| 1 | Wed Oct 19 | vs Hornets | L102-129 | 0-1 | .000 | AT&T Center · San Antonio, TX |
| 2 | Fri Oct 21 | at Pacers | W137-134 | 1-1 | .500 | Gainbridge Fieldhouse · Indianapolis, IN |
| 3 | Sat Oct 22 | at 76ers | W114-105 | 2-1 | .667 | Wells Fargo Center · Philadelphia, PA |
| 4 | Mon Oct 24 | at T-wolves | W115-106 | 3-1 | .750 | Target Center · Minneapolis, MN |
| 5 | Wed Oct 26 | atT-wolves | L122-134 | 3-2 | .600 | Target Center · Minneapolis, MN |
| 6 | Fri Oct 28 | vs Bulls | W129-124 | 4-2 | .667 | AT&T Center · San Antonio, TX |
| 7 | Sun Oct 30 | vsT-wolves | W107-98 | 5-2 | .714 | AT&T Center · San Antonio, TX |
| 8 | Wed Nov 2 | vs Raptors | L100-143 | 5-3 | .625 | AT&T Center · San Antonio, TX |
| 9 | Fri Nov 4 | vs Clippers | L106-113 | 5-4 | .556 | AT&T Center · San Antonio, TX |
| 10 | Sat Nov 5 | at Nuggets | L101-126 | 5-5 | .500 | Ball Arena · Denver, CO |
| 11 | Mon Nov 7 | vsNuggets | L109-115 | 5-6 | .455 | AT&T Center · San Antonio, TX |
| 12 | Wed Nov 9 | vs Grizzlies | L122-124 (OT) | 5-7 | .417 | AT&T Center · San Antonio, TX |
| 13 | Fri Nov 11 | vs Bucks | W111-93 | 6-7 | .462 | AT&T Center · San Antonio, TX |
| 14 | Mon Nov 14 | at Warriors | L95-132 | 6-8 | .429 | Chase Center · San Francisco, CA |
| 15 | Tue Nov 15 | at Blazers | L110-117 | 6-9 | .400 | Moda Center · Portland, OR |
| 16 | Thu Nov 17 | at Kings | L112-130 | 6-10 | .375 | Golden 1 Center · Sacramento, CA |
| 17 | Sat Nov 19 | atClippers | L97-119 | 6-11 | .353 | Crypto.com Arena · Los Angeles, CA |
| 18 | Sun Nov 20 | at Lakers | L92-123 | 6-12 | .333 | Crypto.com Arena · Los Angeles, CA |
| 19 | Wed Nov 23 | vs Pelicans | L110-129 | 6-13 | .316 | AT&T Center · San Antonio, TX |
| 20 | Fri Nov 25 | vsLakers | L94-105 | 6-14 | .300 | AT&T Center · San Antonio, TX |
| 21 | Sat Nov 26 | vsLakers | L138-143 | 6-15 | .286 | AT&T Center · San Antonio, TX |
| 22 | Wed Nov 30 | at Thunder | L111-119 | 6-16 | .273 | Paycom Center · Oklahoma City, OK |
| 23 | Fri Dec 2 | vsPelicans | L99-117 | 6-17 | .261 | AT&T Center · San Antonio, TX |
| 24 | Sun Dec 4 | vs Suns | L95-133 | 6-18 | .250 | AT&T Center · San Antonio, TX |
| 25 | Thu Dec 8 | vs Rockets | W118-109 | 7-18 | .280 | AT&T Center · San Antonio, TX |
| 26 | Sat Dec 10 | at Heat | W115-111 | 8-18 | .308 | FTX Arena · Miami, FL |
| 27 | Mon Dec 12 | vs Cavaliers | W112-111 | 9-18 | .333 | AT&T Center · San Antonio, TX |
| 28 | Wed Dec 14 | vsBlazers | L112-128 | 9-19 | .321 | AT&T Center · San Antonio, TX |
| 29 | Sat Dec 17 | vsHeat | L101-111 | 9-20 | .310 | AT&T Center · San Antonio, TX |
| 30 | Mon Dec 19 | atRockets | W124-105 | 10-20 | .333 | Toyota Center · Houston, TX |
| 31 | Thu Dec 22 | atPelicans | L117-126 | 10-21 | .323 | Smoothie King Center · New Orleans, LA |
| 32 | Fri Dec 23 | at Magic | L113-133 | 10-22 | .313 | Amway Center · Orlando, FL |
| 33 | Mon Dec 26 | vs Jazz | W126-122 | 11-22 | .333 | AT&T Center · San Antonio, TX |
| 34 | Tue Dec 27 | atThunder | L114-130 | 11-23 | .324 | Paycom Center · Oklahoma City, OK |
| 35 | Thu Dec 29 | vs Knicks | W122-115 | 12-23 | .343 | AT&T Center · San Antonio, TX |
| 36 | Sat Dec 31 | vs Mavericks | L125-126 | 12-24 | .333 | AT&T Center · San Antonio, TX |
| 37 | Mon Jan 2 | at Nets | L103-139 | 12-25 | .324 | Barclays Center · Brooklyn, NY |
| 38 | Wed Jan 4 | atKnicks | L114-117 | 12-26 | .316 | Madison Square Garden · Manhattan, NY |
| 39 | Fri Jan 6 | vs Pistons | W121-109 | 13-26 | .333 | AT&T Center · San Antonio, TX |
| 40 | Sat Jan 7 | vs Celtics | L116-121 | 13-27 | .325 | AT&T Center · San Antonio, TX |
| 41 | Mon Jan 9 | atGrizzlies | L113-121 | 13-28 | .317 | FedExForum · Memphis, TN |
| 42 | Wed Jan 11 | atGrizzlies | L129-135 | 13-29 | .310 | FedExForum · Memphis, TN |
| 43 | Fri Jan 13 | vsWarriors | L113-144 | 13-30 | .302 | AT&T Center · San Antonio, TX |
| 44 | Sun Jan 15 | vsKings | L119-132 | 13-31 | .295 | AT&T Center · San Antonio, TX |
| 45 | Tue Jan 17 | vsNets | W106-98 | 14-31 | .311 | AT&T Center · San Antonio, TX |
| 46 | Fri Jan 20 | vsClippers | L126-131 | 14-32 | .304 | AT&T Center · San Antonio, TX |
| 47 | Mon Jan 23 | atBlazers | L127-147 | 14-33 | .298 | Moda Center · Portland, OR |
| 48 | Wed Jan 25 | atLakers | L104-113 | 14-34 | .292 | Crypto.com Arena · Los Angeles, CA |
| 49 | Thu Jan 26 | atClippers | L100-138 | 14-35 | .286 | Crypto.com Arena · Los Angeles, CA |
| 50 | Sat Jan 28 | vsSuns | L118-128 (OT) | 14-36 | .280 | AT&T Center · San Antonio, TX |
| 51 | Mon Jan 30 | vs Wizards | L106-127 | 14-37 | .275 | AT&T Center · San Antonio, TX |
| 52 | Wed Feb 1 | vsKings | L109-119 | 14-38 | .269 | AT&T Center · San Antonio, TX |
| 53 | Fri Feb 3 | vs76ers | L125-137 | 14-39 | .264 | AT&T Center · San Antonio, TX |
| 54 | Mon Feb 6 | atBulls | L104-128 | 14-40 | .259 | United Center · Chicago, IL |
| 55 | Wed Feb 8 | atRaptors | L98-112 | 14-41 | .255 | Scotiabank Arena · Toronto, ON |
| 56 | Fri Feb 10 | atPistons | L131-138 (2OT) | 14-42 | .250 | Little Caesars Arena · Detroit, MI |
| 57 | Sat Feb 11 | at Hawks | L106-125 | 14-43 | .246 | State Farm Arena · Atlanta, GA |
| 58 | Mon Feb 13 | atCavaliers | L109-117 | 14-44 | .241 | Rocket Mortgage FieldHouse · Cleveland, OH |
| 59 | Wed Feb 15 | atHornets | L110-120 | 14-45 | .237 | Spectrum Center · Charlotte, NC |
| 60 | Thu Feb 23 | atMavericks | L116-142 | 14-46 | .233 | American Airlines Center · Dallas, TX |
| 61 | Sat Feb 25 | atJazz | L102-118 | 14-47 | .230 | Vivint Arena · Salt Lake City, UT |
| 62 | Tue Feb 28 | atJazz | W102-94 | 15-47 | .242 | Vivint Arena · Salt Lake City, UT |
| 63 | Thu Mar 2 | vsPacers | W110-99 | 16-47 | .254 | AT&T Center · San Antonio, TX |
| 64 | Sat Mar 4 | vsRockets | L110-122 | 16-48 | .250 | AT&T Center · San Antonio, TX |
| 65 | Sun Mar 5 | atRockets | L110-142 | 16-49 | .246 | Toyota Center · Houston, TX |
| 66 | Fri Mar 10 | vsNuggets | W128-120 | 17-49 | .258 | AT&T Center · San Antonio, TX |
| 67 | Sun Mar 12 | vsThunder | L90-102 | 17-50 | .254 | AT&T Center · San Antonio, TX |
| 68 | Tue Mar 14 | vsMagic | W132-114 | 18-50 | .265 | AT&T Center · San Antonio, TX |
| 69 | Wed Mar 15 | vsMavericks | L128-137 (OT) | 18-51 | .261 | AT&T Center · San Antonio, TX |
| 70 | Fri Mar 17 | vsGrizzlies | L120-126 (OT) | 18-52 | .257 | AT&T Center · San Antonio, TX |
| 71 | Sun Mar 19 | vsHawks | W126-118 | 19-52 | .268 | AT&T Center · San Antonio, TX |
| 72 | Tue Mar 21 | atPelicans | L84-119 | 19-53 | .264 | Smoothie King Center · New Orleans, LA |
| 73 | Wed Mar 22 | atBucks | L94-130 | 19-54 | .260 | Fiserv Forum · Milwaukee, WI |
| 74 | Fri Mar 24 | atWizards | L124-136 | 19-55 | .257 | Capital One Arena · Washington, D.C. |
| 75 | Sun Mar 26 | atCeltics | L93-137 | 19-56 | .253 | TD Garden · Boston, MA |
| 76 | Wed Mar 29 | vsJazz | L117-128 | 19-57 | .250 | AT&T Center · San Antonio, TX |
| 77 | Fri Mar 31 | atWarriors | L115-130 | 19-58 | .247 | Chase Center · San Francisco, CA |
| 78 | Sun Apr 2 | atKings | W142-134 (OT) | 20-58 | .256 | Golden 1 Center · Sacramento, CA |
| 79 | Tue Apr 4 | atSuns | L94-115 | 20-59 | .253 | Footprint Center · Phoenix, AZ |
| 80 | Thu Apr 6 | vsBlazers | W129-127 | 21-59 | .263 | AT&T Center · San Antonio, TX |
| 81 | Sat Apr 8 | vsT-wolves | L131-151 | 21-60 | .259 | AT&T Center · San Antonio, TX |
| 82 | Sun Apr 9 | atMavericks | W138-117 | 22-60 | .268 | American Airlines Center · Dallas, TX |
