
| 74 | Sat Mar 26 | atPelicans | W107-103 | 30-44 | .405 | Smoothie King Center · New Orleans, LA |
| 75 | Mon Mar 28 | atRockets | W123-120 | 31-44 | .413 | Toyota Center · Houston, TX |
| 76 | Wed Mar 30 | vsGrizzlies | L111-112 | 31-45 | .408 | AT&T Center · San Antonio, TX |
| 77 | Fri Apr 1 | vsBlazers | W130-111 | 32-45 | .416 | AT&T Center · San Antonio, TX |
| 78 | Sun Apr 3 | vsBlazers | W113-92 | 33-45 | .423 | AT&T Center · San Antonio, TX |
| 79 | Tue Apr 5 | atNuggets | W116-97 | 34-45 | .430 | Ball Arena · Denver, CO |
| 80 | Thu Apr 7 | atT-wolves | L121-127 | 34-46 | .425 | Target Center · Minneapolis, MN |
| 81 | Sat Apr 9 | vsWarriors | L94-100 | 34-47 | .420 | AT&T Center · San Antonio, TX |
| 82 | Sun Apr 10 | atMavericks | L120-130 | 34-48 | .415 | American Airlines Center · Dallas, TX |
| 0 | Wed Apr 13 | atPelicans | L103-113 | 0-1 | .000 | Smoothie King Center · New Orleans, LA |
